Sleep Center University Hospital Brno – University Hospital Brno and Faculty of Medicine, Masaryk University, Brno

Sleep Center University Hospital Brno - University Hospital Brno and Faculty of Medicine, Masaryk University, Brno

Department of Internal, Geriatrics and Practical Medicine

Sleep Center University Hospital Brno

Contact: Ondrej  
Ludka
Position: Director
Address: Jihlavska 20
City: Brno
Country: Czech Republic
Contact Email: Contact laboratory
RESEARCH DOMAIN: Clinical, Basic Human
KEYWORDS: Others, Sleep and Body Functions (Cardio-Respiratory, Thermoregulation/Metabolism, Endocrine), Behavioural Sleep Disorders

CURRENT ANNOUNCEMENTS:

Laboratory Description:

The Sleep Center deals with the diagnosis, treatment and research of sleep disorders (e.g. insomnia, disorders with excessive sleepiness, parasomnias, sleep-related movement disorders, circadian rhythm disorders, and others) with a special focus on sleep breathing disorders, especially in patients with obesity and cardiovascular diseases. The center consists of 6 electromagnetically sleep laboratories, equipped with state of the art technologies for advanced diagnosis and treatment of sleep breathing disorders. Our sleep specialists are trained, educated and board-certified in Czech Republic, Europe and U.S.

Additional Descriptors, Keywords:

obesity, cardiovascular diseases and sleep breathing disorders

KEY Publications of the Laboratory:

