CENC - Sleep Medicine Center, CENC

CENC - Sleep Medicine Center

Contact:
Teresa Paiva
Position:
Clinical Director
Address:
Rua Conde das Antas 5, 1070-068
City:
Lisbon
Country:
Portugal
Phone:
+351 213715450
Fax:
+351 213715459
Contact E-mail:
Research Domain
Keywords

Laboratory description

The private clinical activity in CENC – Centro do Sono, in terms of PSGs started in 1998 and in terms of patient observation around the year 2000. The full Sleep Center was organized in 2005.

There are written protocols for each recording; the website includes a detailed explanation of each test in terms of procedures and clinical information obtained, so that patients are adequately informed. Furthermore upon booking of a sleep recording the patients receive detailed written information.
The report is given shortly after, the next morning for those patients coming from other country regions, for those requiring urgent solutions and for private patients.
The technical staff is formed by highly trained personnel, with either the Master Degree or post graduation studies in Sleep Medicine. The co-ordinator is the MSc Sofia Rebocho; she is responsible for the supervision of the technical quality of the recordings, data storing and file archiving and the overall coordination of the Sleep Lab (the AASM and ESRS recommendations are implemented). Besides, the permanent technical staff includes Ana Viegas (developing her MSc thesis at present) and Catia Oliveira and 7 non permanent technicians assuring the night recording or the PSG scoring and pre-report.
The PSG reports are supervised by myself and by Richard Staats (German sub specialty in Sleep Medicine)
The Sleep Medicine Center medical staff includes myself, 1 pneumologist: Richard Staats, a Neurologist (Dulce Neutel, and a Psychiatrist: Ana santa Clara) and a dentist (Gabriela Videira)
Furthermore other medical specialties are available, namely Neurology, Neuropediatrics, Psychiatry, Physiatrist, ENT, Cardiology and Internal Medicine.
The Psychology team includes: Helena Rebelo Pinto (Full Professor in Psychology of Education) who deals with cognitive behavior therapy of insomniacs and supervision professional trainings; Teresa Rebelo Pinto (MSc) who supports my clinical consultations and deals with behavior therapy of children and adolescents; Lara Pessoa who is in charge of psychotherapy treatments and Carolina Maruta (Neurophychologist) who deals with cognitive deficits; Catarina Mestre for Children Sleep Medicine, phobias and behavior therapy.
Chronobiology is assured by a biologist, Dr Catia Reis, currently working in her PhD thesis.
The team includes also Nutrition specialists (Mariana Chaves), a specialist in Physical activity and Exercise (Vera Ramos) and a Quiropractitioner (Miguel Otero), Neuromuscular therapist (Filipe Videira)
The administrative personnel is: Ana Coutinho, Isabel Barradas, Clara Rodrigues in full time; they manage all the administrative procedures related with the booking of consultations and laboratorial exams.

The Sleep Medicine Center has been recognized by the Psychologist National Association, by ISPA and by Escola Superior de Educação de Tecnologias da Saúde as competent for pos-graduate training.
In order to promote Portuguese Brazilian collaboration the CENC- Sleep Medicine Center promoted a award for published work in international peer review journals achieved by researchers or clinicians of both countries (for detailed information see www.centrodosono.com ): The Florbela Espanca Award, now in its 4rd edition
The quality and diversity of patients and recordings of the CENC- Sleep Medicine Center has allowed the execution of PhD and MSc thesis, both in Medicine and BME, in the last years, based on our own material and facilities. The present total is 3 PhD completed and 2 currently developping and 34Master thesis in Medicine, Biomedicall Engineering and Informatics).


Technical Capabilities and areas of expertise

The present Sleep Medicine Center has 4 rooms, each one equipped with video polysomnography allowing 21 EEGs channels together with standard cardio respiratory and EMG channels; the esophageal pressure, Ph and penile pletysmography are possible options. Besides, a fifth room equipped with a EEG machine with 64 EEG channels allows cognitive testing and brain mapping.
The PSG recording modalities are adapted to the clinical diagnosis and follow AASM 2007/2012 criteria; however the minimal number of EEG channels used is 8.
Sofar, since October 1998 the CENC- Sleep Medicine Center performed more then 6000 PSGs, type 1 (in Lab) and more than 3000 ambulatory (type 2).
The patient mean age is 49.3 years, with a minimum of 1 years of age; 53% were males.
The patient data base includes 15000 patients, diagnosed and treated directly by myself; around 20% of them are neurological patients without sleep disorders.
The Sleep Medicine Center has been recognized by the Psychologist National Association, by ISPA and by Escola Superior de Educação de Tecnologias da Saúde as competent for pos-graduate training.
5 of the Centre collaborators have the ESRS title of Somnology


