Sleep Disorders Center, Università Vita-Salute San Raffaele

Dept. of Neuroscience

Contact:
Luigi Ferini-Strambi
Position:
Director
Address:
Via Stamira d' Ancona 20, 20127
City:
Milano
Country:
Italy
Phone:
+39 02 26433363
Fax:
+39 02 26433394
Research Domain
  • Clinical
  • Methodology / Technology
Keywords
  • Neurological Sleep Disorders
  • Epidemiology of Sleep
  • Sleep and Psychiatry-Personality Disorders
  • Sleep and Ageing
  • Pharmacology of Sleep
  • Genetics of Sleep
  • Sleep and Medical Disorders
  • Learning, Memory, Cognition
  • Instrumentation-Methodology

Laboratory description

Main research areas are: OSA and cognition, OSA and PAP compliance, insomnia (pharmacological treatment and cognitive-behavioral therapy), RLS and PLMD (pathophysiology and treatment), epilepsy (nocturnal frontal lobe epilepsy), NREM parasomnias, REM sleep behaviour disorders, narcolepsy.

Studies on microstructure of sleep and autonomic functions.
Neuroimaging in sleep disorders (functional MRI, voxel-based morphometry, diffusion tensory imaging).
Neuropsychological evaluation of patients with sleep disorders.

10 hospital beds dedicated to diagnosis and treatment of sleep disorders + 5 PSG beds in sleep lab.
Techniques used: in-lab Video-PSG, in-hospital portable PSG, ambulatory PSG, portable long-EEG monitoring, actigraphy


Technical Capabilities and areas of expertise

Training for macro- and microstructure scoring of human sleep.
Training for CPAP application.
Training fot CBT-I.


Selected Publications in the 5 past years:

Picchietti D, Allen RP, Walters AS, Davidson JE, Myers A, Ferini-Strambi L. Restless legs syndrome: prevalence and impact in children and adolescents–the Peds REST study. Pediatrics. 2007;120(2):253-66.

García-Borreguero D, Kohnen R, Högl B, Ferini-Strambi L, et al.
Validation of the Augmentation Severity Rating Scale (ASRS): a multicentric, prospective study with levodopa on restless legs syndrome. Sleep Med. 2007; 8(5):455-63.

Manconi M, Ferri R, Zucconi M, Oldani A, Fantini ML, Castronovo V, Ferini-Strambi L. First night efficacy of pramipexole in restless legs syndrome and periodic leg movements. Sleep Med. 2007; 8(5): 491-7.

Manconi M, Filippi M, Bonanni, Murri L, Ferini Strambi L. High prevalence of restless legs syndrome in multiple sclerosis. Eur J Neurol. 2007; 14(5):534-9.

Kushida C, Martin M, Nikam P, Blaisdell B, Wallenstein G, Ferini-Strambi L, Ware JE Jr. Burden of restless legs syndrome on health-related quality of life. Qual Life Res. 2007; 16(4): 617-24.

Ferri R, Zucconi M, Rundo F, Spruyt K, Manconi M, Ferini-Strambi L. Heart rate and spectral EEG changes accompanying periodic and non-periodic leg movements during sleep. Clin Neurophysiol. 2007; 118(2): 438-48.

Kemlink D, Polo O, Montagna P, Provini F, Stiasny-Kolster K, Oertel W, de Weerd A, Nevsimalova S, Sonka K, Högl B, Frauscher B, Poewe W, Trenkwalder C, Pramstaller PP, Ferini-Strambi L, et al. Family-based association study of the restless legs syndrome loci 2 and 3 in a European population. Mov Disord. 2007; 22(2): 207-12.

Manconi M, Vitale G, Ferri R, Zucconi M, Ferini-Strambi L.
Periodic leg movements in Cheyne-Stokes respiration. Eur Respir J. 2008;32(6): 1656-62.

Combi R, Ferini-Strambi L, Tenchini ML. Compound heterozygosity with dominance in the Corticotropin Releasing Hormone (CRH) promoter in a case of nocturnal frontal lobe epilepsy. J Sleep Res. 2008; 17(3): 361-2.

Castronovo V, Canessa N, Ferini- Strambi L, et al. Brain activation changes before and after PAP treatment in obstructive sleep apnea. Sleep. 2009; 32(9): 1161-72.

Mallamaci F, Leonardis D, Tripepi R, Parlongo G, Catalano C, Tripepi G, Castronovo V, Ferini-Strambi L, Zoccali C. Sleep Disordered Breathing in Renal Transplant Patients. Am J Transplant. 2009; 9(6): 1373-81.

Manfredi I, Zani AD, Rampoldi L, Pegorini S, Bernascone I, Moretti M, Gotti C, Croci L, Consalez GG, Ferini-Strambi L, Sala M, Pattini L, Casari G. Expression of mutant beta2 nicotinic receptors during development is crucial for epileptogenesis. Hum Mol Genet. 2009; 18(6): 1075-88.

Ferini-Strambi L, Manconi M. Treatment of restless legs syndrome. Parkinsonism Relat Disord. 2009; 15 Suppl 4:S65-70.

Manconi M, Ferri R, Sagrada C, Punjabi NM, Tettamanzi E, Zucconi M, Oldani A, Castronovo V, Ferini-Strambi L. Measuring the error in sleep estimation in normal subjects and in patients with insomnia. J Sleep Res. 2010; 19(3): 478-86.

