St. Vincent's University Hospital

Pulmonary and Sleep Disorders Unit

Contact:
Walter McNicholas
Position:
Director
Address:
Elm Park, 4
City:
Dublin
Country:
Ireland
Phone:
+353-1-2213702
Research Domain
  • others
  • Methodology / Technology
  • Clinical
  • Basic Human
Keywords
  • Pharmacology Human
  • Molecular Biology-Endocrinology-Biochemistry
  • Instrumentation-Methodology
  • Sleep and Medical Disorders
  • Genetics of Sleep
  • Epidemiology of Sleep
  • Sleep and Body Functions (Cardio-Respiratory, Thermoregulation/Metabolism, Endocrine)
  • Sleep Physiology-Neurophysiology in Human

Laboratory description

Laboratory research interests include the pathophysiology, treatment and outcomes of sleep apnoea syndrome, the cardiovascular and metabolic consequences of the disorder, basic cell and molecular mechanisms and consequences of intermittent hypoxia, in addition to sleep disturbances in COPD and other chronic respiratory disorders. The laboratory is also closely involved in the evaluation of novel ambulatory monitoring devices for sleep disorders.


Key Publications of the Laboratory:
1. Sleep-related breathing disorders in adults: Recommendations for syndrome definition and measurement techniques in clinical research. Flemons WW, Buysse D, Redline S, Pack A, Strohl K, Wheatley J, Young T, Douglas N, Levy P, McNicholas W, Fleetham J, White D, Schmidt-Nowarra W, Carley D, Romaniuk J. SLEEP Volume: 22 Issue: 5 Pages: 667-689 Published: AUG 1 1999. Times Cited: 1,964 (from All Databases) 2. Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome. Ryan, S; Taylor, CT; McNicholas, WT. CIRCULATION Volume: 112 Issue: 17 Pages: 2660 2667 DOI: 0.1161/CIRCULATIONAHA.105.556746 Published: OCT 25 2005. Times Cited: 258 (from All Databases) 3. Sleep apnoea as an independent risk factor for cardiovascular disease: current evidence, basic mechanisms and research priorities. McNicholas, W. T.; Bonsignore, M. R. Management Comm EU COST ACTION B26. EUROPEAN RESPIRATORY JOURNAL Volume: 29 Issue: 1 Pages: 156-178. DOI: 10.1183/09031936.00027406 Published: JAN 2007. Times Cited: 251. 4. OBSTRUCTIVE APNEAS DURING SLEEP IN PATIENTS WITH SEASONAL ALLERGIC RHINITIS. MCNICHOLAS, WT; TARLO, S; COLE, P; et al. AMERICAN REVIEW OF RESPIRATORY DISEASE. 126 Issue: 4 Pages: 625 628 . Published: 1982. Times cited: 213 5. Long-term effects of nasal continuous positive airway pressure therapy on cardiovascular outcomes in sleep apnea syndrome. Doherty, LS; Kiely, JL; Swan, V, McNicholas WT. CHEST Volume: 127 Issue: 6. Pages: 2076-2084. DOI: 10.1378/chest.127.6.2076 Published: JUN 2005. Times Cited: 196 (from All Databases) 6. Predictors of elevated nuclear factor-kappa B-dependent genes in obstructive sleep apnea syndrome. Ryan, Silke; Taylor, Cormac T.; McNicholas, Walter T. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Volume: 174 Issue: 7 Pages: 824-830 DOI: 10.1164/rccm.200601-066OC Published: OCT 1 2006 Times Cited: 127 (from All Databases) 7. Predictive value of clinical features for the obstructive sleep apnoea syndrome. Deegan, PC; McNicholas, WT. EUROPEAN RESPIRATORY JOURNAL Volume: 9 Issue: 1 Pages: 117-124 DOI: 10.1183/09031936.96.09010117 Published: JAN 1996. Times Cited: 110 (from All Databases) 8. PATHOPHYSIOLOGY OF OBSTRUCTIVE SLEEP-APNEA Author(s): DEEGAN, PC; MCNICHOLAS, WT. EUROPEAN RESPIRATORY JOURNAL Volume: 8 Issue: 7 Pages: 1161-1178 DOI: 10.1183/09031936.95.08071161 Published: JUL 1995. Times Cited: 109 (from All Databases) 9. Cardiac rhythm disturbances in the obstructive sleep apnea syndrome - Effects of nasal continuous positive airway pressure therapy. Harbison, J; O'Reilly, P; McNicholas, WT. CHEST Volume: 118 Issue: 3 Pages: 591-595 DOI: 10.1378/chest.118.3.591 Published: SEP 2000 Times Cited: 108 (from All Databases) 10. EFFECT OF SUPPLEMENTAL NOCTURNAL OXYGEN ON GAS-EXCHANGE IN PATIENTS WITH SEVERE OBSTRUCTIVE LUNG-DISEASE. GOLDSTEIN, RS; RAMCHARAN, V; BOWES, G; McNicholas WT, Bradley D, Phillipson EA. NEW ENGLAND JOURNAL OF MEDICINE Volume: 310 Issue: 7 Pages: 425-429 DOI: 10.1056/NEJM198402163100704 Published: 1984. Times Cited: 108 (from All Databases) 11. CLINICAL AND PHYSIOLOGICAL HETEROGENEITY OF THE CENTRAL SLEEP-APNEA SYNDROME. BRADLEY, TD; MCNICHOLAS, WT; RUTHERFORD, R; Popkin J, Zamel N, Phillipson