Additional Descriptors, Keywords

Sleep neurophysiology, Insomnia, Hypersomnia, Human Circadian Rhythms and disorders, Movement disorders, Parasomnias and Sleep related epilepsy, Pediatric Sleep, Sleep apnea, Dreams
Sleep awareness and dissemination


Selected Publications in the 5 past years:

1. Reis C, Mestre C, Canhão H, Paiva T, GradwellD Sleep complaints and fatigue of airline pilots. Sleep Science, 2016, Apr-Jun;9(2):73-7. Impact factor:0.144

2. Silva MR G., Pascoal A, Silva HH, Paiva T Assessing sleep, travelling habits and jet-lag in kite surfers according to competition level Biological Rhythm Research, 2016. Biological Rhythm Research. Impact factor 0.695
3. Paiva T, Gaspar T, Matos MG Mutual relations between sleep deprivation, sleep stealers and risk behaviours in adolescents Sleep Science 2016, Jan-Mar;9(1):7-13. http://dx.doi.org/10.1016/j.slsci.2016.02.176. Impact factor:0.144
4. Khatami R, Luca G, Baumann CR, Bassetti CL, Bruni O, Canellas F, DauvilliersY, Del Rio-Villegas R, Feketeova E, Ferri R, Geisler P, Högl B, Jennum P, Kornum BR, Lecendreux M, Martins-da-Silva A, Mathis J, Mayer G, Paiva T, Partinen M, Perait a-Adrados R, Plazzi G, Santamaria J, Sonka K, Riha R, Tafti M, Wierzbicka A, Young P, Lammers GJ, Overeem S; European Narcolepsy Network. The European Narcolepsy Network (EU-NN) database. J Sleep Res. 2016 Jun;25(3):356-64. doi:10.1111/jsr.12374. [Epub ahead of print] PubMed PMID: 26809504.Impact factor: 3.093
5. Matos MG, Gaspar T, Tomé G, Paiva T Sleep variability and fatigue in adolescents: associations with school related features International Journal of Psychology 2016 Oct;51(5):323-31. doi: 10.1002/ijop.12167.PMID:25940538. Impact factor 1.276
6. Silva MG, Paiva T. Poor precompetitive sleep habits, nutrients’ deficiencies, inappropriate body composition and athletic performance in elite gymnasts. Eur J Sport Sci. 2015 Oct 27:1-10. PubMed PMID: 26505326. Impact factor 1.314
7. Paiva T, Gaspar T, Matos MG Sleep deprivation, sleep stealers and risk behaviours in Portuguese adolescents – A cross-cultural comparison MOJ Public Health, 2015, ISSN: 2379-6383
8. Vidigal Costa, Joao; Lucas de Freitas, Carlos; Paiva, Teresa; “Brain Imaging of Advertising: A Neuromarketing Study of Sound and Pictures”, Marketing Review (2015). Impact factor 0.88
9. Uva, Tomás; Lucas de Freitas, Carlos; Paiva, Teresa “Neuroscience Technologies in Marketing: A Study of Gender and TV Advertisements Using Electroencephalography” (2015) International Journal of Technology Marketing IJTM, 10 (4), 362-380. Impact factor 0.28
10. Uva, Tomás; Lucas de Freitas, Carlos; Paiva, Teresa;”Television Advertisements and Gender: Neuromarketing Research Using EEG and an Oddball Paradigm”; Proceedings of the 7th EuroMed Conference, EuroMed Academy of Business, Kristiansand, Norway, September 18th-19th (2014)