Högl B, García-Borreguero D, Kohnen R, Ferini-Strambi L, et al.
Progressive development of augmentation during long-term treatment with levodopa in restless legs syndrome: results of a prospective multi-center study. J Neurol. 2010;257(2): 230-7.

Ferri R, Manconi M, Aricò D, Sagrada C, Zucconi M, Bruni O, Oldani A, Ferini-Strambi L. Acute dopamine-agonist treatment in restless legs syndrome: effects on sleep architecture and NREM sleep instability. Sleep. 2010;33(6): 793-800.

Manconi M, Ferri R, Zucconi M, Clemens S, Giarolli L, Bottasini V, Ferini-Strambi L. Preferential D2 or preferential D3 dopamine agonists in restless legs syndrome. Neurology 2011: Jul 12;77(2): 110-7.

Oertel W, Trenkwalder C, Beneš H, Ferini-Strambi L, Högl B, Poewe W, Stiasny-Kolster K, Fichtner A, Schollmayer E, Kohnen R, García-Borreguero D; on behalf of the SP710 study group. Long-term safety and efficacy of rotigotine transdermal patch for moderate-to-severe idiopathic restless legs syndrome: a 5-year open-label extension study. Lancet Neurol. 2011 Jun 24.

Fantini ML, Farini E, Ortelli P, Zucconi M, Manconi M, Cappa S, Ferini-Strambi L. Longitudinal study of cognitive function in idiopathic REM sleep behavior disorder. Sleep. 2011 May 1;34(5): 619-25.

Ferini-Strambi L, Marelli S, Moccia M, Erro R, Ciacci C, Barone P. Malabsorption is uncommon in restless legs syndrome. Mov Disord. 2011 Apr 7.

Bouchardy I, Steinlein O, Combi R, Ferini-Strambi L, Gambardella A, Rudolf G, Morris MA, Picard F. Mutations of the orexin system, a regulator of sleep arousal, are not a common cause of ADNFLE. Neurology. 2011 Apr 5;76(14): 1272-3.

Manconi M, Ferri R, Zucconi M, Oldani A, Giarolli L, Bottasini V, Ferini-Strambi L. Pramipexole versus ropinirole: polysomnographic acute effects in restless legs syndrome. Mov Disord. 2011 Apr;26(5): 892-5.

Högl B, Garcia-Borreguero D, Trenkwalder C, Ferini-Strambi L, Hening W, Poewe W, Brenner SS, Fraessdorf M, Busse M, Albrecht S, Allen RP. Efficacy and augmentation during 6 months of double-blind pramipexole for restless legs syndrome. Sleep Med. 2011 Apr;12(4): 351-60.

Ferini-Strambi L. Sleep disorders in multiple sclerosis.Handb Clin Neurol. 2011;99: 1139-46.

Canessa N, Castronovo V, Cappa SF, Aloia MS, Marelli S, Falini A, Alemanno F, Ferini-Strambi L. Obstructive sleep apnea: brain structural changes and neurocognitive function before and after treatment. Am J Respir Crit Care Med. 2011 May 15;183(10): 1419-26.


Current/Completed Grants (past 5 years):

PRIN Grants from Ministry of Public Education, University and Research (MIUR).


Other laboratory Members

Title:  MD

Name:  Marco Zucconi

Email:  zucconi.marco@hsr.it

Title:  MD

Name:  Alessandro Oldani

Email:  oldani.alessandro@hsr.it

Title:  PhD

Name:  Vincenza Castronovo

Email:  castronovo.vincenza@hsr.it

Title:  MD

Name:  Paolo Pozzi

Email:  pozzi.paolo@hsr.it

Title:  PhD

Name:  Sara Marelli

Email:  marelli.sara@hsr.it

Title:  PhD

Name:  Laura Giarolli

Email:  giarolli.laura@hsr.it

Name:  Daniele Bizzozero

Position:  Sleep Technologist

Email:  bizzozero.daniele@hsr.it

Name:  Antonio Massimo

Position:  Sleep Technologist

Email:  massimo.antonio@hsr.it

Name:  Cristina Martinelli

Position:  Sleep Technologist

Email:  martinelli.cristina@hsr.it

Name:  Elisa Dalla Ba

Position:  Sleep Technologist

Email:  dallaba.elisa@hsr.it


Collaborations

Title:  PhD MD

Name:  Jacques Montplaisir

Position:  Director Sleep Disorders Center

Institution:  Hopital du Sacre-Coeur Montreal

Name:  Claudio Bassetti

Position:  Director

Institution:  Lugano Neurocentro

Title:  PhD

Name:  Mark Aloia

Institution:  National Jewish Medical and Research Center Denver

Title:  MD

Name:  Diego Garcia Borreguero

Title:  PhD

Name:  Tracy Kuo

Position:  Clinical Psychologist

Institution:  Sleep Disorders Clinic Stanford University

Title:  MD

Name:  Raffaele Ferri

Position:  Director

Institution:  IRCCS Oasi Troina

Title:  MD

Name:  Giuseppe Plazzi

Institution:  Clinica Neurologica Bologna

Title:  MD

Name:  Federica Provini

Institution:  Clinica Neurologica Bologna

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