EA. AMERICAN REVIEW OF RESPIRATORY DISEASE Volume: 134 Issue: 2 Pages: 217-221 Published: AUG 1986. Times Cited: 91 (from All Databases) 12. Cardiovascular risk factors in patients with obstructive sleep apnoea syndrome. Kiely, JL; McNicholas, WT. EUROPEAN RESPIRATORY JOURNAL Volume: 16 Issue: 1 Pages: 128-133 DOI: 10.1034/j.1399-3003.2000.16a23.x Published: JUL 2000. Times Cited: 90 (from All Databases) 13. UPPER AIRWAY-OBSTRUCTION DURING SLEEP IN NORMAL SUBJECTS AFTER SELECTIVE TOPICAL OROPHARYNGEAL ANESTHESIA. MCNICHOLAS, WT; COFFEY, M; MCDONNELL, T; O'Regan R, FitzGerald MX. AMERICAN REVIEW OF RESPIRATORY DISEASE Volume: 135 Issue: 6 Pages: 1316-1319; JUN 1987. Times Cited: 90 (from All Databases) 14. Intranasal corticosteroid therapy for obstructive sleep apnoea in patients with co-existing rhinitis. Kiely, JL; Nolan, P; McNicolas, WT THORAX Volume: 59 Issue: 1 Pages: 50-55 Published: JAN 1 2004. Times Cited: 68 (from All Databases) 15. Systemic inflammation: a key factor in the pathogenesis of cardiovascular complications in obstructive sleep apnoea syndrome? Ryan, S.; Taylor, C. T.; McNicholas, W. T. THORAX Volume: 64 Issue: 7 Pages: 631-636 DOI: 10.1136/thx.2008.105577 Published: JUL 2009 Times Cited: 59 (from All Databases) 16. Cardiovascular risk markers in obstructive sleep apnoea syndrome and correlation with obesity. Ryan, Silke; Nolan, Geraldine M.; Hannigan, Evelyn, Cunningham S, Taylor CT, McNicholas Walter T. THORAX Volume: 62 Issue: 6 Pages: 509-514 DOI: 10.1136/thx.2006.066720 Published: JUN 2007 Times Cited: 58 (from All Databases) 17. THEOPHYLLINE IMPROVES GAS-EXCHANGE DURING REST, EXERCISE, AND SLEEP IN SEVERE CHRONIC OBSTRUCTIVE PULMONARY-DISEASE. MULLOY, E; MCNICHOLAS, WT. AMERICAN REVIEW OF RESPIRATORY DISEASE Volume: 148 Issue: 4 Pages: 1030-1036 Published: OCT 1993. Times Cited: 55 (from All Databases) 18. Comparison of a limited computerized diagnostic system (ResCare Autoset(TM)) with polysomnography in the diagnosis of obstructive sleep apnoea syndrome. Kiely, JL; Delahunty, C; Matthews, S, McNicholas WT. EUROPEAN RESPIRATORY JOURNAL Volume: 9 Issue: 11 Pages: 2360-2364 DOI: 10.1183/09031936.96.09112360 Published: NOV 1996. Times Cited: 53 (from All Databases) 19. ABNORMAL RESPIRATORY PATTERN GENERATION DURING SLEEP IN PATIENTS WITH AUTONOMIC DYSFUNCTION. MCNICHOLAS, WT; RUTHERFORD, R; GROSSMAN, R; et al. AMERICAN REVIEW OF RESPIRATORY DISEASE Volume: 128 Issue: 3 Pages: 429-433 Published: 1983. Times Cited: 53 (from All Databases) 20. Ventilation and gas exchange during sleep and exercise in severe COPD. Mulloy, E; McNicholas, WT. CHEST Volume: 109 Issue: 2 Pages: 387-394 DOI: 10.1378/chest.109.2.387 Published: FEB 1996. Times Cited: 51 (from All Databases) 21. NOCTURNAL DEATHS AMONG PATIENTS WITH CHRONIC-BRONCHITIS AND EMPHYSEMA. MCNICHOLAS, WT; FITZGERALD, MX. BRITISH MEDICAL JOURNAL Volume: 289 Issue: 6449 Pages: 878-878 Published: 1984 Times Cited: 50 (from All Databases) 22. Cardiovascular disease in obstructive sleep apnoea syndrome: the role of intermittent hypoxia and inflammation. Garvey, J. F.; Taylor, C. T.; McNicholas, W. T. EUROPEAN RESPIRATORY JOURNAL Volume: 33 Issue: 5 Pages: 1195-1205 DOI: 10.1183/09031936.00111208 Published: MAY 2009. Times Cited: 49 (from All Databases) 23. Long-acting inhaled anticholinergic therapy improves sleeping oxygen saturation in COPD. McNicholas, WT; Calverley, PMA; Lee, A; et al. EUROPEAN RESPIRATORY JOURNAL Volume: 23 Issue: 6 Pages: 825-831 DOI: 10.1183/09031936.04.00085804 Published: JUN 2004 Times Cited: 49 (from All Databases) 24. A critical role for p38 map kinase in NF-kappa B signaling during intermittent hypoxia/reoxygenation. Ryan, Silke; McNicholas, Walter T.; Taylor, Cormac T. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Volume: 355 Issue: 3 Pages: 728-733 DOI: 10.1016/j.bbrc.2007.02.015 Published: APR 13 2007. Times Cited: 44 (from All Databases) 25. Inspiratory flow limitation during sleep in pre-eclampsia: comparison with normal pregnant and nonpregnant women. Connolly, G; Razak, ARA; Hayanga, A; Russell A, McKenna P, McNicholas WT. EUROPEAN RESPIRATORY JOURNAL Volume: 18 Issue: 4 Pages: 672-676 DOI: 10.1183/09031936.01.00053501 Published: OCT 2001 Times Cited: 42 (from All Databases)
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