  • Ludka O, Štěpánová R, Vyskočilová M, Galková L, Mikolášková M, Bělehrad M, Košťálová J, Mihalová Z, Drozdová A, Hlasenský J, Gacik M, Pudilová L, Mikušová T, Fischerová B, Sert-Kuniyoshi F, Somers VK, Špinar J, Kára T. Sleep apnea prevalence in acute myocardial infarction – The Sleep Apnea in Post-acute Myocardial Infarction Patients (SAPAMI) Study. International journal of cardiology 2014;176:13-19
  • Konecny T., Geske J, Ludka O, Orban M, Brady P, Abudiab M, Albuquerque F, Placek A, Kara T, Sahakyan K, Gersh B, Tajik A, Allison T, Ommen S, Somers V. Decreased Exercise Capacity and Sleep-Disordered Breathing in Patients with Hypertrophic Cardiomyopathy. CHEST 2015;147(6):1574-1581
  • Ludka O, Taborsky M, Sert-Kuniyoshi F, Spinar J, Somers VK, Kara T. Response to the Letter of Dr. Tomoyuki Kawada, “Acute Myocardial Infarction and Sleep Apnea”.  International journal of cardiology 2015;195:51-52
  • Arnardottir ES, Verbraecken J, Goncalves M, Gjerstad MD, Grote L, Puertas FJ, Mihaicuta S, McNicholas WT, Parrino L and The National Representatives as Study Collaborators – Czech Republic –Ludka 0. Variability in recording and scoring of respiratory events during sleep in Europe: a need for uniform standards. J Sleep Res. (2015), DOI: 10.1111/jsr.12353
  • Cundrle I Jr., Belehrad M, Jelinek M, Olson LJ, Ludka O, Sramek V. The utility of perioperative polygraphy in the diagnosis of obstructive sleep apnea. Sleep medicine 2016;25:151-155
  • Ludka O, Stepanova R, Sert-Kunioshi F, Spinar J, Somers VK, Kara T. Differential likelihood of NSTEMI vs STEMI in patients with sleep apnea. Int J Cardiol 2017;248:64-68
  • Ruzek L, Svobodova K, Olson LJ, Ludka O, Cundrle I. Increased microcirculatory heterogeneity in patients with obstructive sleep apnea. PLoS ONE 2017 12(9): e0184291
  • Penzel T, Glos M, Schöbel Ch, He Z, Ludka O, Fietze I. Telemedicine and telemtric recording methods as diagnostic instruments in sleep medicine. Somnologie 2018:1-9
  • Pataka A, Bonsignore MR, Ryan S, Riha RL, Pepin JL, Schiza S, Basoglu OK, Sliwinski P, Ludka O, Steiropoulos P, Anttalainen U, McNicholas WT, Hedner J, Grote L, on behalf of the ESADA study group. Cancer prevalence is increased in females with sleep apnoea: data from the ESADA study. Eur Respir J 2020;53:1900091
  • Gunduz C, Basoglu OK, Hedner J, Bonsignore MR, Hein H, Staats R, Bouloukaki I, Roisman G, Pataka A, Sliwinski P, Ludka O, Pepin JL, Grote L. Hyperlipidemia Prevalence and Cholesterol Control in Obstructive Sleep Apnea: Data from the European Sleep Apnea Database (ESADA). Journal of Internal Medicine 2019;286(6):676-688
  • Dieltjens M, Verbraecken JA, Hedner J, Vanderveken OM, Steiropoulos P, Kvamme JA, Saaresranta T, Tkacova R, Marrone O, Dogas Z, Schiza S, Grote L, Petiet E, Trakada G, Montserrat JM, Fietze I, Penzel T, Ludka O, Rodenstein D, Masa JF, Bouloukaki I, Kent B, McNicholas WT, Ryan S, Riha RL, Schulz R, Zou D, Pepin JL, Levy P, Bailly S, Lavie L, Lavie P, Hein H, Basoglu OK, Tasbakan MS, Varoneckas G, Joppa P, Staats R, Barbe F, Lombardi C, Parati G, Drummond M, van Zeller M, Bonsignore MR, Escourrou P, Roisman G, Pretl M, Vitols A, Galic T, Pataka A, Anttalainen U, Sliwinski P, Plywaczewski R, Bielicki P, Zielinski J. Use of the Clinical Global Impression scale in sleep apnea patients – Results from the ESADA database. SLEEP MEDICINE 2019;SLEEP MEDICINE 59:56-65
  • Marrone O, Cibella F, Pépin JL, Grote L, Verbraecken J, Saaresranta T, Kvamme JA, Basoglu OK, Lombardi C, McNicholas WT, Hedner J, Bonsignore MR, on behalf of the ESADA network (Ludka O). Comment to the Editorial by KS Park and EW Kang “Is only fixed positive airway pressure a robust tool for kidney protection in patients with obstructive sleep apnea?” Journal of Thoracic Disease 2019;11(Supplement 3):S480-482
  • Wächter M, Kantelhardt JW, Bonsignore MR, Bouloukaki I, Escourrou P, Fietze I, Grote L, Korzybski D, Lombardi C, Marrone O, Paranicova I, Pataka A, Ryan S, Schiza S, Sliwinski P, Steiropoulos P, Verbraecken J, Penzel T, ESADA Study Group (Ludka O). Unique sleep-stage transitions determined by obstructive sleep apnea severity, age and gender. J Sleep Research 2019
  • Kec D, Bednařík J, Ludka O, Hamerníková V, Vlčková E. Léčba nespavosti při neuropatické bolesti. Cesk Slov Neurol N 2019; 82/115(5):513-517
  • Kec D, Ludka O, Hamerníková V, Kubánek J, Bednařík J, Vlčková E. Současné trendy v léčbě a diagnostice chronické nespavosti. Čes a slov Psychiatr 2020;116(3):139-149
  • Marrone O, Cibella F, Roisman G, (…), Ludka O, Trakada G. Effects of sleep apnea and kidney dysfunction on objective sleep quality in nondialyzed patients with chronic kidney disease: An ESADA study. Journal of Clinical Sleep Medicine 2020;16(9):1475-1481
  • Grote L, McNicholas WT, Hedner J, (…), Ludka O, (…), Testelmans D. Sleep apnoea management in Europe during the COVID-19 pandemic – Data from the European Sleep Apnoea Database (ESADA). European Respiratory Journal 2020;55(6)
  • Wächter M, Kantelhardt JW, Bonsignore M, (…), Ludka O, (…), van Zeller M. Unique sleep-stage transitions determined by obstructive sleep apnea severity, age and gender. Journal of Sleep Research 2020;29(2),e12895
  • Gunduz C, Basoglu O, Kvamme JA, Verbraecken J, (…),Ludka O, (…), Bielicki P. Long-term positive airway pressure therapy is associated with reduced total cholesterol levels in patients with obstructive sleep apnea: data from the European Sleep Apnea Database (ESADA). Sleep Medicine 2020:75:201-209
  • Bailly S, Grote L, Hedner J, Schizia S, McNIcholas WT, Basoglu OK, Lombardi C, Dogas Z, Roisman G, Pataka A, Bonsignore MR, Pepin JLon behalf of the ESADA Study Group (Ludka O). Clusters of sleep apnoea phenotypes: A large pan-European study from the European Sleep Apnoea Database (ESADA). Respirology 2020, doi: 10.1111/resp.13969
  • Tasbakan M, Grote L, Hedner Jan, Kvamme JA, Verbraecken J, McNicholas WT, Roisman G, (…),Ludka O, (…),Plywaczewski R. Positive airway pressure (PAP) treatment reduces glycated hemoglobin (HbA1c) levels in obstructive sleep apnea patients with concomitant weight loss: Longitudinal data from the ESADA. Journal of Sleep Research 2021;30(5):e13331
  • Konecny T, Khoo M, Edelhofer P, Park J, Bukartyk J, Covassin N, Venkataraman S, Karim S, Chahal A, Kara T, Orban M, Ludka O, Kautzner J, Ommen SR, Somers VK. Increased Heart Rate with Sleep Disordered Breathing in Hypertrophic Cardiomyopathy. International Journal of Cardiology 2021;323:155-160
  • Pengo MF, Faini A, Grote L, Ludka O, Joppa P, Pataka A, Dogas Z, Mihaicuta S, Hein H, Anttalainen U, Ryan S, Lombardi C, Parati G on behalf of the ESADA Working Group. Impact of Sleep Apnea on Cardioembolic Risk in Patients With Atrial Fibrillation. Stroke 2021;52(2):712-715
  • Staats R, Bailly S, Bonsignore MS, Ryan S, Riha R, Schizia S, Verbraecken J, Basoglu OK, Saaresranta T, Pataka A, Ludka O, Lombardi C, Hedner J, Grote L. Impact of temperature on obstructive sleep apnoea in three different climate zones of Europe – data from the European Sleep Apnoea Database (ESADA). Journal of Sleep Research 2021;30:e13315
  • Fietze I, Laharnar N, Bargiotas P, Basoglu OK, Dogas Z, Drummond M, Fanfulla F, Gislason T, Gouveris H, Grote L, Hein H, Jennum P, Joppa P, Kralingen K, Kvamme JA, Lombardi C, Ludka O, Mallin W, Marrone O, McNicholas WT, Mihaicuta S, Montserrat J, Pillar G, Pataka A, Randerath W,  Riha RL, Roisman G, Saaresranta T, Schiza SE, Sliwinski P, Svaza J, Steiropoulos P, Tamisier R, Testelmans D, Trakada G, Verbraecken J, Zablockis R, Penzel T. Management of obstructive sleep apnea in Europe-A 10-year follow-up. Sleep Medicine 2022;97:64-72
  • Svedmyr SHedner JBonsignore MRLombardi CParati GLudka OZou DGrote L. Hypertension treatment in patients with sleep apnea from the European Sleep Apnea Database (ESADA) cohort – towards precision medicine. Journal of Sleep Research 2023;32:el13811
  • Hrayr P Attarian et al. The practice of Sleep Medicine Around the World: Challenges, Knowledge Gaps and Unique Needs. Bentham Science Publisher Pte. Ltd. Singapore 2023, 420 pages, ISBN 978-981-5049-36-7. Nevsimalova S, Ludka O, Vyskocilova J. Current Practice of Sleep Medicine in the Czech Republic, page 390-395
  • Hnatiak J, Zikmund Galkova L, Winnige P, Batalik L, Dosbaba F, Ludka O, Krejci J. Comprehensive home-based telerehabilitation in a morbidly obese male patient with severe obstructive sleep apnea. A case report. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2023; 167
  • Lammintausta A, Anttalainen U, Basoglu ÖK, Bonsignore MR, Gouveris H, Grote L, Hedner J, Ludka O, Mihaicuta S, Pataka A, Trakada G, van Zeller M, Saaresranta T on behalf of the ESADA Study Group et al. Clinical characteristics and positive airway pressure adherence among elderly European sleep apnoea patients from the ESADA cohort. ERJ Open Res 2023;9:00506-2022

COLLABORATIONS:

  • Title:  PhD Name:  Thomas Penzel Position: Professor Institution: Multidisciplinary Sleep Center Charité Hospital, Germany Email:  thomas.penzel@charite.de