London Sleep Centre

London Sleep Centre

Sleep Medicine

London Sleep Centre

Contact: Irshaad  
Position: Medical Director
Address: 137 Harley Street, W1G 6BF
City: London
Country: United Kingdom
Contact Email: Contact laboratory
KEYWORDS: Learning, Memory, Cognition, Sleep and Medical Disorders, Pharmacology of Sleep, Sleep and Ageing, Sleep and Psychiatry-Personality Disorders, Sleep Physiology-Neurophysiology in Human, Behavioural Sleep Disorders, Neurological Sleep Disorders


Laboratory Description:

The London Sleep Centre provides comprehensive clinical and research services for the entire London and South-East Region of England. We have a track record of Clinical Research in all aspects of Sleep Disorders.

Additional Descriptors, Keywords:

We have a second Clinical and Research Site in the UK based in Edinburgh, Scotland –

KEY Publications of the Laboratory:

1. Clarke NA, Williams AJ, Kopelman MD: REM Behaviour Disorder in Dementia. Br J Psych. Vol 176: 189-192, 2000.

2. Lawrence E, Dundas R, Higgens SE, Howard R, Rudd AG, Wolfe C, Williams AJ. The natural history and associations of sleep-disordered breathing in first ever stroke. Internat J Clin Practice 55: 584-588, 2001

3. Ebrahim IO, The three faces of Memory Disorder; Health and Aging, 2000, 14:24 -27;

4. Oka Y, Howard RS, Williams AJ. Review of REM Sleep Behaviour Disorder in a Sleep Disorder Centre in the United Kingdom. J Neurol. Sci 2001; 187: P1563.

5. Williams AJ, Higgins SE, Howard RS. Assessment of Sleepiness in a Clinic Population – the Value {or not} of the Multiple Sleep Latency Test {MSLT} J Neurol. Sci 2001; 187: P1568.

6. Nooman YM, Seers C, Higgins SE, Seed P, Howard RS, Williams AJ. Assessment of Heart Rate Variability During Periodic Limb Movements in Sleep. J Neurol. Sci 2001; 187: P1570.

7. Sam Parnia, D. G. Waller, R. Yeates and P. Fenwick. A qualitative and quantitative study of the incidence, features and aetiology of near death experiences in cardiac arrest survivors. Resuscitation, Volume 48, Issue 2, February 2001

8. Ebrahim IO, Howard R S, Kopelman M D, Sharief M K, and Williams A J. The hypocretin/orexin system. J R Soc Med 2002 95: 227-230;

9. Ebrahim IO, de Lacy S, Semra Y K, Howard R S, Sharief M K, and Williams AJ. CSF Hypocretin levels in Neurologic and Psychiatric conditions, SLEEP 2002;

10. Ebrahim IO, de Lacy S, Semra Y K, Howard R S, Sharief M K, and Williams A J. Narcolepsy with cataplexy, Monosymptomatic Narcolepsy and Primary Hypersomnia: A prospective study in 24 patients including CSF hypocretin levels, SLEEP 2002; 25:

11. Ebrahim IO, Memory Disorders in Psychiatric Practice, BJPsych 2002; 181: 177-178;

12. Ebrahim IO, Sharief MK, de Lacy S, Semra YK, Howard RS, Kopelman MD, Williams AJ. Hypocretin (Orexin) Deficiency in Narcolepsy and Primary Hypersomnia. JNNP 2003; 74(1): 127-130;

13. Ebrahim IO, Williams AJ, et al. CSF Hypocretin (Orexin) in Neurological and Psychiatric disorders. JSR 2003; 12(1).

14. Nooman YM, Seers C, Higgins SE, Howard RS, Williams AJ. The Use of Heart Rate Variability to differentiate between obstructive and non-obstructive sleep apnoea. Am J Resp Crit Care Med.

15. L. C. Liu, P. B. C. Fenwick, et al. The human primary somatosensory cortex response contains components related to stimulus frequency and perception in a frequency discrimination task. Neuroscience, Volume 121, Issue 1, 26 September 2003

16. Ebrahim IO, Fisher JP, de Lacy S, Williams AJ. A prospective, randomized, trial comparing the effectiveness of Cognitive Behaviour Therapy, Pharmacologic Treatment and Combination therapy in patients with Primary Insomnia. SLEEP (2003)

17. Williams AJ, Oka Y, Howard RS, Soliman MGG, de Lacy S, Ebrahim IO REM Sleep Behaviour Disorder – Characteristics of a series of consecutive referrals to a Specialist Sleep disorders Centre in the UK, SLEEP (2003)

18. Ebrahim IO, de Lacy S, Howard RS, Sharief MK, Williams AJ. CSF Hypocretin (Orexin) in Disorders of Excessive Daytime Sleepiness. SLEEP (2003).

19. Nightingale S, Orgill JC, Ebrahim IO, Williams AJ. The Association between Narcolepsy and REM Sleep Behaviour Disorder (RBD). SLEEP (2004)

20. Thannickal TC, Mayhew J Blouin A, Nienhuis R, Williams AJ, Ebrahim IO, Siegel JM. Distribution of Hypocretin (Orexin) Immunoreactivity In The Hypothalamus Of Normal And Narcoleptic Horse. SLEEP (2004)

21. Orgill JC, Bath J, Ebrahim IO, de Lacy SF, Williams AJ. The role of Actigraphy in the study of Sleep and Circadian Rhythms. SLEEP (2004).

22. Y. Nagai, H. D. Critchley, E. Featherstone, P. B. C. Fenwick, M. R. Trimble and R. J. Dolan. Brain activity relating to the contingent negative variation: an fMRI investigation NeuroImage, Volume 21, Issue 4, April 2004,

23. Nagai Y, Goldstein LH, Critchley HD, Fenwick PB. Influence of sympathetic autonomic arousal on cortical arousal: implications for a therapeutic behavioural intervention in epilepsy. Epilepsy Res. 2004 Feb;58(2-3):185-93.