Sleep Research Centre, Oasi Institute, Oasi Research Institute

Department of Neurology I.C.

Raffaele Ferri
Head of Department
via C. Ruggero, 73, 94018
+39 0935 936111
+39 0935 936694
Contact E-mail:
Research Domain
  • Methodology / Technology
  • Clinical
  • Instrumentation-Methodology
  • Learning, Memory, Cognition
  • Sleep and Medical Disorders
  • Sleep and Ageing
  • Sleep Physiology-Neurophysiology in Human
  • Neurological Sleep Disorders

Laboratory description

Main research areas: RLS/PLMD, RBD, Narcolepsy, Sleep microstructure (CAP)
PSG, MSLT, Actigraphy, Advanced signal analysis

Key Publications of the Laboratory:
1. Ferri R, Zucconi M, Marelli S, Plazzi G, Schenck CH, Ferini-Strambi L. Effects of the chronic use of clonazepam on NREM sleep patterns in REM sleep behavior disorder. Sleep Med 2013;14:399-406.
2. Simor P, Bódizs R, Horváth K, Ferri R. Disturbed dreaming and the instability of sleep: altered NREM sleep microstructure in subjects with frequent nightmares as revealed by the cyclic alternating pattern. Sleep 2013;36:413-419.
3. Ferri R, Manconi M, Aricò D, Punjabi NM, Zucconi M. Experimentally induced arousals do not elicit periodic leg motor activity during sleep in normal subjects. Sleep Med 2013;14:85-90.
4. Peirano P, Algarin C, Chamorro R, Manconi M, Lozoff B, Ferri R. Iron deficiency anemia in infancy exerts long-term effects on the tibialis anterior motor activity during sleep in childhood. Sleep Med 2012;13:1006-1012.
5. Manconi M, Ferri R, Zucconi M, Bassetti C, Fulda S, Aricò D, Ferini-Strambi L. Dissociation of periodic leg movements from arousals in restless legs syndrome. Ann Neurol 2012;71:834-844.
6. Ferri R, Fulda S, Cosentino FII, Pizza F, Plazzi G. A Preliminary Quantitative Analysis of REM sleep Chin EMG in Parkinson's Disease with or without REM Sleep Behavior Disorder. Sleep Med 2012;13:707-713.
7. Ferri R. The time structure of leg movement activity during sleep: The theory behind the practice. Sleep Med 2012;13:433-441.
8. Ferri R, Rundo F, Novelli L, Terzano MG, Parrino L, Bruni O. A new quantitative automatic method for the measurement of NREM sleep electroencephalographic amplitude variability. J Sleep Res 2012;21:212-220.
9. Parrino L, Ferri R, Bruni O, Terzano MG. Cyclic Alternating Pattern (CAP): The marker of sleep instanbility. Sleep Med Rev 2012;16:27-45.
10. Manconi M, Ferri R, Zucconi M, Clemens S, Giarolli L, Bottasini V, Ferini-Strambi L. Preferential D2 or preferential D3 dopamine-agonists in Restless Legs Syndrome. Neurology 2011;77:110-117.
11. Manconi M, Ferri R, Zucconi M, Oldani A, Giarolli L, Bottasini V, Ferini-Strambi L. Pramipexole vs. ropinirole: Polysomnographic acute effetcs in restless legs syndrome. Mov Disord 2011;26:892-895.
12. Plazzi G, Moghadam KK, Serra Maggi L, Donadio V, Vetrugno R, Liguori R, Zoccoli G, Poli F, Pizza F, Pagotto U, Ferri R. Autonomic disturbances in narcolepsy. Sleep Med Rev 2011;15:187-196.
13. Raggi A, Plazzi G, Pennisi G, Tasca D, Ferri R. Cognitive evoked potentials in narcolepsy: A review of the literature. Neurosci Biobehav Rev 2011;35:1144-1153.
