Competence Center of Sleep Medicine, Charité - University Medicine Medicine

CC15

Contact:
Heidi Danker-Hopfe
Position:
Head of Laboratory
Address:
Eschenallee 3, 14050
City:
Berlin
Country:
Germany
Phone:
+49 30 8445 8600
Fax:
+49 30 8445 8233
Research Domain
  • Basic Human
  • Methodology / Technology
Keywords
  • Neurological Sleep Disorders
  • Behavioural Sleep Disorders
  • Epidemiology of Sleep
  • Sleep and Psychiatry-Personality Disorders
  • Sleep and Ageing
  • Learning, Memory, Cognition
  • Instrumentation-Methodology
  • Pharmacology Human

Laboratory description

Research Activities

Research projects include:

Quality management of visual sleep stage scoring.
Validation of automatic PSG scoring systems.
Measurement of daytime vigilance.
Sleep and cognition.
Sleep and mobile communication.
Sleep and ADHD in adults.
Clinical trials.


Technical Capabilities and areas of expertise

 


Selected Publications in the 5 past years:

• Sauter C, Danker-Hopfe H, Loretz E, Zeitlhofer J, Geisler P, Popp R: The assessment of vigilance: normative data on the Siesta sustained attention test. Sleep Med. 2013 Jun;14(6):542-8..
• Eggert T, Sauter C, Popp R, Zeitlhofer J, Danker-Hopfe H: The Pupillometric Sleepiness Test in adults: effects of age, gender, and time of day on pupillometric variables. Am J Hum Biol 2012 24(6) 820-828.
• Bettica P, Squassante L, Zamuner S, Nucci G, Danker-Hopfe H, Ratti E: The orexin antagonist SB-649868 promotos and maintains sleep in men with primary insomnia. Sleep 2012, 35(8): 1097-1104.
• Hoever P, Dorffner G, Benes H, Penzel T, Danker-Hopfe H, Barbanoj MJ, Pillar G, Saletu B, Polo O, Kunz D, Zeitlhofer J, Berg S, Partinen M, Bassetti CL, Högl B, Ebrahim IO, Holsboer-Trachsler E, Bengtsson H, Peker Y, Hemmeter UM, Chiossi E, Hajak G, Dingemanse J: Orexon receptor antagonism, a new sleep-enabling paradigm: a proof-of-concept clinical trial. Clin Pharmacol Ther 2012, 91(6): 975-985.
• Schmid G, Bolz T, Uberbacher R, Escorihuela-Navarro A, Bahr A, Dorn, H, Sauter C, Eggert T, Danker-Hopfe H: Design and dosimetric analysis of a 385 MHz TETRA head exposure system for use in human provocation studies. Bioelectromagnetics 2012, 33(7): 594-603.
• Danker-Hopfe H: Growth and development of children with a special focus on sleep. Prog Biophys Mol Biol 2011, 107(3): 333-338.
• Kraemer S, Danker-Hopfe H, Pilhatsch M, Bes F, Bauer M: Effects of supraphysiological doses of levothyroxine on sleep in healthy subjects: a prospective polysomnography study. J Thyroid Res 2011. July 7 Epup ahead of print.
• Sauter C, Dorn H, Bahr A, Hansen ML, Peter A, Bajbouj M, Danker-Hopfe H: Effects of exposure to electromagnetic fields emitted by GSM 900 and WCDMA mobile phones on cognitive function in young male subjects. Bioelectromagnetics. 2011 32(3): 179-190..
• Körtner K, Hansen ML, Danker-Hopfe H, Neuhaus AH, Jockers-Scherübl MC: Persistent deficits of visual recall in Kleine-Levin syndrome. J Clin Neurosci. 2011 Mar;18(3):439-40. Epub 2011 Jan 13.
• Danker-Hopfe H, Dorn H, Bahr A, Anderer P, Sauter C: Effects of electromagnetic fields emitted by mobile phones (GSM 900 and WCDMA/UMTS) on the macrostructure of sleep. J Sleep Res. 2011 Mar;20(1 Pt 1):73-81. doi: 10.1111/j.1365-2869.2010.00850.x.
• Quante A, Luborzewski A, Brakemeier EL, Merkl A, Danker-Hopfe H, Bajbouj M: Effects of 3 different stimulus intensities of ultrabrief stimuli in right unilateral electroconvulsive therapy in major depression: a randomized, double-blind pilot study. J Psychiatr Res. 2011 Feb;45(2):174-8. Epub 2010 Aug 21.
• Sauter C und Danker-Hopfe H: Der Multiple Wachbleibetest (MWT). Zur Praxis der Durchführung in DGSM-akkreditierten Schlaflaboren. Somnologie. 2010, 14:170-177.
• Danker-Hopfe H, Dorn H, Bornkessel C, Sauter C: Do mobile phone base stations affect sleep of residents? Results from an experimental double-blind sham-controlled field study. Am J Hum Biol. 2010 Sep-Oct;22(5):613-8.
