Sleep Unit Turku, University of Turku

Physiology

Contact:
Tarja Saaresranta
Address:
Lemminkäisenkatu 14-18 A 5th Floor, 20520
City:
Turku
Country:
Finland
Phone:
+35823337519
Fax:
+35822410057
Contact E-mail:
Research Domain
Keywords

Laboratory description

The Sleep Research Unit at the University of Turku is conducting both investigator-initiated studies as well as clinical trials sponsored by pharmaceutical industry. Main research areas are sleep-disordered breathing especially in postmenopausal women, insomnia and restless legs syndrome.


Technical Capabilities and areas of expertise

In-laboratory polysomonography with video and transcutaneous carbon dioxide monitoring, possibilities for frequent nocturnal blood sampling, OSLER test


Additional Descriptors, Keywords

autonomic nervous system
trancutaneous CO2


Selected Publications in the 5 past years:

Lampio L, Saaresranta T, Polo O, Polo-Kantola P. Subjective sleep in premenopausal and postmenopausal women during workdays and leisure days: a sleep diary study. Menopause 2013;20(6):655-60.

Anttalainen U, Polo O, Vahlberg T, Saaresranta T. Women with partial upper airway obstruction are not less sleepy than those with obstructive sleep apnea. Sleep Breath 2013;17(2):873-6.

Utriainen KT, Airaksinen JK, Polo O, Raitakari OT, Pietilä MJ, Scheinin H, Helenius HY, Leino KA, Kentala ES, Jalonen JR, Hakovirta H, Salo TM, Laitio TT. Unrecognised obstructive sleep apnoea is common in severe peripheral arterial disease. Eur Respir J 2013;41(3):616-20.

Kalleinen N, Virkki A, Polo O, Himanen SL, Irjala K, Joutsen A, Porkka-Heiskanen T, Polo-Kantola P. The temporal relationship between growth hormone and slow wave sleep is weaker after menopause.
Sleep Med 2012;13(1):96-101.

Winkelmann J, Czamara D, Schormair B, Knauf F, Schulte EC, Trenkwalder C, Dauvilliers Y, Polo O, Högl B, Berger K, Fuhs A, Gross N, Stiasny-Kolster K, Oertel W, Bachmann CG, Paulus W, Xiong L, Montplaisir J, Rouleau GA, Fietze I, Vávrová J, Kemlink D, Sonka K, Nevsimalova S, Lin SC, Wszolek Z, Vilariño-Güell C, Farrer MJ, Gschliesser V, Frauscher B, Falkenstetter T, Poewe W, Allen RP, Earley CJ, Ondo WG, Le WD, Spieler D, Kaffe M, Zimprich A, Kettunen J, Perola M, Silander K, Cournu-Rebeix I, Francavilla M, Fontenille C, Fontaine B, Vodicka P, Prokisch H, Lichtner P, Peppard P, Faraco J, Mignot E, Gieger C, Illig T, Wichmann HE, Müller-Myhsok B, Meitinger T. Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1.
PLoS Genet. 2011;7(7):e1002171

Polo-Kantola P. Sleep problems in midlife and beyond. Maturitas 2011;68(3):224-32.

Hedner J, Grote L, Bonsignore M, McNicholas W, Lavie P, Parati G, Sliwinski P, Barbé F, De Backer W, Escourrou P, Fietze I, Kvamme JA, Lombardi C, Marrone O, Masa JF, Montserrat JM, Penzel T, Pretl M, Riha R, Rodenstein D, Saaresranta T, Schulz R, Tkacova R, Varoneckas G, Vitols A, Vrints H, Zielinski J. The European Sleep Apnoea Database (ESADA): report from 22 European sleep laboratories. Eur Respir J 2011;38(3):635-42.

Fietze I, Penzel T, Alonderis A, Barbe F, Bonsignore MR, Calverly P, De Backer W, Diefenbach K, Donic V, Eijsvogel MM, Franklin KA, Gislason T, Grote L, Hedner J, Jennum P, Lavie L, Lavie P, Levy P, Lombardi C, Mallin W, Marrone O, Montserrat JM, Papathanasiou ES, Parati G, Plywaczewski R, Pretl M, Riha RL, Rodenstein D, Saaresranta T, Schulz R, Sliwinski P, Steiropoulos P, Svaza J, Tomori Z, Tonnesen P, Varoneckas G, Verbraecken J, Vesely J, Vitols A, Zielinski J, McNicholas WT; COST Action B26 Group. Management of obstructive sleep apnea in Europe.
Sleep Med. 2011;12(2):190-7.

Anttalainen U, Liippo K, Saaresranta T. Diagnosis and initiation of nasal continuous positive airway pressure therapy for OSAS without a preceding sleep study? Sleep Breath 2011;15(4):791-7.

Anttalainen U, Polo O, Vahlberg T, Saaresranta T. Reimbursed drugs in patients with sleep-disordered breathing: A static-charge-sensitive bed study. Sleep Med 2010;11(1):49-55.

