Center of Sleep Medicine, Villa Serena Hospital

Neurology

Contact:
Biancamaria Guarnieri
Position:
director
Address:
Viale L. Petruzzi 42, 65123
City:
Città S. Angelo, Pescara
Country:
Italy
Phone:
+39 085 9590237
Fax:
+39 085 9590206
Research Domain
  • Basic Human
  • Clinical
  • Methodology / Technology
Keywords
  • Neurological Sleep Disorders
  • Behavioural Sleep Disorders
  • Epidemiology of Sleep
  • Sleep and Ageing
  • Pharmacology of Sleep
  • Genetics of Sleep
  • Sleep and Medical Disorders
  • Learning, Memory, Cognition
  • Others

Laboratory description

Sleep and ageing , sleep and dementia ( with the department of Neurology, University of Florence): aepidemiology , assessment and management of sleep disorders .
Diagnosis and management of sleep disorders , also SDB ( (AASM , International Classification of sleep disorders): laboratoty PSG, 4 rooms, home PSG and poligrapy, actigraphy
genetic in dementia and neurodegenerative disorders


Technical Capabilities and areas of expertise

PSG-Video PSG ,home PSG and poligraphy also in pediatric patients
Actigraphy
ventilation of SDB ( only adult patients)
EEG also in pediatric patients


Additional Descriptors, Keywords

rehabilitation in stroke with robotic device in virtual reality, using HR EEG


Selected Publications in the 5 past years:

Prevalence of sleep disturbances in mild cognitive impairment and dementing disorders: a multicenter Italian clinical cross-sectional study on 431 patients.
Guarnieri B, Adorni F, Musicco M, Appollonio I, Bonanni E, Caffarra P, Caltagirone C, Cerroni G, Concari L, Cosentino FI, Ferrara S, Fermi S, Ferri R, Gelosa G, Lombardi G, Mazzei D, Mearelli S, Morrone E, Murri L, Nobili FM, Passero S, Perri R, Rocchi R, Sucapane P, Tognoni G, Zabberoni S, Sorbi S.
Dement Geriatr Cogn Disord. 2012;33(1):50-8.
M. Steinisch, B.M. Guarnieri, J. Haueisen, A. Serio, S. Comani: Virtual Reality and Robotics for neuro-motor rehabilitation of ischemic stroke patients, IFMBE Proceedings, World Congress on Medical Physics and Biomedical Engineering, September 7 – 12, 2009, Munich, Germany, 25/9:61-63, 2009.
Lack of implication for CALHM1 P86L common variation in Italian patients with early and late onset Alzheimer’s disease.
Nacmias B, Tedde A, Bagnoli S, Lucenteforte E, Cellini E, Piaceri I, Guarnieri BM, Bessi V, Bracco L, Sorbi S.
J Alzheimers Dis. 2010;20(1):37-41.


Key Publications of the Laboratory:

Prevalence of sleep disturbances in mild cognitive impairment and dementing disorders: a multicenter Italian clinical cross-sectional study on 431 patients.
Guarnieri B, Adorni F, Musicco M, Appollonio I, Bonanni E, Caffarra P, Caltagirone C, Cerroni G, Concari L, Cosentino FI, Ferrara S, Fermi S, Ferri R, Gelosa G, Lombardi G, Mazzei D, Mearelli S, Morrone E, Murri L, Nobili FM, Passero S, Perri R, Rocchi R, Sucapane P, Tognoni G, Zabberoni S, Sorbi S.
Dement Geriatr Cogn Disord. 2012;33(1):50-8.
Multicenter case-control study on restless legs syndrome in multiple sclerosis: the REMS study.
Italian REMS Study Group, Manconi M, Ferini-Strambi L, Filippi M, Bonanni E, Iudice A, Murri L, Gigli GL, Fratticci L, Merlino G, Terzano G, Granella F, Parrino L, Silvestri R, Aricò I, Dattola V, Russo G, Luongo C, Cicolin A, Tribolo A, Cavalla P, Savarese M, Trojano M, Ottaviano S, Cirignotta F, Simioni V, Salvi F, Mondino F, Perla F, Chinaglia G, Zuliani C, Cesnik E, Granieri E, Placidi F, Palmieri MG, Manni R, Terzaghi M, Bergamaschi R, Rocchi R, Ulivelli M, Bartalini S, Ferri R, Lo Fermo S, Ubiali E, Viscardi M, Rottoli M, Nobili L, Protti A, Ferrillo F, Allena M, Mancardi G, Guarnieri B, Londrillo F.
Sleep. 2008 Jul;31(7):944-52.2.
Guidelines for the diagnosis of dementia and Alzheimer’s disease
Journal Neurological Sciences , Publisher Springer Milan
ISSN 1590-1874 (Print) 1590-3478 (Online)
Subject Biomedical and Life Sciences and Medicine
Issue Volume 21, Number 4 / October, 2000
Pages 187-194
Validation of the Guidelines for the Diagnosis of Dementia and Alzheimer’s Disease of the Italian Neurological Society. Study in 72 Italian neurological centres and 1549 patients
Journal Neurological Sciences
Publisher Springer Milan ISSN 1590-1874 (Print) 1590-3478 (Online)
Subject Biomedical and Life Sciences and Medicine
Issue Volume 25, Number 5 / December, 2004
Pages 289-295

