Neuroenergetic and Cellular Dynamic Laboratory - S, CHUV

Center for Psychiatric Neuroscience

Contact:
Petit Jean-Marie
Position:
Responsable de Recherche
Address:
Route du Mont
City:
Prilly
Country:
Switzerland
Phone:
+ 41 21 3146227
Fax:
+ 41 21 693 18 97
Research Domain
  • Clinical
  • Basic Animal
Keywords
  • Molecular Biology-Endocrinology-Biochemistry
  • Sleep Physiology-Neurophysiology in Animal
  • Sleep Physiology-Neurophysiology in Human
  • Biological Rhythms
  • Sleep and Body Functions (Cardio-Respiratory, Thermoregulation/Metabolism, Endocrine)
  • Sleep and Psychiatry-Personality Disorders

Laboratory description

We fovcused our investigations on the role of astrocytes in sleep regulation throughout their involvement in energy metabolism.
We mainly used models of sleep deprivation/ fragmentation in mice.
We also used biosensors for brain metabolites measurements.


Technical Capabilities and areas of expertise

In animals: polygraphic sleep recording, telemetric recordings of locomotor and body temperature rhythms, in vivo biosensors, qPCR


Additional Descriptors, Keywords

Energy metabolism


Selected Publications in the 5 past years:

– The psychostimulant modafinil enhances gap junctional communication in cortical astrocytes. Petit, J-M; Liu, X; Gyger, J; Magistretti, P.J; Giaume, C. Neuropharmacology (2013); ahead of print 05/2013; DOI:10.1016/j.

– Genes Involved in the Astrocyte-Neuron Lactate Shuttle (ANLS) Are Specifically Regulated in Cortical Astrocytes Following Sleep Deprivation in Mice. Petit J-M; Gyger J; Burlet-Godinot S; Fiumelli H; Martin J-L; Magistretti PJ. Sleep (2013); 36(10):1445-1458.

– Sustained sleep fragmentation affects brain temperature, food intake and glucose tolerance in mice. Baud MO; Magistretti PJ; Petit J-M. J. Sleep Res. (2013); 22(1):3-12.

– Metabolic response of the cerebral cortex following gentle sleep deprivation and modafinil administration. Petit, J-M; Tobler, I: Kopp C; Morgenthaler F; Borbély AA; Magistretti PJ. Sleep. (2010); 33(7):901-8.

– Astrocytes and sleep homeostasis. Magistretti PJ; Petit J-M. Front in Neurosci (2009); 3(3):415.


Key Publications of the Laboratory:

n/a


Other laboratory Members

Name:  Sophie Burlet-Godinot

Email:  Sophie.Burlet@chuv.ch


Past Members

Title:  PhD MD

Name:  Maxime Baud

Position:  PhD student

Email:  Maxime.Baud@ucsf.edu

Title:  MSc

Name:  Anna Mikhaleva

Position:  MSc student

Email:  anna.mikhaleva@epfl.ch

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