Cyclotron Research Center, University of Liège

Cyclotron Research Center

Contact:
Pierre Maquet
Position:
Research Director
Address:
Allée du 6 Août n°8, 4000
City:
Liège
Country:
Belgium
Phone:
+32 4 366 3687
Fax:
+32 4 366 2946
Research Domain
  • Methodology / Technology
  • Basic Human
Keywords
  • Learning, Memory, Cognition
  • Genetics of Sleep
  • Sleep and Ageing
  • Sleep Physiology-Neurophysiology in Human
  • Light and Non-Classical Photoreception
  • Biological Rhythms

Laboratory description

CRC is a neuroimaging facility dedicated to the study of brain mechanisms involved in sleep and wake regulation using cutting edge neuroimaging techniques devoted only to research.


Technical Capabilities and areas of expertise

 


Selected Publications in the 5 past years:

1. Photic memory for executive brain responses. Chellappa SL, Ly JQ, Meyer C, Balteau E, Degueldre C, Luxen A, Phillips C, Cooper HM, Vandewalle G. Proc Natl Acad Sci U S A. 2014 Mar 10

2. Altered white matter architecture in BDNF met carriers.Ziegler E, Foret A, Mascetti L, Muto V, Le Bourdiec-Shaffii A, Stender J, Balteau E, Dideberg V, Bours V, Maquet P, Phillips C.PLoS One. 2013 Jul 31;8(7):e69290. doi: 10.1371/journal.pone.0069290.

3. Concurrent synaptic and systems memory consolidation during sleep. Mascetti L, Foret A, Schrouff J, Muto V, Dideberg V, Balteau E, Degueldre C, Phillips C, Luxen A, Collette F, Bours V, Maquet P. J Neurosci. 2013 Jun 12;33(24):10182-90. doi: 10.1523/JNEUROSCI.0284-13.2013.

4. Interaction between hippocampal and striatal systems predicts subsequent consolidation of motor sequence memory. Albouy G, Sterpenich V, Vandewalle G, Darsaud A, Gais S, Rauchs G, Desseilles M, Boly M, Dang-Vu T, Balteau E, Degueldre C, Phillips C, Luxen A, Maquet P. PLoS One. 2013;8(3):e59490. doi: 10.1371/journal.pone.0059490.

5. The impact of visual perceptual learning on sleep and local slow-wave initiation. Mascetti L, Muto V, Matarazzo L, Foret A, Ziegler E, Albouy G, Sterpenich V, Schmidt C, Degueldre C, Leclercq Y, Phillips C, Luxen A, Vandewalle G, Vogels R, Maquet P, Balteau E. J Neurosci. 2013 Feb 20;33(8):3323-31. doi: 10.1523/JNEUROSCI.0763-12.2013.

6. Sleep stabilizes visuomotor adaptation memory: a functional magnetic resonance imaging study.Albouy G, Vandewalle G, Sterpenich V, Rauchs G, Desseilles M, Balteau E, Degueldre C, Phillips C, Luxen A, Maquet P.J Sleep Res. 2013 Apr;22(2):144-54. doi: 10.1111/j.1365-2869.2012.01059.x. Epub 2012 Nov 3.

7. Influence of acute sleep loss on the neural correlates of alerting, orientating and executive attention components.Muto V, Shaffii-le Bourdiec A, Matarazzo L, Foret A, Mascetti L, Jaspar M, Vandewalle G, Phillips C, Degueldre C, Balteau E, Luxen A, Collette F, Maquet P.J Sleep Res. 2012 Dec;21(6):648-58. doi: 10.1111/j.1365-2869.2012.01020.x. Epub 2012 May 18.

8. Decoding semi-constrained brain activity from FMRI using support vector machines and gaussian processes. Schrouff J, Kussé C, Wehenkel L, Maquet P, Phillips C. PLoS One. 2012;7(4):e35860. doi: 10.1371/journal.pone.0035860. Epub 2012 Apr 26.