Insomnia: diagnosis and treatment in general practice. Consensus report
Disease mangement &health outcomes
volume 13, 2005 special issue1 ( pp 3- 33) Adis International
M. Steinisch, B.M. Guarnieri, J. Haueisen, A. Serio, S. Comani: Virtual Reality and Robotics for neuro-motor rehabilitation of ischemic stroke patients, IFMBE Proceedings, World Congress on Medical Physics and Biomedical Engineering, September 7 – 12, 2009, Munich, Germany, 25/9:61-63, 2009.
Lack of implication for CALHM1 P86L common variation in Italian patients with early and late onset Alzheimer’s disease.
Nacmias B, Tedde A, Bagnoli S, Lucenteforte E, Cellini E, Piaceri I, Guarnieri BM, Bessi V, Bracco L, Sorbi S.
J Alzheimers Dis. 2010;20(1):37-41.
Brain-derived neurotrophic factor genetic variants are not susceptibility factors to Alzheimer’s disease in Italy.
Bagnoli S, Nacmias B, Tedde A, Guarnieri BM, Cellini E, Petruzzi C, Bartoli A, Ortenzi L, Sorbi S.
Ann Neurol. 2004 Mar;55(3):447-8

Implication of GAB2 gene polymorphism in Italian patients with Alzheimer’s disease.
Nacmias B, Tedde A, Bagnoli S, Cellini E, Guarnieri BM, Piacentini S, Sorbi S.
J Alzheimers Dis. 2009;16(3):513-5.

Cystatin C and apoe polymorphisms in Italian Alzheimer’s disease.
Nacmias B, Bagnoli S, Tedde A, Cellini E, Guarnieri BM, Bartoli A, Serio A, Piacentini S, Sorbi S.
Neurosci Lett. 2006 Jan 9;392(1-2):110-3. Epub 2005 Sep 26.

Brain-derived neurotrophic factor genetic variants are not susceptibility factors to Alzheimer’s disease in Italy.
Bagnoli S, Nacmias B, Tedde A, Guarnieri BM, Cellini E, Petruzzi C, Bartoli A, Ortenzi L, Sorbi S.
Ann Neurol. 2004 Mar;55(3):447-8. No abstract available.

Cathepsin D polymorphism in Italian sporadic and familial Alzheimer’s disease.
Bagnoli S, Nacmias B, Tedde A, Guarnieri BM, Cellini E, Ciantelli M, Petruzzi C, Bartoli A, Ortenzi L, Serio A, Sorbi S.
Neurosci Lett. 2002 Aug 16;328(3):273-6.

Genetic and clinical analysis of spinocerebellar ataxia type 8 repeat expansion in Italy.
Cellini E, Nacmias B, Forleo P, Piacentini S, Guarnieri BM, Serio A, Calabrò A, Renzi D, Sorbi S.
Arch Neurol. 2001 Nov;58(11):1856-9.

Association between 5-HT(2A) receptor polymorphism and psychotic symptoms in Alzheimer’s disease.
Nacmias B, Tedde A, Forleo P, Piacentini S, Guarnieri BM, Bartoli A, Ortenzi L, Petruzzi C, Serio A, Marcon G, Sorbi S.
Biol Psychiatry. 2001 Sep 15;50(6):472-5. Erratum in: Biol Psychiatry 2001 Nov 15;50(10):821.

