Sleep, Cognition and Health", Karolinska Institute

Clinical Neuroscience

Contact:
John Axelsson
Position:
Associate Professor
Address:
Nobels väg 9, 17177
City:
Stockholm
Country:
Sweden
Phone:
+46 8 52482461
Fax:
+46 8 52482461
Contact E-mail:
Research Domain
Keywords

Laboratory description

With our research we aim to increase the knowledge and awareness of how sleep in the modern life affects our biology, cognition and health. A main focus is to investigate how disturbed sleep affects us both acutely and chronically with respect to immune function, metabolism and subjective health. Another research area includes how disturbed sleep affects cognitive processes and how we interact with our peers. We are also pursuing research in how sickness and disease affects cognition and behaviour.

Our research is strongly interdisciplinary which is also reflected by our methodology, with methods ranging from the photographing of sleep deprived individuals to injections with (dead) bacteria to investigate brain activity with brain imaging techniques when someone is acutely sick.


Technical Capabilities and areas of expertise

Experimental sleep deprivation and quasi experimental set-ups (mainly in shift workers and paitent groups). Human experimental sickness models (injections with lipopolysaccharide, LPS).


Additional Descriptors, Keywords

Shiftwork, Psychoneuroimmunology


Selected Publications in the 5 past years:

Sleep in modern life

Lasselin J, Ingre M, Regenbogen C, Olsson MJ, Garke M, Brytting M, Edgar R, Lekander M & Axelsson J. Sleep during naturally occuring respiratory infections: a pilot study Brain Behavior and Immunity (accepted)

Holding BC, Sundelin T, Lekander M & Axelsson J. Sleep deprivation and its effects on communication during individual and collaborative tasks Scientific Reports (accepted)

Holding BC, Laukka P, Fischer H, Bänziger T, Axelsson J & Sundelin T. Multimodal emotion recognition is resilient to insufficient sleep: Results from cross-sectional and experimental studies SLEEP 2017 Aug 27, zsx145, doi.org/10.1093/sleep/zsx145 [PMID: 28958084]

Sundelin T, Lekander M, Sorjonen K & Axelsson J. Negative Effects of Restricted Sleep on Facial Appearance and Social Appeal, Royal Society Open Source 2017 May 17;4(5):160918. doi: 10.1098/rsos.160918 [PMID: 28572989]

Stothard ER, McHill AW, Depner CM, Birks BR, Moehlman TM, Ritchie HK, Guzzetti JR, Chinoy ED, LeBourgeois MK, Axelsson J, Wright KP. Circadian Entrainment to the Natural Light-Dark Cycle Across Seasons and the Weekend, Current Biology 2017; 27; 1-6. doi: 10.1016/j.cub.2016.12.041 [PMID: 28162893]

Kecklund G & Axelsson J. Health consequences of shift work and insufficient sleep, BMJ 2016 Nov 1;355:i5210. doi: 10.1136/bmj.i5210 [PMID: 27803010]

Disease detection

Axelsson J, Sundelin T, Olsson MJ, Axelsson C, Lasselin J & Lekander M. Identification of acutely sick people and facial cues of sickness, Proceedings Royal Society B 2018:285: 20172430, doi: 10.1098/rspb.2017.2430 [PMID: 29298938]

Regenbogen C, Axelsson J, Lasselin J, Sundelin T, Peter M, Porada D, Lekander M, Lundstrom J, Olsson MJ. Behavioral and neural correlates to multisensory detection of sick humans, Proc Natl Acad Sci U S A. 2017 May 22. pii: 201617357. doi: 10.1073/pnas.1617357114 [PMID: 28533402]

Hedman E, Lekander M, Karshikoff B, Ljótsson B, Axelsson E. & Axelsson J. Health anxiety in a disease-avoidance framework: investigation of anxiety, disgust and disease perception in response to sickness cues, Journal of Abnormal Psychology 2016 Oct;125(7):868-878 [PMID: 27732023]

Olsson M, Lundstrom J, Gordon A, Karshikoff B, Hosseini N, Sorjonen K, Olgart C, Soop A, Axelsson J, Lekander M. The scent of disease: Human body odor contains an early chemosensory cue of sickness, Psychological Science, 2014 Jan 22, 25(3): 817-23 [PMID 24452606]


Key Publications of the Laboratory:

Axelsson J, Sundelin T, Olsson MJ, Axelsson C, Lasselin J & Lekander M. Identification of acutely sick people and facial cues of sickness, Proceedings Royal Society B 2018:285: 20172430, doi: 10.1098/rspb.2017.2430 [PMID: 29298938]

Kecklund G & Axelsson J. Health consequences of shift work and insufficient sleep, BMJ 2016 Nov 1;355:i5210. doi: 10.1136/bmj.i5210 [PMID: 27803010]

Sundelin T, Lekander M, Kecklund G, van Someren E, Olsson A & Axelsson J. Cues of fatigue: Effects of sleep deprivation on facial appearance. Sleep. 2013 Sep 1;36(9):1355-60. doi: 10.5665/sleep.2964. [PMID: 23997369]

Karshikoff B. Lekander M. Soop A. Lindstedt F. Ingvar M, Kosek E. Hoglund CO. Axelsson J. Modality and sex differences in pain sensitivity during human endotoxemia, Brain Behavior and Immunity 2015 May;46:35-43. doi: 10.1016/j.bbi.2014.11.014. [PMID 25486090]

Axelsson J. Sundelin T. Ingre M. Olsson A. van Someren E & Lekander M. Beauty Sleep: Experimental study on the perceived health and attractiveness of sleep deprived people BMJ, 2010 Dec 15. 341:c6614, [PMID: 21156746]

Axelsson J, Ingre M, Åkerstedt T. & Holmbäck U. Effects of displaced sleep on testosterone. J. Clin. Endocrinol. Metab. 2005 Aug;90(8):4530-5. [PMID: 15914523]


Current/Completed Grants (past 5 years):

Present research funding
Karolinska Institute PhD-funding, 110 000 € (PI)
AFA Insurance, 260 000 € (PI)
Swedish Research Council (VR) 270 000 € (Co-PI)
Swedish Research Council for Health, Working Life & Welfare, 430 000 € (Co-PI)
Swedish Foundation for Humanities and Social Sciences (RJ), 560 000 € (PI)
Swedish Research Council (VR) 430 000 € (Co-PI)


Other laboratory Members

Title:  MSc

Name:  Benjamin Holding

Position:  PhD-student

Email:  benjamin.holding@ki.se

Title:  MSc

Name:  Tina Sundelin

Position:  Postdoc

Email:  Tina.Sundelin@ki.se

Title:  PhD

Name:  Michael Ingre

Position:  Researcher

Email:  michael.ingre@gmail.com

Title:  MSc

Name:  Anahita Geranmayeh

Position:  Research assistant

Email:  lukasz.cybulski@ki.se

Title:  MSc

Name:  Christiana Harous

Position:  Research assistant

Email:  christiana.harous@su.se

Title:  BSc

Name:  Göran Härdelin

Position:  Research cordinator

Email:  goran@hardelin.com


Collaborations

Title:  PhD

Name:  Mats Lekander

Name:  Göran Kecklund

Name:  Predrag Petrovic

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