- Basic Animal
- Basic Human
- Pharmacology Human
- Molecular Biology-Endocrinology-Biochemistry
- Genetics of Sleep
- Pharmacology of Sleep
- Sleep and Ageing
- Epidemiology of Sleep
- Sleep Physiology-Neurophysiology in Human
- Sleep Physiology-Neurophysiology in Animal
- Biological Rhythms
Designated research unit with 12 individual bedrooms and and a 12 bedded ward. Unit can be used for longterm sleep and circadian rhythm experiments, including continuous blood sampling, performance assessment, etc. We also have facilities to manipulate light. Animal facilities for sleep and circadian rhythm experiments
Additional Descriptors, Keywords
Sleep, neurophysiology, circadian rhythms, light, biological rhythms, cognitive performance, genetics
Key Publications of the Laboratory:Viola AU, James LM, Archer SN, Dijk DJ. PER3 Polymorphism and Cardiac Autonomic Control: Effects of Sleep Debt and Circadian Phase. American Journal of Physiology - Heart and Circulatory Physiology. 2008; 295(5):H2156-63
Viola AU, James L M, Schlangen LJM, Dijk DJ. Blue-enriched white light in the work place improves self-reported alertness, performance and sleep quality. Scandinavian Journal of Work, Environment & Health. 2008; 34 (4): 297-306
Klerman EB, Dijk DJ. Age-related reduction in the maximal capacity for sleep -implications for insomnia. Current Biology2008; 18(15):1118-23. Epub 2008 Jul 24
Groeger JA, Viola AU, Lo, JCY, von Schantz M, Archer SN, Dijk DJ. Early morning executive functioning during sleep deprivation is compromised by a PERIOD3 polymorphism. SLEEP, 2008; 31(8):1159-1167
Sterr A, Herron K, Dijk DJ, Ellis J.Time to wake-up: sleep problems and daytime sleepiness in long-term stroke survivors.Brain Inj. 2008;22(7):575-579
Lockley SW, Dijk DJ, Kosti O, Skene DJ, Arendt J. Alertness, mood and performance rhythm disturbances associated with circadian sleep disorders in the blind. J Sleep Res, 2008;17(2):207-216.
Archer SN, Viola AU, Kyriakopoulu V, von Schantz M, Dijk DJ. Inter-individual differences in habitual sleep timing and entrained phase of endogenous circadian rhythms in BMAL1, PER2 and PER3 mRNA in human leukocytes. SLEEP. 2008; 31 (5): 608-617
Vandewalle G,Schmidt C, Albouy G, Sterpenich V, Darsaud A, Rauchs G, Berken P.-Y, Balteau E, Degueldre C, Luxen A, Maquet P, Dijk DJ. Brain responses to violet, blue, and green monochromatic light exposures in humans performing a working memory task: prominent role of blue light and the brainstem. Plos One 2007;2(11):e1247
Zeitzer JM, Duffy JF, Lockley SW, Dijk DJ, Czeisler CA. Plasma melatonin rhythms in young and older humans during sleep, sleep deprivation and wake. Sleep.2007; 30 (11):1437-1443.
Viola AU, Archer SN, James LM, Groeger JA, Lo CY, Skene DJ, von Schantz M, Dijk DJ. PER3 polymorphism predicts sleep structure and waking performance. Current Biology 2007 17: 613-618.
Vandewalle G, Gais S, Schabus M, Balteau E, Carrier J, Darsaud A, Sterpenich V, Albouy G, Dijk DJ, Maquet P. Wavelength-Dependent Modulation of Brain Responses to a Working Memory Task by Daytime Light Exposure. Cerebral Cortex, 2007;17(12):2788-2795.
Walsh JK, Deacon S, Dijk DJ, Lundahl J The selective extrasynaptic GABAA agonist, gaboxadol, improves traditional hypnotic efficacy measures and enhances Slow Wave Activity in a model of transient insomnia. SLEEP. 2007; 30(5): 593-602
Vandewalle G, Middleton B, Rajaratnam SMW, Stone BM, Thorleifsdottir B, Arendt J, Dijk DJ. Robust circadian rhythm in heart rate and its variability: influence of exogenous melatonin and photoperiod. J Sleep Res. 200716(2):148-155.
Jones KHS, Ellis J, von Schantz M, Skene DJ, Dijk DJ, Archer SN. Age-related change in the association between a polymorphism in the PER3 gene and preferred timing of sleep and waking activities. J Sleep Res. 2007, 16:12-16
Vandewalle G, Balteau E, Phillips C, Degueldre C, Moreau V, Sterpenich V, Albouy G, Darsaud A, Desseilles M, Dang-Vu T, Peigneux P, Luxen A, Dijk DJ, MaquetP. Daytime light dynamically enhances brain responses. Current Biology 2006,16(16):1616-1621.
Wyatt JK, Dijk DJ, Ritz-De Cecco A, Ronda JM, Czeisler CA. Sleep facilitating effect of exogenous melatonin in healthy young men and women is circadian-phase dependent. Sleep 2006, 29(4) 609-618.
Cropley M, Dijk DJ, Stanley N Job strain, work rumination and sleep in school teachers. European Journal of Work and Organizational Psychology 2006, 15(2):181-196
Klerman EB, Dijk DJ. Inter-individual variation in sleep duration and its association with sleep debt in young adults. Sleep 2005, 28: 1253-1259.
Rajaratnam SMW, Middleton B, Stone BM, Arendt J, Dijk DJ. Melatonin advances the circadian timing of EEG sleep and directly facilitates sleep without altering its duration. J Physiol (Lond), 2004, 561: 339-351
Perrin F, Peigneux P, Fuchs S, Verhaeghe S, Laureys S, Middleton B, Degueldre C, Del Fiore G, Vandewalle G, Balteau E, Poirrier R, Moreau V, Luxen A, Maquet P, Dijk DJ. Non-visual responses to light exposure in the human brain during the circadian night, Current Biol. 2004 14:1842-1846.
Groeger JA, Zijlstra FH, Dijk DJ. Sleep quantity, sleep difficulties and their perceived consequences in a representative sample of some two thousand British adults, J Sleep Res, 2004; 13:359-71.
Wyatt JK, Cajochen C, Ritz- De Cecco A, Czeisler CA, Dijk DJ. Low dose, repeated caffeine administration for circadian-phase dependent performance degradation during extended wakefulness. Sleep 2004; 27: 374-381.Klerman EB, Davis JB, Duffy JF, Dijk DJ, Kronauer RE. Older people awaken more frequently but fall back asleep at the same rate as younger people. Sleep 2004; 27: 793-798.
Rajaratnam SMW, Dijk DJ, Middleton M, Stone BM, Arendt J. Melatonin phase-shifts human circadian rhythms with no evidence of changes in the duration of endogenous melatonin secretion or the 24-h production of reproductive hormones. J Clin Endocrinol Metab 2003; 88: 4303-4309.
Phipps-Nelson J, Redman JR, Dijk DJ, Rajaratnam SMW. Daytime exposure to bright light decreases sleepiness and improves psychomotor vigilance performance. Sleep, 2003; 26: 695-700.
Cajochen C, Jewett ME, Dijk DJ. Human circadian rhythms phase delay during a fixed sleep-wake schedule interspersed with nights of sleep deprivation. J Pineal Res. 2003; 35:149-157.