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- A. Physiological basis of sleep
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- A. 1 Neural control of wakefulness and NREM sleepThis section offers an overview on the basic concepts of sleep: how sleep is defined, measured and regulated. While these questions may appear at first glance trivial, they offer a plethora of questions that are under active research and development. The many interview clips offer views from top scientists on their work and thoughts about sleep and sleep research.25
- 2.1A. 1.1 Definition and structure of sleep.8 Minutes
- 2.2A. 1.1.1 Does every cell sleep? Dr. Krueger discusses the question at what organizational level sleep appears.
- 2.3A. 1.1.2 Sleep on a dish! Dr. Tafti discusses the question whether sleep is a global or local phenomenon
- 2.4A. 1.1.3 What is the definition of sleep? Professors Vyazovskiy, Krueger and Tafti discuss this problem – should sleep be defined differently for different functions of sleep?
- 2.5A. 1.1.4 Is Torpor a form of sleep? Dr. de Boer introduces his views and new interpretation of old experiments.
- 2.6A. 1.1.5 Do plants sleep? Dr. Vyazovskiy and Dr. Borbély discuss the possibility that also plants could sleep.
- 2.7Quiz A. 1.1 Definition and structure of sleep15 Minutes10 Questions
- 2.8A. 1.2 Introduction to measurement of sleep.
- 2.9A. 1.2.1 Can we learn more from the EEG signal? Is there more information in the EEG signal that we presently make use of? Dr. Borbély discusses the question.
- 2.10A. 1.2.2 What is the importance of the EEG signal? Dr. De Boer discusses why we need EEG to define sleep.
- 2.11A. 1.2.3 What are spindles? Dr. Vyazovskiy shares his view on this question.
- 2.12A. 1.3 Neurochemistry and anatomy of sleep regulation.
- 2.13A. 1.4 Sleep-wake regulation and the two-process model.
- 2.14A. 1.4.1 Two-process model. Professor Alex Borbély.
- 2.15A. 1.4.2 Molecular correlates of sleep homeostasis. Professor Alex Borbély.
- 2.16A. 1.4.3 Molecular correlates of sleep homeostasis: Adenosine as sleep factor by Prof. Radhika Basheer, Harvard Medical School Basheer.
- 2.17A. 1.4.4 Interaction of the homeostatic and circadian components. Dr. De Boer.
- 2.18A. 1.5 Genetic regulation of sleep.
- 2.19A. 1.5.1 Restless leg syndrome. Professor Birgit Högl discusses the complex etiology of the first sleep-related disease that was associated with identified genes.
- 2.20A. 1.5.2 Thoughts about epigenetics. Professor Emanuel Mignot shares his views on epigenetics in sleep research.
- 2.21A. 1.5.3 Thoughts about epigenetics. Professor Mehdi Tafti shares his views on epigenetics in sleep research.
- 2.22A. 1.5.4 My view on GWAS. Professor Emanuel Mignot discusses the usefulness and problems of GWAS in genetic research of sleep.
- 2.23A. 1.5.5 My view on GWAS. Professor Mehdi Tafti discusses the usefulness and problems of GWAS in genetic research of sleep.
- 2.24A. 1.5.6 Are there sleep genes? Professor Emmanuel Mignot discusses this question.
- 2.25A. 1.5.7 Are there sleep genes? Professor Mehdi Tafti discusses this question.
- A. 2 The Neurobiology of REM sleepREM sleep appears to remain as paradoxical as it was upon its discovery. The profound changes at the level of brain activity as well as their outcomes in the rest of the body have been explored, but the cause for these remarkable changes has remained unknown.3
- A. 3 Adaptation of bodily functions to sleepWhile sleep is often regarded as a phenomenon tightly associated with brain activity, it is evident that the all body function undergo profound modification during sleep, which are different during NREM and REM sleep.4
- A. 4 Theories on the function of sleepWhat is the function of sleep is perhaps the most important question in sleep research. Despite vast amount of research, we still cannot give a final answer, and some researchers suggest that the entire question is not relevant.1
- A. 5 Sleep and psychology (cognitive and emotional processes)Sleep is important for healthy brain function, be it cognitive or emotional. Very recent research has emphasized the role of sleep in neural plasticity, particularly in learning and memory, but also in emotional health.10
- 6.0A. 5.1 Sleep, learning and memory.
