Sleep Disorders Center, Center for Narcolepsy and , University of Bologna, Department of Biomedical and Neuromotor Sciences

IRCCS Institute of Neurological Sciences, Bologna

Contact:
Giuseppe Plazzi
Position:
Associate Professor of Neurology
Address:
Ospedale Bellaria, Padiglione G, Via Altura 3, 40139
City:
Bologna
Country:
Italy
Phone:
0039 051 4966926
Fax:
0039 051 4966176
Contact E-mail:
Research Domain
Keywords

Laboratory description

3 rooms for outpatients and inpatients continuous teletric videopolysomnography (with a control room), 2 standard sleep lab rooms (with control room), 1 room for daytime videopolygraphy, 2 rooms for patients montage, 1 room for secretary, 1 room for data analysis, 1 room for research staff, access to biological and genetic lab facilities, biobank


Additional Descriptors, Keywords

Narcolepsy
CNS Hypersomnias
All sleep disorders
Multidisciplinary approach to sleep disordered patients


Key Publications of the Laboratory:
1: Vignatelli L, Plazzi G, Barbato A, Ferini-Strambi L, Manni R, Pompei F, D'Alessandro R; GINSEN (Gruppo Italiano Narcolessia Studio Epidemiologico Nazionale. Italian version of the Epworth sleepiness scale: external validity. Neurol Sci. 2003 Feb;23(6):295-300. PubMed PMID: 12624716.
2: Liguori R, Vincent A, Clover L, Avoni P, Plazzi G, Cortelli P, Baruzzi A, Carey T, Gambetti P, Lugaresi E, Montagna P. Morvan's syndrome: peripheral and central nervous system and cardiac involvement with antibodies to voltage-gated potassium channels. Brain. 2001 Dec;124(Pt 12):2417-26. PubMed PMID: 11701596.
3: Provini F, Vetrugno R, Meletti S, Plazzi G, Solieri L, Lugaresi E, Coccagna G, Montagna P. Motor pattern of periodic limb movements during sleep. Neurology. 2001 Jul 24;57(2):300-4. PubMed PMID: 11468316.
4: Provini F, Plazzi G, Tinuper P, Vandi S, Lugaresi E, Montagna P. Nocturnal frontal lobe epilepsy. A clinical and polygraphic overview of 100 consecutive cases. Brain. 1999 Jun;122 ( Pt 6):1017-31. PubMed PMID: 10356056.
5: Plazzi G, Corsini R, Provini F, Pierangeli G, Martinelli P, Montagna P, Lugaresi E, Cortelli P. REM sleep behavior disorders in multiple system atrophy. Neurology. 1997 Apr;48(4):1094-7. PubMed PMID: 9109907.
6: Plazzi G, Montagna P, Provini F, Bizzi A, Cohen M, Lugaresi E. Pontine lesions in idiopathic narcolepsy. Neurology. 1996 May;46(5):1250-4. PubMed PMID: 8628461.
7: Plazzi G, Tinuper P, Montagna P, Provini F, Lugaresi E. Epileptic nocturnal wanderings. Sleep. 1995 Nov;18(9):749-56. PubMed PMID: 8638067.
8: Portaluppi F, Provini F, Cortelli P, Plazzi G, Bertozzi N, Manfredini R, Fersini C, Lugaresi E. Undiagnosed sleep-disordered breathing among male nondippers with essential hypertension. J Hypertens. 1997 Nov;15(11):1227-33. PubMed PMID: 9383171.
9: Tucci V, Stegagno L, Vandi S, Ferrillo F, Palomba D, Vignatelli L, Ferini-Strambi L, Montagna P, Plazzi G. Emotional information processing in patients with narcolepsy: a psychophysiologic investigation. Sleep. 2003 Aug 1;26(5):558-64. PubMed PMID: 12938808.
10: Vignatelli L, D'Alessandro R, Mosconi P, Ferini-Strambi L, Guidolin L, De Vincentiis A, Plazzi G; GINSEN (Gruppo Italiano Narcolessia-Studio Epidemiologico Nazionale). Health-related quality of life in Italian patients with narcolepsy: the SF-36 health survey. Sleep Med. 2004 Sep;5(5):467-75. PubMed PMID: 15341892.
11: Montagna P, Cortelli P, Avoni P, Tinuper P, Plazzi G, Gallassi R, Portaluppi F, Julien J, Vital C, Delisle MB, Gambetti P, Lugaresi E. Clinical features of fatal familial insomnia: phenotypic variability in relation to a polymorphism at codon 129 of the prion protein gene. Brain Pathol. 1998 Jul;8(3):515-20. PubMedPMID: 9669701.
12: Heron SE, Smith KR, Bahlo M, Nobili L, Kahana E, Licchetta L, Oliver KL, Mazarib A, Afawi Z, Korczyn A, Plazzi G, Petrou S, Berkovic SF, Scheffer IE, Dibbens LM. Missense mutations in the sodium-gated potassium channel gene KCNT1 cause severe autosomal dominant nocturnal frontal lobe epilepsy. Nat Genet. 2012 Nov;44(11):1188-90. doi: 10.1038/ng.2440. Epub 2012 Oct 21. PubMed PMID: 23086396.
13: Ferri R, Zucconi M, Manconi M, Bruni O, Ferini-Strambi L, Vandi S, Montagna P, Mignot E, Plazzi G. Different periodicity and time structure of leg movements during sleep in narcolepsy/cataplexy and restless legs syndrome. Sleep. 2006 Dec;29(12):1587-94. PubMed PMID: 17252889.