9. The Fate of Incoming Stimuli during NREM Sleep is Determined by Spindles and the Phase of the Slow Oscillation. Schabus M, Dang-Vu TT, Heib DP, Boly M, Desseilles M, Vandewalle G, Schmidt C, Albouy G, Darsaud A, Gais S, Degueldre C, Balteau E, Phillips C, Luxen A, Maquet P. Front Neurol. 2012 Apr 5;

10. Circadian preference modulates the neural substrate of conflict processing across the day. Schmidt C, Peigneux P, Leclercq Y, Sterpenich V, Vandewalle G, Phillips C, Berthomier P, Berthomier C, Tinguely G, Gais S, Schabus M, Desseilles M, Dang-Vu T, Salmon E, Degueldre C, Balteau E, Luxen A, Cajochen C, Maquet P, Collette F.PLoS One. 2012;7(1):e29658. doi: 10.1371/journal.pone.0029658. Epub 2012 Jan 4.

11. Neural correlates of performance variability during motor sequence acquisition. Albouy G, Sterpenich V, Vandewalle G, Darsaud A, Gais S, Rauchs G, Desseilles M, Boly M, Dang-Vu T, Balteau E, Degueldre C, Phillips C, Luxen A, Maquet P.Neuroimage. 2012 Mar;60(1):324-31. doi: 10.1016/j.neuroimage.2011.12.049. Epub 2011 Dec 28.

12. Hierarchical clustering of brain activity during human nonrapid eye movement sleep. Boly M, Perlbarg V, Marrelec G, Schabus M, Laureys S, Doyon J, Pélégrini-Issac M, Maquet P, Benali H. Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):5856-61. doi: 10.1073/pnas.1111133109. Epub 2012 Mar 26.

13. Adapting test timing to the sleep-wake schedule: effects on diurnal neurobehavioral performance changes in young evening and older morning chronotypes.Schmidt C, Peigneux P, Cajochen C, Collette F. Chronobiol Int. 2012 May;29(4):482-90. doi: 10.3109/07420528.2012.658984. Epub 2012 Apr 5.

14. Experience-dependent induction of hypnagogic images during daytime naps: a combined behavioural and EEG study. Kusse C, Shaffii-LE Bourdiec A, Schrouff J, Matarazzo L, Maquet P. J Sleep Res. 2012 Feb;21(1):10-20. doi: 10.1111/j.1365-2869.2011.00939.x. Epub 2011 Aug 16.

15. Interplay between spontaneous and induced brain activity during human non-rapid eye movement sleep. Dang-Vu TT, Bonjean M, Schabus M, Boly M, Darsaud A, Desseilles M, Degueldre C, Balteau E, Phillips C, Luxen A, Sejnowski TJ, Maquet P. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15438-43. doi: 10.1073/pnas.1112503108. Epub 2011 Sep 6.

16. Abnormal hypothalamic response to light in seasonal affective disorder.Vandewalle G, Hébert M, Beaulieu C, Richard L, Daneault V, Garon ML, Leblanc J, Grandjean D, Maquet P, Schwartz S, Dumont M, Doyon J, Carrier J. Biol Psychiatry. 2011 Nov 15;70(10):954-61. doi: 10.1016/j.biopsych.2011.06.022. Epub 2011 Aug 6.

17. Effects of light on cognitive brain responses depend on circadian phase and sleep homeostasis.Vandewalle G, Archer SN, Wuillaume C, Balteau E, Degueldre C, Luxen A, Dijk DJ, Maquet P. J Biol Rhythms. 2011 Jun;26(3):249-59. doi: 10.1177/0748730411401736.

18. fMRI artefact rejection and sleep scoring toolbox. Leclercq Y, Schrouff J, Noirhomme Q, Maquet P, Phillips C. Comput Intell Neurosci. 2011;2011:598206. doi: 10.1155/2011/598206. Epub 2011 Mar 13.

19. Sleep contributes to the strengthening of some memories over others, depending on hippocampal activity at learning. Rauchs G, Feyers D, Landeau B, Bastin C, Luxen A, Maquet P, Collette F.J Neurosci. 2011 Feb 16;31(7):2563-8. doi: 10.1523/JNEUROSCI.3972-10.2011.

