Human Sleep Psychopharmacology Laboratory, University of Zürich

Institute of Pharmacology and Toxicology

Contact:
Hans-Peter Landolt
Position:
Senior Researcher
Address:
Winterthurerstrasse 190, 8057
City:
Zürich
Country:
Switzerland
Phone:
+41 44 635 59 53
Fax:
+41 44 635 57 07
Contact E-mail:
Research Domain
Keywords

Laboratory description

We are interested in the molecular mechanisms underlying individual differences in sleep, waking performance and response to sleep and wake promoting pharmacological agents in humans. To elucidate such mechanisms in health and disease, we combine and integrate methods of human genetics, selective pharmacology, multi-channel EEG, neuropsychological/cognitive testing and molecular brain imaging.


Selected Publications in the 5 past years:

– Valomon A, Holst SC, Bachmann V, Viola AU, Schmidt C, Zürcher J, Berger W, Cajochen C, and Landolt HP. Genetic polymorphisms of DAT1 and COMT differently affect actigraphy-derived sleep-wake cylces in humans. Chronobiol Int, in press.

– Holst SC, Bersagliere A, Bachmann V, Berger W, Achermann P, and Landolt HP. Dopaminergic role in regulating neurophysiological markers of sleep homeostasis in humans. J Neurosci 34, 566-573, 2014.

– Bosch OG, Rihm JS, Scheidegger M, Landolt HP, Stämpfli P, Brakowski J, Esposito F, Rasch B, and Seifritz E. Sleep deprivation increases dorsal nexus connectivity to the dorsolateral prefrontal cortex in humans. Proc Natl Acad Sci USA 110, 19597-15602, 2013.

– Hefti K, Holst SC, Sovago J, Bachmann V, Buck A, Ametamey SM, Scheidegger M, Bethold T, Gomez-Mancilla B, Seifritz E, and Landolt HP. Increased metabotropic glutamate receptor subtype 5 availability in human brain after one night without sleep. Biol Psychiatry 73, 161-168, 2013.

– Bachmann V, Klaus F, Bodenmann S, Schäfer N, Brugger P, Huber S, Berger W, and Landolt HP. Functional ADA polymorphism increases sleep depth and reduces vigilant attention in humans. Cereb Cortex 22, 962-970, 2012.

– Bachmann V, Klein C, Bodenmann S, Schäfer N, Berger W, Brugger P, and Landolt HP. The BDNF Val66Met polymorphism modulates sleep intensity: EEG frequency- and state-specificity. Sleep 35, 335-344, 2012.

– Bodenmann S, Hohoff C, Freitag C, Deckert J, Rétey JV, Bachmann V, and Landolt HP. Polymorphisms of ADORA2A modulate psychomotor vigilance and the effects of caffeine on neurobehavioral performance and sleep EEG after sleep deprivation. Br J Pharmacol 165, 1904-1913, 2012.

– Bodenmann S, Xu S, Luhmann UFO, Arand M, Berger W, Jung HH and Landolt HP (2009). Pharmacogenetics of modafinil after sleep loss: Catechol-O-Methyltransferase genotype modulates waking functions but not recovery sleep. Clin Pharmacol Ther 85, 296-304.

– Bodenmann S, Rusterholz T, Dürr R, Stoll C, Bachmann V, Geissler E, Jaggi-Schwarz K and Landolt HP (2009). The functional Val158Met polymorphism of COMT predicts individual differences in brain alpha oscillations. J Neurosci 29, 10855-10862.


Key Publications of the Laboratory:

– Holst SC, Bersagliere A, Bachmann V, Berger W, Achermann P, and Landolt HP. Dopaminergic role in regulating neurophysiological markers of sleep homeostasis in humans. J Neurosci 34, 566-573, 2014.