Anttalainen U, Polo O, Saaresranta T. Is ‘MILD’ sleep-disordered breathing in women really mild?
Acta Obstet Gynecol Scand. 2010;89(5):605-11.

Aittokallio J, Hiissa J, Saaresranta T, Polo-Kantola P, Aittokallio T, Polo O. Nocturnal transcutaneous carbon dioxide tension in postmenopausal estrogen users and non-users. Menopause Int 2009;15(3):107-12.

Aittokallio J, Saaresranta T, Virkki A, Karppinen N, Heinonen OJ, Aittokallio T, Polo O. Transcutaneous carbon dioxide profile during sleep reveals metabolic risk factors in post-menopausal females. Eur Respir J 2009;34(5):1132-9.

Aittokallio T, Virkki A, Polo O. Understanding sleep-disordered breathing through mathematical modelling. Sleep Med Rev 2009;13(5):333-43.

Kemlink D, Polo O, Frauscher B, Gschliesser V, Högl B, Poewe W, Vodicka P, Vavrova J, Sonka K, Nevsimalova S, Schormair B, Lichtner P, Silander K, Peltonen L, Gieger C, Wichmann HE, Zimprich A, Roeske D, Müller-Myhsok B, Meitinger T, Winkelmann J. Replication of restless legs syndrome loci in three European populations. J Med Genet. 2009;46(5):315-8.

Aittokallio J, Hiissa J, Saaresranta T, Polo-Kantola P, Aittokallio T, Polo O. Nocturnal transcutaneous carbon dioxide tension in postmenopausal estrogen users and non-users. Menopause Int 2009;15(3):107-12.

Sjösten N, Vahtera J, Salo P, Oksanen T, Saaresranta T, Virtanen M, Pentti J, Kivimäki M. Increased risk of lost workdays prior to the diagnosis of sleep apnea. Chest. 2009;136(1):130-6.

Sjösten N, Kivimäki M, Oksanen T, Salo P, Saaresranta T, Virtanen M, Pentti J, Vahtera J. Obstructive sleep apnoea syndrome as a predictor of work disability. Respir Med. 2009;103(7):1047-55.


Key Publications of the Laboratory:

Utriainen KT, Airaksinen JK, Polo O, Raitakari OT, Pietilä MJ, Scheinin H, Helenius HY, Leino KA, Kentala ES, Jalonen JR, Hakovirta H, Salo TM, Laitio TT. Unrecognised obstructive sleep apnoea is common in severe peripheral arterial disease. Eur Respir J 2013;41(3):616-20.

Hedner J, Grote L, Bonsignore M, McNicholas W, Lavie P, Parati G, Sliwinski P, Barbé F, De Backer W, Escourrou P, Fietze I, Kvamme JA, Lombardi C, Marrone O, Masa JF, Montserrat JM, Penzel T, Pretl M, Riha R, Rodenstein D, Saaresranta T, Schulz R, Tkacova R, Varoneckas G, Vitols A, Vrints H, Zielinski J. The European Sleep Apnoea Database (ESADA): report from 22 European sleep laboratories. Eur Respir J 2011;38(3):635-42.

Aittokallio J, Saaresranta T, Virkki A, Karppinen N, Heinonen OJ, Aittokallio T, Polo O. Transcutaneous carbon dioxide profile during sleep reveals metabolic risk factors in post-menopausal females. Eur Respir J 2009;34(5):1132-9.

Aittokallio T, Virkki A, Polo O. Understanding sleep-disordered breathing through mathematical modelling. Sleep Med Rev 2009;13(5):333-43.

Sjösten N, Vahtera J, Salo P, Oksanen T, Saaresranta T, Virtanen M, Pentti J, Kivimäki M. Increased risk of lost workdays prior to the diagnosis of sleep apnea. Chest. 2009;136(1):130-6.

Kalleinen N, Polo-Kantola P, Irjala K, Porkka-Heiskanen T, Vahlberg T, Virkki A, Polo O. 24-hour serum levels of growth hormone, prolactin, and cortisol in pre- and postmenopausal women: the effect of combined estrogen and progestin treatment. J Clin Endocrinol Metab 2008;93(5):1655-61.

Aittokallio J, Polo O, Hiissa J, Virkki A, Toikka J, Raitakari O, Saaresranta T, Aittokallio T. Overnight variability in transcutaneous carbon dioxide predicts vascular impairment in women.
Exp Physiol. 2008;93(7):880-91.

Anttalainen U, Saaresranta T, Kalleinen N, Aittokallio J, Vahlberg T, Polo O. CPAP adherence and partial upper airway obstruction during sleep. Sleep Breath 2007;11(3):171-6.

