Students learn a set of core concepts and then attend a series of practicals in which they are welcome to test sleep-wake questionnaires, actigraphs, a polysomnography machine, temperature sensors and other relevant tools. The course started in academic year 2015-2016 and was opened by Professor Debra Skene (UK), past President of European Biological Rhythms Society.
Students learn about the neurogenetic bases of circadian rhythmicity, and the functional organization of the biological clock in model organisms, including humans. In addition, they learn about mechanisms of clock synchronisation and about the consequences of desynchronisation/misalignment. Practicals include genotyping for clock gene polymorphisms, definition of chronotype and direct experience of the effects of morning light administration on sleep-wake patterns and melatonin urinary metabolites.
Over the last few years we have studied the pathophysiology and the management of circadian and sleep disorders in patients with liver disease. We are currently using our experience with the liver as a model, and applying it to other, specific areas of medicine both in the outpatient and inpatient setting. We also have a particular interest in hospitalisation-related insomnia.
We have utilised/developed:
– Standard and patient-directed, specific questionnaires
– Wake and sleep EEG
– Continuous, high-resolution temperature monitoring
– Models for the induction or simulation of hepatic and other metabolic encephalopaties.
sleep, genetics of sleep, circadian rhythms
1. Marnetto D, Pankratov V, Mondal M, Montinaro F, Pärna K, Vallini L, Molinaro L, Saag L, Loog L, Montagnese S, Costa R, Estonian Biobank Research Team, Metspalu M, Eriksson A, Pagani L. (2022) Ancestral genomic contributions to complex traits in contemporary Europeans. Current Biology
2. Haspel J, Kim M, Zee P, Schwarzmeier T, Montagnese S, Panda S, Albani A, Merrow M. (2021) A Time Call to Arms; COVID-19, the Circadian Clock, and Critical Care. Journal of Biological Rhythms
3. Costa R, Montagnese S. (2021) The role of astrocytes in generating circadian rhythmicity in health and disease. Journal of Neurochemistry
4. Montagnese S, Zarantonello L, Formentin C, Zancato C, Bonetto M B, Biscontin A, Cusumano P, Costa R. (2021) Sleep, Circadian Rhythmicity and Response to Chronotherapy in University Students: Tips from Chronobiology Practicals. Journal of Circadian Rhythms
5. Formentin C, Carraro S, Turco M, Zarantonello L, Angeli P, Montagnese S. (2020) Effect of Morning Light Glasses and Night Short-Wavelength Filter Glasses on Sleep-Wake Rhythmicity in Medical Inpatients. Frontiers in physiology
6. Ghotbi N, Pilz LK, Winnebeck EC, Vetter C, Zerbini G, Lenssen D, Frighetto G, Salamanca M, Costa R, Montagnese S, Roenneberg T. (2019) The µMCTQ: An Ultra-Short Version of the Munich ChronoType Questionnaire. Journal of Biological Rhythms
7. Formentin C, De Rui M, Zoncapè M, Ceccato S, Zarantonello L, Senzolo M, Burra P, Angeli P, Amodio P, Montagnese S. (2019) The Psychomotor Vigilance Task: Role in the Diagnosis of Hepatic Encephalopathy and Relationship with Driving Ability. Journal of Hepatology
8. Turco M, Cazzagon N, Franceschet I, Formentin C, Frighetto G, Giordani F, Cellini N, Mazzotta G, Costa R, Middleton B, Skene DJ, Floreani A, Montagnese S. (2018) Morning Bright Light Treatment for Sleep-Wake Disturbances in Primary Biliary Cholangitis: A Pilot Study. Frontiers in Physiology
9. Ferrazzi E, Romualdi C, Ocello M, Frighetto G, Turco M, Vigolo S, Fabris F, Angeli P, Vettore G, Costa R, Montagnese S. (2018) Changes in Accident & Emergency Visits and Return Visits in Relation to the Enforcement of Daylight Saving Time and Photoperiod. Journal of Biological Rhythms.
10. Formentin C, Garrido M, Montagnese S. (2018) Assessment and Management of Sleep Disturbance in Cirrhosis. Current Hepatology Reports.
