Experimental Sleep Studies, Universidad Autonoma de Madrid

Anatomía, Histología y Neurociencia

Isabel Trinidad DE ANDRES
Full Professor
Arzobispo Morcillo 4, 28029
34 91 4975337
34 91 4975338
Contact E-mail:
Research Domain
  • Basic Animal
  • Sleep Physiology-Neurophysiology in Animal
Current Announcements

Neurobiology of Sleep and its Disorders. (Posgraduate course within the Master in Neuroscience. Universidad Autonoma of Madrid). May 2012

Laboratory description

1. Neuroanatomical, neurophysiological and neurochemical sleep mechanisms.
2. Acute and chronic effects of opiates on sleep and EEG

Additional Descriptors, Keywords

Acetylcholine, carbachol, morphine, GABA, hypocretin/orexin, pontine tegmentum, basal forebrain

Key Publications of the Laboratory:
Reinoso-Suárez F. Die Auswirkungen der Ausschaltung eines Nucleus ruber auf die Hirnrinde (Electroencephalographische Untersuchungen an der Katze). Dtsch.Z.Nervenheilk. 172: 201-219. 1954.
Camacho A., F. Reinoso-Suárez. Activating and synchronizing centers in cat brain. Science. 146: 268-270. 1964.
Obrador S., F. Reinoso-Suárez, J. Carbonell, A. Córdoba, E. Martínez-Moreno, V. Navarro, H. Oliva, JC. Oliveros. Comatose state maintained during eight years following a vascular ponto mesencephalic lesion. Electroenceph. Clin. Neurophysiol. 38: 21-26. 1975.
Llamas A., F. Reinoso-Suárez, E. Martínez-Moreno. Projections to the gyrus proreus from the brain stem tegmentum (locus coeruleus, raphe nuclei) in the cat, demonstrated by retrorade transport of horseradish peroxidase. Brain Res. 89: 331-336. 1975.
De Andrés I. and F. Reinoso-Suárez. Cerebellar participation in the regulation of sleep-wakefulness cycle through the superior cerebellar peduncle. Arch. ital. Biol. ll7:l40-l63. l979.
Cunchillos J.D. and I. de Andrés. Participation of the cerebellum in the regulation of the sleep- wakefulness cycle. Results in cerebellectomized cats. Electroenceph. Clin. Neurophysiol. 53:549-558. l982.
Caballero A. and I. de Andrés. Unilateral lesions in the Locus coeruleus area enhance paradoxical sleep. Electroenceph. Clin. Neurophysiol. 64:339-346. 1986.
Corpas I. and I. de Andrés. Morphine effects in brainstem transected cats : I. EEG and sleep-wakefulness in the isolated forebrain. Beh. Brain Res. 44: 11-19. 1991
De Andrés I. and I. Corpas. Morphine effects in brainstem transected cats : II. Sleep and behavior of the decerebrate cat. Beh. Brain Res. 44: 21-26. 1991.
Nuñez A., I. de Andrés and E. García-Austt. Relationships of the nucleus reticularis pontis oralis neuronal activity with sensory and carbachol evoked hippocampal theta rhytm. Exp.Brain Res. 87: 303-308. 1991.
Arpa J. and I. de Andrés. Re-examination of the effects of raphe lesions on the sleep-wakefulness cycle states in cats. J. Sleep Res. 2:96-102. 1993.
Reinoso-Suárez F., I. de Andrés, ML. Rodrigo-Angulo and E. Rodriguez-Veiga. Location and anatomical connections of a paradoxical sleep induction site in the brainstem of the cat. Eur. J. Neurosci. 6 : 1829-1836. 1994
Reinoso-Barbero F. and I. de Andrés. Effects of opioid microinjections in the nucleus of the solitary tract on the sleep-wakefulness cycle states in cats. Anesthesiology. 82: 144-152. 1995.
Garzón, M., I. de Andrés, and F. Reinoso-Suárez. Neocortical and hippocampal electrical activities are similar in spontaneous and cholinergic-induced REM sleep. Brain Res. 766: 266-270. 1997.
Núñez A., C.de la Roza, ML. Rodrigo-Angulo, W. Buño and F.Reinoso-Suárez. Electrophysiological properties and cholinergic responses of rat ventral oral pontine reticular neurons in vitro. Brain Res. 754: 1-11. 1997.
Garzón M., I. de Andrés, and F. Reinoso-Suárez. Sleep patterns after carbachol delivery in the ventral oral pontine tegmentum of the cat. Neuroscience 83:1137-1144. 1998.
Núñez A., W.Buño, F.Reinoso-Suárez. Neurotransmitter actions on oral pontine tegmental neurons of the rat: an in vitro study. Brain Res. 804: 144-148, 1998.
Rodrigo-Angulo ML., E. Rodríguez-Veiga and F. Reinoso-Suárez . Serotonergic connections to the ventral oral pontine tegmentum. Implication in paradoxical sleep modulation. J. Comp. Neurol. 418: 93-105. 2000.
de la Roza C., F.Reinoso-Suárez. Ultrastructure and synaptic organization of axon terminals of the ventral part of the oral pontine reticular nucleus. J. Comp. Neurol. 418:93-105, 2000
Reinoso-Suárez F., I. de Andrés, ML. Rodrigo-Angulo, and M. Garzón. Brain structures and mechanisms involved in the generation of Rem sleep. Sleep Med. Rev. 5: 63-77. 2001.
Villablanca JR., I. de Andrés and Ch E Olmstead. Sleeping and waking develop independently in the isolated forebrain and decerebrate cat after a mesencephalic transection early postnatally. Neuroscience 106: 717-731. 2001.
Núñez A., ML. Rodrigo, I. de Andrés and F. Reinoso- Suárez. Firing activity and postsynaptic propierties of morphologically identified neurons of the ventral oral pontine reticular nucleus. Neuroscience. 115: 1165-1175. 2002.
De Andrés I., M. Garzón and J. Villablanca. The disconnected brain stem does not support rapid eye movement sleep rebound following selective deprivation. Sleep. 26: 419-435; 2003.
De Andrés I., M. Garzón and JR. Villablanca. The brain stem but not the forebrain independently supports basic morphine´s tolerance and withdrawal effects. A study in cats with midbrain transection Beh. Brain Res. 148:133-144. 2004.
Rodrigo-Angulo ML., E. Rodriguez-Veiga and F. Reinoso-Suarez . A quantitative study of the brainstem cholinergic projections to the ventral part of the oral pontine reticular nucleus (REM sleep induction site) in the cat. Exp Brain Res. 160:334-343, 2005.


Title:  PhD MD

Name:  Jaime R Villablanca

Position:  Distinguished Professor Emeritus

Institution:  Mental Retardation Research Center, Brain Research Institute, University of California, Los Angeles

Name:  Virginia M Pickel

Position:  Full Professor

Institution:  Weill Medical College of Cornell University New York

Title:  PhD

Name:  Julio Rodriguez

Position:  Research Professor

Institution:  Universidad del País Vasco

Title:  PhD

Name:  Elisa Mengual

Position:  Research Professor

Institution:  Universidad de Navarra

Title:  PhD

Name:  Ester Luqin

Position:  Research fellow

Institution:  Universidad de Navarra

Title:  PhD MD

Name:  Javier Arpa

Position:  Neurology

Institution:  Hospital Universitario La PAZ

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