11. Vidigal Costa, João; Lucas de Freitas, Carlos; Paiva, Teresa; “Assessment of the Brain Reactions to Sound and Picture in Advertising”; Proceedings of the 7th EuroMed Conference of the EuroMed Academy of Business, Kristiansand, Norway September 18th-19th (2014)
12. Conceição, Cristina; Lucas de Freitas, Carlos; Paiva, Teresa; “Pricing and Brands: A Neuromarketing Study”; Proceedings of the International Conference on Innovation and Entrepreneurship in Marketing and Consumer Behaviour ICIEMC2014, Aveiro 2-3 May (2014).
13. Reis, C., Mestre, C., Tecedeiro, M., & Paiva, T. (2014). Translation, cross-cultural adaptation and psychometric properties of the Jenkins Sleep Scale in a sample of Portuguese shift workers. Laboratório de Psicologia, 12, 89-98.
14. Silva MR, Paiva T. Low energy availability and low body fat of female gymnasts before an international competition. Eur J Sport Sci. 2014 Oct 16:1-9. [Epub ahead of print] PubMed PMID: 25318582. Impact factor 1.314
15. Penzel T, Pevernagie D, Dogas Z, Grote L, de Lacy S, Rodenbeck A, Bassetti C, Berg S, Cirignotta F, d’Ortho MP, Garcia-Borreguero D, Levy P, Nobili L, Paiva T, Peigneux P, Pollmächer T, Riemann D, Skene DJ, Zucconi M, Espie C; For The Sleep Medicine Committee and The European Sleep Research Society. Catalogue of knowledge and skills for sleep medicine. J Sleep Res. 2013 Oct 7. doi:10.1111/jsr.12095. [Epub ahead of print] PubMed PMID: 24118650. Impact factor 2.949
16. Domingues A, Paiva T, Sanches J. Sleep and Wakefulness State Detection in Nocturnal Actigraphy Based on Movement Information. IEEE Trans Biomed Eng. 2013 Sep 4. Impact factor 2.233
17. Domingues A, Paiva T, Sanches JM. An actigraphy heterogeneous mixture model for sleep assessment. Conf Proc IEEE Eng Med Biol Soc. 2012 Aug;2012:2275-8.doi:10.1109/EMBC. 2012.6346416. PubMed PMID: 23366377. Impact factor 2.727
18. J. Costa; M.D. Ortigueira; A. Batista; T. Paiva. “Sleep Spindles Detection: a Mixed Method Using STFT and WMSD”. International Journal of Bioelectromagnetism, Vol. 14 No.4, pp229-233, 2012
19. Poli F, Overeem S, Lammers GJ, Plazzi G, Lecendreux M, Bassetti CL, Dauvilliers Y, Keene D, Khatami R, Li Y, Mayer G, Nohynek H, Pahud B, Paiva T, Partinen M, Scammell TE, Shimabukuro T, Sturkenboom M, van Dinther K, Wiznitzer M, Bonhoeffer J. Narcolepsy as an adverse event following immunization: Case definition and guidelines for data collection, analysis and presentation. Vaccine. 2012 Dec 16. doi:pii: S0264-410X(12)01781-1. 10.1016/j.vaccine.2012.12.014. [Epub ahead of print] PubMed PMID: 23246545. Impact factor 3.383
20. Lecendreux M, Bruni O, Franco P, Gringras P, Konofal E, Nevsimalova S, Paiva T, Partinen M, Peeters E, Peraita-Adrados R, Plazzi G, Poli F. Clinical experience suggests that modafinil is an effective and safe treatment for paediatric narcolepsy. J Sleep Res. 2012 Jan 28. doi: 10.1111/j.1365-2869.2011.00991.x. PubMed PMID: 22283810. Impact factor 2.949
21. David A, Constantino F, Santos JM, Paiva T. Health-related quality of life in Portuguese patients with narcolepsy. Sleep Med. 2012 Jan 24. [Epub ahead of print] PubMed PMID: 22281002. Impact factor 3.656


Key Publications of the Laboratory:

