Leiden University Medical Center, Laboratory for Neurophysiology

Molecular Cell Biology, LUMC S-05-P

Contact:
Tom DeBoer
Position:
Assistant Professor
Address:
PO Box 9600, 2300
City:
Leiden
Country:
Netherlands
Phone:
+31 71 526 9771
Fax:
+31 71 526 8270
Contact E-mail:
Research Domain
  • Basic Animal
Keywords
  • Biological Rhythms
  • Sleep Physiology-Neurophysiology in Animal
  • Sleep and Body Functions (Cardio-Respiratory, Thermoregulation/Metabolism, Endocrine)
  • Sleep and Ageing

Laboratory description

Our group is involved in research on sleep regulation with emphasis on the interaction between the circadian clock and sleep regulatory mechanisms. Research is mainly approached in rats and mice applying long-term recordings of the electroencephalogram (EEG) sometimes in combination with neuronal activity in the suprachiasmatic nucleus (SCN) of the hypothalamus, the location of the circadian clock in mammals, on the multi-unit and single-unit level together with behavioral techniques to record daily rest-activity patterns.


Technical Capabilities and areas of expertise

 


Selected Publications in the 5 past years:

Deboer T, van Diepen HC, Ferrari MD, Van den Maagdenberg AMJM, Meijer JH (2012) Reduced sleep and low adenosinergic sensitivity in Cacna1a R192Q mice. Sleep.

Farajnia S, Michel S, Deboer T, VanderLeest HT, Houben T, Rohling J, Ramkisoensing A, Yasenkov R, Meijer JH (2012) Evidence for neuronal desynchrony in the aged suprachiasmatic nucleus clock. J Neurosci 32: 5891-5899.

Yasenkov R, Deboer T (2012) Circadian modulation of sleep in rodents. Prog Brain Res 99: 203-218.

Yasenkov R, Deboer T (2011) Interrelations and circadian changes of EEG frequencies under baseline conditions and constant sleep pressure in the rat. Neurosci 180: 212-221.

Krauchi K, Deboer T (2010) The interrelationship between sleep regulation and thermoregulation. Front Biosci 15: 604-625.

Yasenkov R, Deboer T (2010) Circadian regulation of sleep and the sleep EEG under constant sleep pressure in the rat. Sleep 33: 631-641.

Deboer T (2009) Sleep and sleep homeostasis in constant darkness in the rat. J Sleep Res 18: 357-364.

VanOosterhout FFTO, Michel S, Deboer T, Houben T, VandeVen RCG, Albus H, Westerhout J, Vansteensel MJ, Ferrari MD, VandenMaagdenberg AMJM, Meijer JH (2008) Enhanced circadian phase resetting in R192Q Cav2.1 calcium channel migraine mice. Ann Neurol. 64: 315-324.

Deboer T (2007) Technologies of sleep research. Cell Mol Life Sci 64: 1227-1235.

Deboer T, Detari L, Meijer JH (2007) Long term effects of sleep deprivation on the mammalian circadian pacemaker. Sleep 30: 257-262.

Deboer T, Ruijgrok G, Meijer JH (2007) Short light-dark cycles affect sleep in mice. Eur J Neurosci 26: 3518-3523


Key Publications of the Laboratory:

Yasenkov R, Deboer T (2011) Interrelations and circadian changes of EEG frequencies under baseline conditions and constant sleep pressure in the rat. Neurosci 180: 212-221.

Yasenkov R, Deboer T (2010) Circadian regulation of sleep and the sleep EEG under constant sleep pressure in the rat. Sleep 33: 631-641.

Deboer T, Detari L, Meijer JH (2007) Long term effects of sleep deprivation on the mammalian circadian pacemaker. Sleep 30: 257-262.

Deboer T, Ruijgrok G, Meijer JH (2007) Short light-dark cycles affect sleep in mice. Eur J Neurosci 26: 3518-3523.

Deboer T, Overeem S Visser NAH, Duindam H, Frölich M, Lammers GJ, Meijer JH (2004) Convergence of circadian and sleep regulatory mechanisms on hypocretin-1. Neurosci 129: 727-732.

Deboer T, Vansteensel MJ, Detari L, Meijer JH (2003) Sleep states alter neuronal activity of the suprachiasmatic nucleus. Nat Neurosci 6: 1086-1090.


Current/Completed Grants (past 5 years):

2011-2016. Technology foundation STW grant P10-18/12193, On Time: How to fix a broken clock, PI in a consortium involving six laboratories from The Netherlands. € 407000

2009-2012. Netherlands Organization for Scientific Research (NWO) grant 818.02.016. Sleep and the ticking of the circadian clock, as PI. € 195000

2005-2008. European Union (EU) grant LSHM-CT-2005-518189, Enough sleep, PI in a consortium involving eight laboratories from five European Countries. € 130000


Other laboratory Members

Title:  MSc

Name:  Marti Boss

Position:  PhD Student

Email:  M.Boss@lumc.nl

Title:  MSc

Name:  Hester VanDiepen

Position:  PhD Student

Email:  H.C.van_Diepen@lumc.nl


Past Members

Title:  PhD

Name:  Roman Yasenkov

Position:  Postdoc

Email:  yasenkovr@gmail.com

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