Sleep-Wake-Centre Inselspital, University Hospital

Dept of Neurology

Contact:
Johannes MATHIS
Position:
Neurological head
Address:
Freiburgstr. 10, 3010
City:
Bern
Country:
Switzerland
Phone:
004131 6322693
Fax:
004131 6329448
Research Domain
  • Clinical
Keywords
  • Others
  • Sleep and Medical Disorders
  • Sleep and Ageing
  • Sleep and Psychiatry-Personality Disorders
  • Epidemiology of Sleep
  • Sleep and Body Functions (Cardio-Respiratory, Thermoregulation/Metabolism, Endocrine)
  • Neurological Sleep Disorders

Laboratory description

The clinical sleep-wake-centre Inselspital is a tertiary multidisciplinary sleep centre with close co-operation between neurology, pneumology and psychiatry. The main clinical research area is narcolepsy and other hypersomnias, driving capability in sleepy subjects, parasomnia & nocturnal seizures, restless legs syndrome and sleep apnoea syndrome.


Technical Capabilities and areas of expertise

all techniques for clinical workup in sleep-wake disorders are available: polysomnography, multiple sleep latency test, maintenance of wakefulness test, pupillography, steer clear vigilance test, psychomotor vigilance test, driving simulator, actigraphy


Additional Descriptors, Keywords

narcolepsy, restless legs syndrome, sleep apnoea syndrome, motor vehicle accidents, excessive daytime sleepiness, nonorganic hypersomnia, parasomnia and epilepsy in sleep


Selected Publications in the 5 past years:

1. H.P. Landolt, M. Glatzel, T. Blättler, P. Achermann, C. Roth, J. Mathis, J. Weis, I. Tobler, A. Aguzzi, C.L. Bassetti. Sleep-wake disturbances in sporadic Creutzfeldt-Jakob disease, Neurology 66:1418-1424, 2006.

2. K. E. Hersberger, V.P. Renggli, A. C. Nirkko, J. Mathis, K. Schwegler, K. E. Bloch. Screening for sleep disorders in community pharmacies – evaluation of a campaign in Switzerland. Journal of Clinical Pharmacy and Therapeutics 31:35-41, 2006.

3. J.Zavodny, C.Roth, C.Bassetti, J.Mathis, N.J.Douglas, M.Gugger. Effects of sleep fragmentation on the arousability to resistive loading in NREM and REM sleep in normal men. Sleep 29: 525-532, 2006.

4. K. Schwegler, R. Klaghofer, A. Nirkko, J. Mathis, K. Hersberger, K. Bloch. Sleep and wakefulness disturances in Swiss Pharmacy customers. 2006

5. R.Khatami, D.Zutter, A.Siegel, J.Mathis, F.Donati, C.L.Bassetti. Sleep-wake habits and disorder in a series of 100 adult epilepsy patients – A prospective study. Seizure 15: 299-306, 2006.

6. A.G.Guggisberg, Ch.W.Hess, J.Mathis. The significance of the sympathetic nervous system in the pathophysiology of periodic leg movemnts in sleep. Sleep 30: 755-766, 2007.

7. A.G.Guggisberg, J.Mathis, U.S.Herrmann, Ch.W. Hess. The functional relationship between yawning and vigilance. Behavioural Brain research 179: 159-166, 2007.

8. C.Trenkwalder, H.Benes, G.Luder, H.Svenja, B.Högl, J.Mathis, G.Saletu-Zylharz, M.Leroux. Cabergoline compared to levodopa in the treatment of patients with severe Restless Legs Syndrome: Results from a multicenter, randomized, double-blind, active controlled trial. Mov. Disorders 22:696-703, 2007.

9. R. Khatami, H.P. Landolt, P. Achermann, J. Retey, E. Werth, J. Mathis, C.L. Bassetti. Insufficient Non-REM sleep intensity in narcolepsy-cataplexy. Sleep, Vol. 30, No. 8, 2007.

10. K. Schindler, T. Nyffeler, R. Wiest, M. Hauf, J. Mathis, Ch. W. Hess, R. Müri Theta burst transcranial magenetic stimulation is associated with increased EEG synchronization in the stimulated relative to unstimulated cerebral hemisphere. Neuroscience Letters 438: 31-34, 2008

11. Adrian G. Guggisberg, MD; Christian W. Hess, MD; Johannes Mathis, a Reponse to Drs. Ferri and Zucconi, SLEEP, Vol. 31, No. 1 2008

12. K. Jann, R. Wiest, M. Hauf, K. Meyer, C. Boesch, J. Mathis, G. Schroth, Th. Dierks, Th. Koenig. Bold correlates of continuously fluctuating epileptic activity isolated by independent component analysis. Neuroimage 42: 645-648, 2008.

