Sleep and Rhythms in Medicine – University of Padova

Sleep and Rhythms in Medicine - University of Padova

Department of Medicine

Sleep and Rhythms in Medicine

Contact: Sara  
Position: Reader in Medicine
Address: Via Giustiniani, 2
City: Padova
Country: Italy
Contact Email: Contact laboratory
KEYWORDS: Pharmacology Human, Learning, Memory, Cognition, Sleep and Medical Disorders, Sleep and Body Functions (Cardio-Respiratory, Thermoregulation/Metabolism, Endocrine), Sleep Physiology-Neurophysiology in Human, Molecular Biology-Endocrinology-Biochemistry


SLEEP & RHYTMS IN MEDICINE for medical students.

Students learn a set of core concepts and then attend a series of practicals in which they are welcome to test sleep-wake questionnaires, actigraphs, a polysomnography machine, temperature sensors and other relevant tools. The course started in academic year 2015-2016 and was opened by Professor Debra Skene (UK), past President of European Biological Rhythms Society.

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NEUROBIOLOGY for the Master’s in Molecular Biology.

Students learn about the neurogenetic bases of circadian rhythmicity, and the functional organization of the biological clock in model organisms, including humans. In addition, they learn about mechanisms of clock synchronisation and about the consequences of desynchronisation/misalignment. Practicals include genotyping for clock gene polymorphisms, definition of chronotype and direct experience of the effects of morning light administration on sleep-wake patterns and melatonin urinary metabolites.

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Laboratory Description:

Over the last few years we have studied the pathophysiology and the management of circadian and sleep disorders in patients with liver disease. We are currently using our experience with the liver as a model, and applying it to other, specific areas of medicine both in the outpatient and inpatient setting. We also have a particular interest in hospitalisation-related insomnia.

We have utilised/developed:
– Standard and patient-directed, specific questionnaires
– Actigraphy
– Wake and sleep EEG
– Continuous, high-resolution temperature monitoring
– Models for the induction or simulation of hepatic and other metabolic encephalopaties.

Additional Descriptors, Keywords:

sleep, genetics of sleep, circadian rhythms

KEY Publications of the Laboratory:

1. Marnetto D, Pankratov V, Mondal M, Montinaro F, Pärna K, Vallini L, Molinaro L, Saag L, Loog L, Montagnese S, Costa R, Estonian Biobank Research Team, Metspalu M, Eriksson A, Pagani L. (2022) Ancestral genomic contributions to complex traits in contemporary Europeans. Current Biology

2. Haspel J, Kim M, Zee P, Schwarzmeier T, Montagnese S, Panda S, Albani A, Merrow M. (2021) A Time Call to Arms; COVID-19, the Circadian Clock, and Critical Care. Journal of Biological Rhythms

3. Costa R, Montagnese S. (2021) The role of astrocytes in generating circadian rhythmicity in health and disease. Journal of Neurochemistry

4. Montagnese S, Zarantonello L, Formentin C, Zancato C, Bonetto M B, Biscontin A, Cusumano P, Costa R. (2021) Sleep, Circadian Rhythmicity and Response to Chronotherapy in University Students: Tips from Chronobiology Practicals. Journal of Circadian Rhythms

5. Formentin C, Carraro S, Turco M, Zarantonello L, Angeli P, Montagnese S. (2020) Effect of Morning Light Glasses and Night Short-Wavelength Filter Glasses on Sleep-Wake Rhythmicity in Medical Inpatients. Frontiers in physiology

6. Ghotbi N, Pilz LK, Winnebeck EC, Vetter C, Zerbini G, Lenssen D, Frighetto G, Salamanca M, Costa R, Montagnese S, Roenneberg T. (2019) The µMCTQ: An Ultra-Short Version of the Munich ChronoType Questionnaire. Journal of Biological Rhythms

7. Formentin C, De Rui M, Zoncapè M, Ceccato S, Zarantonello L, Senzolo M, Burra P, Angeli P, Amodio P, Montagnese S. (2019) The Psychomotor Vigilance Task: Role in the Diagnosis of Hepatic Encephalopathy and Relationship with Driving Ability. Journal of Hepatology

8. Turco M, Cazzagon N, Franceschet I, Formentin C, Frighetto G, Giordani F, Cellini N, Mazzotta G, Costa R, Middleton B, Skene DJ, Floreani A, Montagnese S. (2018) Morning Bright Light Treatment for Sleep-Wake Disturbances in Primary Biliary Cholangitis: A Pilot Study. Frontiers in Physiology

9. Ferrazzi E, Romualdi C, Ocello M, Frighetto G, Turco M, Vigolo S, Fabris F, Angeli P, Vettore G, Costa R, Montagnese S. (2018) Changes in Accident & Emergency Visits and Return Visits in Relation to the Enforcement of Daylight Saving Time and Photoperiod. Journal of Biological Rhythms.

10. Formentin C, Garrido M, Montagnese S. (2018) Assessment and Management of Sleep Disturbance in Cirrhosis. Current Hepatology Reports.

