Meerlo Lab, University of Groningen

Center for Behavior and Neurosciences

Contact:
Peter Meerlo
Position:
Assistant Professor
Address:
P.O. Box 11103, 9700 CC
City:
Groningen
Country:
Netherlands
Phone:
+31 50 3632334
Fax:
+31 50 3632331
Contact E-mail:
Research Domain
  • Basic Animal
Keywords
  • Learning, Memory, Cognition
  • Sleep and Psychiatry-Personality Disorders
  • Sleep and Body Functions (Cardio-Respiratory, Thermoregulation/Metabolism, Endocrine)
  • Sleep Physiology-Neurophysiology in Animal

Laboratory description

The main research topics in the Meerlo lab are: 1) the regulation and function of sleep with special emphasis on the role of sleep in neuronal plasticity and memory processes; and 2) the consequences of chronically restricted or disrupted sleep and the role of sleep disturbances in psychiatric diseases and cognitive disorders. The research involves various experimental animal models of sleep disruption and sleep restriction, focusing on the question how chronically insufficient sleep affects neuroendocrine stress systems and neurobiological systems involved in emotional regulation and cognitive function.


Technical Capabilities and areas of expertise

 


Selected Publications in the 5 past years:

Meerlo P, Sgoifo A, Suchecki D. Restricted and disrupted sleep: effects on autonomic function, neuroendocrine stress systems and stress responsivity. Sleep Medicine Reviews 12: 197-210, 2008.

Novati A, Roman V, Cetin T, Hagewoud R, Den Boer JA, Luiten PGM, Meerlo P. Chronically restricted sleep leads to depression-like changes in neurotransmitter receptor sensitivity and neuroendocrine stress reactivity in rats. Sleep 31: 1579-1585, 2008.

Meerlo P, Mistlberger R, Jacobs BL, Heller C, McGinty D. New neurons in the adult brain: the role of sleep and consequences of sleep loss. Sleep Medicine Reviews 13: 187-194, 2009.

Lucassen PJ , Meerlo P, Naylor AS, Van Dam AM, Dayer AG, Fuchs E, Oomen CA, Czeh B. Regulation of adult neurogenesis by stress, sleep disruption, exercise and inflammation: implications for depression and antidepressant action. European Neuropsychopharmacology 20: 1-17, 2010.

Hagewoud R, Havekes R, Novati A, Keijser JN, Van der Zee EA, Meerlo P. Sleep deprivation impairs spatial working memory and reduces hippocampal AMPA receptor phosphorylation. Journal of Sleep Research 19: 280-288, 2010.

Hagewoud R, Whitcomb S, Heeringa AN, Havekes R, Koolhaas JM, Meerlo P. A time for learning and a time for sleep: the effect of sleep deprivation on contextual fear conditioning at different times of the day. Sleep 33: 1315-1322, 2010.

Hagewoud R, Havekes R, Tiba P, Novati A, Hogenelst K, Weinreder P, Van der Zee EA, Meerlo P. Coping with sleep deprivation: shifts in regional brain activity and learning strategy. Sleep 33: 1465-1473, 2010.

Hagewoud R, Bultsma L, Koolhaas JM, Meerlo P. Sleep deprivation impairs contextual fear conditioning and attenuates subsequent behavioral, endocrine and neuronal responses. Journal of Sleep Research 20: 259-266, 2011.

Novati A, Hulshof HJ, Koolhaas JM, Lucassen PJ, Meerlo P. Chronic sleep restriction causes a decrease in hippocampal volume in adolescent rats that is not explained by changes in glucocorticoid levels or neurogenesis. Neuroscience 190:145-155, 2011.

Koolhaas JM, Bartolumucci A, Buwalda B, de Boer SF, Flügge G, Korte SM, Meerlo P, Murison R, Olivier B, Palanza P, Richter-Levin G, Sgiofo A, Steimer T, Stiedl O, Van Dijk G, Wöhr M, Fuchs E. Stress revisited: a critical review of the stress concept. Neuroscience and Biobehavioral Reviews 35: 1291-1301, 2011.

Kamphuis J, Meerlo P, Koolhaas JM, Lancel M. Poor sleep as a potential causal factor in aggression and violence. Sleep Medicine 13: 327-334, 2012.

Novati A, Hulshof HJ, Granic I, Meerlo P. Chronic partial sleep deprivation reduces brain sensitivity to glutamate N-Methyl-D-aspartate receptor mediated neurotoxicity. Journal of Sleep Research 21: 3-9, 2012.

Barf RP, Van Dijk G, Scheurink AJW, Hoffmann K, Novati A, Hulshof HJ, Fuchs E, Meerlo P. Metabolic consequences of chronic sleep restriction in rats: changes in body weight regulation and energy expenditure. Physiology & Behavior 107: 322-328, 2012.

Coolen A, Plassman K, Barf P, Fuchs E, Meerlo P. Telemetric study of sleep architecture and sleep homeostasis in the day-active tree shrew Tupaia belangeri. Sleep 35: 879-888, 2012.


Key Publications of the Laboratory:

Meerlo P, Sgoifo A, Suchecki D. Restricted and disrupted sleep: effects on autonomic function, neuroendocrine stress systems and stress responsivity. Sleep Medicine Reviews 12: 197-210, 2008.

Meerlo P, Mistlberger R, Jacobs BL, Heller C, McGinty D. New neurons in the adult brain: the role of sleep and consequences of sleep loss. Sleep Medicine Reviews 13: 187-194, 2009.

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