Sleep and Chronobiology Laboratory, University of Colorado at Boulder

Integrative Physiology/ Neuroscience

Contact:
Kenneth P Wright
Position:
Associate Professor
Address:
1725 Pleasant Street; Clare Small 112, 80309-0354
City:
Boulder
Country:
United States
Phone:
+1 303 735 1923
Fax:
+1 303 492 4009
Research Domain
Keywords

Laboratory description

Health and safety consequences of sleep and circadian disruption.

Influence of sleep and circadian rhythms on human physiology (neuroendocrine, metabolic and immune function) and behavior (sleepiness, memory, learning, mood, cognitive and balance performance) with application to public health and safety.

Countermeasures to improve sleep and wakefulness and shift the circadian clock

Pathophysiology and treatment of circadian sleep disorders


Technical Capabilities and areas of expertise

4 research suites (sleep and chronobiology studies).

Whole room calorimeter (24 hour energy expenditure assessment; minute per minute changes in energy expenditure and macronutrient utilization).

4 protocol rooms in University of Colorado Boulder Clinical Translational Research Center (physicians, nurses, nutritionists, research technicians).

12 protocol rooms in University of Colorado School of Medicine Clinical Research Center (Inpatient Studies)(physicians, nurses, nutritionists, research technicians, core laboratory for biological specimen processing).

4 Compumedics Siesta digital ambulatory sleep and physiology recorders (32 channels)

Quantitative EEG analysis software and development

Cognitive function assessment computers

2 driving simulators

15 Actiwatch ambulatory activity and light monitors

4 ambulatory body temperature recording devices

Galvanic skin response recorder

30 skin temperature recording devices

Exercise testing/metabolic carts

Body composition (DEXA) lab

Wet lab for handling and processing blood, saliva and urine

ELISA, RIA and HLPC lab for analyzing biological specimen


Selected Publications in the 5 past years:

Åkerstedt T. Wright KP Jr. Sleep Loss and Fatigue in Shift Work and Shift Work Disorder. Sleep Med Clinics. 4: 257–271. 2009.

Drake CL, Friedman NP, Wright KP Jr, Roth T. Sleep reactivity and insomnia: genetic and environmental influences. Sleep 34: 1179-1188, 2011.

Drake CL, Wright KP Jr. Shift work, shift work disorder, and jet lag. Principles and Practice of Sleep Medicine 784-798, 2011.

Duffy JF, Cain SW, Chang AM, Phillips AJ, Münch MY, Gronfier C, Wyatt JK, Dijk DJ, Wright KP Jr, Czeisler CA. Sex difference in the near-24-hour intrinsic period of the human circadian timing system. Proceedings of the National Academy of Sciences 108 Suppl 3: 15602-15608, 2011.

Frey DJ, Fleshner M, Wright KP Jr. The effects of 40 hours of total sleep deprivation on inflammatory markers in healthy young adults. Brain Behav. Immun. 2007;21:1050-7.

Frey DJ, Ortega JD, Wiseman C, Farley CT, Wright KP Jr. Influence of Zolpidem on balance and cognition during nighttime awakening: a randomized placebo controlled trial. Journal of the American Geriatric Society 59: 73-81, 2011.

Friedman NP, Corley RP, Hewitt JK, Wright KP Jr. Individual Differences in Childhood Sleep Problems Predict Later Cognitive Executive Control. Sleep. 2009; 32:323-33.

Jung CM, Melanson EL, Perreault L, Eckel RH, Wright KP Jr. Energy expenditure during sleep, sleep deprivation and sleep following sleep deprivation in humans. Journal of Physiology 589: 235-44. 2011.

Jung CM, Khalsa SB, Scheer FAJL, Cajochen C, Lockley S, Czeisler CA, Wright KP Jr. Acute Effects of Bright Light Exposure on Nighttime Cortisol Levels in Humans. Journal of Biological Rhythms. 25:208-16. 2010.

Jung CM, Ronda JM, Czeisler CA, Wright KP Jr. Comparison of sustained attention assessed by auditory and visual psychomotor vigilance tasks prior to and during sleep deprivation. Journal of Sleep Research 20: 348-55, 2011.

Markwald RR, Wright KP Jr. Circadian misalignment and sleep disruption in shift work: implications for fatigue and risk of weight gain and obesity. Sleep Loss and Obesity: Intersecting Epidemics. Springer, LLC. 101-118, 2012.

Wright KP, Lowry CA, LeBourgeois MK. Circadian and wakefulness-sleep modulation of cognition in humans. Frontiers in Molecular Neuroscience 5(50): 1-12, 2012.

Wright KP Jr, Burke TM, Smith MR. Light Exposure for Improving Cognition During Sleep Loss and Circadian Misalignment. Ed NJ Wesensten Sleep Deprivation, Stimulant Medications, and Cognition. Cambridge University Press. 184-198, 2012.

Wright Jr. KP, Bogan RK, Wyatt JK. Shift Work and the Assessment and Management of Shift Work Disorder (SWD). Sleep Medicine Reviews.17:41-54. 2013.


Key Publications of the Laboratory:

Czeisler CA, Walsh JK, Roth T, Hughes RJ, Wright KP Jr. Kingbury L, Arora S, Schwartz JRL, Niebler GE, Dinges DF. Modafinil for Excessive Sleepiness Associated With Shift Work Sleep Disorder. New Engl. J. Med. 2005; 353:476-486.

Frey DJ, Ortega JD, Wiseman C, Farley CT, Wright KP Jr. Influence of Zolpidem on balance and cognition during nighttime awakening: a randomized placebo controlled trial. Journal of the American Geriatric Society 59: 73-81, 2011.

Friedman NP, Corley RP, Hewitt JK, Wright KP Jr. Individual Differences in Childhood Sleep Problems Predict Later Cognitive Executive Control. Sleep. 2009; 32:323-33.

Jung CM, Melanson EL, Perreault L, Eckel RH, Wright KP Jr. Energy expenditure during sleep, sleep deprivation and sleep following sleep deprivation in humans. Journal of Physiology 589: 235-44. 2011.

Wertz AT, Ronda JM, Czeisler, CA, Wright KP Jr. The Influence of Sleep Inertia on Cognition. JAMA, 2006; 295:163-164.


Current/Completed Grants (past 5 years):

Current Research Support

R01 HL109706 Wright (PI) 07/11 – 06/15
NIH/NHLBI “Metabolic and Cognitive Consequences of Sleep Loss”.

R21 DK092624 Wright (PI) 05/12 – 04/14
NIH/NIDDK “Circadian Misalignment and Energy Metabolism”

R01 HL111478 Wright (Subcontract PI) 05/12 – 04/17
NIH/NHLBI Multi-Center Trial of Limiting PGY 2&3 Resident Work Hours in ICU Patient Safety – CCC

T32 AG00279 Schwartz (PI) 05/02 – 04/17
NIH/NIA “INTEGRATIVE PHYSIOLOGY OF AGING TRAINING GRANT”

Completed Research Support

R01 HL085705 Wright (PI) 07/09-06/12
NIH/NHLBI “Health and Safety Consequences of Sleep Loss”.

R01 HL081761 Wright (PI) 05/06 – 03/11
NIH/NHLBI “Circadian Integration of Photic and Non-photic Stimuli”
HFP00002 Wright (PI) 02/09 – 08/10
National Space Biomedical Research Institute “Operational Evaluation of a Photic Countermeasure to Improve Alertness, Performance, and Mood during Nightshift Work on a 105-day Simulated Human Exploration Mission”

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