Matos MG, Paiva T, Costa D, Gaspar T, Galvao D Caffeine, Sleep Duration and Adolescents’ Perception of Health Related Quality of Life. British Journal of Education, Society & Behavioural Science 2016, 16(2):1-9. Impact factor 31
1. Reis C, Mestre C, CanhãoH, Paiva T, GradwellD Sleep and fatigue differences in the two most common types of commercial flight operations Aviat Space Environ Med. 2016, Sep;87(9):811-5. Impact factor 0,875
Paiva T, Gaspar T, Matos MG Sleep deprivation in adolescents: correlations with health complaints and health related quality of life, Sleep Medicine, 2015, Sleep Med. 2015 Apr;16(4):521-7. doi: 10.1016/j.sleep.2014.10.010. Epub 2015 Jan 20 PMID: 25754385. Impact factor 3.656
Domingues A, Paiva T, Sanches J. Hypnogram and Sleep Parameter Computation from Activity and Cardiovascular data. IEEE Transactions on Biomedical Engineering. 2014, Jun;61(6):1711-9. Impact factor 2.233
Rebelo-Pinto T, Carneiro Pinto J, Rebelo-Pinto H, Paiva T. Validation of a three-dimensional model about sleep: habits, personal factors and environmental factors, Sleep Science, 2014, vol 7(4): 197-202.


Current/Completed Grants (past 5 years):

GRANTS and Projects:
1) MCTQ in Insomniacs and Sleep Phase Delay Syndrome (2016) – T Paiva and Catia Reis (CENC), Till Roenneberg (Univ Munchen)
2) Biomarcadores do Stress – (2015-2016) Catia Reis and Teresa Paiva (CENC) Alexandre Domingues e João Sanches (IST); supported by Ecofusion – Israel
3) Sleep Schools Project – Coordination – T Paiva and H Rebelo Pinto, 2010-2014, supported by CENC and FMUL
4) FCT (Fundação Ciencia e Tecnologia): Detection of brain microstates in Fibromyalgia – Coordinator – Joao Sanches –(IST) -2010-2012
5) ETEN/2004/1 – ENN-ICS – European Neurological Network – Interactive Communication System, Contract 517418 – European Commission- TenTelecom – eten. 2005-2006. (1.000.000€)
CLINICAL TRIALS
International Project Pierre Fabre: Minalcipran in Fibromyalgia treatment (2007) Double blind, multicentre, International study.
• International Project Pierre Fabre: Minalcipran in Fibromyalgia long term treatment (2007-2008)
• Dreams – Sanofi Aventis (2008 -2009) – Double blind, multicentre, European study of the efficacy of eplivanserin in Insomnia treatment. CENC – research centre. National Coordinator (Teresa Paiva)
• BIA 2093-210 – Project from BIAL (2009) Double blind, multicentre, European study of the efficacy of eslicarbamazepine versus placebo in Fibromyalgia treatment. CENC – research centre.
• BIA 2093-209 -Project from BIAL (2009)- Double blind, multicentre, European study of the efficacy of eslicarbamazepine versus placebo in Headache prophylaxis. CENC – research centre.


Other laboratory Members

Title:  MSc

Name:  Ana Viegas

Position:  Technician

Email:  ana_isabel_viegas@msn.com

Title:  MSc

Name:  Sofia Rebocho

Position:  Technician, Somnologist

Email:  sofia.rebocho@gmail.com

Title:  MSc

Name:  Catia Reis

Position:  Biologist

Email:  reis.catia@gmail.com

Title:  MD

Name:  Ana Santa Clara

Position:  Psychiatrist

Email:  anarosariosantaclara@gmail.com

Title:  MSc

Name:  Teresa Rebelo Pinto

Position:  Psychologist, Somnologist

Email:  trebelopinto@gmail.com

Title:  MSc MD

Name:  Dulce Neutel

Position:  Neurologist, Somnologist

Email:  dneutel@gmail.com

Title:  MD

Name:  Richard Staats

Position:  Pneumologist, Somnologist

Email:  ristaats@web.de

Title:  PhD

Name:  Carolina Maruta

Position:  Neurropsychologist

Email:  carolmaruta@gmail.com

Title:  PhD

Name:  Helena Rebelo Pinto

Position:  Psychologist

Email:  rebelopinto@sapo.pt

Title:  BSc

Name:  Catia Oliveira

Position:  Technician

Email:  catia.f.oliveira@hotmail.com

Title:  MSc PhD

Name:  Tathiana Alvarenga

Position:  Biomedic

Email:  tafalvarenga@gmail.com

Title:  MSc MD

Name:  Joana Vaz Castro

Position:  ENT Physician

Email:  joanavazdecastro@gamil.com

Title:  MSc

Name:  Paulo Gaiao

Position:  Psychologist

Email:  pgaiao1@gmail.com

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