• Anderer P, Moreau A, Woertz M, Ross M, Gruber G, Parapatics S, Loretz E, Heller E, Schmidt A, Boeck M, Moser D, Kloesch G, Saletu B, Saletu-Zyhlarz GM, Danker-Hopfe H, Zeitlhofer J, Dorffner G: Computer-assisted sleep classification according to the standard of the American Acadamy of Sleep Medicine: validation study of the AASM version of the Somnolyzer 24 x 7. Neuropsychobiology. 2010;62(4). Epub 2010 Sep 9.
• Sartorius A, Hellweg R, Litzke J, Vogt M, Dormann C, Vollmayr B, Danker-Hopfe H, Gass P. Pharmacopsychiatry. 2009 Nov;42(6):270-6. Epub 2009 Nov 18.
• Ziegenhorn AA, Roepke S, Schommer NC, Merkl A, Danker-Hopfe H, Perschel FH, Heuser I, Anghelescu IG, Lammers CH: Clonidine improves hyperarousal in borderline personality disorder with or without comorbid posttraumatic stress disorder: a randomized, double-blind, placebo-controlled trial. J Clin Psychopharmacol. 2009, 29(2) 170-3
• Schulte-Herbrüggen O, Fuchs E, Abumaria N, Ziegler A, Danker-Hopfe H, Hiemke C, Hellweg R: Effects of escitalopram on the regulation of brain-derived neurotrophic factor and nerve growth factor protein levels in a rat model of chronic stress.J Neurosci Res. 2009 Apr 9
• Danker-Hopfe H, Anderer P, Zeitlhofer J, Boeck M, Dorn H, Gruber G, Heller E, Loretz E, Moser D, Parapatics S, Saletu B, Schmidt A, Dorffner G: Interrater reliability for sleep scoring according to the Rechtschaffen & Kales and the new AASM standard. J Sleep Res. 2009, 18(1) 74-84
• Moser D, Anderer P, Gruber G, Parapatics S, Loretz E, Boeck M, Kloesch G, Heller E, Schmidt A, Danker-Hopfe H, Saletu B, Zeitlhofer J, Dorffner G: Sleep classification according to AASM and Rechtschaffen & Kales: effects on sleep scoring parameters. Sleep. 2009, 32(2) 139-49
• Hornung OP, Regen F, Dorn H, Anghelescu I, Kathmann N, Schredl M, Danker-Hopfe H, Heuser I: The effects of donepezil on postlearning sleep EEG of healthy older adults. Pharmacopsychiatry. 2009 Jan;42(1):9-13
• Lang UE, Günther L, Scheuch K, Klein J, Eckhart S, Hellweg R, Danker-Hopfe H, Oehler J: Higher BDNF concentrations in the hippocampus and cortex of an aggressive mouse strain. Behav Brain Res. 2009, 197(1) 246-249
• Jakob F, Brakemeier EL, Schommer N, Quante A, Merkl A, Danker-Hopfe H, Anghelescu I, Heuser I, Bajbouj M: Ultrahigh frequency repetitive transcranial magnetic stimulation in unipolar depression. J Clin Psychopharmacol 2008, 28(4) 474-476
• Schulte-Herbrüggen O, Eckart S, Deicke U, Kühl A, Otten U, Danker-Hopfe A, Abramowski D, Staufenbiel M, Hellweg: Age-dependent time course of cerebral brain-derived neurotrophic factor, nerve growth factor, and neutrophin-3 in APP23 transgenic mice. J Neurosci Res 2008, 86(12) 2774-2783
• Brakemeier EL, Wilbertz G, Rodax S, Danker-Hopfe H, Zinka B, Zwanzger P, Grossheinrich N, Várkuti B, Rupprecht R, Bajbouj M, Padberg E: Patterns of response to repetitive transcranial magnetic stimulation (rTMS) in major depression: replication study in drug-free patients, J Affect Disord, 2008 108(1-2), 59-70.
• Hornung OP, Regen F, Danker-Hopfe H, Heuser I, Lammers CH: Declarative and procedural memory consolidation during sleep in patients with borderline personality disorder. J Psychiatr Research, 2008, 42(8), 653-658.


Current/Completed Grants (past 5 years):

Research grants from Federal Office of Radiation Protection and from pharmaceutical companies for participation in clinical trials


Other laboratory Members

Title:  MD

Name:  Marie-Luise Hansen

Position:  Medical head of laboratory, somnologist

Email:  marie-luise.hansen@charite.de

Title:  MD

Name:  Anita Peter

Position:  Somnologist

Email:  anita.peter@charite.de

Title:  MD

Name:  Hans Dorn

Position:  engineer

Email:  hans.dorn@charite.de

Title:  PhD

Name:  Cornelia Sauter

Position:  research assistant, somnologist, sleep scientist

Email:  cornelia.sauter@charite.de

Title:  MA

Name:  Torsten Eggert

Email:  torsten.eggert@charite.de


Collaborations

Title:  PhD

Name:  Gernot Schmid

Institution:  Seibersdorf Laboratories GmbH

Title:  PhD

Name:  Peter Anderer

Institution:  Medical University Vienna

Title:  PhD MD

Name:  Malek Bajbouj

Institution:  Free University of Berlin

Title:  PhD MD

Name:  Josef Zeitlhofer

Institution:  Medical University Vienna

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