Neurobiology of sleep-waking cycle, Russian Academy of Sciences

Institute Higher Nervous Activity/Neurophysilogy

Contact:
Vladimir B. Dorokhov
Position:
Head of the Lab
Address:
5A Butlerova str., 117485
City:
Moscow
Country:
Russia
Phone:
+7 495 3347200
Fax:
+7 499 7430056
Contact E-mail:
Research Domain
  • Basic Animal
  • Basic Human
Keywords
  • Learning, Memory, Cognition
  • Genetics of Sleep
  • Sleep Physiology-Neurophysiology in Human
  • Sleep Physiology-Neurophysiology in Animal

Laboratory description

human studies: sleepiness in drivers; memory recall after daytime nap; forced sleepiness and forced waking; performance during mental fatigue and recovery afterdaytime nap. Special driving simulator, polygraphy and eye tracking are used

animal studies: sleep deprivation and memory recall in rats; MPTP model of Parkinson disease and sleep in mice; Morris water maze supplied with an automatic video recording and processing (Noldus EthoVision) are used for behavioral measurements; a carousel method of sleep deprivation is used; polygraphic registration in small rodents including Neurologgers is used


Technical Capabilities and areas of expertise

special driving simulator, polygraphy and eye tracking are used for human studies

Morris water maze supplied with an automatic video recording and processing (Noldus EthoVision) are used for behavioral measurements; a carousel method of sleep deprivation is used; polygraphic registration in small rodents including Neurologgers is used for animal studies


Additional Descriptors, Keywords

the study of the relation of hibernation and sleep is now started


Selected Publications in the 5 past years:

Dorokhov V.B., Kozhedub R.G., Arsenyev G.N., Kozhechkin S.N., Ukraintseva Y.V., Kovalzon V.M. Sleep deprivation effect upon spatial memory consolidation in rats after 1-day learning in a Morris water maze // J. Sleep Res. 2010. V. 19. Suppl. 1. P. 91.

Dorokhov V.B.; Arsenyev G.N.; Tkachenko O.N.; Zakharchenko D.V.; Dementienko V.V. Eye-hand coordination errors during monotonous activity. // Abstracts of the 15th European Conference on Eye Movements. 2009. p. 159

Puchkova A.N., Ukraintseva Yu.V., Kovalzon V.M., Dorokhov V.B. Effect of day time nap on human declarative memory recall // J. Sleep Res. 2010. V. 19. Suppl. 1. P. 118.

Puchkova A.N., Tkachenko O.N., Dorokhov V.B. Daytime nap recuperates psychomotor activity affected by mental fatigue. //Abstracts of the 51st Annual Meeting of Society for Psychophysiological Research. Boston, MA, USA, 2011. p. 133 http://www.sprweb.org/meeting/2011/pdf/2011SPR.pdf

Puchkova A.N., Tkachenko O.N., Dorokhov V.B., Dementienko V.V. Evaluation of mental fatigue by eye and hand movement parameters. // Abstracts of the 16th European Conference on Eye Movements 2011, p.172

Dolgikh V.V., Kovalzon V.M., Dorokhov V.B. Searching for early markers of Parkinson disease: sleep structure dynamics in MPTP-treated mice // Abstracts of the 6th International workshop “Sleep: a window to the world of wakefulness”. p. 52-53. http://www.sleep.ru/conf/Sbornik6conf.pdf

Zakharchenko D.V., Lemeshko K.A., Dementienko V.V., Dorokhov V.B. Heterochrony of EEG, cognitive and behavioral activity during decreased the arousal level caused by monotony performance with closed eye // Abstracts of the 6th International workshop “Sleep: a window to the world of wakefulness”. p. 108-109.

Kovalzon V.M., Fesenko G.N. et al. “Hidden” Properties of Neuropeptides: Hypnogenic Activity of the Tripeptide Complex DSIP + NPY + ANP // Neurochemical Journal (Pleiades Publ.), 2007. Vol. 1. No. 1. P. 74–77.

Kovalzon V.M. Peptide complexes and sleep // International Journal of Psychophysiology. 2008. Volume 69. Issue 3. P. 154-155.

