Human Sleep Psychopharmacology Laboratory - University of Zürich
Institute of Pharmacology and Toxicology
Human Sleep Psychopharmacology Laboratory
Contact: Hans-Peter
Landolt
Position: Scientific Section Leader
Address: Winterthurerstrasse 190
City: Zürich
Country: Switzerland
Phone: +41 44 635 59 53
Contact Email: landolt@pharma.uzh.ch
RESEARCH DOMAIN: Basic Human
KEYWORDS: Sleep Physiology-Neurophysiology in Human, Pharmacology of Sleep, Sleep and Medical Disorders, Genetics of Sleep
Laboratory Description:
Our research combines and integrates methods of specific pharmacology, neurophysiology, metabolomics, human genetics, pupillometry, brain imaging and neurocognitive testing, to investigate the roles for distinct molecules (e.g., neuromodulators, receptors and transporters) in regulating sleep-associated brain functions in health and disease.
KEY Publications of the Laboratory:
https://pubmed.ncbi.nlm.nih.gov/?term=landolt+sleep&sort=date
Five representative recent publications of the laboratory:
- Stucky B, Henckel L, Maathuis MH, Haba-Rubio J, Marques-Vidal P, Siclari F, Heinzer R, and Landolt HP. Community-based causal evidence that high habitual caffeine consumption alters distinct polysomnography-derived sleep variables. J Psychopharmacol, in press.
- Schnider LK, Ratajczak M, Wespi R, Kientsch JG, Bavato F, Marten L, Kost J, Puchkov M, Eicher C, Boxler M, Voegel CD, Bosch OG, van Someren E, Dornbierer D, and Landolt HP. Effects of sub-anesthetic oro-mucosal dexmedetomidine on sleep in humans: A pharmacokinetics-pharmacodynamics study. Anesthesiol 142, 476-487, 2025.
- Sousouri G, Eicher C, d’Angelo RM, Billecocq M, Fussinger T, Studler M, Capstick M, Kuster N, Achermann P, Huber R, and Landolt HP. 5G radio-frequency electromagnetic-field effects on the human sleep electroencephalogram: A randomized controlled study in CACNA1C geno-typed volunteers. NeuroImage 317, e121340, 2025.
- Stucky B. We are the sensors of consciousness! A review and analysis of how awakenings during sleep influence dream recall. Nat Sci Sleep 17, 709-729, 2025.
- Scholz M, Lakaemper S, Steuer AE, Dobay A, Landolt HP*, and Krämer T*. Assessing the influence of sleep and sampling time on metabolites in oral fluid: Implications for metabolomics studies. Metabolomics 20, e97, 2024.
COLLABORATIONS: