Leiden University Medical Center, Laboratory for Neurophysiology

Molecular Cell Biology, LUMC S-05-P

Contact:
Tom DeBoer
Position:
Assistant Professor
Address:
PO Box 9600, 2300
City:
Leiden
Country:
Netherlands
Phone:
+31 71 526 9771
Fax:
+31 71 526 8270
Contact E-mail:
Research Domain
  • Basic Animal
Keywords
  • Biological Rhythms
  • Sleep Physiology-Neurophysiology in Animal
  • Sleep and Body Functions (Cardio-Respiratory, Thermoregulation/Metabolism, Endocrine)
  • Sleep and Ageing

Laboratory description

Our group is involved in research on sleep regulation with emphasis on the interaction between the circadian clock and sleep regulatory mechanisms. Research is mainly approached in rats and mice applying long-term recordings of the electroencephalogram (EEG) sometimes in combination with neuronal activity in the suprachiasmatic nucleus (SCN) of the hypothalamus, the location of the circadian clock in mammals, on the multi-unit and single-unit level together with behavioral techniques to record daily rest-activity patterns.


Key Publications of the Laboratory:
Yasenkov R, Deboer T (2011) Interrelations and circadian changes of EEG frequencies under baseline conditions and constant sleep pressure in the rat. Neurosci 180: 212-221.

Yasenkov R, Deboer T (2010) Circadian regulation of sleep and the sleep EEG under constant sleep pressure in the rat. Sleep 33: 631-641.

Deboer T, Detari L, Meijer JH (2007) Long term effects of sleep deprivation on the mammalian circadian pacemaker. Sleep 30: 257-262.

Deboer T, Ruijgrok G, Meijer JH (2007) Short light-dark cycles affect sleep in mice. Eur J Neurosci 26: 3518-3523.

Deboer T, Overeem S Visser NAH, Duindam H, Frölich M, Lammers GJ, Meijer JH (2004) Convergence of circadian and sleep regulatory mechanisms on hypocretin-1. Neurosci 129: 727-732.

Deboer T, Vansteensel MJ, Detari L, Meijer JH (2003) Sleep states alter neuronal activity of the suprachiasmatic nucleus. Nat Neurosci 6: 1086-1090.
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