14: Plazzi G, Pizza F, Palaia V, Franceschini C, Poli F, Moghadam KK, Cortelli P, Nobili L, Bruni O, Dauvilliers Y, Lin L, Edwards MJ, Mignot E, Bhatia KP. Complex movement disorders at disease onset in childhood narcolepsy with cataplexy. Brain. 2011 Dec;134(Pt 12):3477-89. doi: 10.1093/brain/awr244. Epub 2011 Sep 19. PubMed PMID: 21930661; PubMed Central PMCID: PMC3235554.
15: Serra L, Montagna P, Mignot E, Lugaresi E, Plazzi G. Cataplexy features in childhood narcolepsy. Mov Disord. 2008 Apr 30;23(6):858-65. doi:10.1002/mds.21965. PubMed PMID: 18307264.
16: Plazzi G, Serra L, Ferri R. Nocturnal aspects of narcolepsy with cataplexy. Sleep Med Rev. 2008 Apr;12(2):109-28. doi: 10.1016/j.smrv.2007.08.010. Epub 2008 Feb 20. Review. PubMed PMID: 18282773.
17: Poli F, Plazzi G, Di Dalmazi G, Ribichini D, Vicennati V, Pizza F, Mignot E, Montagna P, Pasquali R, Pagotto U. Body mass index-independent metabolic alterations in narcolepsy with cataplexy. Sleep. 2009 Nov;32(11):1491-7. PubMed PMID: 19928388; PubMed Central PMCID: PMC2768955.
18: Montagna P, Provini F, Plazzi G, Liguori R, Lugaresi E. Propriospinal myoclonus upon relaxation and drowsiness: a cause of severe insomnia. Mov Disord. 1997 Jan;12(1):66-72. PubMed PMID: 8990056.
19: La Manna G, Pizza F, Persici E, Baraldi O, Comai G, Cappuccilli ML, Centofanti F, Carretta E, Plazzi G, Colì L, Montagna P, Stefoni S. Restless legs syndrome enhances cardiovascular risk and mortality in patients with end-stage kidney disease undergoing long-term haemodialysis treatment. Nephrol Dial Transplant. 2011 Jun;26(6):1976-83. doi: 10.1093/ndt/gfq681. Epub 2010 Nov 5. PubMed PMID: 21056943.
20: Poli F, Pizza F, Mignot E, Ferri R, Pagotto U, Taheri S, Finotti E, Bernardi F, Pirazzoli P, Cicognani A, Balsamo A, Nobili L, Bruni O, Plazzi G. High prevalence of precocious puberty and obesity in childhood narcolepsy with cataplexy. Sleep. 2013 Feb 1;36(2):175-81. doi: 10.5665/sleep.2366. PubMed PMID: 23372264; PubMed Central PMCID: PMC3543059.
21: Vetrugno R, Liguori R, Cortelli P, Plazzi G, Vicini C, Campanini A, D'Angelo R, Provini F, Montagna P. Sleep-related stridor due to dystonic vocal cord motion and neurogenic tachypnea/tachycardia in multiple system atrophy. Mov Disord. 2007 Apr 15;22(5):673-8. PubMed PMID: 17266093.
22: Plazzi G, Ferri R, Antelmi E, Bayard S, Franceschini C, Cosentino FI, Abril B, Spruyt K, Provini F, Montagna P, Dauvilliers Y. Restless legs syndrome is frequent in narcolepsy with cataplexy patients. Sleep. 2010 May;33(5):689-94. PubMed PMID: 20469811; PubMed Central PMCID: PMC2864884.
23: Vignatelli L, Plazzi G, Peschechera F, Delaj L, D'Alessandro R. A 5-year prospective cohort study on health-related quality of life in patients with narcolepsy. Sleep Med. 2011 Jan;12(1):19-23. doi: 10.1016/j.sleep.2010.07.008. Epub 2010 Sep 17. PubMed PMID: 20851047.
24: Pizza F, Moghadam KK, Vandi S, Detto S, Poli F, Mignot E, Ferri R, Plazzi G. Daytime continuous polysomnography predicts MSLT results in hypersomnias of central origin. J Sleep Res. 2013 Feb;22(1):32-40. doi: 10.1111/j.1365-2869.2012.01032.x. Epub 2012 Jun 20. PubMed PMID: 22716477.
25: Plazzi G, Moghadam KK, Maggi LS, Donadio V, Vetrugno R, Liguori R, Zoccoli G, Poli F, Pizza F, Pagotto U, Ferri R. Autonomic disturbances in narcolepsy. Sleep Med Rev. 2011 Jun;15(3):187-96. doi: 10.1016/j.smrv.2010.05.002. Epub 2010 Jul 14. Review. PubMed PMID: 20634114.

Collaborations

Title:  PhD MD

Name:  Uberto Pagotto

Position:  Full Professor of Endocrinology

Institution:  University of Bologna

Title:  PhD MD

Name:  Francesca Ingravallo

Position:  Associate Professor of Legal Medicine

Institution:  University of Bologna

Title:  PhD MD

Name:  Emmanuel Mignot

Position:  Full Professor of Psychiatry

Institution:  Stanford University

Title:  PhD MD

Name:  Yves Dauvilliers

Position:  Full Professor of Physiology

Institution:  Montpellier University

Title:  PhD MD

Name:  Ferri Raffaele

Position:  Director of Neurology Department

Institution:  IRCCS Oasi

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