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Experimental Sleep Studies – Universidad Autonoma de Madrid

Experimental Sleep Studies - Universidad Autonoma de Madrid

Anatomía, Histología y Neurociencia

Experimental Sleep Studies

Contact: Isabel  
Trinidad  
DE ANDRES
Position: Full Professor
Address: Arzobispo Morcillo 4, 28029
City: Madrid
Country: Spain
Phone: 34 91 4975337
Contact Email: Contact laboratory
Website: http://www.ahnfmed.uam.es/index.php
RESEARCH DOMAIN: Basic Animal
KEYWORDS: Sleep Physiology-Neurophysiology in Animal

CURRENT ANNOUNCEMENTS:

Neurobiology of Sleep and its Disorders. (Posgraduate course within the Master in Neuroscience. Universidad Autonoma of Madrid). May 2012

Laboratory Description:

1. Neuroanatomical, neurophysiological and neurochemical sleep mechanisms.
2. Acute and chronic effects of opiates on sleep and EEG

Additional Descriptors, Keywords:

Acetylcholine, carbachol, morphine, GABA, hypocretin/orexin, pontine tegmentum, basal forebrain

KEY Publications of the Laboratory:

Reinoso-Suárez F. Die Auswirkungen der Ausschaltung eines Nucleus ruber auf die Hirnrinde (Electroencephalographische Untersuchungen an der Katze). Dtsch.Z.Nervenheilk. 172: 201-219. 1954.
Camacho A., F. Reinoso-Suárez. Activating and synchronizing centers in cat brain. Science. 146: 268-270. 1964.
Obrador S., F. Reinoso-Suárez, J. Carbonell, A. Córdoba, E. Martínez-Moreno, V. Navarro, H. Oliva, JC. Oliveros. Comatose state maintained during eight years following a vascular ponto mesencephalic lesion. Electroenceph. Clin. Neurophysiol. 38: 21-26. 1975.
Llamas A., F. Reinoso-Suárez, E. Martínez-Moreno. Projections to the gyrus proreus from the brain stem tegmentum (locus coeruleus, raphe nuclei) in the cat, demonstrated by retrorade transport of horseradish peroxidase. Brain Res. 89: 331-336. 1975.
De Andrés I. and F. Reinoso-Suárez. Cerebellar participation in the regulation of sleep-wakefulness cycle through the superior cerebellar peduncle. Arch. ital. Biol. ll7:l40-l63. l979.
Cunchillos J.D. and I. de Andrés. Participation of the cerebellum in the regulation of the sleep- wakefulness cycle. Results in cerebellectomized cats. Electroenceph. Clin. Neurophysiol. 53:549-558. l982.
Caballero A. and I. de Andrés. Unilateral lesions in the Locus coeruleus area enhance paradoxical sleep. Electroenceph. Clin. Neurophysiol. 64:339-346. 1986.
Corpas I. and I. de Andrés. Morphine effects in brainstem transected cats : I. EEG and sleep-wakefulness in the isolated forebrain. Beh. Brain Res. 44: 11-19. 1991
De Andrés I. and I. Corpas. Morphine effects in brainstem transected cats : II. Sleep and behavior of the decerebrate cat. Beh. Brain Res. 44: 21-26. 1991.
Nuñez A., I. de Andrés and E. García-Austt. Relationships of the nucleus reticularis pontis oralis neuronal activity with sensory and carbachol evoked hippocampal theta rhytm. Exp.Brain Res. 87: 303-308. 1991.
Arpa J. and I. de Andrés. Re-examination of the effects of raphe lesions on the sleep-wakefulness cycle states in cats. J. Sleep Res. 2:96-102. 1993.
Reinoso-Suárez F., I. de Andrés, ML. Rodrigo-Angulo and E. Rodriguez-Veiga. Location and anatomical connections of a paradoxical sleep induction site in the brainstem of the cat. Eur. J. Neurosci. 6 : 1829-1836. 1994