11. Marini S, Santangeli O, Saarelainen P, Middleton B, Chowdhury N, Skene DJ, Costa R, Porkka-Heiskanen T, Montagnese S. (2017) Abnormalities in the Polysomnographic, Adenosine and Metabolic Response to Sleep Deprivation in an Animal Model of Hyperammonemia. Frontiers in Physiology

12. Turco M, Biscontin A, Corrias M, Caccin L, Bano M, Chiaromanni F, Salamanca M, Mattei D, Salvoro C, Mazzotta G, De Pittà C, Middleton B, Skene DJ, Montagnese S, Costa R. (2017) Diurnal preference, mood and the response to morning light in relation to polymorphisms in the human clock gene PER3. Scientific Reports

13. Garrido M, Saccardo D, De Rui M, Vettore E, Verardo A, Carraro P, Di Vitofrancesco N, Mani AR, Angeli P, Bolognesi M, Montagnese S. (2017) Abnormalities in the 24-hour rhythm of skin temperature in cirrhosis: Sleep-wake and general clinical implications. Liver International

14. Longato E, Garrido M, Saccardo D, Montesinos Guevara C, Mani AR, Bolognesi M, Amodio P, Facchinetti A, Sparacino G, Montagnese S. (2017) Expected accuracy of proximal and distal temperature estimated by wireless sensors, in relation to their number and position on the skin. PLoS One.

15. Cagnin A, Fragiacomo F, Camporese G, Turco M, Bussè C, Ermani M, Montagnese S. (2017) Sleep-Wake Profile in Dementia with Lewy Bodies, Alzheimer’s Disease, and Normal Aging. Journal of Alzheimer’s Disease

16. Garrido M, Skorucak J, Raduazzo D, Turco M, Spinelli G, Angeli P, Amodio P, Achermann P, Montagnese S. (2016) Vigilance and wake EEG architecture in simulated hyperammonaemia: a pilot study on the effects of L-Ornithine-L-Aspartate (LOLA) and caffeine. Metabolic Brain Disease

17. Turco M, Corrias M, Chiaromanni F, Bano M, Salamanca M, Caccin L, Merkel C, Amodio P, Romualdi C, De Pittà C, Costa R, Montagnese S. (2015) The self-morningness/eveningness (Self-ME): An extremely concise and totally subjective assessment of diurnal preference. Chronobiology International

18. Montagnese S, Turco M, Amodio P. (2015) Hepatic encephalopathy and sleepiness: an interesting connection? Journal of Clinical and Experimental Hepatology

19. Montagnese S, Middleton B, Corrias M, Mani AR, Skene DJ, Morgan MY. (2015) Assessment of 6-sulfatoxymelatonin rhythms and melatonin response to light in disease states: lessons from cirrhosis. Chronobiol International

20. Casula EP, Bisiacchi PS, Corrias M, Schiff S, Merkel C, Amodio P, Montagnese S. (2015) Acute hyperammonaemia induces a sustained decrease in vigilance, which is modulated by caffeine. Metabolic Brain Disease

21. Bano M, Chiaromanni F, Corrias M, Turco M, De Rui M, Amodio P, Merkel C, Gatta A, Mazzotta G, Costa R, Montagnese S. (2014) The influence of environmental factors on sleep quality in hospitalized medical patients. Frontiers in Neurology

22. De Rui M, Middleton B, Sticca A, Gatta A, Amodio P, Skene DJ, Montagnese S. (2014) Sleep and circadian rhythms in hospitalized patients with decompensated cirrhosis: effect of light therapy. Neurochemistry Research

23. Montagnese S, De Pittà C, De Rui M, Corrias M, Turco M, Merkel C, Amodio P, Costa R, Skene DJ, Gatta A. (2014) Sleep-wake abnormalities in patients with cirrhosis. Hepatology

24. De Rui M, Schiff S, Aprile D, Angeli P, Bombonato G, Bolognesi M, Sacerdoti D, Gatta A, Merkel C, Amodio P, Montagnese S. (2013) Excessive daytime sleepiness and hepatic encephalopathy: it is worth asking. Metabolic Brain Disease

25. Montagnese S, Nsemi LM, Cazzagon N, Facchini S, Costa L, Bergasa NV, Amodio P, Floreani A. (2013) Sleep-Wake profiles in patients with primary biliary cirrhosis. Liver Transplantation

26. Bersagliere A, Raduazzo ID, Schiff S, Gatta A, Merkel C, Amodio P, Achermann P, Montagnese S. (2013) Ammonia-related changes in cerebral electrogenesis in healthy subjects and patients with cirrhosis. Clinical Neurophysiology

27. De Rui M, Gaiani S, Middleton B, Skene DJ, Schiff S, Gatta A, Merkel C, Amodio P, Montagnese S. (2011) Bright times for patients with cirrhosis and delayed sleep habits: a case report on the beneficial effect of light therapy. American Journal of Gastroenterology

28. Bersagliere A, Raduazzo ID, Nardi M, Schiff S, Gatta A, Amodio P, Achermann P, Montagnese S. (2012) Induced hyperammonemia may compromise the ability to generate restful sleep in patients with cirrhosis. Hepatology.


  • Title:  Name:  Debra Skene Position: Professor of Neuroendocrinology Institution: University of Surrey Email: 
  • Title:  Name:  Rodolfo Costa Position: Professor of Genetics Institution: University of Padova Email: 
  • Title:  Name:  Till Roenneberg Position: Professor of Chronobiology Institution: LMU, Munich, Germany Email: 
  • Title:  Name:  Alireza Mani Position: Senior Clinical Research Fellow Institution: University College London Email: 
  • Title:  Name:  Erik Herzog Position: Professor of Biology Institution: Washington University in St. Louis Email: