University of Oxford Sleep Research Centre – University of Oxford

University of Oxford Sleep Research Centre - University of Oxford

Nuffield Department of Clinical Neurosciences

University of Oxford Sleep Research Centre

Contact: Colin  
Position: Professor of Sleep Medicine
Address: John Radcliffe Hospital, OX3 9DU
City: Oxford
Country: United Kingdom
Contact Email: Contact laboratory
RESEARCH DOMAIN: Clinical, Basic Human, Basic Animal
KEYWORDS: Biological Rhythms, Behavioural Sleep Disorders, Sleep Physiology-Neurophysiology in Animal, Others


Our online MSc/ PgDip in Sleep Medicine will be launched in 2015.
Enquiries to Dr Chris Harvey (

Laboratory Description:

Human: Clinical and behavioural assessment of sleep disorders, actigraphy, ambulatory PSG, online evaluations.

Animal: Equipment for in vivo electrophysiology, automated touchscreen set up for rodent behaviour, equipment for optogenetics, animal models of disease (at the Sleep, Brain and Behaviour Lab,

KEY Publications of the Laboratory:;d=TkxP

1. Espie, C.A., Kyle, S.D, Williams, C., Ong, J.C., Douglas, N.J., Hames, P., Brown, J.S.L. (2012) A randomized, placebo-controlled, trial of online Cognitive Behavioral Therapy for chronic Insomnia Disorder delivered via an automated media-rich web application. SLEEP, Vol. 35, No. 6, 769-781

2. Espie, C.A., Barrie, L.M., Forgan, G.S. (2012) Comparative investigation of the psychophysiological and idiopathic Insomnia Disorder phenotypes: psychological characteristics, patients’ perspectives and implications for clinical management. SLEEP, Vol. 35, No. 3, 385-393

3. Green, M., Benzeval, M., Espie, C.A., Hunt, K. (2012) The longitudinal course of insomnia symptoms: inequalities by gender and occupational class among two different age cohorts followed for 20 years in the West of Scotland. SLEEP 35, 815-823

4. Espie., C.A., Kyle, S.D., Hames, P., Cyhlarova E., Benzeval, M. (2012) The daytime impact of DSM-5 Insomnia Disorder: comparative analysis of insomnia subtypes from the Great British Sleep Survey (n=11,129) Journal of Clinical Psychiatry 73, e1478-e1484

5. Espie, C.A., Kyle, S.D., Hames, P., Gardani, M., Fleming, L., Cape, J. (2014). The Sleep Condition Indicator: a clinical screening tool to evaluate Insomnia Disorder. BMJOpen 4 (3): e004183

6. Vyazovskiy VV, Harris KD (2013) Sleep and the single neuron: the role of global slow oscillations in individual cell rest. Nat Rev Neurosci 14: 443-451.

7. Vyazovskiy VV, Olcese U, Hanlon EC, Nir Y, Cirelli C, et al. (2011) Local sleep in awake rats. Nature 472: 443-447.

8. Leemburg S, Vyazovskiy VV, Olcese U, Bassetti CL, Tononi G, et al. (2010) Sleep homeostasis in the rat is preserved during chronic sleep restriction. Proc Natl Acad Sci U S A 107: 15939-15944.

9. Vyazovskiy VV, Olcese U, Lazimy YM, Faraguna U, Esser SK, et al. (2009) Cortical firing and sleep homeostasis. Neuron 63: 865-878.

10. Vyazovskiy VV, Cirelli C, Pfister-Genskow M, Faraguna U, Tononi G (2008) Molecular and electrophysiological evidence for net synaptic potentiation in wake and depression in sleep. Nature Neurosci 11: 200-208.

11. Freeman, D., Pugh, K., Vorontsova, N. & Southgate, L. (2009). Insomnia and paranoia. Schizophrenia Research, 108, 280-284.

12. Freeman, D., Pugh, K., Antley, A., Slater, M., Bebbington, P., Gittins, M., Dunn, G., Kuipers, E., Fowler, D., & Garety, P. A (2008). A virtual reality study of paranoid thinking in the general population. British Journal of Psychiatry, 192, 258-263.

13. Freeman, D. (2007). Suspicious minds: the psychology of persecutory delusions. Clinical Psychology Review, 27, 425-457.

14. Freeman, D., Garety, P.A., Kuipers, E., Fowler, D., & Bebbington, P.E. (2002). A cognitive model of persecutory delusions. British Journal of Clinical Psychology, 41, 331-347.

15. Garety, P.A. & Freeman, D. (1999). Cognitive approaches to delusions: a critical review of theories and evidence. British Journal of Clinical Psychology, 38, 113-154.