sleep&development@KISPI, University Children's Hospital Zurich

Child Development Center

Contact:
Reto Huber
Position:
Prof. SNF
Address:
Steinwiesstrasse 75, 8032
City:
Zurich
Country:
Switzerland
Phone:
+41 44 266 81 60
Fax:
+41 44 266 78 66
Research Domain
Keywords

Laboratory description

Topics:
Sleep in healthy subjects and clinical populations (ADHD, early onset shizophrenia, sleep disordered breathing, mental retardation) in relation to:
– development/brain maturation
– synaptic plasticity
– learning&memory
– cognition
– genetics
Manipulation of human sleep with radiofrequency electromagnetic fields
Sleep, behaviour and developement in rodents

Methods:
Human studies
– high density EEG
– anatomical/structural MR
– different learning tasks (e.g. Motor Task Manager, Motor sequence learning)
– IQ measures
– Different questionnaires

Animal studies
– ECoG
– Histology


Selected Publications in the 5 past years:

Huber R, Ghilardi MF, Massimini M, Ferrarelli F, Riedner BA, Peterson MJ, Tononi G. Arm immobilization, cortical plasticity, and local sleep homeostasis. Nature Neuroscience 9: 1169-1176, 2006

Kurth S, Jenni OG, Riedner BA, Tononi G, Carskadon MA, Huber R. Characteristics of sleep slow-waves in children and adolescents. Sleep, 33: 475-80, 2010.

Buchmann A, Ringli M, Kurth S, Schaerer M, Geiger A, Jenni OG, Huber R. EEG sleep slow-wave activity as a mirror of cortical maturation. Cerebral Cortex, Epub ahead of print, 2010.

Kurth S, Ringli M, Geiger A, LeBourgeois M, Jenni OG, Huber R. Mapping of cortical activity in the first two decades of life: a high-density sleep EEG study. Journal of Neuroscience, 30: 13211-13219, 2010.

Bölsterli BK, Schmitt B, Bast T, Critelli H, Jenni OG, Huber R. Evidence for a disruption of synaptic downscaling during sleep in Encephalopathy with Status Epilepticus during Sleep (ESES/CSWS). Clinical Neurophysiology, 122: 1779-1787, 2011.

Buchmann A, Kurth S, Ringli M, Geiger A, Jenni OG, Huber R. Anatomical markers of sleep slow wave activity derived from structural magnetic resonance images. Journal of Sleep Research, Epub ahead of print, 2011.

Ringli M, Huber R. Developmental aspects of sleep slow waves: Linking sleep, brain maturation and behavior. Progress in Brain Research, in press.

Geiger A, Huber R, Kurth S, Ringli M, Jenni OG, Achermann P. The sleep EEG as an individual trait and marker of intellectual ability in school age children. Sleep 34: 181-9, 2010.


Current/Completed Grants (past 5 years):

01.2007 – 12.2009 Sleep and cognition of children and adults in health and disease: a cooperative and integrative approach. Zurich Center for Integrative Human Physiology. Co-applicants: PD O. Jenni, PD. HP Landolt, Prof. P. Achermann, Prof. C. Bassetti, Prof. P. Brugger.

07.2007 – 06.2011 Sleep and brain plasticity during development. Professorship of the Swiss National Science Foundation.

05.2008 – 04.2009 Do epileptic encephalopathies and sleep share common physiological mechanisms? Evidence from the EEG in children with continuous spikes and waves during slow-wave sleep (CSWS) and Landau-Kleffner Syndrome. Anne Mueller Grocholski-Foundation. Co-applicants: Prof. B. Schmidt and PD O. Jenni.

12.2008 – 11.2009 Comparison of anatomical and electrophysiological markers of brain maturation. Competitive funds from the University Children’s Hospital Zurich.

03.2009 – 02.2011 Cell phones, sleep and cognitive performance. Research Foundation Mobile Communication.

04.2009 – 03.2011 Synaptic homeostasis and sleep. Neuroscience Center Zurich.

01.2010 – 12.2011 Synaptic homeostasis in normal and mentally retarded children and adolescents: from genes to behavior. Zurich Center for Integrative Human Physiology. Main applicant. Co-applicants: Prof. A. Rauch, Prof. L. Jäncke, Prof. M. Wolf, PD O. Jenni, Prof. P. Achermann.

01.2010 – 12.2011 Sleep, breathing and psychomotor performance at altitude. Zurich Center for Integrative Human Physiology. Co-applicants: Prof. K. Bloch, Prof. Peter Achermann, PD M. Kohler.

03.2010 – 12.2012 Adolescence: a sensitive period for cortical development. EU Mundus Joint Doctoral Program. Partner PI: Prof. E. Van Someren, Netherlands Institute for Neuroscience, Amsterdam.

06.2010 – 05.2016 Innovative movement therapy in childhood. Private sponsor grant (Mäxi Foundation). Main applicant: Dr. A. Meyer-Heim, Paediatric Rehabilitation Centre.

08.2011 – 07.2012 Effects of hypothermia on sleep slow-wave activity and cortical plasticity. Donation UBS AG.

07.2011 – 03.2012 Is extensive caffeine use during adolescence linked to maturational alterations? EMDO Foundation Zurich.


Other laboratory Members

Title:  PhD

Name:  Salomé Kurth

Position:  Postdoc

Email:  Kurth.Salome@kispi.uzh.ch

Title:  MA

Name:  Maya Ringli

Position:  PhD student

Email:  Maya.Ringli@kispi.uzh.ch

Title:  MSc

Name:  Nadja Olini

Position:  PhD student

Email:  Nadja.Olini@kispi.uzh.ch

Title:  MSc

Name:  Caroline Lustenberger

Position:  PhD student

Email:  Caroline.Lustenberger@kispi.uzh.ch

Title:  MSc

Name:  Fiona Pugin

Position:  PhD student

Email:  Fiona.Pugin@kispi.uzh.ch

Title:  MA

Name:  Anne-Laure Mouthon

Position:  PhD student

Email:  Anne-Laure.Mouthan@kispi.uzh.ch

Title:  MA

Name:  Noemi Tesler

Position:  PhD student

Email:  Noemi.Tesler@kispi.uzh.ch

Title:  MSc

Name:  Sara Fattinger

Position:  PhD student

Email:  Sara.Fattinger@kispi.uzh.ch

Title:  BA

Name:  Angelina Maric

Position:  Master student

Email:  Angelina.Maric@kispi.uzh.ch

Title:  BSc

Name:  Iru Rothfuchs

Position:  Master student

Email:  Iru.Rothfuchs@kispi.uzh.ch

Title:  BA

Name:  Madlaina Stauffer

Position:  Master student

Email:  Madlaina.Stauffer@kispi.uzh.ch

Title:  BA

Name:  Urs Bachofner

Position:  Master student

Email:  Urs.Bachofner@kispi.uzh.ch


Collaborations

Title:  PhD MD

Name:  Giulio Tononi

Title:  PhD MD

Name:  Marcello Massimini

Title:  PhD

Name:  Peter Achermann

Title:  PhD MD

Name:  Oskar Jenni

Title:  MD

Name:  Bernhard Schmitt

Title:  MD

Name:  Bea Latal


Past Members

Title:  PhD

Name:  Andreas Buchmann

Email:  buchmann2@wisc.edu

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