Split Sleep Medicine Center, University of Split, School of Medicine

Neuroscience

Contact:
Zoran Dogas
Position:
Vice Dean, Department Head
Address:
Soltanska 2, 21000
City:
Split
Country:
Croatia
Phone:
+385 21 557 858
Fax:
+385 21 557 955
Contact E-mail:
Research Domain
  • Methodology / Technology
  • Clinical
  • Basic Human
  • Basic Animal

Laboratory description

Neural control of breathing, Long-term facilitation of breathing induced by acute intermittent hypoxia, Electrophysiological recordings of the phrenic nerve, Microinjections of neurotransmitter analogs,
Human polysomnography and polygraphy, Transcranial magnetic stimulations, Evoked potentials


Technical Capabilities and areas of expertise

Neural control of breathing in animals
PSG, PG, MSLT, MWT, CPAP titration in human


Selected Publications in the 5 past years:

1. Ivancev B, Carev M, Pecotic R, Valic M, Pavlinac Dodig I, Karanovic N, Dogas Z. Remifentanil reversibly abolished phrenic long term facilitation in rats subjected to acute intermittent hypoxia. J Physiol Pharmacol. 2013;64:485-92.
2. Marinov V, Valic M, Pecotic R, Karanovic N, Dodig IP, Carev M, Valic Z, Dogas Z. Sevoflurane and isoflurane monoanesthesia abolished the phrenic long-term facilitation in rats. Respir Physiol Neurobiol. 2013; doi: pii: S1569-9048(13)00270-X. 10.1016/j.resp.2013.07.026.
3. Vidović N, Mestrović S, Dogas Z, Buković D, Brakus I, Brakus RB, Kovacić I. Craniofacial morphology of Croatian patients with obstructive sleep apnea. Coll Antropol. 2013;37(1):271-9.
4. Allebrandt KV, Amin N, Müller-Myhsok B, Esko T, Teder-Laving M, Azevedo RV, Hayward C, van Mill J, Vogelzangs N, Green EW, Melville SA, Lichtner P, Wichmann HE, Oostra BA, Janssens AC, Campbell H, Wilson JF, Hicks AA, Pramstaller PP, Dogas Z, Rudan I, Merrow M, Penninx B, Kyriacou CP, Metspalu A, van Duijn CM, Meitinger T, Roenneberg T. A K(ATP) channel gene effect on sleep duration: from genome-wide association studies to function in Drosophila. Mol Psychiatry. 2013;18(1):122-32. doi: 10.1038/mp.2011.142.
5. Pecotic R, Dodig IP, Valic M, Ivkovic N, Dogas Z. The evaluation of theCroatian version of the Epworth sleepiness scale and STOP questionnaire asscreening tools for obstructive sleep apnea syndrome. Sleep Breath. 2012;16:793-802. doi: 10.1007/s11325-011-0578-x.
6. Zibar L, Kristić A, Krnjeta D, Dogas Z. Risk for sleep apnea syndrome and excessive daily sleepiness in chronic hemodialysis patients. Acta Med Croatica. 2011;65 Suppl 3:30-5. Croatian.
7. Pavlinac Dodig I, Pecotic R, Valic M, Dogas Z. Acute intermittent hypoxia induces phrenic long-term facilitation which is modulated by 5-HT(1A) receptor in the caudal raphe region of the rat. J Sleep Res. 2011; doi: 10.1111/j.1365-2869.2011.00948.x.
8. Carev M, Karanović N, Bagatin J, Matulić NB, Pecotić R, Valić M, Marinović-Terzić I, Karanović S, Dogas Z. Blood pressure dipping and salivary cortisol as markers of fatigue and sleep deprivation in staff anesthesiologists. Coll Antropol. 2011;35 Suppl 1:133-8.
9. Mustapic S, Radocaj T, Sanchez A, Dogas Z, Stucke AG, Hopp FA, Stuth EA, Zuperku EJ. Clinically relevant infusion rates of mu-opioid agonist remifentanil cause bradypnea in decerebrate dogs but not via direct effects in the pre-Bötzinger complex region. J Neurophysiol. 2010 Jan;103(1):409-18. doi: 10.1152/jn.00188.2009.
10. Valic M, Pecotic R, Pavlinac I, Valic Z, Peros K, Dogas Z. Microinjection of methysergide into the raphe nucleus attenuated phrenic long-term facilitation in rats. Exp Brain Res. 2010;202:583-9.
11. Carev M, Valic M, Pecotic R, Karanovic N, Valic Z, Pavlinac I, Dogas Z. Propofol abolished the phrenic long-term facilitation in rats. Respir Physiol Neurobiol. 2010;170:83-90.
12. Karanovic N, Pecotic R, Valic M, Jeroncic A, Carev M, Karanovic S, Ujevic A, Dogas Z. The acute hypoxic ventilatory response under halothane, isoflurane, and sevoflurane anaesthesia in rats. Anaesthesia. 2010;65:227-34.
13. Pavlinac I, Pecotic R, Dogas Z, Valic M. Role of 5-HT₁(A) receptors in induction and preservation of phrenic long-term facilitation in rats. Respir Physiol Neurobiol. 2011;175(1):146-52. doi: 10.1016/j.resp.2010.10.005. Epub 2010 Oct 28.
14. Karanovic N, Carev M, Kardum G, Pecotic R, Valic M, Karanovic S, Ujevic A, Dogas Z. The impact of a single 24 h working day on cognitive and psychomotor performance in staff anaesthesiologists. European journal of anaesthesiology. 2009;26:825-32.
15. Pecotic R, Dogas Z, Valic Z, Valic M. Blockade of 5-HT(1A) receptors in the phrenic nucleus of the rat attenuated raphe induced activation of the phrenic nerve activity. J Physiol Pharmacol. 2009;60(3):167-72.
16. 1: Pecotić R, Valić M, Kardum G, Sevo V, Dogas Z. [Sleep habits of medical students, physicians and nurses regarding age, sex, shift work and caffeine consumption]. Lijec Vjesn. 2008;130(3-4):87-91. Croatian.
17. Carev M, Karanović N, Dogas Z. [Obstructive sleep apnea and anesthesia]. Lijec Vjesn. 2008;130(3-4):78-86. Review. Croatian.
18. Dogas Z, Valić M, Pecotić R, Pupić MC, Carev M, Bojić L, Racić G. [Sleep disordered breathing]. Lijec Vjesn. 2008;130(3-4):69-77. Review. Croatian.
19. Dogas Z. [Introduction to sleep medicine]. Lijec Vjesn. 2008;130(3-4):68. Croatian.
20. Valic M, Pecotic R, Dogas Z. Phrenic nerve activity is enhanced by 5-HT1A receptor agonist 8-OH-DPAT in spontaneously breathing anesthetized rats. J Physiol Pharmacol. 2008;59(1):17-25.