Kovalzon V.M., Strekalova T.V., Cespuglio R. Depressive-like state and sleep in laboratory mice // Journal of Sleep Research. 2008. V. 17. Suppl. 1. P. 529.

Kovalzon V.M. A portrait of Maria Manasseina, pioneer sleep scientist // SRS Bulletin. 2009. V. 15. No.2. P. 27-28.

Kovalzon V.M. Some notes on the biography of Maria Manasseina // J. Hist. Neurosci. 2009. V. 18. No.3. P. 312-319.

Strekalova T., Cespuglio R., Kovalzon V. Sleep structure during chronic stress and anhedonia in the mouse model of depression // Experimental Animal Models in Neurobehavioral Research / Eds. Kalueff A.V., LaPorte J.L. (Nova Science Publishers, N.Y.) 2009. P. 123-137. (ISBN 978-1-60692-022-0)

Kovalzon V.M., Dorokhov V.B., Loginov V.V. Effects of factors inducing diffuse damage to brain tissue on sleep structure in laboratory rats // Neuroscience and Behavioral Physiology. 2010. V. 40. No. 5. P. 507-512.

Kovalzon V.M., Strekalova T., Cespuglio R., Bachurin S.O. Towards identification of neurochemical and sleep EEG markers of anhedonia in a new mouse model of depression // Sleep. 2010. V. 33. Supplement А. P. A23.

Pavlova T.V., Fesenko G.N., Gekht A.B., Gulyaeva N.V., Kovalzon V.M. Convulsive activity in the electroencephalogram in rats sensitive and tolerant to pentylenetetrazol kindling // Neurosci.Behav.Physiol. 2010. V. 40. No. 3. P. 239-244.

Kovalzon V.M. Central mechanisms of the sleep–wakefulness cycle control // Human Physiology (Pleiades Publ.). 2011. V. 37. No. 4. Р. 500–508.

Kovalzon V., Evdokimenko A., Rusakova I., Rutskova E., Dorokhov V., Loginov V., Fesenko G. Paradoxical sleep and restorative function of cerebral tissue // Sleep. 2007. V. 30. Suppl. A. P. A25-A26.

Kovalzon V.M., Dorokhov V.B., Loginov V.V. Effects of factors inducing diffuse damage to brain tissue on sleep structure in laboratory rats // Neuroscience and Behavioral Physiology. 2010. V. 40. No. 5. P. 507-512.

Kovalzon V.M., Strekalova T., Cespuglio R., Bachurin S.O. Towards identification of neurochemical and sleep EEG markers of anhedonia in a new mouse model of depression // Sleep. 2010. V. 33. Supplement А. P. A23.

Kovalzon V.M. Central mechanisms of the sleep–wakefulness cycle control // Human Physiology (Pleiades Publ.). 2011. V. 37. No. 4. Р. 500–508.

Manolov A.I., Ukraintseva Y.V., Dorokhov V.B. Effect of day time nap on human declarative memory recall. //Abstracts of the 51st Annual Meeting of Society for Psychophysiological Research. Boston, MA, USA, 2011. P. 132 http://www.sprweb.org/meeting/2011/pdf/2011SPR.pdf http://www.sleep.ru/conf/Sbornik6conf.pdf

Lavrova T.N., Dorokhov V.B. Inter-individual differences in quality of performingprolonged and continuous night work // Abstracts of the 6th International workshop “Sleep: a window to the world of wakefulness”. p. 76-77. http://www.sleep.ru/conf/Sbornik6conf.pdf

Pudikov I.V.,Dorokhov V.B. Effects of combined ultraviolet and optical light on the sleep-wake cycle in patients with seasonal depressions. //Abstracts of the 6th International workshop “Sleep: a window to the world of wakefulness”. p. 92-93. http://www.sleep.ru/conf/Sbornik6conf.pdf


Key Publications of the Laboratory:

Dorokhov V. B. ,Kozhedub R. G., Arsenyev G. N.,
Kozhechkin S. N.,Ukraintseva Yu. V. , Kulikov M. A., Manolov A. I., Kovalzon V. M. . Sleep Deprivation Effect upon Spatial Memory Consolidation in Rats after One Day Learning in a Morris Water Maze // J. Higher Nerv. Activ. 2011. V. 61.No.3. P.1–10. (In Russian)

Koval’zon V.M. Central mechanisms of the sleep–wakefulness cycle control // Human Physiology (Pleiades Publ.). 2011. V. 37. No. 4. Р. 500–508.

