Human Sleep Psychopharmacology Laboratory – University of Zürich

Human Sleep Psychopharmacology Laboratory - University of Zürich

Institute of Pharmacology and Toxicology

Human Sleep Psychopharmacology Laboratory

Contact: Hans-Peter  
Landolt
Position: Senior Researcher
Address: Winterthurerstrasse 190, 8057
City: Zürich
Country: Switzerland
Contact Email: Contact laboratory
RESEARCH DOMAIN: Basic Human, Clinical
KEYWORDS: Sleep Physiology-Neurophysiology in Human, Sleep and Ageing, Pharmacology of Sleep, Genetics of Sleep, Sleep and Medical Disorders, Pharmacology Human

CURRENT ANNOUNCEMENTS:

Laboratory Description:

We are interested in the molecular mechanisms underlying individual differences in sleep, waking performance and response to sleep and wake promoting pharmacological agents in humans. To elucidate such mechanisms in health and disease, we combine and integrate methods of human genetics, selective pharmacology, multi-channel EEG, neuropsychological/cognitive testing and molecular brain imaging.

KEY Publications of the Laboratory:

– Holst SC, Bersagliere A, Bachmann V, Berger W, Achermann P, and Landolt HP. Dopaminergic role in regulating neurophysiological markers of sleep homeostasis in humans. J Neurosci 34, 566-573, 2014.

– Hefti K, Holst SC, Sovago J, Bachmann V, Buck A, Ametamey SM, Scheidegger M, Bethold T, Gomez-Mancilla B, Seifritz E, and Landolt HP. Increased metabotropic glutamate receptor subtype 5 availability in human brain after one night without sleep. Biol Psychiatry 73, 161-168, 2013.

– Bachmann V, Klaus F, Bodenmann S, Schäfer N, Brugger P, Huber S, Berger W, and Landolt HP. Functional ADA polymorphism increases sleep depth and reduces vigilant attention in humans. Cereb Cortex 22, 962-970, 2012.

– Rétey JV, Adam M, Khatami R, Luhmann UFO, Jung HH, Berger W, and Landolt HP. A genetic variation on the adenosine A2A receptor gene (ADORA2A) contributes to individual sensitivity to caffeine effects on sleep. Clin Pharmacol Ther 81, 692-698, 2007.

– Rétey JV, Adam M, Honegger E, Khatami R, Luhmann U, Jung HH, Berger W and Landolt HP (2005). A functional genetic variation of adenosine deaminase affects the duration and intensity of deep sleep in humans. Proc Natl Acad Sci USA 102, 15676-15681.

COLLABORATIONS:

  • Title:  PhD Name:  Peter Brugger Position:  Institution: Department of Neurology, University Hospital, Zürich, Switzerland Email: 
  • Title:  MD Name:  Erich Seifritz Position:  Institution: Clinic of Affective Disorders and General Psychiatry, Psychiatric University Hospital, Zürich, Switzerland Email: 
  • Title:  MD Name:  Christian Baumann Position:  Institution: Department of Neurology, University Hospital, Zürich, Switzerland Email: 
  • Title:  PhD Name:  Wolfgang Berger Position:  Institution: Institute of Medical Molecular Genetics, University of Zürich, Schwerzenbach, Switzerland Email: 
  • Title:  PhD Name:  Christian Cajochen Position:  Institution: Centre for Chronobiology, Psychiatric Hospital of the University of Basel, Basel, Switzerland Email: