Research Laboratory, Klinikum Ingolstadt

Centre of Mental Health

Contact:
Thomas R. Pollmächer
Position:
Director
Address:
Krumenauerstr. 25, 85049
City:
Ingolstadt
Country:
Germany
Phone:
+49 841 880 2201
Fax:
+49 841 880 2209
Research Domain
Keywords

Laboratory description

The sleep research lab at Klinikum Ingolstadt is closely connected to a 6-bed clinical sleep medicine facility at the same location. Research is focussed on basic human and clinical studies. Major areas are sleep and sleep disorders in psychiatric patients, insomnia, RLS and narcolepsy. The major areas of basic research are metabolic functions and immunoendocrine networks during sleep and waking in healthy people and patients with sleep disorders.

The sleep research lab is attached to the Centre of Mental Health, a 300 bed inpatient facility with a huge outpatient department. The Centre of Mental Health is a teaching hospital of the Ludwig-Maximilians-University Munich. Long-term collaborations are established with the Max Planck Institute of Psychiatry in Munich, the Neurocentro della Svizzera Italiana in Lugano, Karls University at Prague, and Peking University.

The head of the sleep research lab, Thomas Pollmächer, is director of the Centre of Mental Health, deputy Medical Director of Klinikum Ingolstadt and Professor of Psychiatry at the Ludwig-Maximilians-University Munich. He has been president of the ESRS from 2004-2008.


Technical Capabilities and areas of expertise

Combined PSG and hormonal measurements facilities
Neuropsychological laboratory,
Metabolic assessments


Additional Descriptors, Keywords

Sleep in psychiatric disorders, insomnia, narcolepsy, RLS, sleep and metabolism, sleep and immunoendocrine networks.


Selected Publications in the 5 past years:

Lattova Z, Keckeis M, Maurovich-Horvat E, Wetter TC, Wilde-Frenz J, Schuld A, Pollmächer T (2011) The stress hormone system in various sleep disorders. J Psychiatr Res. 2011 [Epub ahead of print]

Riemann D, Spiegelhader K, Espie C, Pollmächer T, Léger D, Bassetti C, Someren v E. (2011) Chronic Insomnia Clinical and research challenges – an agenda. Pharmacopsychiatry 44:1-14.

Keckeis M, Lattova Z, Maurich- Horvat E, Beitinger PA, Birkmann S, Lauer CJ, Wetter TC, Wilde Frenz J, Pollmächer T (2010) Impaired glucose tolerance in sleep disorders. PLoS One. 5: 9444.

Hennings JM, Ising M, Grautoff S, Himmerich H, Pollmächer T, Schaaf L (2010) Glucose tolerance in depressed inpatients under treatment with mirtazapine and in healthy controls. Exp Clin Endocrinol Diabetes. 118: 98-100.

Pollmächer T (2010) Schlafstörungen. In: Möller HJ, Laux G, Kapfhammer HP (Hrsg.) Psychiatrie, Psychotherapie und Psychosomatik. Springer, Heidelberg. 913-954.

Schuld A, Lauer CJ, Pollmächer T (2010) Sleep during antipsychotic treatment. In: Pandi- Perumal SR, Kramer M (Hrsg.): Sleep and mental illness. Cambridge University Press 2010; 289- 294.

Dzaja A, Wehrle R, Landel M, Pollmächer T (2009) Elevated estradiol plasma levels in women with restless legs during pregnancy. Sleep 32: 169-174.

Maurovich-Horvat E, Pollmächer TZ, Sonka K (2008) The effects of sleep and sleep deprivation on metabolic, endocrine and immune parameters. Prague Med Rep. 109:275-285

Pollmächer T, Wetter TC. Schlafstörungen. In: Holsboer F, Gründer G, Benkert O. (Hrsg.) (2008) Handbuch der Psychopharmakotherapie; Springer Medizin Verlag, Heidelberg 997- 995.

Kümpfel T, Schwan M, Pollmächer T, Yassouridis A, Uhr M, Trenkwalder C, Weber F (2007) Time of interferon-beta 1a injection and duration of treatment affect clinical side effects and acute changes of plasma hormone and cytokine levels in multiple sclerosis patients. Mult Scler 13 : 1138-45.

Wehrle R, Kaufmann C, Wetter TC, Holsboer F, Auer DP, Pollmächer T, Czisch M (2007) Functional microstates within human REM sleep: first evidence from fMRI of thalamocortical network specific for phasic REM periods. Eur J Neurosci 25: 863 – 71.

Pollmächer T, Dalal M, Schuld A (2007) Immunoendocrine abnormalities and narcolepsy. Sleep Medicine Clinics 2: 293-302.

Pollmächer T, Beitinger EB, Schuld A. Metabolic abnormalities in human narcolepsy. In: Bassetti CL, Billiard M, Mignot E (Eds.) (2007): Narcolepsy and hypersomnia. Informa Health Care, New York 459 – 465.

Pollmächer T, Dalal M, Schuld A. Immunoendocrine abnormalities in narcolepsy. In: Vgontzas,A.N. (Eds.) (2007): Sleep Medicine Clinics; Saunders, Philadelphia 2: 293 – 302.

Mayer G, Pollmächer T (Hrsg.) (2007) Narkolepsie – Neue Chancen in Diagnostik und Therapie; Georg Thieme Verlag, Stuttgart .

Schuld A. Haack M. Mullington J. Pollmächer T (2007) Changes in sleep and behavior following experimental immune stimulation using bacterial endotoxin in humans. In: S.R. Pandi-Perumal, D.P. Cardinal, G. Chrousos (Eds.): Neuroimmunology of sleep; Springer, New York 227-231.


Current/Completed Grants (past 5 years):

Sino-German Science Foundation. Several grants since 2008 (e.g. GZ538 “Sino German Center for Sleep Research” 2009-2012)

Sanofi-Aventis ESRS Research Grant 2010 (awarded to Marietta Keckeis)

Sanofi-Aventis IIT Grant “Metabolic changes in primary insomnia” (awarded to Thomas Pollmächer, 2010/2011)

European Union, “Consequences of sleep restriction” (MCRTN-CT-2004-512362) 2005-2010


Other laboratory Members

Title:  PhD

Name:  Christoph J. Lauer

Position:  Head of the Sleep Disorders Center

Email:  christoph.lauer@klinikum-ingolstadt.de

Title:  MD

Name:  Andreas Schuld

Position:  Consultant psychiatrist

Email:  andreas.schuld@klinikum-ingolstadt.de

Title:  MD

Name:  Steffen Birkmann

Position:  Psychiatrist

Email:  steffen.birkmann@klinikum-ingolstadt.de

Name:  Andrea Zahl

Position:  Psychologist

Email:  andrea.zahl@klinikum-ingolstadt.de

Title:  MD

Name:  Dusan Trstensky

Position:  Psychiatrist

Email:  dusan.trstensky@klinikum-ingolstadt.de


Collaborations

Title:  MD

Name:  Karel Sonka

Institution:  Karls University Prag, Czech Repubilc

Title:  MD

Name:  Claudio Bassetti

Institution:  Neurocentro Della Svizzera Italiana, Lugano, Switzerland

Title:  MD

Name:  Fang Han

Institution:  University of Peking, China

Title:  MD

Name:  Axel Steiger

Institution:  Max Planck Institute of Psychiatry, Munich, Germany


Past Members

Title:  PhD

Name:  Renate Wehrle

Email:  renate. wehrle@barmherzige-muenchen.de

Title:  MD

Name:  Eszter Maurovich-Horvath

Email:  e.maurovich@gmail.com

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