Cardiovascular Sleep Research Center, St. Anne's University Hospital Brno

International Clinical Research Center

Contact:
Ondrej Ludka
Position:
Subprogramme Director
Address:
Pekarska 53, 65691
City:
Brno
Country:
Czech Republic
Phone:
+420 543 185 492
Fax:
+420 543 185 492
Contact E-mail:
Research Domain
Keywords

Laboratory description

The cardiovascular sleep research center Brno is specialized in diagnosis and treatment of sleep apnea in patients with cardiovasulcar diseases. The center consists of 4 electromagnetically shielded sleep laboratories, equipped with state of the art technologies for advanced diagnosis and treatment of SA. Our sleep specialists are trained, educated and board-certified in Czech Republic and U.S. (Mayo Clinic)


Technical Capabilities and areas of expertise

Diagnosis and treatment of obstructive and central sleep apnea in patients with cardiovascular diseases in various clinical and research protocols.


Additional Descriptors, Keywords

cardiovascular diseases and sleep-disordered breathing


Selected Publications in the 5 past years:

LUDKA, O., ŠTĚPÁNOVÁ, R., VYSKOČILOVÁ, M., GALKOVÁ, L., MIKOLÁŠKOVÁ, M., BĚLEHRAD, M., KOŠŤÁLOVÁ, J., MIHALOVÁ, Z., DROZDOVÁ, A., HLÁSENSKÝ, J., GACIK, M., PUDILOVÁ, l., MIKUŠOVÁ, T., FISCHEROVÁ, B., SERT-KUNIYOSHI, F., SOMERS, V., ŠPINAR, J., KÁRA, T. Sleep apnea prevalence in acute myocardial infarction – The Sleep Apnea in Post-acute Myocardial Infarction Patients (SAPAMI) Study. International Journal of Cardiology. 2014, 176(1), 13-19. ISSN 0167-5273.

KONEČNÝ, T., KHANNA, A., NOVÁK, J., JAMA, A., ZAWADOWSKI, G., ORBAN, M., PRESSMAN, G., BUKARTYK, J., KÁRA, T., CETTA, F., BORLAUG, B., SOMERS, V., REEDER,
G. Interatrial pressure gradients during simulated obstructive sleep apnea: A catheter-based study. Catheterization and Cardiovascular Interventions. 2014, 84(7), 1138-1145. ISSN 1522-1946.

KONEČNÝ, T., SOMERS, V. Sleep-Disordered Breathing in Hypertrophic Cardiomyopathy:
Challenges and Opportunities. Chest. 2014, 146(1), 228-34. ISSN 0012-3692.

KONEČNÝ, T., KÁRA, T., SOMERS, V. Obstructive sleep apnea and hypertension: an update.
Hypertension. 2014, 63(2), 203-9. ISSN 0194-911X.
ČUNDRLE, I., SOMERS, V., SINGH, P., JOHNSON, B., SCOTT, C., VAN DER WALT, C., OLSON, L. Leptin Deficiency Promotes Central Sleep Apnea in Patients With Heart Failure.
Chest. 2014, 145(1), 72-78. ISSN 0012-3692.

LUDKA, O., KONEČNÝ, T., POZDÍŠEK, Z., ČERNÝ, J., ŠPINAR, J. Right ventricular mass in an asymptomatic HIV positive patient. Journal of Cardiac Surgery. 2012, 27(3), 322-324. ISSN 0886-0440.

LUDKA, O., ŠPINAR, J., TOMANDL, J., KONEČNÝ, T. Comparison of NT-proBNP levels in hemodialysis versus peritoneal dialysis patients. Biomedical papers. 2013, 157(4), 325-330. ISSN 1213-8118.

MANSUKHANI, M., KÁRA, T., CAPLES, S., SOMERS, V. Chemoreflexes, sleep apnea, and sympathetic dysregulation. Current Hypertension Reports. 2014, 16(9), 476. ISSN 1522-6417.

HERING, D., KUCHARSKA, W., KÁRA, T., SOMERS, V., NARKIEWICZ, K. Resting sympathetic outflow does not predict the morning blood pressure surge in hypertension. Journal of
Hypertension. 2011, 29(12), 2381-2386. ISSN 0263-6352.