14. Svetnik V, Ferri R, Ray S, Ma J, Walsh JK, Snyder E, Ebert B, Deacon S. Alterations in Cyclic Alternating Pattern associated with phase advanced sleep are differentially modulated by gaboxadol and zolpidem. Sleep 2010;33:1562-1570.
15. Ferri R, Manconi M, Aricò D, Sagrada C, Zucconi M, Bruni O, Oldani A, Ferini-Strambi L. Acute dopamine-agonist treatment in Restless Legs Syndrome. Effects on sleep architecture and NREM sleep instability. Sleep 2010;33:793-800.
16. Ferri R, Drago V, Aricò D, Bruni O, Remington RW, Stamatakis K, Punjabi NM. The effects of experimental sleep fragmentation on cognitive processing. Sleep Med 2010;11:378-385.
17. Ferri R, Franceschini C, Zucconi M, Vandi S, Poli F, Bruni O, Cipolli C, Montagna P, Plazzi G. Searching for a marker of REM sleep behavior disorder: Submentalis muscle EMG amplitude analysis during sleep in patients with narcolepsy/cataplexy. Sleep 2008;31:1409-1417.
18. Ferri R, Rundo F, Bruni O, Terzano MG, Pennisi G, Stam CJ. The functional connectivity of different EEG bands moves towards small-world network organization during sleep. Clin Neurophysiol 2008;119:2026-2036.
19. Ferri R, Huber R, Aricò D, Drago V, Rundo F, Ghilardi MF, Massimini M, Tononi G. The slow-wave components of the Cyclic Alternating Pattern (CAP) have a role in sleep-related learning processes. Neurosci Lett 2008;432:228-231.
20. Ferri R, Manconi M, Plazzi G, Bruni O, Vandi S, Montagna P, Ferini-Strambi L, Zucconi M. A quantitative statistical analysis of the submentalis muscle EMG amplitude during sleep in normal controls and patients with REM sleep behavior disorder. J Sleep Res 2008;17:89-100.
21. Cosentino FII, Bosco P, Drago F, Prestianni G, Lanuzza B, Iero I, Tripodi M, Spada RS, Toscano G, Caraci F, Ferri R. The APOE e4 allele increases the risk of lower spatial working memory performance in obstructive sleep apnea. Sleep Med 2008;9:831-839.
22. Ferri R, Zucconi M, Manconi M, Bruni O, Ferini-Strambi L, Vandi S, Montagna P, Mignot Plazzi G. Different periodicity and time structure of leg movements during sleep in narcolepsy/cataplexy and restless legs syndrome Sleep 2006;29:1587-1594.
23. Ferri R, Zucconi M, Manconi M, Plazzi G, Bruni O, Ferini-Strambi L. New Approaches to the Study of Periodic Leg Movements during Sleep in Restless Legs Syndrome Sleep 2006;29:759-769.
24. Zucconi M, Ferri R, Allen R, Baier PC, Bruni O, Chokroverty S, Ferini-Strambi L, Fulda S, Garcia-Borreguero D, Hening WA, Hirshkowitz M, Högl B, Hornyak M, King P, Montagna P, Parrino L, Plazzi G, Terzano MG. The official World Association of Sleep Medicine (WASM) standards for recording and scoring periodic leg movements in sleep (PLMS) and wakefulness (PLMW) developed in collaboration with a task force from the International Restless Legs Syndrome Study Group (IRLSSG). Sleep Med 2006;7:175-183.
25. Ferri R, Miano S, Bruni O, Vankova J, Nevsimalova S, Vandi S, Montagna P, Ferini-Strambi L, Plazzi G. NREM Sleep Alterations in Narcolepsy/Cataplexy. Clin Neurophysiol 2005;116:2675-2684.


Name:  Luigi Ferini Strambi

Title:  MD

Name:  Giuseppe Plazzi

Title:  MD

Name:  Marco Zucconi

Title:  PhD MD

Name:  Mauro Manconi

Title:  MD

Name:  Oliviero Bruni