20. Does sleep promote false memories? Darsaud A, Dehon H, Lahl O, Sterpenich V, Boly M, Dang-Vu T, Desseilles M, Gais S, Matarazzo L, Peters F, Schabus M, Schmidt C, Tinguely G, Vandewalle G, Luxen A, Maquet P, Collette F. J Cogn Neurosci. 2011 Jan;23(1):26-40. doi: 10.1162/jocn.2010.21448.

21. Functional magnetic resonance imaging-assessed brain responses during an executive task depend on interaction of sleep homeostasis, circadian phase, and PER3 genotype. Vandewalle G, Archer SN, Wuillaume C, Balteau E, Degueldre C, Luxen A, Maquet P, Dijk DJ. J Neurosci. 2009 Jun 24;29(25):7948-56. doi: 10.1523/JNEUROSCI.0229-09.2009.

22. Homeostatic sleep pressure and responses to sustained attention in the suprachiasmatic area. Schmidt C, Collette F, Leclercq Y, Sterpenich V, Vandewalle G, Berthomier P, Berthomier C, Phillips C, Tinguely G, Darsaud A, Gais S, Schabus M, Desseilles M, Dang-Vu TT, Salmon E, Balteau E, Degueldre C, Luxen A, Maquet P, Cajochen C, Peigneux P.Science. 2009 Apr 24;324(5926):516-9. doi: 10.1126/science.1167337.

23. Light as a modulator of cognitive brain function.Vandewalle G, Maquet P, Dijk DJ.Trends Cogn Sci. 2009 Oct;13(10):429-38. doi: 10.1016/j.tics.2009.07.004.

24. Sleep promotes the neural reorganization of remote emotional memory.Sterpenich V, Albouy G, Darsaud A, Schmidt C, Vandewalle G, Dang Vu TT, Desseilles M, Phillips C, Degueldre C, Balteau E, Collette F, Luxen A, Maquet P.J Neurosci. 2009 Apr 22;29(16):5143-52. doi: 10.1523/JNEUROSCI.0561-09.2009.


Key Publications of the Laboratory:

1. Photic memory for executive brain responses. Chellappa SL, Ly JQ, Meyer C, Balteau E, Degueldre C, Luxen A, Phillips C, Cooper HM, Vandewalle G. Proc Natl Acad Sci U S A. 2014 Mar 10.

2. Altered white matter architecture in BDNF met carriers.Ziegler E, Foret A, Mascetti L, Muto V, Le Bourdiec-Shaffii A, Stender J, Balteau E, Dideberg V, Bours V, Maquet P, Phillips C.PLoS One. 2013 Jul 31;8(7):e69290. doi: 10.1371/journal.pone.0069290.

3. Concurrent synaptic and systems memory consolidation during sleep. Mascetti L, Foret A, Schrouff J, Muto V, Dideberg V, Balteau E, Degueldre C, Phillips C, Luxen A, Collette F, Bours V, Maquet P. J Neurosci. 2013 Jun 12;33(24):10182-90. doi: 10.1523/JNEUROSCI.0284-13.2013.

4. Interaction between hippocampal and striatal systems predicts subsequent consolidation of motor sequence memory. Albouy G, Sterpenich V, Vandewalle G, Darsaud A, Gais S, Rauchs G, Desseilles M, Boly M, Dang-Vu T, Balteau E, Degueldre C, Phillips C, Luxen A, Maquet P. Hippocampus. 2013 Nov;23(11):985-1004. doi: 10.1002/hipo.22183.

5. The impact of visual perceptual learning on sleep and local slow-wave initiation. Mascetti L, Muto V, Matarazzo L, Foret A, Ziegler E, Albouy G, Sterpenich V, Schmidt C, Degueldre C, Leclercq Y, Phillips C, Luxen A, Vandewalle G, Vogels R, Maquet P, Balteau E. J Neurosci. 2013 Feb 20;33(8):3323-31. doi: 10.1523/JNEUROSCI.0763-12.2013.

6. Sleep stabilizes visuomotor adaptation memory: a functional magnetic resonance imaging study.Albouy G, Vandewalle G, Sterpenich V, Rauchs G, Desseilles M, Balteau E, Degueldre C, Phillips C, Luxen A, Maquet P.J Sleep Res. 2013 Apr;22(2):144-54. doi: 10.1111/j.1365-2869.2012.01059.x. Epub 2012 Nov 3.