- 6.1A. 5.2.1 Sleep and mental health. Professor Anna Wirz-Justice emphasizes the importance of entrained circadian rhythm to health, including mental health.
- 6.2A. 5.2.2 What is insomnia? Professor Eus van Someren discusses the features of insomnia.
- 6.3A. 5.2.3 Types of insomnia. Professor Eus van Someren explains how insomnia can be subtyped and what the clinical relevance of subtyping may be.
- 6.4A. 5.2.4 Psyche and insomnia. Professor Dieter Riemann discusses aspects that promote the development of insomnia.
- 6.5A. 5.2.5 Is insomnia increasing? Professor Dieter Riemann discusses the question whether insomnia or rather awareness of its existence are increasing.
- 6.6A. 5.2.6 Who will develop insomnia? Professor Eus van Someren discusses factors that contribute to development of insomnia.
- 6.7A. 5.2.7 Dreaming of insomnia! Professor Dieter Riemann explains how patients with insomnia feel about their sleep and what could explain it.
- 6.8A. 5.2.8 Coping with insomnia. Professor Van Someren explains present treatment strategies for insomnia and how effective they are.
- 6.9A. 5.2.9 Neurobiology and insomnia. Professor Eus van Someren discusses the question whether insomnia is a neurobiological or behavioral problem.
- A. 6. Effects of acute and chronic sleep deprivationCurtailment of sleep is a common problem in modern societies, be it due to work or social factors. Deprivation of sleep is also a common procedure in sleep research.3
- A. 7.1 Sleep and dreamingIn sleep we dream – disconnected from environment, the brain produces vivid simulations of many waking-time activities.1
- A. 8 Sleep in the course of life span (early development, adolescence, geriatric sleep)Sleep changes throughout the life span, from newborn to old age. Some of the changes are gradual, some more abrupt.1
- A. 9 Gender differences in sleepMen and women do not sleep equally – a realization that is slowly developing.2
- A. 10 Circadian biology/ChronobiologyCircadian component in the two-process model of sleep regulation guides the body to sleep at a proper time. Many sleep problems can be alleviated by restoring a proper circadian rhythm.11
- 11.0A. 10.1 Basics of the circadian rhythms.
- 11.1A. 10.1.1 Professor Debra Skene argues that the effects of light have more components than just the wave-length and gives advice how to minimize the harmful effects of (blue) light.
- 11.2A. 10.1.2 Diurnal vs. circadian rhythms. Professors Cajochen and Skene explain what the difference between these rhythms is, and what practical consequences separating the two will induce.
- 11.3A. 10.1.3 Sleep and circadian rhythms go together. Professor Zee explains why in practical work it is not meaningful to separate the two.
- 11.4A. 10.1.4 Effects of light; melanopsin receptor – Discussion with Cajochen, Gronli and van Dongen.
- 11.5A. 10.1.5 Light therapy – Who benefits from light therapy? Dr. Wirz-Justice answers the question.
- 11.6A. 10.1.6 How to educate health professionals in chronobiology.
- 11.7A. 10.2 Jet lag and shift work.
- 11.8A. 10.2.1 Melatonin. How does melatonin work? Is it safe to use melatonin? Can shift-workers benefit from melatonin administration? Professor Debra Skene discusses these questions.
- 11.9A. 10.2.2 Misalignment in shift work. Professor Debra Skene discusses the problem of misalignment and what would be needed in order to deal with this problem.
- 11.10A. 10.2.3 Shift work and the circadian clock. Professor Debra Skene discusses what happens to circadian rhythms in shift work and how we can try to treat the problems.
- A. 11 The effect of pharmacological treatments on sleepMany common pharmacological treatments affect vigilance state. However, this side effect is rarely taken in consideration when introducing treatments.1