Reinoso-Barbero F. and I. de Andrés. Effects of opioid microinjections in the nucleus of the solitary tract on the sleep-wakefulness cycle states in cats. Anesthesiology. 82: 144-152. 1995.
Garzón, M., I. de Andrés, and F. Reinoso-Suárez. Neocortical and hippocampal electrical activities are similar in spontaneous and cholinergic-induced REM sleep. Brain Res. 766: 266-270. 1997.
Núñez A., C.de la Roza, ML. Rodrigo-Angulo, W. Buño and F.Reinoso-Suárez. Electrophysiological properties and cholinergic responses of rat ventral oral pontine reticular neurons in vitro. Brain Res. 754: 1-11. 1997.
Garzón M., I. de Andrés, and F. Reinoso-Suárez. Sleep patterns after carbachol delivery in the ventral oral pontine tegmentum of the cat. Neuroscience 83:1137-1144. 1998.
Núñez A., W.Buño, F.Reinoso-Suárez. Neurotransmitter actions on oral pontine tegmental neurons of the rat: an in vitro study. Brain Res. 804: 144-148, 1998.
Rodrigo-Angulo ML., E. Rodríguez-Veiga and F. Reinoso-Suárez . Serotonergic connections to the ventral oral pontine tegmentum. Implication in paradoxical sleep modulation. J. Comp. Neurol. 418: 93-105. 2000.
de la Roza C., F.Reinoso-Suárez. Ultrastructure and synaptic organization of axon terminals of the ventral part of the oral pontine reticular nucleus. J. Comp. Neurol. 418:93-105, 2000
Reinoso-Suárez F., I. de Andrés, ML. Rodrigo-Angulo, and M. Garzón. Brain structures and mechanisms involved in the generation of Rem sleep. Sleep Med. Rev. 5: 63-77. 2001.
Villablanca JR., I. de Andrés and Ch E Olmstead. Sleeping and waking develop independently in the isolated forebrain and decerebrate cat after a mesencephalic transection early postnatally. Neuroscience 106: 717-731. 2001.
Núñez A., ML. Rodrigo, I. de Andrés and F. Reinoso- Suárez. Firing activity and postsynaptic propierties of morphologically identified neurons of the ventral oral pontine reticular nucleus. Neuroscience. 115: 1165-1175. 2002.
De Andrés I., M. Garzón and J. Villablanca. The disconnected brain stem does not support rapid eye movement sleep rebound following selective deprivation. Sleep. 26: 419-435; 2003.
De Andrés I., M. Garzón and JR. Villablanca. The brain stem but not the forebrain independently supports basic morphine´s tolerance and withdrawal effects. A study in cats with midbrain transection Beh. Brain Res. 148:133-144. 2004.
Rodrigo-Angulo ML., E. Rodriguez-Veiga and F. Reinoso-Suarez . A quantitative study of the brainstem cholinergic projections to the ventral part of the oral pontine reticular nucleus (REM sleep induction site) in the cat. Exp Brain Res. 160:334-343, 2005.

COLLABORATIONS:

  • Title:  PhD, MD Name:  Jaime R Villablanca Position: Distinguished Professor Emeritus Institution: Mental Retardation Research Center, Brain Research Institute, University of California, Los Angeles Email: 
  • Title:  Name:  Virginia M Pickel Position: Full Professor Institution: Weill Medical College of Cornell University New York Email: 
  • Title:  PhD Name:  Julio Rodriguez Position: Research Professor Institution: Universidad del País Vasco Email: 
  • Title:  PhD Name:  Elisa Mengual Position: Research Professor Institution: Universidad de Navarra Email: 
  • Title:  PhD Name:  Ester Luqin Position: Research fellow Institution: Universidad de Navarra Email: 
  • Title:  PhD, MD Name:  Javier Arpa Position: Neurology Institution:  Hospital Universitario La PAZ Email: 
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