Human Sleep Psychopharmacology Laboratory, University of Zürich

Institute of Pharmacology and Toxicology

Contact:
Hans-Peter Landolt
Position:
Senior Researcher
Address:
Winterthurerstrasse 190, 8057
City:
Zürich
Country:
Switzerland
Phone:
+41 44 635 59 53
Fax:
+41 44 635 57 07
Contact E-mail:
Research Domain
  • Basic Human
  • Clinical
Keywords
  • Sleep Physiology-Neurophysiology in Human
  • Sleep and Ageing
  • Pharmacology of Sleep
  • Genetics of Sleep
  • Sleep and Medical Disorders
  • Pharmacology Human

Laboratory description

We are interested in the molecular mechanisms underlying individual differences in sleep, waking performance and response to sleep and wake promoting pharmacological agents in humans. To elucidate such mechanisms in health and disease, we combine and integrate methods of human genetics, selective pharmacology, multi-channel EEG, neuropsychological/cognitive testing and molecular brain imaging.


Key Publications of the Laboratory:
- Holst SC, Bersagliere A, Bachmann V, Berger W, Achermann P, and Landolt HP. Dopaminergic role in regulating neurophysiological markers of sleep homeostasis in humans. J Neurosci 34, 566-573, 2014.

- Hefti K, Holst SC, Sovago J, Bachmann V, Buck A, Ametamey SM, Scheidegger M, Bethold T, Gomez-Mancilla B, Seifritz E, and Landolt HP. Increased metabotropic glutamate receptor subtype 5 availability in human brain after one night without sleep. Biol Psychiatry 73, 161-168, 2013.

- Bachmann V, Klaus F, Bodenmann S, Schäfer N, Brugger P, Huber S, Berger W, and Landolt HP. Functional ADA polymorphism increases sleep depth and reduces vigilant attention in humans. Cereb Cortex 22, 962-970, 2012.

- Rétey JV, Adam M, Khatami R, Luhmann UFO, Jung HH, Berger W, and Landolt HP. A genetic variation on the adenosine A2A receptor gene (ADORA2A) contributes to individual sensitivity to caffeine effects on sleep. Clin Pharmacol Ther 81, 692-698, 2007.

- Rétey JV, Adam M, Honegger E, Khatami R, Luhmann U, Jung HH, Berger W and Landolt HP (2005). A functional genetic variation of adenosine deaminase affects the duration and intensity of deep sleep in humans. Proc Natl Acad Sci USA 102, 15676-15681.

Collaborations

Title:  PhD

Name:  Peter Brugger

Institution:  Department of Neurology, University Hospital, Zürich, Switzerland

Title:  MD

Name:  Erich Seifritz

Institution:  Clinic of Affective Disorders and General Psychiatry, Psychiatric University Hospital, Zürich, Switzerland

Title:  MD

Name:  Christian Baumann

Institution:  Department of Neurology, University Hospital, Zürich, Switzerland

Title:  PhD

Name:  Wolfgang Berger

Institution:  Institute of Medical Molecular Genetics, University of Zürich, Schwerzenbach, Switzerland

Title:  PhD

Name:  Christian Cajochen

Institution:  Centre for Chronobiology, Psychiatric Hospital of the University of Basel, Basel, Switzerland

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