Centre de Sommeil, Sce d'Explorations Fonctionnell, AP-HP and Denis Diderot University

Sce d'Explorations Fonctionnelles, DHU FIRE

Contact:
Marie-Pia d ORTHO
Position:
Full professor
Address:
46 rue Henri Huchard, 75019
City:
Paris
Country:
France
Phone:
+3340258401
Fax:
+3340258800
Research Domain
Keywords

Laboratory description

Sleep disordered breathing, narcolepsy and hypersomnia, insomnia, sleep and cardiovascular diseases


Technical Capabilities and areas of expertise

7 bed with full video-polysomnography, actigraphy, MSLT, MWT, full video EEG, ambulatory polygraphy


Selected Publications in the 5 past years:

1: Gellen B, Canouï-Poitrine F, Boyer L, Drouot X, Le Thuaut A, Bodez D, Covali-Noroc A, D’ortho MP, Guendouz S, Rappeneau S, Kharoubi M, Dubois-Rande JL, Hittinger L, Adnot S, Bastuji-Garin S, Damy T. Apnea-hypopnea and desaturations in heart failure with reduced ejection fraction: Are we aiming at the right target? Int J Cardiol. 2016 Jan 15;203:1022-8. doi: 10.1016/j.ijcard.2015.11.108. Epub 2015 Nov 18. PubMed PMID: 26630630.

2: Vecchierini MF, Attali V, Collet JM, d’Ortho MP, El Chater P, Kerbrat JB, Leger D, Monaca C, Monteyrol PJ, Morin L, Mullens E, Pigearias B, Meurice JC; ORCADES investigators. A custom-made mandibular repositioning device for obstructive sleep apnoea-hypopnoea syndrome: the ORCADES study. Sleep Med. 2016 Mar;19:131-40. doi: 10.1016/j.sleep.2015.05.020. Epub 2015 Jun 29. PubMed PMID: 26364869.

3: Cowie MR, Woehrle H, Wegscheider K, Angermann C, d’Ortho MP, Erdmann E, Levy P, Simonds AK, Somers VK, Zannad F, Teschler H. Adaptive Servo-Ventilation for Central Sleep Apnea in Systolic Heart Failure. N Engl J Med. 2015 Sep 17;373(12):1095-105. doi: 10.1056/NEJMoa1506459. Epub 2015 Sep 1. PubMed PMID: 26323938; PubMed Central PMCID: PMC4779593.

4: Parisot J, Damy T, Gellen B, Covali-Noroc A, Bodez D, Rappeneau S, Guellich A, Adnot S, Bastuji-Garin S, Hittinger L, d’Ortho MP, Boyer L, Canouï-Poitrine F. Sleep-disordered breathing in chronic heart failure: development and validation of a clinical screening score. Sleep Med. 2015 Sep;16(9):1094-101. doi: 10.1016/j.sleep.2014.11.022. Epub 2015 Mar 30. PubMed PMID: 26298785.

5: Drouot X, Bridoux A, Thille AW, Roche-Campo F, Cordoba-Izquierdo A, Katsahian S, Brochard L, d’Ortho MP. Sleep continuity: a new metric to quantify disrupted hypnograms in non-sedated intensive care unit patients. Crit Care. 2014 Nov 25;18(6):628. doi: 10.1186/s13054-014-0628-4. PubMed PMID: 25420997; PubMed Central PMCID: PMC4271438.

6: Philippe C, Boussadia Y, Prulière-Escabasse V, Papon JF, Clérici C, Isabey D, Coste A, Escudier E, d’Ortho MP. Airway cell involvement in intermittent hypoxia-induced airway inflammation. Sleep Breath. 2015 Mar;19(1):297-306. doi: 10.1007/s11325-014-1019-4. Epub 2014 Jul 4. PubMed PMID: 24993984.

7: Penzel T, Pevernagie D, Dogas Z, Grote L, de Lacy S, Rodenbeck A, Bassetti C, Berg S, Cirignotta F, d’Ortho MP, Garcia-Borreguero D, Levy P, Nobili L, Paiva T, Peigneux P, Pollmächer T, Riemann D, Skene DJ, Zucconi M, Espie C; Sleep Medicine Committee; European Sleep Research Society. Catalogue of knowledge and skills for sleep medicine. J Sleep Res. 2014 Apr;23(2):222-38. doi: 10.1111/jsr.12095. Epub 2013 Oct 7. PubMed PMID: 24118650.