Psychosis, serotonin receptor polymorphism and Alzheimer’s disease.
Nacmias B, Tedde A, Forleo P, Piacentini S, Latorraca S, Guarnieri BM, Ortenzi L, Bartoli A, Petruzzi C, Serio A, Sorbi S.
Arch Gerontol Geriatr Suppl. 2001;7:279-83. No abstract available.

Alpha2-macroglobulin polymorphisms in Italian sporadic and familial Alzheimer’s disease.
Nacmias B, Tedde A, Cellini E, Forleo P, Orlacchio A, Guarnieri BM, Petruzzi C, D’Andrea F, Serio A, Sorbi S.
Neurosci Lett. 2001 Feb 16;299(1-2):9-12.

No implication of apolipoprotein E polymorphism in Italian schizophrenic patients.
Sorbi S, Nacmias B, Tedde A, Latorraca S, Forleo P, Guarnieri BM, Petruzzi C, Daneluzzo E, Ortenzi L, Piacentini S, Amaducci L.
Neurosci Lett. 1998 Mar 13;244(2):118-20.

Analysis of apolipoprotein E, alpha1-antichymotrypsin and presenilin-1 genes polymorphisms in dementia caused by normal pressure hydrocephalus in man.
Nacmias B, Tedde A, Guarnieri BM, Petruzzi C, Ortenzi L, Serio A, Amaducci L, Sorbi S.
Neurosci Lett. 1997 Jul 4;229(3):177-80.

Apolipoprotein E and alpha1-antichymotrypsin polymorphism in Alzheimer’s disease.
Nacmias B, Tedde A, Latorraca S, Piacentini S, Bracco L, Amaducci L, Guarnieri BM, Petruzzi C, Ortenzi L, Sorbi S.
Ann Neurol. 1996 Oct;40(4):678-80.
No evidence of linkage between schizophrenia and D2 dopamine receptor gene locus in Italian pedigrees.
Grassi E, Mortilla M, Amaducci L, Pallanti S, Pazzagli A, Galassi F, Guarnieri BM, Petruzzi C, Bolino F, Ortenzi L, Nistico R, De Cataldo S, Rossi A, Sorbi S.
Neurosci Lett. 1996 Mar 15;206(2-3):196-8.
Angiotensin converting enzyme insertion/deletion polymorphism in sporadic and familial Alzheimer’s disease and longevity.
Nacmias B, Bagnoli S, Tedde A, Cellini E, Bessi V, Guarnieri B, Ortensi L, Piacentini S, Bracco L, Sorbi S.
Arch Gerontol Geriatr. 2007 Sep-Oct;45(2):201-6. Epub 2006 Dec 19.
Atypical Friedreich ataxia with a very late onset and an unusual limited GAA repeat.
Sorbi S, Forleo P, Cellini E, Piacentini S, Serio A, Guarnieri B, Petruzzi C.
Arch Neurol. 2000 Sep;57(9):1380-2..


Current/Completed Grants (past 5 years):

grant from the Italian Minister of Health (2008- 2010) to study prevalece of sleep disorders in MCI and Dementia patients (multicenter study)


Other laboratory Members

Title:  PhD MD

Name:  Lucia Velluto

Position:  direct collaborator full time neurologist

Email:  luciavelluto@gmail.com

Name:  Gianluigi Cerroni

Position:  psychologist

Email:  cerroni_psi@libero.it

Title:  PhD

Name:  Massimiliano Di Giosia

Position:  sleep dentist, internal consultant

Email:  mdigiosia@mac.com

Name:  Linda Vernamonte

Position:  technologist

Email:  bmariaguarnieri@villaserena.it

Name:  Sandra Ciccarella

Position:  technologist

Email:  bmariaguarnieri@villaserena.it

Name:  Loredana Primavera

Position:  technologist

Email:  bmariaguarnieri@villaserena.it

Name:  Cinzia Di Pompeo

Position:  head nurse, dept neurology

Email:  bmariaguarnieri@villaserena.it

Name:  Chiara Di Claudio

Position:  head nurse of the ambulatory section of the Center

Email:  bmariaguarnieri@villaserena.it


Collaborations

Title:  PhD MD

Name:  Sandro Sorbi

Position:  director

Institution:  Dept Neurology University of Florence

Title:  PhD MD

Name:  Enrica Bonanni

Position:  director

Institution:  Center sleep medicine dept Neurology, university Pisa

Name:  Silvia Comani

Position:  director of BIND -Behavioral Imaging and Neural Dynamics Center-

Institution:  Associate Professor of Applied Physics, University of Chieti – Italy

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