Key Publications of the Laboratory:

1. Ivancev B, Carev M, Pecotic R, Valic M, Pavlinac Dodig I, Karanovic N, Dogas Z. Remifentanil reversibly abolished phrenic long term facilitation in rats subjected to acute intermittent hypoxia. J Physiol Pharmacol. 2013;64:485-92.
2. Marinov V, Valic M, Pecotic R, Karanovic N, Dodig IP, Carev M, Valic Z, Dogas Z. Sevoflurane and isoflurane monoanesthesia abolished the phrenic long-term facilitation in rats. Respir Physiol Neurobiol. 2013; doi: pii: S1569-9048(13)00270-X. 10.1016/j.resp.2013.07.026.
3. Vidović N, Mestrović S, Dogas Z, Buković D, Brakus I, Brakus RB, Kovacić I. Craniofacial morphology of Croatian patients with obstructive sleep apnea. Coll Antropol. 2013;37(1):271-9.
4. Allebrandt KV, Amin N, Müller-Myhsok B, Esko T, Teder-Laving M, Azevedo RV, Hayward C, van Mill J, Vogelzangs N, Green EW, Melville SA, Lichtner P, Wichmann HE, Oostra BA, Janssens AC, Campbell H, Wilson JF, Hicks AA, Pramstaller PP, Dogas Z, Rudan I, Merrow M, Penninx B, Kyriacou CP, Metspalu A, van Duijn CM, Meitinger T, Roenneberg T. A K(ATP) channel gene effect on sleep duration: from genome-wide association studies to function in Drosophila. Mol Psychiatry. 2013;18(1):122-32. doi: 10.1038/mp.2011.142.
5. Pecotic R, Dodig IP, Valic M, Ivkovic N, Dogas Z. The evaluation of theCroatian version of the Epworth sleepiness scale and STOP questionnaire asscreening tools for obstructive sleep apnea syndrome. Sleep Breath. 2012;16:793-802. doi: 10.1007/s11325-011-0578-x.
6. Zibar L, Kristić A, Krnjeta D, Dogas Z. Risk for sleep apnea syndrome and excessive daily sleepiness in chronic hemodialysis patients. Acta Med Croatica. 2011;65 Suppl 3:30-5. Croatian.
7. Pavlinac Dodig I, Pecotic R, Valic M, Dogas Z. Acute intermittent hypoxia induces phrenic long-term facilitation which is modulated by 5-HT(1A) receptor in the caudal raphe region of the rat. J Sleep Res. 2011; doi: 10.1111/j.1365-2869.2011.00948.x.
8. Carev M, Karanović N, Bagatin J, Matulić NB, Pecotić R, Valić M, Marinović-Terzić I, Karanović S, Dogas Z. Blood pressure dipping and salivary cortisol as markers of fatigue and sleep deprivation in staff anesthesiologists. Coll Antropol. 2011;35 Suppl 1:133-8.
9. Mustapic S, Radocaj T, Sanchez A, Dogas Z, Stucke AG, Hopp FA, Stuth EA, Zuperku EJ. Clinically relevant infusion rates of mu-opioid agonist remifentanil cause bradypnea in decerebrate dogs but not via direct effects in the pre-Bötzinger complex region. J Neurophysiol. 2010 Jan;103(1):409-18. doi: 10.1152/jn.00188.2009.
10. Valic M, Pecotic R, Pavlinac I, Valic Z, Peros K, Dogas Z. Microinjection of methysergide into the raphe nucleus attenuated phrenic long-term facilitation in rats. Exp Brain Res. 2010;202:583-9.
11. Carev M, Valic M, Pecotic R, Karanovic N, Valic Z, Pavlinac I, Dogas Z. Propofol abolished the phrenic long-term facilitation in rats. Respir Physiol Neurobiol. 2010;170:83-90.
12. Karanovic N, Pecotic R, Valic M, Jeroncic A, Carev M, Karanovic S, Ujevic A, Dogas Z. The acute hypoxic ventilatory response under halothane, isoflurane, and sevoflurane anaesthesia in rats. Anaesthesia. 2010;65:227-34.
13. Pavlinac I, Pecotic R, Dogas Z, Valic M. Role of 5-HT₁(A) receptors in induction and preservation of phrenic long-term facilitation in rats. Respir Physiol Neurobiol. 2011;175(1):146-52. doi: 10.1016/j.resp.2010.10.005. Epub 2010 Oct 28.
14. Karanovic N, Carev M, Kardum G, Pecotic R, Valic M, Karanovic S, Ujevic A, Dogas Z. The impact of a single 24 h working day on cognitive and psychomotor performance in staff anaesthesiologists. European journal of anaesthesiology. 2009;26:825-32.
15. Pecotic R, Dogas Z, Valic Z, Valic M. Blockade of 5-HT(1A) receptors in the phrenic nucleus of the rat attenuated raphe induced activation of the phrenic nerve activity. J Physiol Pharmacol. 2009;60(3):167-72.
16. 1: Pecotić R, Valić M, Kardum G, Sevo V, Dogas Z. [Sleep habits of medical students, physicians and nurses regarding age, sex, shift work and caffeine consumption]. Lijec Vjesn. 2008;130(3-4):87-91. Croatian.
17. Carev M, Karanović N, Dogas Z. [Obstructive sleep apnea and anesthesia]. Lijec Vjesn. 2008;130(3-4):78-86. Review. Croatian.
18. Dogas Z, Valić M, Pecotić R, Pupić MC, Carev M, Bojić L, Racić G. [Sleep disordered breathing]. Lijec Vjesn. 2008;130(3-4):69-77. Review. Croatian.
19. Dogas Z. [Introduction to sleep medicine]. Lijec Vjesn. 2008;130(3-4):68. Croatian.
20. Valic M, Pecotic R, Dogas Z. Phrenic nerve activity is enhanced by 5-HT1A receptor agonist 8-OH-DPAT in spontaneously breathing anesthetized rats. J Physiol Pharmacol. 2008;59(1):17-25.


