Leiden University Medical Center, Laboratory for Neurophysiology

Cell and Chemical Biology, LUMC S-05-P

Contact:
Tom DeBoer
Position:
Assistant Professor
Address:
PO Box 9600, 2300
City:
Leiden
Country:
Netherlands
Phone:
+31 71 526 9771
Fax:
+31 71 526 8270
Contact E-mail:
Research Domain
  • Basic Animal
Keywords
  • Biological Rhythms
  • Sleep Physiology-Neurophysiology in Animal
  • Sleep and Body Functions (Cardio-Respiratory, Thermoregulation/Metabolism, Endocrine)
  • Sleep and Ageing

Laboratory description

Our group is involved in research on sleep regulation with emphasis on the interaction between the circadian clock and sleep regulatory mechanisms. Research is mainly approached in rats and mice applying long-term recordings of the electroencephalogram (EEG) sometimes in combination with neuronal activity in the suprachiasmatic nucleus (SCN) of the hypothalamus, the location of the circadian clock in mammals, on the multi-unit and single-unit level together with behavioral techniques to record daily rest-activity patterns.


Key Publications of the Laboratory:
Panagiotou M, Vyazovskiy VV, Meijer JH, Deboer T (2017) Differences in electroencephalographic non-rapid eye movement sleep slow-wave characteristics between young and old mice. Sci Rep 7: 43656.

Borbély AA, Daan S, Wirz-Justice A, Deboer T (2016) The two process model of sleep regulation: a reappraisal. J Sleep Res 25: 131-143.

Stenvers DJ, van Dorp R, Foppen E, Mendoza J, Opperhuizen AL, Fliers E, Bisschop PH, Meijer JH, Kalsbeek A, Deboer T (2016) Dim light at night disturbs the daily sleep- wake cycle in the rat. Sci Rep 6: 35662.

Farajnia S, Michel S, Deboer T, VanderLeest HT, Houben T, Rohling J, Ramkisoensing A, Yasenkov R, Meijer JH (2012) Evidence for neuronal desynchrony in the aged suprachiasmatic nucleus clock. J Neurosci 32: 5891-5899.

Deboer T, Detari L, Meijer JH (2007) Long term effects of sleep deprivation on the mammalian circadian pacemaker. Sleep 30: 257-262.

Deboer T, Vansteensel MJ, Detari L, Meijer JH (2003) Sleep states alter neuronal activity of the suprachiasmatic nucleus. Nat Neurosci 6: 1086-1090.
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