The center is a national center which receives patient from all part of Denmark, with all diagnoses of sleep areas including children and adults.
Main clinical areas includes sleep and neurological diseases including neurodegenerative disorders, parasomnias, epilepsy, movement disorders etc, sleep disordered breathing, circadian disorders and insomnias.
The laboratory include 6 in-hospital video-PSG beds in addition to the epilepsy monitoring unit with in total 8 beds. In addition full equipment facilities for ambulatory monitoring (PSG, cardio-respiratory monitoring, actigraphy etc.).
Treatment includes all types of positive airway pressure, medical treatment, psychology etc.
The laboratory present facilities for blood samples, saliva, spinal-fluid. The hospital includes full facilities for other diagnostic procedures (physiology, biochemetry, molecular biology, magnetic resonance, DAT scans etc.). Clinical departments includes neurology, psychiatry, internal medicine etc.
Human sleep research
Pathophysiology of sleep disorders
Jennum P, Kjellberg J. Health, social and economical consequences of sleep-disordered breathing: a controlled national study. Thorax. 2011 Jul;66(7):560-6. Epub 2011 Jan 2. PubMed PMID: 21199816.
Hor H, Kutalik Z, Dauvilliers Y, Valsesia A, Lammers GJ, Donjacour CE, Iranzo A, Santamaria J, Peraita Adrados R, Vicario JL, Overeem S, Arnulf I, Theodorou I, Jennum P, Knudsen S, Bassetti C, Mathis J, Lecendreux M, Mayer G, Geisler P, Benetó A, Petit B, Pfister C, Bürki JV, Didelot G, Billiard M, Ercilla G, Verduijn W, Claas FH, Vollenweider P, Waeber G, Waterworth DM, Mooser V, Heinzer R, Beckmann JS, Bergmann S, Tafti M. Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy. Nat Genet. 2010 Sep;42(9):786-9. Epub 2010 Aug 15. Erratum in: Nat Genet. 2011 Apr;43(4):388.
Kornum BR, Kawashima M, Faraco J, Lin L, Rico TJ, Hesselson S, Axtell RC, Kuipers H, Weiner K, Hamacher A, Kassack MU, Han F, Knudsen S, Li J, Dong X, Winkelmann J, Plazzi G, Nevsimalova S, Hong SC, Honda Y, Honda M, Högl B, Ton TG, Montplaisir J, Bourgin P, Kemlink D, Huang YS, Warby S, Einen M, Eshragh JL, Miyagawa T, Desautels A, Ruppert E, Hesla PE, Poli F, Pizza F, Frauscher B, Jeong JH, Lee SP, Strohl KP, Longstreth WT Jr, Kvale M, Dobrovolna M, Ohayon MM, Nepom GT, Wichmann HE, Rouleau GA, Gieger C, Levinson DF, Gejman PV, Meitinger T, Peppard P, Young T, Jennum P, Steinman L, Tokunaga K, Kwok PY, Risch N, Hallmayer J, Mignot E. Common variants in P2RY11 are associated with narcolepsy. Nat Genet. 2011 Jan;43(1):66-71
Knudsen S, Jennum PJ, Alving J, Sheikh SP, Gammeltoft S. Validation of the ICSD-2 criteria for CSF hypocretin-1 measurements in the diagnosis of narcolepsy in the Danish population. Sleep. 2010 Feb;33(2):169-76.
Knudsen S, Gammeltoft S, Jennum PJ. Rapid eye movement sleep behaviour disorder in patients with narcolepsy is associated with hypocretin-1 deficiency. Brain. 2010 Feb;133(Pt 2):568-79.