KUNIYOSHI, F., ZELLMER, M., CALVIN, A., LOPEZ-JIMENEZ, F., ALBUQUERQUE, F., VAN DER WALT, C., TROMBETTA, I., CAPLES, S., SHAMSUZZAMAN, A., BUKARTYK, J.,
KONEČNÝ, T., GAMI, A., KÁRA, T., SOMERS, V. Diagnostic Accuracy of the Berlin Questionnaire in Detecting Sleep- Disordered Breathing in Patients With a Recent Myocardial
Infarction. Chest. 2011, 140(5), 1192-1197. ISSN 0012-3692.

HERING, D., KUCHARSKA, W., KÁRA, T., SOMERS, V., PARATI, G., NARKIEWICZ, K. Effects of acute and long-term slow breathing exercise on muscle sympathetic nerve activity in untreated male patients with hypertension. Journal of Hypertension. 2013, 31(4), 739-746. ISSN 0263-6352.


Key Publications of the Laboratory:

ALBUQUERQUE, F., CALVIN, A., KUNIYOSHI, F., KONEČNÝ, T., LOPEZ-JIMENEZ, F., PRESSMAN, G., KÁRA, T., FRIEDMAN, P., AMMASH, N., SOMERS, V., CAPLES, S. SleepDisordered Breathing and Excessive Daytime Sleepiness in Patients With Atrial Fibrillation. Chest. 2012, 141(4), 967-973. ISSN 0012-3692.

KONEČNÝ, T., GESKE, J., LUDKA, O., ORBAN, M., BRADY, P., ABUDIAB, M., ALBUQUERQUE, F., PLACEK, A., KARA, T., SAHAKYAN, K., GERSH, B., TAJIK, A., ALLISON, T., OMMEN, S., SOMERS, V. Decreased Exercise Capacity and Sleep Disordered Breathing in Patients with Hypertrophic Cardiomyopathy. Chest. 2015, 147(6), 1574-1581. ISSN 0012-3692.

MELUZÍN, J., KÁRA, T., BĚLEHRAD, M., STÁREK, Z., ŠTĚPÁNOVÁ, R., MIKUŠOVÁ, T., PODROUŽKOVÁ, H., ŠPINAROVÁ, M., SOUČEK, M., SOŠKA, V. Significant association of
diastolic dysfunction and heart failure with severe sleep apnea-induced hypoxemia in patients with drug-resistant hypertension. Experimental and Clinical Cardiology. 2014, 20(8), 3204-3217. ISSN 1205-6626.

BĚLEHRAD, M., KÁRA, T., MATUŠKA, P., KLIČKOVÁ, H., NEČASOVÁ, E., KOŠŤÁLOVÁ, J., HRUBÁ, I., NOVÁK, M., LEINVEBER, P., HOMOLKA, P., SOUČEK, F., LUDKA, O., MORÁŇ, M., JURÁK, P., VÍTOVEC, J., SOUČEK, M. Vyšetření poruch dýchání ve spánku od A do Z. Kardiologická revue. 2013, 15(2), 79-86. ISSN 1212-4540.

LUDKA, O., KÁRA, T., DROZDOVÁ, A., MORÁŇ, M., MATUŠKA, P., HOMOLKA, P., SOUČEK, F., BĚLEHRAD, M., HUDE, P., KREJČÍ, J., ŠPINAROVÁ, L., HRUBÁ, I., VÍTOVEC, J., SOUČEK, M., ŠPINAR, J. Spánková apnoe a kardiovaskulární onemocnění. Kardiologická revue. 2013, 15(2), 87-93. ISSN 1212-4540.

MATUŠKA, P., KÁRA, T., HOMOLKA, P., BĚLEHRAD, M. Advances in the management of sleepdisordered breathing in heart failure. Cor et Vasa. 2013, 2013(55), e411–e418. ISSN 0010-8650

MATUŠKA, P., KÁRA, T., HOMOLKA, P., BĚLEHRAD, M., LUDKA, O., SOUČEK, M. Léčba poruch dýchání vázaných na spánek u pacientů s onemocněním kardiovaskulárního systému. Kardiologická revue. 2013, 15(2), 94-98. ISSN 1212-4540

Thomas Penzel, Jan W. Kantelhardt, Ronny P. Bartsch, Maik Riedl, Jan F. Kraemer, Niels Wessel, Carmen Garcia, Martin Glos, Ingo Fietze and Christoph Schöbel
Modulations of Heart Rate, ECG, and Cardio-Respiratory Coupling Observed in Polysomnography (Front. Physiol., 25 October 2016)

Saaresranta T1,2, Hedner J3,4, Bonsignore MR5,6, Riha RL7, McNicholas WT8,9, Penzel T10,11, Anttalainen U1,2, Kvamme JA12, Pretl M13,14, Sliwinski P15, Verbraecken J16,17, Grote L3,4; ESADA Study Group.
Clinical Phenotypes and Comorbidity in European Sleep Apnoea Patients (PLos One 2016)

