University of Oxford Sleep Research Centre, University of Oxford

Nuffield Department of Clinical Neurosciences

Contact:
Colin A Espie
Position:
Professor of Sleep Medicine
Address:
John Radcliffe Hospital, OX3 9DU
City:
Oxford
Country:
United Kingdom
Phone:
+44 (0)7809 111626
Research Domain
  • Clinical
  • Basic Human
  • Basic Animal
Keywords
  • Biological Rhythms
  • Behavioural Sleep Disorders
  • Sleep Physiology-Neurophysiology in Animal
  • Others
Current Announcements

Our online MSc/ PgDip in Sleep Medicine will be launched in 2015.
Enquiries to Dr Chris Harvey (christopher-james.harvey@ndcn.ox.ac.uk)


Laboratory description

Human: Clinical and behavioural assessment of sleep disorders, actigraphy, ambulatory PSG, online evaluations.

Animal: Equipment for in vivo electrophysiology, automated touchscreen set up for rodent behaviour, equipment for optogenetics, animal models of disease (at the Sleep, Brain and Behaviour Lab, http://vvlab.org)


Key Publications of the Laboratory:
www.ndcn.ox.ac.uk/colin-espie
http://www.psych.ox.ac.uk/team/PIs/daniel-freeman
http://www.eye.ox.ac.uk/team/principal-investigators/katharina-wulff
http://www.ndcn.ox.ac.uk/team/support-staff/christopher-james-harvey;d=TkxP

1. Espie, C.A., Kyle, S.D, Williams, C., Ong, J.C., Douglas, N.J., Hames, P., Brown, J.S.L. (2012) A randomized, placebo-controlled, trial of online Cognitive Behavioral Therapy for chronic Insomnia Disorder delivered via an automated media-rich web application. SLEEP, Vol. 35, No. 6, 769-781

2. Espie, C.A., Barrie, L.M., Forgan, G.S. (2012) Comparative investigation of the psychophysiological and idiopathic Insomnia Disorder phenotypes: psychological characteristics, patients’ perspectives and implications for clinical management. SLEEP, Vol. 35, No. 3, 385-393

3. Green, M., Benzeval, M., Espie, C.A., Hunt, K. (2012) The longitudinal course of insomnia symptoms: inequalities by gender and occupational class among two different age cohorts followed for 20 years in the West of Scotland. SLEEP 35, 815-823

4. Espie., C.A., Kyle, S.D., Hames, P., Cyhlarova E., Benzeval, M. (2012) The daytime impact of DSM-5 Insomnia Disorder: comparative analysis of insomnia subtypes from the Great British Sleep Survey (n=11,129) Journal of Clinical Psychiatry 73, e1478-e1484

5. Espie, C.A., Kyle, S.D., Hames, P., Gardani, M., Fleming, L., Cape, J. (2014). The Sleep Condition Indicator: a clinical screening tool to evaluate Insomnia Disorder. BMJOpen 4 (3): e004183

6. Vyazovskiy VV, Harris KD (2013) Sleep and the single neuron: the role of global slow oscillations in individual cell rest. Nat Rev Neurosci 14: 443-451.

7. Vyazovskiy VV, Olcese U, Hanlon EC, Nir Y, Cirelli C, et al. (2011) Local sleep in awake rats. Nature 472: 443-447.

8. Leemburg S, Vyazovskiy VV, Olcese U, Bassetti CL, Tononi G, et al. (2010) Sleep homeostasis in the rat is preserved during chronic sleep restriction. Proc Natl Acad Sci U S A 107: 15939-15944.

9. Vyazovskiy VV, Olcese U, Lazimy YM, Faraguna U, Esser SK, et al. (2009) Cortical firing and sleep homeostasis. Neuron 63: 865-878.

10. Vyazovskiy VV, Cirelli C, Pfister-Genskow M, Faraguna U, Tononi G (2008) Molecular and electrophysiological evidence for net synaptic potentiation in wake and depression in sleep. Nature Neurosci 11: 200-208.

11. Freeman, D., Pugh, K., Vorontsova, N. & Southgate, L. (2009). Insomnia and paranoia. Schizophrenia Research, 108, 280-284.

12. Freeman, D., Pugh, K., Antley, A., Slater, M., Bebbington, P., Gittins, M., Dunn, G., Kuipers, E., Fowler, D., & Garety, P. A (2008). A virtual reality study of paranoid thinking in the general population. British Journal of Psychiatry, 192, 258-263.

13. Freeman, D. (2007). Suspicious minds: the psychology of persecutory delusions. Clinical Psychology Review, 27, 425-457.

14. Freeman, D., Garety, P.A., Kuipers, E., Fowler, D., & Bebbington, P.E. (2002). A cognitive model of persecutory delusions. British Journal of Clinical Psychology, 41, 331-347.

15. Garety, P.A. & Freeman, D. (1999). Cognitive approaches to delusions: a critical review of theories and evidence. British Journal of Clinical Psychology, 38, 113-154.
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