7. Influence of acute sleep loss on the neural correlates of alerting, orientating and executive attention components.Muto V, Shaffii-le Bourdiec A, Matarazzo L, Foret A, Mascetti L, Jaspar M, Vandewalle G, Phillips C, Degueldre C, Balteau E, Luxen A, Collette F, Maquet P.J Sleep Res. 2012 Dec;21(6):648-58. doi: 10.1111/j.1365-2869.2012.01020.x. Epub 2012 May 18.

8. Decoding semi-constrained brain activity from FMRI using support vector machines and gaussian processes. Schrouff J, Kussé C, Wehenkel L, Maquet P, Phillips C. PLoS One. 2012;7(4):e35860. doi: 10.1371/journal.pone.0035860. Epub 2012 Apr 26.

9. The Fate of Incoming Stimuli during NREM Sleep is Determined by Spindles and the Phase of the Slow Oscillation. Schabus M, Dang-Vu TT, Heib DP, Boly M, Desseilles M, Vandewalle G, Schmidt C, Albouy G, Darsaud A, Gais S, Degueldre C, Balteau E, Phillips C, Luxen A, Maquet P. Front Neurol. 2012 Apr 5;

10. Circadian preference modulates the neural substrate of conflict processing across the day. Schmidt C, Peigneux P, Leclercq Y, Sterpenich V, Vandewalle G, Phillips C, Berthomier P, Berthomier C, Tinguely G, Gais S, Schabus M, Desseilles M, Dang-Vu T, Salmon E, Degueldre C, Balteau E, Luxen A, Cajochen C, Maquet P, Collette F.PLoS One. 2012;7(1):e29658. doi: 10.1371/journal.pone.0029658. Epub 2012 Jan 4.

11. Neural correlates of performance variability during motor sequence acquisition. Albouy G, Sterpenich V, Vandewalle G, Darsaud A, Gais S, Rauchs G, Desseilles M, Boly M, Dang-Vu T, Balteau E, Degueldre C, Phillips C, Luxen A, Maquet P.Neuroimage. 2012 Mar;60(1):324-31. doi: 10.1016/j.neuroimage.2011.12.049. Epub 2011 Dec 28.

12. Hierarchical clustering of brain activity during human nonrapid eye movement sleep. Boly M, Perlbarg V, Marrelec G, Schabus M, Laureys S, Doyon J, Pélégrini-Issac M, Maquet P, Benali H. Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):5856-61. doi: 10.1073/pnas.1111133109. Epub 2012 Mar 26.

13. Adapting test timing to the sleep-wake schedule: effects on diurnal neurobehavioral performance changes in young evening and older morning chronotypes.Schmidt C, Peigneux P, Cajochen C, Collette F. Chronobiol Int. 2012 May;29(4):482-90. doi: 10.3109/07420528.2012.658984. Epub 2012 Apr 5.

14. Experience-dependent induction of hypnagogic images during daytime naps: a combined behavioural and EEG study. Kusse C, Shaffii-LE Bourdiec A, Schrouff J, Matarazzo L, Maquet P. J Sleep Res. 2012 Feb;21(1):10-20. doi: 10.1111/j.1365-2869.2011.00939.x. Epub 2011 Aug 16.

15. Interplay between spontaneous and induced brain activity during human non-rapid eye movement sleep. Dang-Vu TT, Bonjean M, Schabus M, Boly M, Darsaud A, Desseilles M, Degueldre C, Balteau E, Phillips C, Luxen A, Sejnowski TJ, Maquet P. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15438-43. doi: 10.1073/pnas.1112503108. Epub 2011 Sep 6.

16. Abnormal hypothalamic response to light in seasonal affective disorder.Vandewalle G, Hébert M, Beaulieu C, Richard L, Daneault V, Garon ML, Leblanc J, Grandjean D, Maquet P, Schwartz S, Dumont M, Doyon J, Carrier J. Biol Psychiatry. 2011 Nov 15;70(10):954-61. doi: 10.1016/j.biopsych.2011.06.022. Epub 2011 Aug 6.