13. U.S. Herrmann, Ch. W. Hess, A. Guggisberg, C. Roth, M. Gugger, J. Mathis, Sleepiness is not always perceived before falling asleep in healthy, sleep deprived subjects. Sleep Medicine 11: 747-751, 2010

14. H. Hor, Z. Kutalik, Y. Dauvilliers, A. Valesia, G. J. Lammers, C. E. H. M. Donjacour, A. Iranzo, J. Santamaria, R. Peraita Adrados, J. L. Vicario, S. Overeem, I. Arnulf, Th. Ioannis, P. Jennum, S. Knudsen, C. Bassetti, J. Mathis, M. Lecendreux, G. Mayer, P. Geisler, A. Beneto, B. Petit, C. Pfister, J. Vienne, G. Didlot, M. Billiard, G. Ercilla, W. Verduijn, F. H. J. Class, P. Vollenwider, G. Waeber, D. Waterworth, V. Mooser, R. Heinzer, J. S. Beckmann, S. Bergmann, M. Tafti, Genome-wide association study identifies new HLA Class II variants strongly protective against narcolepsy. Nat. Genet. 2010 Sep; 42(9):786-9. Epub 2010 Aug 15

15. C. Rummel, H. Gast, K. Schindler, M. Müller, F. Amor, Ch. W. Hess, J. Mathis, Periodic leg movement during sleep – Detecting hidden periodicities and data-driven group formation. Frontiers in Neuroscience 4:1-14, 2010

16. F. Gradinger, A. Glässel, M. Gugger, A. Cieza, N. Braun, R. Khatami, A. Stucki, W.Schmitt, J. Mathis. Identification of problems in functioning of persons with sleep disorders in a clinical setting using the International Classification of Functioning Disability and Health (ICF): a cross-sectional study. J. Sleep Res. 2010 Sept. 30; doi:10.1111/j. 1365-2869.2010.00888.x

17. U. Kallweit, R. Khatami, F. Pizza, J. Mathis, C. Bassetti, Dopaminergic Treatment in Idiopathic Restless Legs Syndrome: Effects on Subjective Sleepiness, Clinical Neuropharmacology Nov./Dez. 2010/ 33, 276-278

18. F. Gradinger, B. Köhler, R. Khatami, J. Mathis, A. Stucki, A. Cieza, C. Bassetti, Identification of problems in functioning of persons with sleep disorders from the patient perspective using the International Classification of Functioning, Disability and Health (ICF): a qualitative study. Accepted J.Sleep Res. 2011 Mar; 20: 171-82: doi:10.1111/j. 1365-2869.2010.00888.x

19. H.M Vu , C. Hurni, J. Mathis, C.Roth, C.L. Bassetti. Selective REM sleep deprivation in narcolepsy. J.Sleep Res. 20: 50-56 (2011).


Key Publications of the Laboratory:

1. U. S. Herrmann, C. W. Hess, A. G. Guggisberg, C. Roth, M. Gugger, and J. Mathis. Sleepiness is not always perceived before falling asleep in healthy, sleep-deprived subjects. Sleep Med 11 (8):747-751, 2010.

2. F. Gradinger, A. Glässel, M. Gugger, A. Cieza, N. Braun, R. Khatami, A. Stucki, W.Schmitt, J. Mathis. Identification of problems in functioning of persons with sleep disorders in a clinical setting using the International Classification of Functioning Disability and Health (ICF): a cross-sectional study. J. Sleep Res. 2010 Sept. 30; doi:10.1111/j. 1365-2869.2010.00888.

3. C. Rummel, H. Gast, K. Schindler, M. Müller, F. Amor, Ch. W. Hess, J. Mathis, Periodic leg movement during sleep – Detecting hidden periodicities and data-driven group formation. Frontiers in Neuroscience 4:1-14, 2010

4. H.M Vu , C. Hurni, J. Mathis, C.Roth, C.L. Bassetti. Selective REM sleep deprivation in narcolepsy. J.Sleep Res. 20: 50-56 (2011).

5. A.G.Guggisberg, Ch.W.Hess, J.Mathis. The significance of the sympathetic nervous system in the pathophysiology of periodic leg movements in sleep. Sleep 30: 755-766, 2007.

6. J.Zavodny, C.Roth, C.Bassetti, J.Mathis, N.J.Douglas, M.Gugger. Effects of sleep fragmentation on the arousability to resistive loading in NREM and REM sleep in normal men. Sleep 29: 525-532, 2006.


Other laboratory Members

Title:  MD

Name:  Matthias Gugger

Position:  Pneumological head

Email:  matthias.gugger@insel.ch

Title:  PhD

Name:  Corinne Roth

Position:  Somnologist, head of sleep laboratory

Email:  corinne.roth@insel.ch

Title:  MD

Name:  Wolfgang Schmitt

Position:  Consultant Psychiatry

Email:  wolfgang.schmitt@gef.be.ch


Collaborations

Title:  MD

Name:  Claudio L. Bassetti

Position:  Head Neurocentro Svizzera Italiana

Title:  PhD

Name:  Katharina Henke

Position:  Assistant Professor Tenur Track

Institution:  University Bern

Title:  PhD

Name:  Mehdi Tafti

Position:  Head Centre of Integrative Genomics

Institution:  University of Lausanne


Past Members

Title:  MD

Name:  Uli Herrmann

Email:  uli.herrmann@students.unibe.ch

Title:  MD

Name:  Adrian Guggisberg

Email:  aguggis@gmail.com

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