Sleep Unit, Neurological Hospital & CRNL- Neuropain Team

Neuropain Team

Hospital Physician
59 Bd Pinel, F-69677
+33 472357168
+33 472357105
Contact E-mail:
Research Domain
  • Basic Human
  • Sleep Physiology-Neurophysiology in Human

Laboratory description

Processing of nociceptive information during sleep; thalamo-cortical functionning during sleep

Scalp and intra-cerebral electrophysiology. Somatosensory laser stimulation

Technical Capabilities and areas of expertise


Selected Publications in the 5 past years:

– H. BASTUJI, C. PERCHET, V. LEGRAIN, C. MONTES, L. GARCIA LARREA. Laser evoked responses to painful stimulation persist during sleep and predict subsequent arousals. Pain 2008, 137 : 589-599.
– Magnin M, Rey M, Bastuji H, Guillemant P, Mauguière F, Garcia-Larrea L. Thalamic deactivation at sleep onset precedes that of the cerebral cortex in humans. PNAS 2010, 107 : 3829-3833
– F. CHOUCHOU, V. PICHOT, C. PERCHET, V. LEGRAIN, L. GARCIA LARREA, F. ROCHE, H. BASTUJI. Autonomic pain responses during sleep: A study of heart rate variability. Eur J Pain, 2011, 15: 554-560.

– BASTUJI, H., Mazza, S., Perchet, C., Frot, M., Mauguière, F., Magnin, M., & Garcia-Larrea, L. (2011). Filtering the reality: Functional dissociation of lateral and medial pain systems during sleep in humans. Human brain mapping, 33(11), 2638–2649. doi:10.1002/hbm.21390
– S. MAZZA, M. MAGNIN, H.BASTUJI. Pain and sleep: from reaction to action. Neurophysiologie Clinique/ Clinical Neurophysiology 2012, 42 (5) : 337-344.

Key Publications of the Laboratory:

H. BASTUJI, L. GARCIA-LARREA, F. MAUGUIÈRE. Brain processing of stimulus deviance during slow-wave and paradoxical sleep. A study of human auditory evoked responses using the oddball paradigm. J. Clin Neurophysiol, 1995, 12 : 155-167.
1999-1 H. BASTUJI, L. GARCIA LARREA. Evoked potentials as a tool for the investigation of human sleep. Sleep Medicine reviews, 1999, 3 : 23-45.

1999-2 H. BASTUJI, L. GARCIA LARREA. Sleep-wake abnormalities in patients with periodic leg movements during sleep: factor analysis on data from 24-hours ambulatory polygraphy. Journal of Sleep Research, 1999, 8 : 217-223.

1999-3 F. PERRIN, L. GARCIA LARREA, F. MAUGUIÈRE, H. BASTUJI. A differential brain response to the subject’s own name persists during sleep. Clin. Neurophysiol., 1999, 110 : 2153-2164.

2000-1 F. PERRIN, L. GARCIA LARREA, F. MAUGUIÈRE, H. BASTUJI. Functional dissociation of the early and late portions of human K-complexes. Neuroreport, 2000, 11 : 1637-1640.

2002-1 F. PERRIN, H. BASTUJI, L. GARCIA LARREA. Detection of verbal discordances during sleep. Neuroreport, 2002, 13 : 1345-1349.
H. BASTUJI, F. PERRIN, L. GARCIA LARREA. Semantic analysis of auditory input during sleep : Studies with event related potentials. International Journal of Psychophysiology, 2002, 46 : 243-255.
M. MAGNIN, H. BASTUJI, L. GARCIA LARREA, F. MAUGUIÈRE. What makes dream not reality : role of the thalamic medial pulvinar nucleus. Cerebral Cortex, 2004, 14 : 858-862.

M. REY, H. BASTUJI, L. GARCIA LARREA, P. GUILLEMANT, F. MAUGUIÈRE M. MAGNIN. Human thalamic and cortical activities assessed by dimension of activation and spectral edge frequency during sleep wake cycles. Sleep, 2007, 30 : 907-912.

Current/Completed Grants (past 5 years):

grant for 3 years of the region Rhônes alpes ARC 2 for a doctoral thesis
grant fro one year of the SFRMS for a doctoral thesis

Other laboratory Members

Title:  PhD

Name:  Stéphanie Mazza

Position:  MCU


Title:  PhD MD

Name:  Luis Garcia-Larrea

Position:  Researcher INSERM



Title:  PhD

Name:  Stéphanie Mazza

Position:  MCU

Institution:  Laboratoire d’étude des mécanismes cognitifs, Université Lumière Lyon

Title:  PhD MD

Name:  Frédéric Roche

Position:  PHU

Institution:  EA SNA-EPIS, Saint-Etienne

Past Members

Title:  PhD

Name:  Michel Magnin

Position:  DR INSERM


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