8: Dauvilliers Y, Arnulf I, Lecendreux M, Monaca Charley C, Franco P, Drouot X, d’Ortho MP, Launois S, Lignot S, Bourgin P, Nogues B, Rey M, Bayard S, Scholz S, Lavault S, Tubert-Bitter P, Saussier C, Pariente A; Narcoflu-VF study group. Increased risk of narcolepsy in children and adults after pandemic H1N1 vaccination in France. Brain. 2013 Aug;136(Pt 8):2486-96. doi: 10.1093/brain/awt187. PubMed PMID: 23884811.

9: Bridoux A, Moutereau S, Covali-Noroc A, Margarit L, Palfi S, Nguyen JP, Lefaucheur JP, Césaro P, d’Ortho MP, Drouot X. Ventricular orexin-A (hypocretin-1) levels correlate with rapid-eye-movement sleep without atonia in Parkinson’s disease. Nat Sci Sleep. 2013 Jun 12;5:87-91. doi: 10.2147/NSS.S41245. Print 2013. PubMed PMID: 23847436; PubMed Central PMCID: PMC3704548.

10: Cowie MR, Woehrle H, Wegscheider K, Angermann C, d’Ortho MP, Erdmann E, Levy P, Simonds A, Somers VK, Zannad F, Teschler H. Rationale and design of the SERVE-HF study: treatment of sleep-disordered breathing with predominant central sleep apnoea with adaptive servo-ventilation in patients with chronic heart failure. Eur J Heart Fail. 2013 Aug;15(8):937-43. doi: 10.1093/eurjhf/hft051. Epub 2013 Mar 27. PubMed PMID: 23535165; PubMed Central PMCID: PMC3721574.

11: Roche-Campo F, Thille AW, Drouot X, Galia F, Margarit L, Córdoba-Izquierdo A, Mancebo J, d’Ortho MP, Brochard L. Comparison of sleep quality with mechanical versus spontaneous ventilation during weaning of critically III tracheostomized patients. Crit Care Med. 2013 Jul;41(7):1637-44. doi: 10.1097/CCM.0b013e318287f569. PubMed PMID: 23507721.

12: Damy T, Margarit L, Noroc A, Bodez D, Guendouz S, Boyer L, Drouot X, Lamine A, Paulino A, Rappeneau S, Stoica MH, Dubois-Randé JL, Adnot S, Hittinger L, d’Ortho MP. Prognostic impact of sleep-disordered breathing and its treatment with nocturnal ventilation for chronic heart failure. Eur J Heart Fail. 2012 Sep;14(9):1009-19. doi: 10.1093/eurjhf/hfs085. Epub 2012 Jun 22. PubMed PMID: 22730336.

13: Drouot X, Roche-Campo F, Thille AW, Cabello B, Galia F, Margarit L, d’Ortho MP, Brochard L. A new classification for sleep analysis in critically ill patients. Sleep Med. 2012 Jan;13(1):7-14. doi: 10.1016/j.sleep.2011.07.012. Epub 2011 Dec 6. PubMed PMID: 22153778.

14: Fischer J, Dogas Z, Bassetti CL, Berg S, Grote L, Jennum P, Levy P, Mihaicuta S, Nobili L, Riemann D, Puertas Cuesta FJ, Raschke F, Skene DJ, Stanley N, Pevernagie D; Executive Committee (EC) of the Assembly of the National Sleep Societies (ANSS); Board of the European Sleep Research Society (ESRS), Regensburg, Germany. Standard procedures for adults in accredited sleep medicine centres in Europe. J Sleep Res. 2012 Aug;21(4):357-68. doi: 10.1111/j.1365-2869.2011.00987.x. Epub 2011 Dec 2. PubMed PMID: 22133127.

15: Drouot X, Moutereau S, Lefaucheur JP, Palfi S, Covali-Noroc A, Margarit L, Stoïca-Herman M, Nguyen JP, Césaro P, d’Ortho MP. Low level of ventricular CSF orexin-A is not associated with objective sleepiness in PD. Sleep Med. 2011 Oct;12(9):936-7. doi: 10.1016/j.sleep.2011.08.002. Epub 2011 Oct 5. PubMed PMID: 21978722.

16: Blumen MB, Quera Salva MA, Vaugier I, Leroux K, d’Ortho MP, Barbot F, Chabolle F, Lofaso F. Is snoring intensity responsible for the sleep partner’s poor quality of sleep? Sleep Breath. 2012 Sep;16(3):903-7. doi: 10.1007/s11325-011-0554-5. Epub 2011 Jul 10. PubMed PMID: 21744233.

