Sleep and Wake Disorders center, 1. National Refer – Sleep Unit, Departement Neurology

Sleep and Wake Disorders center, 1. National Refer - Sleep Unit, Departement Neurology

Gui-de-Chauliac Hospital, Inserm U1061, University

Sleep and Wake Disorders center, 1. National Refer

Contact: Yves  
Position: Professor
Address: 80 av augustin fliche, 34295
City: Montpellier
Country: France
Contact Email: Contact laboratory
KEYWORDS: Neurological Sleep Disorders, Behavioural Sleep Disorders, Sleep Physiology-Neurophysiology in Human, Sleep and Psychiatry-Personality Disorders, Sleep and Ageing, Genetics of Sleep, Sleep and Medical Disorders


Laboratory Description:

National Reference Network for Orphan Diseases : Narcolepsy and Idiopathic Hypersomnia.
Many research studies in the diagnosis, epidemiology, pathophysiology and therapy of several sleep disorders, mainly neurological disorders including narcolepsy but also other central hypersomnias, parasomnias and RLS.

Additional Descriptors, Keywords:

Neurology and Sleep, Pathophysiology of Hypersomnia, Sleep and Ageing

KEY Publications of the Laboratory:

1. Dauvilliers Y, Arnulf I, Mignot E. Narcolepsy with cataplexy. Lancet. 2007;369:499-511
2. Maret S, Franken P, Dauvilliers Y, Ghyselinck NB, Chambon P, Tafti M. Retinoic acid signaling affects cortical synchrony during sleep. Science. 2005; 7:111-3 -A
3. Ohayon MM, Dauvilliers Y, Reynolds CF 3rd. Operational definitions and algorithms for excessive sleepiness in the general population: implications for DSM-5 nosology. Archives of General Psychiatry. 2012;69(1):71-9.
4. Jaussent I, Bouyer J, Ancelin ML, Akbaraly T, Pérès K, Ritchie K, Besset A, Dauvilliers Y. Insomnia and daytime sleepiness are risk factors for depressive symptoms in the elderly. Sleep. 2011 Aug 1;34(8):1103-10.
5. Winkelmann J, Czamara D, Schormair B, Knauf F, Schulte EC, Trenkwalder C, Dauvilliers Y, et al Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1. PLoS Genet. 2011 Jul;7(7):e1002171.
6. Blachier M, Dauvilliers Y, Jaussent I, Helmer C, Ritchie K, Jouven X, Tzourio C, Amouyel P, Besset A, Ducimetiere P, Empana JP. Excessive daytime sleepiness and vascular events: the 3 City Study. Annals of Neurology 2012;71(5):661-7.
7. Hor H, Kutalik Z, Dauvilliers Y al. Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy. Nature Genetics 2010;42:786-789.
8. Cvetkovic-Lopes V, Bayer L, Dorsaz S, Maret S, Pradervand S, Dauvilliers Y, Lecendreux M, Lammers GJ, Donjacour CE, Du Pasquier RA, Pfister C, Petit B, Hor H, Mühlethaler M, Tafti M.Elevated Tribbles homolog 2-specific antibody levels in narcolepsy patients. J Clin Invest. 2010 Mar 1;120(3):713-9
9. Ohayon M, Reynolds C, Dauvilliers Y. Excessive Quantity of Sleep and its links to excessive sleepiness – Implications for the DSM-5. Ann Neurol in press
10. Dauvilliers Y et al. Hypothalamic immunopathology in anti-Ma-associated diencephalitis with narcolepsy-cataplexy. JAMA neurology in press
11. Dauvilliers Y, Arnulf I, Lecendreux M, Monaca Charley C, Franco P, Drouot X, d’Ortho MP, Launois S, Lignot S, Bourgin P, Nogues B, Rey M, Bayard S, Scholz S, Lavault S, Tubert-Bitter P, Saussier C, Pariente A; Narcoflu-VF study group. Increased risk of narcolepsy in children and adults after pandemic H1N1 vaccination in France. Brain. 2013 Aug;136(Pt 8):2486-96