Centre d'exploration du Sommeil et de la Vigilanc, Clinique et Maternité Sainte Elisabeth


Jean Benoît Martinot
Head of the Sleep Laboratory
Place Louise Godin 15, 5000
Contact E-mail:
Research Domain
  • Methodology / Technology
  • Clinical
  • Pharmacology Human
  • Instrumentation-Methodology
  • Sleep and Medical Disorders
  • Paediatric Sleep Disorders
Current Announcements

Opening of 4 new beds with private facilities, dedicated to sleep clinical research in Selma Residence at Erpent -Namur Belgium

Laboratory description

detection and analysis of the respiratory effort during sleep
by magnetometry
detection and quantification of the air flow during sleep
by sensors of hygrometry

Technical Capabilities and areas of expertise

*mandibular position and movements recorded with magnometer
*pulse transit times sampled at 1000 hz
*oro-nasal flow quantified with the changes in air hygrometry between inspiration and expiration
*grayscale mathematical morphometry apllied to respiratory signals
*new EPAP device with variable airflow resistance in development

Additional Descriptors, Keywords

sustained flow limitation , snoring , mandibular movements ,respiratory effort during overlap syndrome , respiratory effort during Cheyne Stokes breathing

Selected Publications in the 5 past years:

Pulmonary capillary blood volume and membrane conductance in Andeans and lowlanders at high altitude: A cross-sectional study
C . de Bisschop ; L . Kiger ;MC. Marden ;A. Ajata ;S. Huez ;V. Faoro ;JB Martinot ;R .Naeije ;H .Guénard
Nitric Oxide 2010 Nov 1;23(3):187-93. Epub 2010 May 31

Altitude Improvement in lung diffusion by endothelin receptor blockade at high altitude
C . de Bisschop , JB Martinot , G. Leurquin-Sterk, V. Faoro, H. Guénard, R.Naieje
J Appl Physiol 112:20-25, 2012.

Exercise Pathophysiology In Patients With Chronic Mountain Sickness.
Groepenhoff H, Overbeek MJ, Mulè M, van der Plas M, Argiento P, Villafuerte FC, Beloka S, Faoro V, Macarlupu JL, Guenard H, de Bisschop C, Martinot JB, Vanderpool R, Penaloza D, Naeije R.
Chest. 2012 Feb 2.DOI 10.1378/chest.11-2845.

Lung membrane conductance and capillary volume derived from the no and co transfer in high altitude newcomers.
Jean-Benoît Martinot, Massimiliano Mulè, Claire de Bisschop, Maria J. Overbeek, Nhat-Nam Le-Dong, Robert Naeije, Hervé Guénard.
J Appl Physiol (1985). 2013 Jul 15;115(2):157-66.

Pulmonary vascular reserve and exercise capacity at sea level and at high altitude.
Pavelescu A, Faoro V, Guenard H, de Bisschop C, Martinot JB, Mélot C, Naeije R.
High Alt Med Biol. 2013 Mar;14(1):19-26.

Pulmonary circulation and gas exchange at exercise in sherpas at high altitude.
Vitalie Faoro, Sandrine Huez, Rebecca Vanderpool, Herman Groepenhoff, Claire de Bisschop, Jean-Benoit Martinot, Michel Lamotte, Adriana Pavelescu, Hervé Guénard, and Robert Naeije.
J Appl Physiol (1985). 2014 Apr;116(7):919-26.

Partial versus maximal forced exhalations in COPD: Enhanced signal detection for novel therapies.
Martinot JB, Chambellan A, Kays C, Silkoff PE, Guenard H.
Pulm Pharmacol Ther. 2014 Mar 21.

Jean-Benoit Martinot and Hervé Jean-Pierre Guénard
TLNO/TLCO ratio is not the end of the road Eur Respir J
2014 43:1535-1536; doi:10.1183/09031936.00012314

Nitrogen monoxide and Carbon monoxide transfer interpretation: state of the art
Martinot JB, Guénard H, Dinh-Xuan AT, Gin H , Dromer C
Accepted for publication in Clinical Physiology and Functional Imaging .

Key Publications of the Laboratory:

10.1164/ajrccm-conference.2013.187.1_MeetingAbstracts.A5189 A5189
Mandibular Movements Recorded During Child’s Sleep Apnea Syndrome Could Provide Useful Surrogate Markers For Cortical Arousals
Read More: http://www.atsjournals.org/doi/abs/10.1164/ajrccm- conference.2013.187.1_MeetingAbstracts.A5189

Mandibular Movements Identify Respiratory Efforts Due to Obstructive Sleep Apnoea in a Pre-school Child
Jean B. Martinot, Stéphane J. Denison, Frédéric H. Senny, Thibert A. Robillard, Umakanth Khatwa and Hervé Guenard
The Open Sleep Journal [DOI: 10.2174/1874620901407010001]

Mandibular Movements Identify Respiratory Effort in Pediatric Obstructive Sleep Apnea
Jean-Benoît Martinot; Fréderic Senny; Stéphane Denison; Valérie Cuthbert; Emmanuelle Gueulette; Hervé Guénard; Jean Louis- Pépin J Clin Sleep Med 2015 ; 11 (5) : 567-574

Nasal obstruction and male gender contribute to the persistence of mouth opening during sleep in CPAP-treated obstructive sleep apnea
Marius Lebret MSc, Nathalie Arnol MSc, Olivier Contal PhD, Jean Benoît Martinot, Renaud Tamisier , Jean-Louis Pepin MD-PhD , Jean-Christian Borel PhD
Accepted for publication in Respirology

Current/Completed Grants (past 5 years):

the research sleep lab is supported by the Fondation RG Havaux

Other laboratory Members

Title:  MSc

Name:  Stephane Denison

Email:  Stephane.DENISON@cmsenamur.be

Title:  BSc

Name:  Valerie Cuthbert

Email:  cuthbertvalerie@yahoo.fr

Title:  MD

Name:  Nathalie Coppens

Position:  somnologist

Email:  ncoppens12@hotmail.com


Title:  PhD

Name:  Geoffroy Gosset

Position:  Head of Institute of Information and Communication Technologies, Electronics and Applied Mathematics (ICTEAM)

Institution:  niversité catholique de Louvain (UCL)

Title:  PhD MD

Name:  David Gozal

Position:  Chair of pediatrics

Institution:  Department of Pediatrics Chicago University

Title:  PhD

Name:  Jacques Destiné

Position:  Chargé de Cours

Institution:  Department of Electrical Enginnering and Computer Sciences CHU Liége Belgium

Title:  MD

Name:  Umakanth Khatwa

Position:  Director, Sleep Laboratory

Institution:  Children's Hospital Boston

Title:  PhD MD

Name:  Jean Louis Pepin

Position:  Head of ; Inserm U1042, Grenoble, France. CHU de Grenoble, Laboratoire EFCR, Secteur Physiologie Sommeil et Exercice

Institution:  CHU Grenoble France

Title:  PhD

Name:  Jean Christian Borel

Position:  AGIRàdom. Association 38‐Meylan

Institution:  CHU Grenoble France

Title:  MD

Name:  Fei Xu

Position:  Chief Sleep Center

Institution:  Beijing Children Hospital

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