Dorokhov V.B., Kozhedub R.G., Arsenyev G.N., Kozhechkin S.N., Ukraintseva Yu.V., Kovalzon V.M. Sleep deprivation effect upon spatial memory consolidation in rats after 1-day learning in a Morris water maze // J. Sleep Res. 2010. V. 19. Suppl. 1. P. 91.

Dorokhov V.B., Arsenev G.N., Tkachenko O.N., Zakharchenko D.V., Lavrova T.P., Dementienko V.V. The psychomotor test for research of eye-hand coordination at performance of monotonous activity on tracking target. //Zh Vyssh Nerv Deiat Im I P Pavlova. 2011 Jul-Aug;61(4):476-84. Russian.

Ukraintseva Yu.V., Dorokhov V.B. [Effect of daytime nap on consolidation of declarative memory in humans. //Zh Vyssh Nerv Deiat Im I P Pavlova. 2011 Mar-Apr;61(2):161-9. Russian.

Dorokhov V.B., Kozhedub R.G., Arsenyev G.N., Kozhechkin S.N., Puchkova A.N.,Ukraintseva Yu.V., Dorokhov V.B., Kovalzon V.M. Effect of day time nap on human declarative memory recall. // J.Sleep Res. 2010. V.19. Suppl. 1. P.118.

Dorokhov VB, Verbitskaya YS, Lavrova TP. Auditory evoked potentials and impairments to psychomotor activity evoked by falling asleep. //Neurosci Behav Physiol. 2010 May;40(4):411-9. Epub 2010 Mar 26.

Strekalova T., Cespuglio R., Kovalzon V. Sleep structure during chronic stress and anhedonia in the mouse model of depression // Experimental Animal Models in Neurobehavioral Research / Eds. Kalueff A.V., LaPorte J.L. (Nova Science Publishers, N.Y.) 2009. P. 123-137. (ISBN 978-1-60692-022-0)

Kovalzon V.M. Peptide complexes and sleep // International Journal of Psychophysiology. 2008. Volume 69. Issue 3. Pages 154-155.


Current/Completed Grants (past 5 years):

The role of sleep in formation of spatial memory related to hippocampal cholinergic sysytem, RFBR (2009-2011)

Eye movements and driving mistakes in autosimulator during the reduced wakefulness, RFH (2008-2010)

The role of sleep in formation of spatial memory related to hippocampal cholinergic sysytem, RFBR (2009-2011)

Eye-hand coordination and the reduction of the attention during the lowered level of wakefulness RFBR (2009-2011)

Daytime nap: structure and functional role of separate states, RFH (2008-2010)

Study of influence of combined long-wave ultraviolet (UVA) and optical radiation on night sleep structure in patients with seasonal depression, RFH (2011-2012)

Psychological mechanisms of sleep regulation, RFH (2011)

Adaptive function of daytime nap in mental fatigue, RFH (2012-2013)

Organisation of the 5th International workshop “Sleep: a window to the world of wakefulness”, IBRO (2009), RFH (2009)

Organisation of the 6th International workshop “Sleep: a window to the world of wakefulness”, IBRO (2011), RFH (2011), RFBR (2011) (abstracts on http://www.sleep.ru/conf/Sbornik6conf.pdf)


Other laboratory Members

Title:  PhD

Name:  Vladimir M. Kovalzon

Position:  Principle Researcher

Email:  kovalzon@yandex.ru

Name:  Alexandra N. Puchkova

Position:  Postgrad student

Email:  puchkovaan@gmail.com

Name:  Olga N. Tkachenko

Position:  Research worker

Email:  tkachenkoon@gmail.com

Name:  Gleb N. Arsenyev

Position:  Research worker

Email:  byron100z@gmail.com

Name:  Gleb N. Arsenyev

Position:  Research worker

Email:  byron100z@gmail.com

Name:  Tatiana P. Lavrova

Position:  Research worker

Email:  lavt@mail.ru

Name:  Yulia V. Ukraintseva

Position:  Research worker

Email:  ukraintseva@yandex.ru

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