– Hefti K, Holst SC, Sovago J, Bachmann V, Buck A, Ametamey SM, Scheidegger M, Bethold T, Gomez-Mancilla B, Seifritz E, and Landolt HP. Increased metabotropic glutamate receptor subtype 5 availability in human brain after one night without sleep. Biol Psychiatry 73, 161-168, 2013.

– Bachmann V, Klaus F, Bodenmann S, Schäfer N, Brugger P, Huber S, Berger W, and Landolt HP. Functional ADA polymorphism increases sleep depth and reduces vigilant attention in humans. Cereb Cortex 22, 962-970, 2012.

– Rétey JV, Adam M, Khatami R, Luhmann UFO, Jung HH, Berger W, and Landolt HP. A genetic variation on the adenosine A2A receptor gene (ADORA2A) contributes to individual sensitivity to caffeine effects on sleep. Clin Pharmacol Ther 81, 692-698, 2007.

– Rétey JV, Adam M, Honegger E, Khatami R, Luhmann U, Jung HH, Berger W and Landolt HP (2005). A functional genetic variation of adenosine deaminase affects the duration and intensity of deep sleep in humans. Proc Natl Acad Sci USA 102, 15676-15681.


Current/Completed Grants (past 5 years):

– Swiss National Science Foundation # 320030-135414: “Glutamatergic mechanisms in sleep-wake homeostasis in health and disease – molecular brain imaging and pharmacogenetics”

– Zürich Center for Integrative Human Physiology (ZIHP): “Inhibiting COMT – Neuroprotection and wake-promotion?”

– University of Zürich: Clinical Research Priority Program “Sleep and Health”


Other laboratory Members

Title:  PhD

Name:  Sebastian Camillo Holst

Position:  Postdoctoral fellow

Email:  holst@pharma.uzh.ch

Title:  MSc

Name:  Emily Urry

Position:  PhD student

Email:  emily.urry@pharma.uzh.ch

Title:  MSc

Name:  Amandine Valomon

Position:  PhD student

Email:  avalomon@yahoo.fr

Title:  MSc

Name:  Alexandra Sousek

Position:  PhD Student

Email:  alexandra.sousek@pharma.uzh.ch

Title:  MSc

Name:  Susanne Münzing

Position:  PhD Student

Email:  susanne.muenzing@pharma.uzh.ch

Title:  BSc

Name:  Darya Erkhova

Position:  Scientific assistant

Email:  derkhova@gmail.com

Title:  BSc

Name:  Ian Clark

Position:  Scientific assistant

Email:  Ian.Clark@uzh.ch


Collaborations

Title:  PhD

Name:  Peter Brugger

Institution:  Department of Neurology, University Hospital, Zürich, Switzerland

Title:  MD

Name:  Erich Seifritz

Institution:  Clinic of Affective Disorders and General Psychiatry, Psychiatric University Hospital, Zürich, Switzerland

Title:  MD

Name:  Christian Baumann

Institution:  Department of Neurology, University Hospital, Zürich, Switzerland

Title:  PhD

Name:  Wolfgang Berger

Institution:  Institute of Medical Molecular Genetics, University of Zürich, Schwerzenbach, Switzerland

Title:  PhD

Name:  Christian Cajochen

Institution:  Centre for Chronobiology, Psychiatric Hospital of the University of Basel, Basel, Switzerland


Past Members

Title:  PhD

Name:  Katharina Hefti

Position:  PhD student

Email:  katharina.hefti@pharma.uzh.ch

Title:  PhD

Name:  Valérie Bachmann

Position:  PhD student

Email:  valerie.bachmann@gmail.com

Title:  PhD

Name:  Sereina Bodenmann

Position:  PhD student

Email:  sereina@gmx.net

Title:  PhD

Name:  Eva Geissler

Position:  PhD student

Email:  eva.geissler@pharma.ethz.ch

Title:  PhD

Name:  Julia Rétey

Email:  jretey@gmx.ch

© 2019 European Sleep Research Society. All rights reserved.
X