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Sleep Unit Turku – University of Turku

Sleep Unit Turku - University of Turku

Physiology
37-Sleep-Research-Centre-Turku

Sleep Unit Turku

Contact: Tarja  
Saaresranta
Address: Lemminkäisenkatu 14-18 A 5th Floor, 20520
City: Turku
Country: Finland
Phone: +35823337519
Contact Email: Contact laboratory
Website: http://www.med.utu.fi/sivustot/unitutkimus/en
RESEARCH DOMAIN: Methodology / Technology, Clinical
KEYWORDS: Pharmacology Human, Instrumentation-Methodology, Learning, Memory, Cognition, Sleep and Medical Disorders, Sleep and Ageing, Sleep and Body Functions (Cardio-Respiratory, Thermoregulation/Metabolism, Endocrine), Sleep Physiology-Neurophysiology in Human, Neurological Sleep Disorders

CURRENT ANNOUNCEMENTS:

Laboratory Description:

The Sleep Research Unit at the University of Turku is conducting both investigator-initiated studies as well as clinical trials sponsored by pharmaceutical industry. Main research areas are sleep-disordered breathing especially in postmenopausal women, insomnia and restless legs syndrome.

Additional Descriptors, Keywords:

autonomic nervous system
trancutaneous CO2

KEY Publications of the Laboratory:

Utriainen KT, Airaksinen JK, Polo O, Raitakari OT, Pietilä MJ, Scheinin H, Helenius HY, Leino KA, Kentala ES, Jalonen JR, Hakovirta H, Salo TM, Laitio TT. Unrecognised obstructive sleep apnoea is common in severe peripheral arterial disease. Eur Respir J 2013;41(3):616-20.

Hedner J, Grote L, Bonsignore M, McNicholas W, Lavie P, Parati G, Sliwinski P, Barbé F, De Backer W, Escourrou P, Fietze I, Kvamme JA, Lombardi C, Marrone O, Masa JF, Montserrat JM, Penzel T, Pretl M, Riha R, Rodenstein D, Saaresranta T, Schulz R, Tkacova R, Varoneckas G, Vitols A, Vrints H, Zielinski J. The European Sleep Apnoea Database (ESADA): report from 22 European sleep laboratories. Eur Respir J 2011;38(3):635-42.

Aittokallio J, Saaresranta T, Virkki A, Karppinen N, Heinonen OJ, Aittokallio T, Polo O. Transcutaneous carbon dioxide profile during sleep reveals metabolic risk factors in post-menopausal females. Eur Respir J 2009;34(5):1132-9.

Aittokallio T, Virkki A, Polo O. Understanding sleep-disordered breathing through mathematical modelling. Sleep Med Rev 2009;13(5):333-43.

Sjösten N, Vahtera J, Salo P, Oksanen T, Saaresranta T, Virtanen M, Pentti J, Kivimäki M. Increased risk of lost workdays prior to the diagnosis of sleep apnea. Chest. 2009;136(1):130-6.

Kalleinen N, Polo-Kantola P, Irjala K, Porkka-Heiskanen T, Vahlberg T, Virkki A, Polo O. 24-hour serum levels of growth hormone, prolactin, and cortisol in pre- and postmenopausal women: the effect of combined estrogen and progestin treatment. J Clin Endocrinol Metab 2008;93(5):1655-61.

Aittokallio J, Polo O, Hiissa J, Virkki A, Toikka J, Raitakari O, Saaresranta T, Aittokallio T. Overnight variability in transcutaneous carbon dioxide predicts vascular impairment in women.
Exp Physiol. 2008;93(7):880-91.

Anttalainen U, Saaresranta T, Kalleinen N, Aittokallio J, Vahlberg T, Polo O. CPAP adherence and partial upper airway obstruction during sleep. Sleep Breath 2007;11(3):171-6.

Kemlink D, Polo O, Montagna P, Provini F, Stiasny-Kolster K, Oertel W, de Weerd A, Nevsimalova S, Sonka K, Högl B, Frauscher B, Poewe W, Trenkwalder C, Pramstaller PP, Ferini-Strambi L, Zucconi M, Konofal E, Arnulf I, Hadjigeorgiou GM, Happe S, Klein C, Hiller A, Lichtner P, Meitinger T, Müller-Myshok B, Winkelmann J. Family-based association study of the restless legs syndrome loci 2 and 3 in a European population.Mov Disord 2007;22(2):207-12.

Saaresranta T, Polo-Kantola P, Virtanen I, Vahlberg T, Irjala K, Polo O. Menopausal estrogen therapy predicts better nocturnal oxyhemoglobin saturation. Maturitas 2006;55(3):255-63.

Saaresranta T, Irjala K, Aittokallio T, Polo O Sleep quality, daytime sleepiness and fasting insulin levels in women with chronic obstructive pulmonary disease. Respir Med. 2005;99(7):856-63.

Aittokallio T, Gyllenberg M, Saaresranta T, Polo O. Prediction of inspiratory flow shapes during sleep with a mathematic model of upper airway forces. Sleep 2003;26(7):857-63.

Saaresranta T, Polo O. Sleep-disordered breathing and hormones.Eur Respir J 2003;22(1):161-72.

Saaresranta T, Polo-Kantola P, Rauhala E, Polo O. Medroxyprogesterone in postmenopausal females with partial upper airway obstruction during sleep. Eur Respir J 2001;18(6):989-95.

Polo-Kantola P, Rauhala E, Erkkola R, Irjala K, Polo O. Estrogen replacement therapy and nocturnal periodic limb movements: a randomized controlled trial. Obstet Gynecol 2001;97(4):548-54.

Aittokallio T, Saaresranta T, Polo-Kantola P, Nevalainen O, Polo O. Analysis of inspiratory flow shapes in patients with partial upper-airway obstruction during sleep. Chest 2001;119(1):37-44.

Polo O. Continuous positive airway pressure for treatment of sleep apnoea.
Lancet 1999;353(9170):2086-7.

Polo-Kantola P, Erkkola R, Irjala K, Pullinen S, Virtanen I, Polo O. Effect of short-term transdermal estrogen replacement therapy on sleep: a randomized, double-blind crossover trial in postmenopausal women. Fertil Steril 1999;71(5):873-80.

Polo-Kantola P, Erkkola R, Helenius H, Irjala K, Polo O. When does estrogen replacement therapy improve sleep quality? Am J Obstet Gynecol 1998;178(5):1002-9.

Polo O, Berthon-Jones M, Douglas NJ, Sullivan CE. Management of obstructive sleep apnoea/hypopnoea syndrome. Lancet 1994;344(8923):656-60.

Douglas NJ, Polo O. Pathogenesis of obstructive sleep apnoea/hypopnoea syndrome. Lancet 1994;344(8923):653-5.

Ekholm EM, Polo O, Rauhala ER, Ekblad UU. Sleep quality in preeclampsia. Am J Obstet Gynecol 1992;167(5):1262-6.

Polo O. Partial upper airway obstruction during sleep. Studies with the static charge-sensitive bed (SCSB). Acta Physiol Scand Suppl 1992;606:1-118.

Polo OJ, Tafti M, Fraga J, Porkka KV, Déjean Y, Billiard M. Why don’t all heavy snorers have obstructive sleep apnea? Am Rev Respir Dis 1991;143(6):1288-93.

Polo O, Brissaud L, Sales B, Besset A, Billiard M. The validity of the static charge sensitive bed in detecting obstructive sleep apnoeas. Eur Respir J 1988;1(4):330-6.

COLLABORATIONS: