Sleep and Epilepsy Unit, Gregorio Marañón University Hospital- Complutense University of Madrid (UCM)

Clinical Neurophysiology

Rosa Peraita-Adrados
Head Sleep Unit
Dr. Esquerdo, 46, 28007
+34 91 4265187; +34
+34 91 5868018
Research Domain
  • Clinical
  • Sleep and Medical Disorders
  • Genetics of Sleep
  • Paediatric Sleep Disorders
  • Neurological Sleep Disorders
Current Announcements

No staff vacancies

10th Edition Master online Sleep: Physiology and Medicine (in Spanish and Portuguese):

Laboratory description

Sleep and respiration ontogeny
SIDS, ALTE (arousal mechanisms, CAP)
OSA in children (comorbidities)
OSA in adults. CPAP and BiPAP titration.
Nocturnal seizures in children
Parasomnias. RSBD
Hypersomnias of central origin: Kleine-Levin Syndrome
Narcolepsy-Cataplexy (Genetics, immunogenetics, comorbidities)
Sleep and Multiple Sclerosis
RLS in blood donors
RLS and Hyperferritinemia; RLS and DIOS
video-PSG (VPSG)

Technical Capabilities and areas of expertise

It is a 2 bed clinical laboratory, myself as a Head, 2 residents in neurology/clinical neurophysiology/year
3 nurses/techniciens, 1 secretary
Outpatient consultation in sleep disorders (children and adults)twice a week
For Areas of Expertise see above information
6 VPSG/ week
3 video-EEG-PSG- nap recordings/week
2 MLST/week

Additional Descriptors, Keywords

EEG, Video-EEG; Video-Polysomnography, MSLT
Circadian sleep disorders: shift workers

Selected Publications in the 5 past years:

Peraita-Adrados R. EEG, Polysomnography and other sleep recording systems. In: Parmeggiani PL, Velluti R, eds. The Physiological Nature of Sleep. Imperial College Press, London 2005. p 103-122.

Miano S, Villa MP, Blanco D, Zamora E, Rodriguez R, Ferri R, Bruni O, Peraita R. Development of NREM Sleep Instability/Continuity (Cyclic Alternating Pattern) in Healthy Term Infants Aged 14 months. Sleep 2009; 32 (1): 83-90.

Miano S, Paolino MC, Peraita R, Montesano M, Barbieri S, Villa MP. Prevalence of EEG paroxysmal activity in a population of children with obstructive sleep apnea síndrome. Sleep 2009; 32(4):522-529.

Lammers G J et al. Sodium oxybate is an effective and safe treatment for narcolepsy. Sleep Medicine 2010; 11(1):105-106.

Miano S, Bachiller C, Gutierrez M, Salcedo A, Villa MP, Peraita-Adrados R. Paroxysmal activity and seizures associated with sleep breathing disorder in children: a possible overlap between diurnal and nocturnal symptoms. Seizure: European Journal of Epilepsy 2010 (19): 547–552.

Miano S, Peraita-Adrados R, Montesano M, Castaldo R, Forlani M, Villa MP. Development of Sleep Arousal Mechanisms as Measured by the Cyclic Alternating Pattern Analysis in Healthy Children During the First Year of Life: A Nap-Polysomnographic Study During the Morning. Brain Dev. 2011;33(5):421-7

H Hor, Z Kutalik, Y Dauvilliers, A Valsesia, GJ. Lammers, C Donjacour, A Iranzo, J Santamaria, R Peraita Adrados, JL. Vicario, et al. Genome-wide association study identifies new HLA Class II haplotypes strongly protective against narcolepsy. Nature Genetics 2010; 42(9): 786-789.

Peraita-Adrados R, Miano S, Vicario JL, García-Peñas JJ, Ruiz-Falcó ML, Gutiérrez-Solana L, López-Esteban P, Aparicio-Meix M. Clinical, polysomnographic and laboratory characteristics of narcolepsy-cataplexy in a sample of children and adolescents. Sleep Medicine 2011; 12: 24–7.

R Peraita-Adrados, P López-Esteban, J J. García-Peñas, José L. Vicario, C Escudero, J Santamaría, R Casamitjana, LG. Gutierrez-Solana.
Narcolepsy-cataplexy induced by a cow milk oral immunotherapy protocol? (Letter to the Editor) Sleep Medicine 2011 Aug;12(7):730-1

H Hor, L Bartesaghi, Z Kutalik, J L. Vicário, C de Andrés, C Pfister, G J. Lammers, R Chrast, M Tafti, R Peraita-Adrados.
A Missense Mutation in Myelin Oligodendrocyte Glycoprotein as a Cause of Familial Narcolepsy with Cataplexy Am J Hum Genet. 2011 Sep 9;89(3):474-9

Peraita-Adrados R, Duque-Ramírez LG, Vela-Bueno A. Restless legs syndrome in patients with high ferritin and normal iron level. Rev de Neurolog 2011;53:385-9.

6.1.26 S Miano, R Castaldo; R Ferri; R Peraita-Adrados; M Montesano; MP Villa. Sleep cyclic alternating pattern analysis in children with apparent life-threatening events: A daytime polysomnographic study (Clinical Neurophysiolog, in press)

R. Peraita-Adrados, JL. Vicario, M. García de León, M. Tafti, M. Billiard. Monozygotic twins affected with Kleine-Levin syndrome. (Sleep, in press)

Lecendreux M, Bruni O, Franco P, Gringras P, Konofal E, Nevsimalova S, Paiva T, Partinen M, Peeters E, Peraita-Adrados R, Plazzi G, Poli F.
Modafinil is an effective and safe treatment for pediatric narcolepsy. (Journal of Sleep Research, in press).

Key Publications of the Laboratory:

infant, cyclic alternating pattern, arousal, sleep,apparent life-epilepsy in chilhood, nocturnal frontal lobe seizures (NFLE), parasomnias, sleep disorders, video-EEG-PSG recordings, threatening event, child development, clinical neurophysiology,
high serum ferritin, normal iron, periodic leg movements (PLMS), RLS, video-polisomnography, chilhood and adolescent sporadic narcolepsy-cataplexy, diagnosis,treatment, familial narcolepsy-cataplexy, genetics, Kleine-Levin Syndrome, immunogenetics.

Current/Completed Grants (past 5 years):

Training grant for a research fellow on Sleep and Multiple Sclerosis from the Research Directorate of the Education Council of the Community of Madrid (2006-2007).

Other laboratory Members

Title:  MSc

Name:  Maria-José Dominguez

Position:  Nurse/ EEG-Sleep Technician


Title:  BA

Name:  Silvia Domínguez

Position:  Secretary


Title:  BSc

Name:  Nunci Pereda

Position:  Nurse


Title:  PhD

Name:  Antonia García

Position:  Nurse/EEG-Sleep Technician



Title:  PhD MD

Name:  Antonio Vela-Bueno

Position:  Professor of Psychiatry

Institution:  Autonomous University of Madrid

Title:  PhD MD

Name:  Marisa Pedemonte

Position:  Professor of Physiology

Institution:  CLAEH School of Medicine and Directyor Sleep Disorders Center, Punta del Este, Uruguay

Title:  PhD MD

Name:  Hyun Hor

Position:  Postdoctoral fellow

Institution:  Center for Genomics Regulation. Barcelona

Title:  PhD MD

Name:  Luis Gutierrez-Solana

Position:  Head Neuropediatric Division

Institution:  Division of Neuropediatrics. University Hospital "Niño Jesús", Madrid

Title:  PhD MD

Name:  Silvia Miano

Position:  Research

Institution:  1Department of Pediatrics, Sleep Disease Centre, University of Rome La Sapienza-S. Andrea Hospital, Rome, Italy

Title:  PhD

Name:  José-Luis Vicario

Position:  Head Histocompatibility Laboratory

Institution:  Histocompatibility, Blood Center of the Community of Madrid

Title:  PhD

Name:  Mehdi Tafti

Position:  Professor of Genetics

Institution:  Center for Integrative Genomics (CIG) University of Lausanne, Switzerland

Title:  PhD MD

Name:  Celso Arango

Position:  Professor of Psychiatry

Institution:  Adolescents Unit- Psyuchiatry Department-University Hospital Gregorio Marañón

Past Members

Title:  PhD MD

Name:  Juana Rondon

Position:  Visiting specialist from Venezuela


Title:  PhD MD

Name:  Luis-Guillermo Duque-Ramirez

Position:  Post doctoral fellow from Colombia


Title:  PhD MD

Name:  Pilar López-Esteban

Position:  Head Neurophysiology Lab. Niño Jesús University Hospital.Autonomous University of Madrid.


Title:  PhD MD

Name:  Rafael Del Rio-Villegas

Position:  Post Doctoral Fellow


Title:  PhD MD

Name:  Marisa Pedemonte

Position:  Visiting Professor from Uruguay


Title:  PhD MD

Name:  Marcin Zaroswky

Position:  ESRS fellowship

Title:  PhD MD

Name:  Francesca Cañellas-Dols

Position:  Researcher EU-NN


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