Unit of Sleep Medicine and Epilepsy, National Institute of Neurology IRCCS "C. Mondino"


Raffaele Manni
Via Mondino 2 (ex Via Ferrata), 27100
Research Domain
  • Clinical
  • Neurological Sleep Disorders
  • Sleep and Medical Disorders

Laboratory description

Sleep and epilepsy
Sleep and Neurodegenerative Disorders
OSA and Stroke

In Lab Video Polysomnography
In Hospital Portable Video Polysomnography
Ambulatory Polysomnography
Ambulatory EEG

Technical Capabilities and areas of expertise


Selected Publications in the 5 past years:

Sleep 2006;29(7):934-7.Interictal , potentially misleading, epileptiform eeg abnormalities in REM sleep behaviour disorder. R.Manni, M.Terzaghi, E.Zambrelli, C.Pacchetti

Sleep 2006;29(5):701-4. Relationship of epileptic discharges to arousal instability and periodic leg movements in a case of Nocturnal Frontal Lobe Epilepsy: a Stereo-EEG study. L.Nobili. I.Sartori., M.Terzaghi, S. Francione, R.Mai, L.Tassi, L. Parrino, M. Cossu, G.Lo Russo

Neurological Sciences 2006;27(6):436-8. Non-convulsive status epilepticus and generalised tonic-clonic seizures persisting in old age in a patient with idiopathic generalised epilepsy: a long-term observation. Zambrelli E, Terzaghi M, Sinforiani E, Manni R.

Neurological Sciences 2007;28 Suppl 1:S1-5. Sleep disorders in Parkinson’s disease: facts and new perspectives. Manni R, Terzaghi M, Pacchetti C, Nappi G.

Epilepsia 2006;47 Suppl 5:78-81. REM Sleep Behaviour Disorder and epileptic phenomena: clinical aspects of the comorbidity. R. Manni, M. Terzaghi, E. Zambrelli

Epilepsia. 2007;48(2):335-41. Sleep-related minor motor events in nocturnal frontal lobe epilepsy. Terzaghi M, Sartori I, Mai R, Tassi L, Francione S, Cardinale F, Castana L, Cossu M, LoRusso G, Manni R, Nobili L.

Neurological Sciences 2007;28(2):96-9. Hallucinations and sleep-wake cycle in Alzheimer’s disease: a questionnaire-based study in 218 patients. Sinforiani E, Terzaghi M, Pasotti C, Zucchella C, Zambrelli E, Manni R.

Movement Disorders 2007;22(12):1797-800. Rhythmic movements in idiopathic REM sleep behavior disorder. Manni R, Terzaghi M.

Epilepsy Research 2007;77(2-3):128-33. REM sleep behaviour disorder in elderly subjects with epilepsy: Frequency and clinical aspects of the comorbidity. Manni R, Terzaghi M, Zambrelli E.

Sleep Med. 2008;9(4):343-51. Cognitive performance in REM sleep behaviour disorder: a possible early marker of neurodegenerative disease? Terzaghi M, Sinforiani E, Zucchella C, Zambrelli E, Pasotti C, Rustioni V, Manni R.

Epilepsia. 2008;49(4):670-6. Coupling of minor motor events and epileptiform discharges with arousal fluctuations in NFLE. Terzaghi M, Sartori I, Mai R, Tassi L, Francione S, Cardinale F, Castana L, Cossu M, Lorusso G, Manni R, Nobili L.

Epilepsia. 2008; 49(9):1581-5. The FLEP scale in diagnosing nocturnal frontal lobe epilepsy, NREM and REM parasomnias: Data from a tertiary sleep and epilepsy unit. Manni R, Terzaghi M, Repetto A.

European Journal of Neurology 2008;15(8):e78-9. Paroxysmal dystonia persisting during sleep in asymmetric Parkinsonism: dishinibition of a Central Pattern Generator? M.Terzaghi, I.Sartori, V.Rustioni, R.Manni

Sleep. 2008;31(7):944-52. Multicenter case-control study on restless legs syndrome in multiple sclerosis: the REMS study. Italian REMS Study Group, Manconi M, Ferini-Strambi L, Filippi M, Bonanni E, Iudice A, Murri L, Gigli GL, Fratticci L, Merlino G, Terzano G, Granella F, Parrino L, Silvestri R, Aricò I, Dattola V, Russo G, Luongo C, Cicolin A, Tribolo A, Cavalla P, Savarese M, Trojano M, Ottaviano S, Cirignottta F, Simioni V, Salvi F, Mondino F, Perla F, Chinaglia G, Zuliani C, Cesnik E, Granieri E, Placidi F, Palmieri MG, Manni R, Terzaghi M, Bergamaschi R, Rocchi R, Ulivelli M, Bartalini S, Ferri R, Lo Fermo S, Ubiali E, Viscardi M, Rottoli M, Nobili L, Protti A, Ferrillo F, Allena M, Mancardi G, Guarnieri B, Londrillo F.

Neurogastroenterol Motil. 2009;21(1):95-6. Cyclic vomiting syndrome in adults: disregarding a possible epileptic component? Terzaghi M, Sartori I, Rustioni V, Manni R.

Sleep. 2009;32(2):241-5. Motor-behavioral episodes in REM sleep behavior disorder and phasic events during REM sleep. Manni R, Terzaghi M, Glorioso M.

Sleep 2009;32(3):409-412. Evidence of dissociated arousal states during NREM parasomnia from an intracerebral neurophysiological study. Terzaghi M; Sartori I; Tassi L; Didato G; Rustioni V; LoRusso G; Manni R; Nobili L.

Movement Disorders 2010;25(5):647-9. Agrypnia with nocturnal confusional behaviours in dementia with Lewy bodies: immediate efficacy of rivastigmine. Terzaghi M, Rustioni V, Manni R, Pacchetti C, Zangaglia R, Ossola M.

Movement Disorders 2010;25(8):985-90. Complex paroxysmal nocturnal behaviors in Parkinson’s disease. Manni R, Terzaghi M, Repetto A, Zangaglia R, Pacchetti C.

Haedache 2010;50(6):1050-4. Episodic Cluster Headache: NREM Prevalence of Nocturnal Attacks. Time to Look Beyond Macrostructural Analysis? Terzaghi M, Ghiotto N, Sances G, Rustioni V, Nappi G, Manni R.

Neurology 2010;75(4):373-4.Status Epilepticus Migrainosus: Clinical, Electrophysiological and Imaging characteristics. Perucca P, Terzaghi M, Manni R.

Epilepsy Research 2010;90(3):171-7. Comorbidity Between Epilepsy And Sleep Disorders. Manni R, Terzaghi M

Consciousness and Cognition 2010. Hallucinations and REM sleep behaviour disorder in Parkinson’s disease: Dream imagery intrusions and other hypotheses. Manni R, Terzaghi M, Ratti PL, Repetto A, Zangaglia R, Pacchetti C.

Other laboratory Members

Title:  MD

Name:  Michele Terzaghi

Position:  Assistant

Email:  michele.terzaghi@mondino.it

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