Current/Completed Grants (past 5 years):

Neural control of breathing in sleep and wakefulness, Scientific Research Grant supported by the Croatian Ministry of Science, #216-2163166-0513, PI, 2007-2013
Neural control of cardiovascular system, Scientific Research Grant supported by the Croatian Ministry of Science, #216-2163166-3342, Investigator, 2007-2013
Neural control of cardiovascular system, Scientific Research Grant supported by the Croatian Science Foundation, #09/165, Investigator, 2013-
Co-creator of the Interactive Medical Center for Education of four Croatian medical schools. (web link: http://viktor.mefos.hr/moodle/)
Catalogue of Knowledge and Skills for medical students in Croatia, National Co-ordinator, 2008.


Other laboratory Members

Title:  PhD MD

Name:  Maja Valic

Position:  Laboratory for basic neuroscience, Director

Email:  mvalic@mefst.hr

Title:  PhD MD

Name:  Renata Pecotic

Position:  Education Department, Head

Email:  rpecotic@mefst.hr

Name:  Goran Racic

Position:  ENT specialist, somnologist

Email:  racic@kbsplit.hr

Title:  MD

Name:  Ivana Pavlinac Dodig

Position:  researcher

Email:  ivana.pavlinac@mefst.hr

Title:  MSc

Name:  Linda Lusic

Position:  Psychologist/Researcher

Email:  linda.lusic@mefst.hr

Title:  BSc

Name:  Natalija Ivkovic

Position:  Sleep technologist

Email:  nivkovic96@gmail.com

Name:  Dijana Radanovic

Position:  Nurse/technician

Email:  dijana.radanovic78@gmail.com

Title:  PhD MD

Name:  Nenad Karanovic

Position:  Anesthesiologist/Researcher

Email:  nkaranov@yahoo.com

Title:  PhD MD

Name:  Mladen Carev

Position:  Anesthesiologist/Researcher

Email:  mladen.carev1@gmail.com

Title:  PhD MD

Name:  Maja Rogic

Position:  Researcher

Email:  mrogic@mefst.hr

Name:  Jelena Baricevic

Position:  Tecnician

Title:  PhD MD

Name:  Zeljka Roje

Position:  ENT specialist/Researcher

Email:  zroje@mefst.hr


Collaborations

Title:  PhD MD

Name:  Dušan Šuput

Position:  Dean, Director of MRI unit

Institution:  Univ of Ljubljana, School of Medicine

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