Kemlink D, Polo O, Montagna P, Provini F, Stiasny-Kolster K, Oertel W, de Weerd A, Nevsimalova S, Sonka K, Högl B, Frauscher B, Poewe W, Trenkwalder C, Pramstaller PP, Ferini-Strambi L, Zucconi M, Konofal E, Arnulf I, Hadjigeorgiou GM, Happe S, Klein C, Hiller A, Lichtner P, Meitinger T, Müller-Myshok B, Winkelmann J. Family-based association study of the restless legs syndrome loci 2 and 3 in a European population.Mov Disord 2007;22(2):207-12.

Saaresranta T, Polo-Kantola P, Virtanen I, Vahlberg T, Irjala K, Polo O. Menopausal estrogen therapy predicts better nocturnal oxyhemoglobin saturation. Maturitas 2006;55(3):255-63.

Saaresranta T, Irjala K, Aittokallio T, Polo O Sleep quality, daytime sleepiness and fasting insulin levels in women with chronic obstructive pulmonary disease. Respir Med. 2005;99(7):856-63.

Aittokallio T, Gyllenberg M, Saaresranta T, Polo O. Prediction of inspiratory flow shapes during sleep with a mathematic model of upper airway forces. Sleep 2003;26(7):857-63.

Saaresranta T, Polo O. Sleep-disordered breathing and hormones.Eur Respir J 2003;22(1):161-72.

Saaresranta T, Polo-Kantola P, Rauhala E, Polo O. Medroxyprogesterone in postmenopausal females with partial upper airway obstruction during sleep. Eur Respir J 2001;18(6):989-95.

Polo-Kantola P, Rauhala E, Erkkola R, Irjala K, Polo O. Estrogen replacement therapy and nocturnal periodic limb movements: a randomized controlled trial. Obstet Gynecol 2001;97(4):548-54.

Aittokallio T, Saaresranta T, Polo-Kantola P, Nevalainen O, Polo O. Analysis of inspiratory flow shapes in patients with partial upper-airway obstruction during sleep. Chest 2001;119(1):37-44.

Polo O. Continuous positive airway pressure for treatment of sleep apnoea.
Lancet 1999;353(9170):2086-7.

Polo-Kantola P, Erkkola R, Irjala K, Pullinen S, Virtanen I, Polo O. Effect of short-term transdermal estrogen replacement therapy on sleep: a randomized, double-blind crossover trial in postmenopausal women. Fertil Steril 1999;71(5):873-80.

Polo-Kantola P, Erkkola R, Helenius H, Irjala K, Polo O. When does estrogen replacement therapy improve sleep quality? Am J Obstet Gynecol 1998;178(5):1002-9.

Polo O, Berthon-Jones M, Douglas NJ, Sullivan CE. Management of obstructive sleep apnoea/hypopnoea syndrome. Lancet 1994;344(8923):656-60.

Douglas NJ, Polo O. Pathogenesis of obstructive sleep apnoea/hypopnoea syndrome. Lancet 1994;344(8923):653-5.

Ekholm EM, Polo O, Rauhala ER, Ekblad UU. Sleep quality in preeclampsia. Am J Obstet Gynecol 1992;167(5):1262-6.

Polo O. Partial upper airway obstruction during sleep. Studies with the static charge-sensitive bed (SCSB). Acta Physiol Scand Suppl 1992;606:1-118.

Polo OJ, Tafti M, Fraga J, Porkka KV, Déjean Y, Billiard M. Why don’t all heavy snorers have obstructive sleep apnea? Am Rev Respir Dis 1991;143(6):1288-93.

Polo O, Brissaud L, Sales B, Besset A, Billiard M. The validity of the static charge sensitive bed in detecting obstructive sleep apnoeas. Eur Respir J 1988;1(4):330-6.


Current/Completed Grants (past 5 years):

Governmental EVO Grant (2009-13)
Jalmari and Rauha Ahokas Foundation (2012)
Turku University Foundation (2012-14)
Finnish Anti-Tuberculosis Association Foundation (2009-10, 2012-13)
Research Foundation for Respiratory Diseases 2010


Other laboratory Members

Title:  MD

Name:  Mia Aro

Position:  PhD Student

Email:  mmisot@utu.fi

Title:  MD

Name:  Karri Utriainen

Position:  PhD Student

Email:  katout@utu.fi

Title:  MD

Name:  Laura Lampio

Position:  PhD Student

Email:  lmlamp@utu.fi

Title:  PhD MD

Name:  Salla Lamusuo

Position:  Senior Researcher

Email:  salla.lamusuo@utu.fi

Title:  PhD MD

Name:  Ulla Anttalainen

Position:  Senior Researcher

Email:  ulla.anttalainen@utu.fi

Title:  PhD MD

Name:  Nea Kalleinen

Position:  Senior Researcher

Email:  neelka@utu.fi

Title:  PhD MD

Name:  Olli Polo

Position:  Professor

Email:  olli.polo@unesta.fi

Title:  PhD MD

Name:  Päivi Polo-Kantola

Position:  Senior Researcher

Email:  paivi.polo@tyks.fi

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