Kristian Brat, Zuzana Tothova, Zdenek Merta, Alice Taskova, Pavel Homolka, Martina Vasakova, Jana Skrickova, Vladimir Sramek, Lyle J.Olson, Ivan Cundrle
Resting End-tidal Carbon Dioxide Predicts Respiratpry Complications in Patients Undergoing Thoracic Surgicql procedures http://www.annalsthoracicsurgery.org/article/S0003-4975(16)30565-3/fulltext (The annals of thoracic surgery)

Prochnow L, Zimmermann S, Penzel T
Predictor of obstructive sleep apnea- Anthropomentic measurements and their significance
(Somnologie 2016.20:113-118)

Gurianova V, Stroy D, Ciccocioppo R, Gasparova I, petrovic D, Soucek M, Dosenko V, Kruzliak P
Stress response factors as hub-regulators of microRNA biogenesis: implication to the diseased heart (Cell Biochem.Funct.)


Current/Completed Grants (past 5 years):

2008-2011 “Role of Sleep Apnea in Pathophysiology and Treatment of Atrial Fibrillation”. Grant Project of Internal Grant Agency of Ministry of Health of the Czech Republic. Co-investigator

2009-2013 IIOS – “Integrated Interventional Imaging Operating System”. The scope of the project was to provide technology and training for the integration of ultrasound and biophotonics based imaging guidance with magnetic resonance. PITN-GA-2009-238802, Grant agreement Nr.: 238802.

2009-2011 “Interaction between pulse pressure, pulse wave velocity, augmentation index, natriuretic peptides and echocardiography and their predictive value in acute heart failure”. Grant Agency of Ministry of Health of the Czech Republic.

2011-2015 “The role of sleep apnea in patients with hypertrophic cardiomyopathy”. Grant Project of Internal Grant Agency of Ministry of Health of the Czech Republic

2012-2015 “Postdok Cardio – ICRC Human Bridge – Project has created a position for one post-doc student who has become engaged in FNUSA-ICRC research program “Development of new strategies for timely diagnosis and advanced treatment of cardiovascular diseases”. The main activities of this post-doc are research and development, educational activities (giving lectures for students of Medical Faculty, discussions with post gradual students and physicians before their attestation). Post-doc will undertake a half-year internship at Mayo Clinic, USA. Post-doc is supposed to present all outputs and results of his or her research work at international conferences (projects expects the post-doc to attend 4 such conferences). Grant from Operation Programme for Education and Competitiveness.

2014-2015 „The influence of the ten days combined training with controlled ventilation training on cardiorespiratory parameters in patients with chronic heart failure“. Internal Hospital Grant.


Other laboratory Members

Name:  Libuse Martinakova

Position:  Senior Coordinator

Email:  libuse.martinakova@fnusa.cz

Title:  PhD MD

Name:  Ondrej Assoc. prof. Ludka

Position:  Subprogram director

Email:  oludka@yahoo.com

Title:  MSc

Name:  Radka Stepanova

Position:  Research Administrator

Email:  radka.stepanova@fnusa.cz

Title:  MD

Name:  Lukáš Růžek

Position:  Ph.D. student

Email:  lukas.ruzek@fnusa.cz

Title:  PhD MD

Name:  Miroslav Prof. Soucek

Position:  Senior Researcher

Email:  miroslav.soucek@fnusa.cz

Title:  PhD MD

Name:  Blanka Fischerova

Position:  Postdoctoral Researcher

Email:  blanka.fischerova@fnusa.cz

Title:  PhD MD

Name:  Ivan Cundrle

Position:  Postdoctoral Researcher

Email:  ivan.cundrle@fnusa.cz

Name:  Sylva Marsikova

Position:  research nurse

Email:  sylva.marsikova@fnusa.cz

Name:  Lujza Zikmund Galkova

Position:  Ph.D.student

Email:  lujza.galkova@gmail.com

Title:  PhD MD

Name:  Thomas Penzel

Position:  senior researcher

Email:  thomas.penzel@charite.de


Collaborations

Title:  MD

Name:  Ctirad Bastl

Position:  Director

Institution:  Sleep lab Sebnitz


Past Members

Title:  PhD MD

Name:  Tomas Assoc. prof. Kara

Position:  Past Subprogram Director

Email:  Kara.Tomas@mayo.edu

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