11. Marini S, Santangeli O, Saarelainen P, Middleton B, Chowdhury N, Skene DJ, Costa R, Porkka-Heiskanen T, Montagnese S. (2017) Abnormalities in the Polysomnographic, Adenosine and Metabolic Response to Sleep Deprivation in an Animal Model of Hyperammonemia. Frontiers in Physiology
12. Turco M, Biscontin A, Corrias M, Caccin L, Bano M, Chiaromanni F, Salamanca M, Mattei D, Salvoro C, Mazzotta G, De Pittà C, Middleton B, Skene DJ, Montagnese S, Costa R. (2017) Diurnal preference, mood and the response to morning light in relation to polymorphisms in the human clock gene PER3. Scientific Reports
13. Garrido M, Saccardo D, De Rui M, Vettore E, Verardo A, Carraro P, Di Vitofrancesco N, Mani AR, Angeli P, Bolognesi M, Montagnese S. (2017) Abnormalities in the 24-hour rhythm of skin temperature in cirrhosis: Sleep-wake and general clinical implications. Liver International
14. Longato E, Garrido M, Saccardo D, Montesinos Guevara C, Mani AR, Bolognesi M, Amodio P, Facchinetti A, Sparacino G, Montagnese S. (2017) Expected accuracy of proximal and distal temperature estimated by wireless sensors, in relation to their number and position on the skin. PLoS One.
15. Cagnin A, Fragiacomo F, Camporese G, Turco M, Bussè C, Ermani M, Montagnese S. (2017) Sleep-Wake Profile in Dementia with Lewy Bodies, Alzheimer’s Disease, and Normal Aging. Journal of Alzheimer’s Disease
16. Garrido M, Skorucak J, Raduazzo D, Turco M, Spinelli G, Angeli P, Amodio P, Achermann P, Montagnese S. (2016) Vigilance and wake EEG architecture in simulated hyperammonaemia: a pilot study on the effects of L-Ornithine-L-Aspartate (LOLA) and caffeine. Metabolic Brain Disease
17. Turco M, Corrias M, Chiaromanni F, Bano M, Salamanca M, Caccin L, Merkel C, Amodio P, Romualdi C, De Pittà C, Costa R, Montagnese S. (2015) The self-morningness/eveningness (Self-ME): An extremely concise and totally subjective assessment of diurnal preference. Chronobiology International
18. Montagnese S, Turco M, Amodio P. (2015) Hepatic encephalopathy and sleepiness: an interesting connection? Journal of Clinical and Experimental Hepatology
19. Montagnese S, Middleton B, Corrias M, Mani AR, Skene DJ, Morgan MY. (2015) Assessment of 6-sulfatoxymelatonin rhythms and melatonin response to light in disease states: lessons from cirrhosis. Chronobiol International
20. Casula EP, Bisiacchi PS, Corrias M, Schiff S, Merkel C, Amodio P, Montagnese S. (2015) Acute hyperammonaemia induces a sustained decrease in vigilance, which is modulated by caffeine. Metabolic Brain Disease
21. Bano M, Chiaromanni F, Corrias M, Turco M, De Rui M, Amodio P, Merkel C, Gatta A, Mazzotta G, Costa R, Montagnese S. (2014) The influence of environmental factors on sleep quality in hospitalized medical patients. Frontiers in Neurology
22. De Rui M, Middleton B, Sticca A, Gatta A, Amodio P, Skene DJ, Montagnese S. (2014) Sleep and circadian rhythms in hospitalized patients with decompensated cirrhosis: effect of light therapy. Neurochemistry Research
23. Montagnese S, De Pittà C, De Rui M, Corrias M, Turco M, Merkel C, Amodio P, Costa R, Skene DJ, Gatta A. (2014) Sleep-wake abnormalities in patients with cirrhosis. Hepatology
24. De Rui M, Schiff S, Aprile D, Angeli P, Bombonato G, Bolognesi M, Sacerdoti D, Gatta A, Merkel C, Amodio P, Montagnese S. (2013) Excessive daytime sleepiness and hepatic encephalopathy: it is worth asking. Metabolic Brain Disease
25. Montagnese S, Nsemi LM, Cazzagon N, Facchini S, Costa L, Bergasa NV, Amodio P, Floreani A. (2013) Sleep-Wake profiles in patients with primary biliary cirrhosis. Liver Transplantation
26. Bersagliere A, Raduazzo ID, Schiff S, Gatta A, Merkel C, Amodio P, Achermann P, Montagnese S. (2013) Ammonia-related changes in cerebral electrogenesis in healthy subjects and patients with cirrhosis. Clinical Neurophysiology
27. De Rui M, Gaiani S, Middleton B, Skene DJ, Schiff S, Gatta A, Merkel C, Amodio P, Montagnese S. (2011) Bright times for patients with cirrhosis and delayed sleep habits: a case report on the beneficial effect of light therapy. American Journal of Gastroenterology
28. Bersagliere A, Raduazzo ID, Nardi M, Schiff S, Gatta A, Amodio P, Achermann P, Montagnese S. (2012) Induced hyperammonemia may compromise the ability to generate restful sleep in patients with cirrhosis. Hepatology.