Sleep and Wake Disorders center, 1. National Refer, Sleep Unit, Departement Neurology

Gui-de-Chauliac Hospital, Inserm U1061, University

Contact:
Yves Dauvilliers
Position:
Professor
Address:
80 av augustin fliche, 34295
City:
Montpellier
Country:
France
Phone:
0033467337478
Fax:
0033467337285
Contact E-mail:
Research Domain
Keywords

Laboratory description

National Reference Network for Orphan Diseases : Narcolepsy and Idiopathic Hypersomnia.
Many research studies in the diagnosis, epidemiology, pathophysiology and therapy of several sleep disorders, mainly neurological disorders including narcolepsy but also other central hypersomnias, parasomnias and RLS.


Technical Capabilities and areas of expertise

Neurology and Sleep, Pathophysiology of Hypersomnia, Sleep and Ageing


Additional Descriptors, Keywords

Neurology and Sleep, Pathophysiology of Hypersomnia, Sleep and Ageing


Selected Publications in the 5 past years:

1. Dauvilliers Y, Arnulf I, Mignot E. Narcolepsy with cataplexy. Lancet. 2007;369:499-511
2. Maret S, Franken P, Dauvilliers Y, Ghyselinck NB, Chambon P, Tafti M. Retinoic acid signaling affects cortical synchrony during sleep. Science. 2005; 7:111-3 -A
3. Ohayon MM, Dauvilliers Y, Reynolds CF 3rd. Operational definitions and algorithms for excessive sleepiness in the general population: implications for DSM-5 nosology. Archives of General Psychiatry. 2012;69(1):71-9.
4. Jaussent I, Bouyer J, Ancelin ML, Akbaraly T, Pérès K, Ritchie K, Besset A, Dauvilliers Y. Insomnia and daytime sleepiness are risk factors for depressive symptoms in the elderly. Sleep. 2011 Aug 1;34(8):1103-10.
5. Winkelmann J, Czamara D, Schormair B, Knauf F, Schulte EC, Trenkwalder C, Dauvilliers Y, et al Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1. PLoS Genet. 2011 Jul;7(7):e1002171.
6. Blachier M, Dauvilliers Y, Jaussent I, Helmer C, Ritchie K, Jouven X, Tzourio C, Amouyel P, Besset A, Ducimetiere P, Empana JP. Excessive daytime sleepiness and vascular events: the 3 City Study. Annals of Neurology 2012;71(5):661-7.
7. Hor H, Kutalik Z, Dauvilliers Y al. Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy. Nature Genetics 2010;42:786-789.
8. Cvetkovic-Lopes V, Bayer L, Dorsaz S, Maret S, Pradervand S, Dauvilliers Y, Lecendreux M, Lammers GJ, Donjacour CE, Du Pasquier RA, Pfister C, Petit B, Hor H, Mühlethaler M, Tafti M.Elevated Tribbles homolog 2-specific antibody levels in narcolepsy patients. J Clin Invest. 2010 Mar 1;120(3):713-9
9. Ohayon M, Reynolds C, Dauvilliers Y. Excessive Quantity of Sleep and its links to excessive sleepiness – Implications for the DSM-5. Ann Neurol in press
10. Dauvilliers Y et al. Hypothalamic immunopathology in anti-Ma-associated diencephalitis with narcolepsy-cataplexy. JAMA neurology in press
11. Dauvilliers Y, Arnulf I, Lecendreux M, Monaca Charley C, Franco P, Drouot X, d’Ortho MP, Launois S, Lignot S, Bourgin P, Nogues B, Rey M, Bayard S, Scholz S, Lavault S, Tubert-Bitter P, Saussier C, Pariente A; Narcoflu-VF study group. Increased risk of narcolepsy in children and adults after pandemic H1N1 vaccination in France. Brain. 2013 Aug;136(Pt 8):2486-96


Key Publications of the Laboratory:

1. Dauvilliers Y, Arnulf I, Mignot E. Narcolepsy with cataplexy. Lancet. 2007;369:499-511
2. Maret S, Franken P, Dauvilliers Y, Ghyselinck NB, Chambon P, Tafti M. Retinoic acid signaling affects cortical synchrony during sleep. Science. 2005; 7:111-3 -A
3. Ohayon MM, Dauvilliers Y, Reynolds CF 3rd. Operational definitions and algorithms for excessive sleepiness in the general population: implications for DSM-5 nosology. Archives of General Psychiatry. 2012;69(1):71-9.
4. Jaussent I, Bouyer J, Ancelin ML, Akbaraly T, Pérès K, Ritchie K, Besset A, Dauvilliers Y. Insomnia and daytime sleepiness are risk factors for depressive symptoms in the elderly. Sleep. 2011 Aug 1;34(8):1103-10.
5. Winkelmann J, Czamara D, Schormair B, Knauf F, Schulte EC, Trenkwalder C, Dauvilliers Y, et al Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1. PLoS Genet. 2011 Jul;7(7):e1002171.
6. Blachier M, Dauvilliers Y, Jaussent I, Helmer C, Ritchie K, Jouven X, Tzourio C, Amouyel P, Besset A, Ducimetiere P, Empana JP. Excessive daytime sleepiness and vascular events: the 3 City Study. Annals of Neurology 2012;71(5):661-7.
7. Hor H, Kutalik Z, Dauvilliers Y al. Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy. Nature Genetics 2010;42:786-789.
8. Cvetkovic-Lopes V, Bayer L, Dorsaz S, Maret S, Pradervand S, Dauvilliers Y, Lecendreux M, Lammers GJ, Donjacour CE, Du Pasquier RA, Pfister C, Petit B, Hor H, Mühlethaler M, Tafti M.Elevated Tribbles homolog 2-specific antibody levels in narcolepsy patients. J Clin Invest. 2010 Mar 1;120(3):713-9
9. Ohayon M, Reynolds C, Dauvilliers Y. Excessive Quantity of Sleep and its links to excessive sleepiness – Implications for the DSM-5. Ann Neurol in press
10. Dauvilliers Y et al. Hypothalamic immunopathology in anti-Ma-associated diencephalitis with narcolepsy-cataplexy. JAMA neurology in press
11. Dauvilliers Y, Arnulf I, Lecendreux M, Monaca Charley C, Franco P, Drouot X, d’Ortho MP, Launois S, Lignot S, Bourgin P, Nogues B, Rey M, Bayard S, Scholz S, Lavault S, Tubert-Bitter P, Saussier C, Pariente A; Narcoflu-VF study group. Increased risk of narcolepsy in children and adults after pandemic H1N1 vaccination in France. Brain. 2013 Aug;136(Pt 8):2486-96


Current/Completed Grants (past 5 years):

Grant from National Academic Hospital Agency on Rare Diseases (PHRC orphan disease) “Prospective and longitudinal phenotypic and biological cohort on primary hypersomnia (narcolepsy, idiopathic hypersomnia, Kleine-Levin syndrome)” 2007.
Grant from National Research Agency on Rare Diseases (ANR orphan disease) “Genetics of sporadic and familial narcolepsy” 2007.
Grant from Regional Academic Hospital Agency (AOI) “Emotional and olfaction regulation in narcolepsy” 2009.
Grant from Regional Academic Hospital Agency (AOI) “Physical activity training on sleep apnea syndrome” 2010
Grant from French Sleep Research Society (SFRMS) “Physical activity training on sleep apnea syndrome” 2011
Grant from the National Brain Research Federation. “Autoimmunity in narcolepsy” 2009.
Grant from National Research Agency on H1N1 and Narcolepsy 2010
Grant from Industry to assess cardiovascular function in Restless legs syndrome 2012 Grant from Inter-Regional Academic Hospital Agency (PHRC) on “cognition and Resless Legs syndrome” 2012

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