17: Damy T, Paulino A, Margarit L, Drouot X, Stoica M, Vermes E, Gueret P, Adnot S, Rande JL, D’Ortho MP, Hittinger L. Left ventricle remodelling is associated with sleep-disordered breathing in non-ischaemic cardiopathy with systolic dysfunction. J Sleep Res. 2011 Mar;20(1 Pt 1):101-9. doi: 10.1111/j.1365-2869.2009.00817.x. PubMed PMID: 20408922.

18: Roche Campo F, Drouot X, Thille AW, Galia F, Cabello B, d’Ortho MP, Brochard L. Poor sleep quality is associated with late noninvasive ventilation failure in patients with acute hypercapnic respiratory failure. Crit Care Med. 2010 Feb;38(2):477-85. doi: 10.1097/CCM.0b013e3181bc8243. PubMed PMID: 19789439.

19: Damy T, D’Ortho MP, Estrugo B, Margarit L, Mouillet G, Mahfoud M, Roudot-Thoraval F, Vermes E, Hittinger L, Roche F, Macquin-Mavier I. Heart rate increment analysis is not effective for sleep-disordered breathing screening in patients with chronic heart failure. J Sleep Res. 2010 Mar;19(1 Pt 2):131-8. doi: 10.1111/j.1365-2869.2009.00779.x. Epub 2009 Aug 31. PubMed PMID: 19732315.


Key Publications of the Laboratory:

Vecchierini MF, Attali V, Collet JM, d’Ortho MP, El Chater P, Kerbrat JB, Leger D, Monaca C, Monteyrol PJ, Morin L, Mullens E, Pigearias B, Meurice JC; ORCADES investigators. A custom-made mandibular repositioning device for obstructive sleep apnoea-hypopnoea syndrome: the ORCADES study. Sleep Med. 2016 Mar;19:131-40. doi: 10.1016/j.sleep.2015.05.020. Epub 2015 Jun 29. PubMed

Cowie MR, Woehrle H, Wegscheider K, Angermann C, d’Ortho MP, Erdmann E, Levy P, Simonds AK, Somers VK, Zannad F, Teschler H. Adaptive Servo-Ventilation for Central Sleep Apnea in Systolic Heart Failure. N Engl J Med. 2015 Sep 17;373(12):1095-105. doi: 10.1056/NEJMoa1506459. Epub 2015 Sep 1. PubMed PMID:
26323938; PubMed Central PMCID: PMC4779593.

Drouot X, Bridoux A, Thille AW, Roche-Campo F, Cordoba-Izquierdo A, Katsahian S, Brochard L, d’Ortho MP. Sleep continuity: a new metric to quantify disrupted hypnograms in non-sedated intensive care unit patients. Crit Care. 2014 Nov 25;18(6):628. doi: 10.1186/s13054-014-0628-4. PubMed PMID: 25420997; PubMed
Central PMCID: PMC4271438.

Penzel T, Pevernagie D, Dogas Z, Grote L, de Lacy S, Rodenbeck A, Bassetti C, Berg S, Cirignotta F, d’Ortho MP, Garcia-Borreguero D, Levy P, Nobili L, Paiva T,Peigneux P, Pollmächer T, Riemann D, Skene DJ, Zucconi M, Espie C; Sleep Medicine Committee; European Sleep Research Society. Catalogue of knowledge and skills for sleep medicine. J Sleep Res. 2014 Apr;23(2):222-38. doi: 10.1111/jsr.12095. Epub
2013 Oct 7. PubMed PMID: 24118650.

Damy T, Margarit L, Noroc A, Bodez D, Guendouz S, Boyer L, Drouot X, Lamine A, Paulino A, Rappeneau S, Stoica MH, Dubois-Randé JL, Adnot S, Hittinger L,d’Ortho MP. Prognostic impact of sleep-disordered breathing and its treatment with nocturnal ventilation for chronic heart failure. Eur J Heart Fail. 2012 Sep;14(9):1009-19. doi: 10.1093/eurjhf/hfs085. Epub 2012 Jun 22.


Other laboratory Members

Title:  MD

Name:  Anny Rouvel

Position:  senior practionar

Email:  anny.rouvel@aphp.fr

Title:  MD

Name:  Helene Benzaquen

Position:  Senior practionar

Email:  helene.benzaquen@aphp.fr

Title:  PhD MD

Name:  Justine Frija

Position:  junior lecturer

Email:  justine.frija@aphp.fr


Past Members

Title:  PhD MD

Name:  Francoise Goldenberg

Position:  Senior lecturer

Email:  francoise.goldenberg@aphp.fr

Title:  MD

Name:  Cyril Chaufton

Position:  Junior practionar

Email:  cyril.chaufton@aphp.fr

© 2019 European Sleep Research Society. All rights reserved.
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