Memory and Sleep lab – UvA, University of Amsterdam

Brain & Cognition

Contact:
W.F. Hofman / L.M. Talamini
Position:
Principal investigators
Address:
Weesperplein 4, 1018 XA
City:
Amsterdam
Country:
Netherlands
Phone:
+31 20 5256742
Fax:
+31 20 6291656
Contact E-mail:
Research Domain
Keywords

Laboratory description

The group’s main research themes regard the interplay of sleep and wake time cognitive and emotional function. These themes are investigated both from a behavioural perspective and with regard to the underlying neural mechanisms. Research includes both fundamental and clinical topics.

Fundamental research
Fundamental research revolves around the role of sleep in information processing, addressing for instance the reorganisation of memory over time and sleep, information (re)processing during sleep and the role of sleep oscillations, such as spindles and slow waves, in consolidation and reorganization type processes. Substantial research effort also regards the relation between sleep and emotional processing, with special attention again for sleep physiological and neural mechanisms. A program with high societal interest regards the sleep characteristics of adolescents in relation to performance.

Clinical research
Clinically oriented studies address the relation between sleep problems and cognitive/emotional deficits in neurological and psychological disorders. A current programs regards the interplay between emotional memory processing deficits and sleep problems in PTSD. Another concerns cognitive problems related to sleep disordered breathing and cognitive rehabilitation. Further lines of research regard new treatment strategies for insomnia.

Facilities
Laboratory description: 2 bedroom sleep laboratory, control room, large lounge, kitchen and bathroom facilities. Possibility for circadian rhythm studies.


Technical Capabilities and areas of expertise

Traditional PSG, ambulatory PSG, high-density EEG. MRI/fMRI (3 and soon 7 Tesla), EEG/fMRI set up, transcranial magnetic stimulation (TMS), eye-tracking, diverse monitoring equipment.
Specialized sleep analysis and diagnostic software, integrated stimulus presentation and recording software and setups. Web-based tool for insomnia studies.


Selected Publications in the 5 past years:

Talamini L.M. and van der Werf Y. Slaap en geheugen. In: Handboek Slaap (eds. J. Verbraecken, B. Buyse, H. Hamburger, V. van Kasteel en R. van Steenwijk). Uitgeverij ACCO. In press.

Woudenberg, F., Devilee, J., Perenboom, R. J. M., Hofman, W. F., van Kamp, I., & Kempen, E. E. M. M. v. (2013). Geluid en gezondheid (In Press ed.). Den Haag: Sdu Uitgevers.

Kylstra, W., Aaronson, J. A., Hofman, W. F., & Schmand, B. (2012). Neuropsychological functioning after CPAP treatment in obstructive sleep apnea: A meta-analysis. Sleep Medicine Reviews, In press

Hofman, W. F. (2013). Slaapverstoring. In F. Woudenberg, J. Devilee, R. J. M. Perenboom, W. F. Hofman, I. van Kamp & E. E. M. M. v. Kempen (Eds.), Geluid en gezondheid (In Press ed., pp. In Press). Den Haag: Sdu Uitgevers.

Aaronson, J. A., Bezeij, T. v., Aardweg, J. G. v. d., Bennekom, C. Talamini, L. M. and Van der Werf Y. (2012) De rol van slaap in cognitie en affect. Tijdschrift voor Neuropsychologie 7(3), 122-129.

Roy Cox, Winni F. Hofman & Lucia M. Talamini (2012). Involvement of spindles in memory consolidation is slow wave sleep-specific. Learning and Memory. Learn Mem. 19(7):264-7.

Lucia M. Talamini and Eva Gorree (2012). Ageing memories: differential decay of episodic memory components. Learning and Memory. Learn Mem. 19(6):239-46.

A. M. v., & Hofman, W. F. (2012). Diagnostic accuracy of nocturnal oximetry for detection of sleep apnea syndrome in stroke rehabilitation. Stroke, 43, 2491-2493.

Tielemans NS, Hendriks MP, Talamini L, Wester AJ, Meeter M, Kessels RP (2012). Facilitation of memory by contextual cues in patients with diencephalic or medial temporal lobe dysfunction. Neuropsychologia 50(7):1603-8.

Roy Cox, Winni F. Hofman & Lucia M. Talamini (2011). Retention-dependent increases in sleep spindle density: a specific SWS phenomenon. Sleep-Wake Research in the Netherlands, 22, 48-51.