17. Effects of light on cognitive brain responses depend on circadian phase and sleep homeostasis.Vandewalle G, Archer SN, Wuillaume C, Balteau E, Degueldre C, Luxen A, Dijk DJ, Maquet P. J Biol Rhythms. 2011 Jun;26(3):249-59. doi: 10.1177/0748730411401736.

18. fMRI artefact rejection and sleep scoring toolbox. Leclercq Y, Schrouff J, Noirhomme Q, Maquet P, Phillips C. Comput Intell Neurosci. 2011;2011:598206. doi: 10.1155/2011/598206. Epub 2011 Mar 13.

19. Sleep contributes to the strengthening of some memories over others, depending on hippocampal activity at learning. Rauchs G, Feyers D, Landeau B, Bastin C, Luxen A, Maquet P, Collette F.J Neurosci. 2011 Feb 16;31(7):2563-8. doi: 10.1523/JNEUROSCI.3972-10.2011.

20. Does sleep promote false memories? Darsaud A, Dehon H, Lahl O, Sterpenich V, Boly M, Dang-Vu T, Desseilles M, Gais S, Matarazzo L, Peters F, Schabus M, Schmidt C, Tinguely G, Vandewalle G, Luxen A, Maquet P, Collette F. J Cogn Neurosci. 2011 Jan;23(1):26-40. doi: 10.1162/jocn.2010.21448.

21. Functional magnetic resonance imaging-assessed brain responses during an executive task depend on interaction of sleep homeostasis, circadian phase, and PER3 genotype. Vandewalle G, Archer SN, Wuillaume C, Balteau E, Degueldre C, Luxen A, Maquet P, Dijk DJ. J Neurosci. 2009 Jun 24;29(25):7948-56. doi: 10.1523/JNEUROSCI.0229-09.2009.

22. Homeostatic sleep pressure and responses to sustained attention in the suprachiasmatic area. Schmidt C, Collette F, Leclercq Y, Sterpenich V, Vandewalle G, Berthomier P, Berthomier C, Phillips C, Tinguely G, Darsaud A, Gais S, Schabus M, Desseilles M, Dang-Vu TT, Salmon E, Balteau E, Degueldre C, Luxen A, Maquet P, Cajochen C, Peigneux P.Science. 2009 Apr 24;324(5926):516-9. doi: 10.1126/science.1167337.

23. Light as a modulator of cognitive brain function.Vandewalle G, Maquet P, Dijk DJ.Trends Cogn Sci. 2009 Oct;13(10):429-38. doi: 10.1016/j.tics.2009.07.004.

24. Sleep promotes the neural reorganization of remote emotional memory.Sterpenich V, Albouy G, Darsaud A, Schmidt C, Vandewalle G, Dang Vu TT, Desseilles M, Phillips C, Degueldre C, Balteau E, Collette F, Luxen A, Maquet P.J Neurosci. 2009 Apr 22;29(16):5143-52. doi: 10.1523/JNEUROSCI.0561-09.2009.


Collaborations

Title:  PhD

Name:  Christian Cajochen

Position:  Laboratory Head

Institution:  University of Basel

Title:  PhD MD

Name:  Derk-Jan Dijk

Position:  Laboratory Head

Institution:  University of Surrey

Title:  PhD

Name:  Philippe Peigneux

Position:  Laboratory Head

Institution:  Université Libre de Bruxelles

Title:  PhD

Name:  Sophie Schwartz

Position:  Laboratory Head

Institution:  Neurology and Imaging of Cognition; University of Geneva

Title:  PhD

Name:  Hans-Peter Landolt

Position:  Laboratory Head

Institution:  Institute of Pharmacology & Toxicology, University of Zurich

Title:  PhD MD

Name:  Marcello Massimini

Position:  Laboratory Head

Institution:  Department of Biomedical and Clinical Sciences, University of Milan

Title:  PhD

Name:  Julie Carrier

Position:  Laboratory Head

Institution:  Psychology Department, University of Montréal

Title:  PhD

Name:  Howard Cooper

Institution:  Stem Cell and Brain Research Institute, University of Lyon

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