Danish Center for Sleep Medicine, Department of Clinical Neurophysiology

Glostrup Hospital/University of Copenhagen

Contact:
Poul Jennum
Position:
Professor
Address:
Nordre Ringvej 57, 2600
City:
Glostrup
Country:
Denmark
Phone:
+4538632505
Fax:
+4543233933
Contact E-mail:
Research Domain
  • Methodology / Technology
  • Clinical
  • Basic Human
Keywords
  • Molecular Biology-Endocrinology-Biochemistry
  • Sleep and Medical Disorders
  • Genetics of Sleep
  • Sleep and Ageing
  • Sleep and Psychiatry-Personality Disorders
  • Sleep and Body Functions (Cardio-Respiratory, Thermoregulation/Metabolism, Endocrine)
  • Sleep Physiology-Neurophysiology in Human
  • Paediatric Sleep Disorders
  • Neurological Sleep Disorders
Current Announcements

The center is a national center which receives patient from all part of Denmark, with all diagnoses of sleep areas including children and adults.
Main clinical areas includes sleep and neurological diseases including neurodegenerative disorders, parasomnias, epilepsy, movement disorders etc, sleep disordered breathing, circadian disorders and insomnias.


Laboratory description

The laboratory include 6 in-hospital video-PSG beds in addition to the epilepsy monitoring unit with in total 8 beds. In addition full equipment facilities for ambulatory monitoring (PSG, cardio-respiratory monitoring, actigraphy etc.).

Treatment includes all types of positive airway pressure, medical treatment, psychology etc.

The laboratory present facilities for blood samples, saliva, spinal-fluid. The hospital includes full facilities for other diagnostic procedures (physiology, biochemetry, molecular biology, magnetic resonance, DAT scans etc.). Clinical departments includes neurology, psychiatry, internal medicine etc.


Additional Descriptors, Keywords

Epidemiology
Clinical research
Human sleep research
Pathophysiology of sleep disorders


Key Publications of the Laboratory:
Jennum P, Kjellberg J. Health, social and economical consequences of sleep-disordered breathing: a controlled national study. Thorax. 2011 Jul;66(7):560-6. Epub 2011 Jan 2. PubMed PMID: 21199816.

Hor H, Kutalik Z, Dauvilliers Y, Valsesia A, Lammers GJ, Donjacour CE, Iranzo A, Santamaria J, Peraita Adrados R, Vicario JL, Overeem S, Arnulf I, Theodorou I, Jennum P, Knudsen S, Bassetti C, Mathis J, Lecendreux M, Mayer G, Geisler P, Benetó A, Petit B, Pfister C, Bürki JV, Didelot G, Billiard M, Ercilla G, Verduijn W, Claas FH, Vollenweider P, Waeber G, Waterworth DM, Mooser V, Heinzer R, Beckmann JS, Bergmann S, Tafti M. Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy. Nat Genet. 2010 Sep;42(9):786-9. Epub 2010 Aug 15. Erratum in: Nat Genet. 2011 Apr;43(4):388.

Kornum BR, Kawashima M, Faraco J, Lin L, Rico TJ, Hesselson S, Axtell RC, Kuipers H, Weiner K, Hamacher A, Kassack MU, Han F, Knudsen S, Li J, Dong X, Winkelmann J, Plazzi G, Nevsimalova S, Hong SC, Honda Y, Honda M, Högl B, Ton TG, Montplaisir J, Bourgin P, Kemlink D, Huang YS, Warby S, Einen M, Eshragh JL, Miyagawa T, Desautels A, Ruppert E, Hesla PE, Poli F, Pizza F, Frauscher B, Jeong JH, Lee SP, Strohl KP, Longstreth WT Jr, Kvale M, Dobrovolna M, Ohayon MM, Nepom GT, Wichmann HE, Rouleau GA, Gieger C, Levinson DF, Gejman PV, Meitinger T, Peppard P, Young T, Jennum P, Steinman L, Tokunaga K, Kwok PY, Risch N, Hallmayer J, Mignot E. Common variants in P2RY11 are associated with narcolepsy. Nat Genet. 2011 Jan;43(1):66-71

Knudsen S, Jennum PJ, Alving J, Sheikh SP, Gammeltoft S. Validation of the ICSD-2 criteria for CSF hypocretin-1 measurements in the diagnosis of narcolepsy in the Danish population. Sleep. 2010 Feb;33(2):169-76.

Knudsen S, Gammeltoft S, Jennum PJ. Rapid eye movement sleep behaviour disorder in patients with narcolepsy is associated with hypocretin-1 deficiency. Brain. 2010 Feb;133(Pt 2):568-79.

Collaborations

Title:  MSc PhD

Name:  Helge D Sørensen

Position:  Assoc Prof

Institution:  The Technical University of Denmark

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