Laura F. Bringmann, Winni F. Hofman & Lucia M. Talamini (2011). The effect of emotional stimuli on sleep architecture in healthy subjects. Sleep-Wake Research in the Netherlands, 22, 40-43.

Lucia M. Talamini, Lieuwe de Haan MD, Dorien H. Nieman, Don H. Linszen, Martijn Meeter. (2010) Reduced context effects on retrieval in first-episode schizophrenia. PloS ONE, 5(4):e10356.

Talamini L.M. Slapen en Breinleren. In: Breinboek voor opleiders (eds. N. Lazeron en R. van Dinteren). Bohn Stafleu van Loghum te Houten, 2010.

Hofman, W. F., & Kumar, A. (2010). Online treatment of insomnia using behavioral techniques. Sleep Diagnosis and Therapy, 5(3), 28-32.

White, K., Hofman, W. F., & van Kamp, I. (2010). Noise sensitivity in relation to baseline arousal, physiological response and psychological features to noise exposure during task performance. Internoise 2010, Lisbon, Portugal. 1-7.

Talamini, L. M., Sweegers, C. C., & Hofman, W. F. (2010). Daytime napping and emotional and declarative memory. In T. de Boer, V. van Kasteel, B. Koch, G. van Luijtelaar & J. Verbraecken (Eds.), Sleep-Wake Research in the Netherlands (Vol. 21, pp. 136). Leiden.

Hofman, W. F., Cox, R., & Talamini, L. M. (2010). Effects of an emotional film on sleep EEG: relation with emotional attenuation over sleep. In T. de Boer, V. van Kasteel, B. Koch, G. van Luijtelaar & J. Verbraecken (Eds.), Sleep-Wake Research in the Netherlands (Vol. 21, pp. 128). Leiden.

Talamini L.M. and Meeter M. (2009) Dominance of objects over context in a mediotemporal lobe model of schizophrenia. PloS ONE, 4(8):e6505.

Atsuko Takashima, Ingrid Nieuwenhuis, Ole Jensen, Lucia Talamini, Mark Rijpkema, Guillen Fernandez. (2009) Shift from hippocampal to neocortical centered retrieval network with consolidation. J. Neurosci., 29(32):10087-93. I.f. 8.2

Lucia M. Talamini, Ingrid L.C. Nieuwenhuis, Atsuko Takashima and Ole Jensen. (2008) Sleep directly following learning benefits consolidation of spatial associative memory. Learning and Memory. 15(4):233-7. I.f. 5.2

Hofman, W. F., & Toonen-Derks, P. C. M. (2008). Effects of cultural differences on adolescent sleep. Sleep-wake research in the netherlands (pp. 67-70). Oss: NSWO.

Meier, A. M., & Hofman, W. F. (2008). Assessment en protocollaire behandeling van slaapproblemen bij kinderen. In C. Braet, & S. Bögels (Eds.), Protocollaire behandelingen voor kinderen met psychische klachten (pp. 49-73). Amsterdam: Boom.


Key Publications of the Laboratory:

Learning, Memory, Cognition
Sleep and Medical Disorders
Sleep and Psychiatry-Personality Disorders
Sleep Physiology-Neurophysiology in Human


Current/Completed Grants (past 5 years):

VIDI grant, NWO, 2008. “Sleep and memory consolidation: cleaning up the hard disc”, (016.095.358).

CSCA Cognition Programme grant, UvA, 2009. “Keeping emotional memories at bay: From molecule to patient”.

Bial Foundation, 2012. “REM-sleep, the regulation of self-conscious emotion and hyperarousal in psychophysiological insomnia”.


Other laboratory Members

Title:  MSc

Name:  Roy Cox

Position:  PhD student

Email:  r.cox@uva.nl

Title:  MSc

Name:  Carly C. G. Sweegers

Position:  PhD student

Email:  c.c.g.sweegers@uva.nl

Title:  MSc

Name:  Marieke de Boer

Position:  Researcher; Lab Coordinator

Email:  m.deboer2@uva.nl


Collaborations

Name:  Miranda Olff

Position:  Professor

Institution:  Academic Medical Centre Amsterdam

Title:  MSc

Name:  Mirjam J. Nijdam

Position:  Postdoc

Institution:  Academic Medical Centre Amsterdam

Name:  A.C.H.G. (Twan) Driessen

Position:  General director

Institution:  Centrum '45

Title:  MD

Name:  Ruud A. Jongedijk

Position:  Psychiatrist / Director of Innovation and Patient Care

Institution:  Centrum '45 / Arq Psychotrauma Expert Group

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