Oivauni Sleep Clinic

Sleep Clinic

Contact:
Henri Tuomilehto
Position:
medical director
Address:
Puijonkatu 12B and Pyhäjärvenkatu 5A, 70100
City:
Kuopio And Tampere
Country:
Finland
Phone:
+358447300001
Research Domain
Keywords
Current Announcements

Oivauni Sleep Clinic (EU-validated non-profit research entity, PIC 961156414) from Finland will be responsible for providing sleep part of the upcoming “Sleep disorders and diabetes in Europe-the effect of lifestyle intervention with weight reduction”-project. The study is a multi-centre trial (22 centres in 17 European countries) based on EU-funded Early Prevention of Diabetes Complications in Europe (ePREDICE)-study and will commence in the summer 2012.


Laboratory description

Oivauni Sleep Clinic (EU-validated non-profit research entity, PIC 961156414) from Finland, will be responsible for providing sleep recording devices, training for all the clinical study centers and perform all the analyses of the sleep recordings regarding the upcoming “Sleep disorders and diabetes in Europe-the effect of lifestyle intervention with weight reduction”-project. Associate professor Henri Tuomilehto is a specialist of sleep medicine and the medical director of Sleep Clinic Oivauni and also principal investigator for the sleep part of the study. The study is a multi-centre trial (22 centres in 17 European countries) based on EU-funded Early Prevention of Diabetes Complications in Europe (ePREDICE)-study and will commence in the summer 2012. This is an innovative investigator initiated, non-commercial, clinical trial. The study is an interventional, long-term (5-year), randomised, open-label, lifestyle-controlled, four parallel groups trial with a total sample size of 3.000 individuals. Complete assessments (as at baseline) will be repeated at months 36th and 60th, including assessments of sleep (including nocturnal cardio-respiratory recordings). The primary aim of the proposal is to assess the effect of 3-year treatment with liraglutide, sitagliptine or metformin plus lifestyle intervention (diet and exercise), compared to lifestyle intervention alone, with a follow-up up to 5 years as a treatment of OSA and RLS in people with different degrees of hyperglycaemia. The proposal also aims to determine the impact of co-existing OSA and RLS in the likelihood of developing both micro- (biomarkers, endothelial function, intima-media thickness) and macrovascular (cardiovascular diseases, retinopathy) complications among people with hyperglycaemia, and further to identify the possible underlying mechanisms causing the association between OSA, RLS and hyperglycaemia.


Technical Capabilities and areas of expertise

The Oivauni Sleep Clinic is a sleep medicine laboratory that meets international standards (including in-laboratory polysomnographies, cardiorespiratory recordings, actigraphs). In addition to identifying and treating sleep disorders, the staff at Oivauni Sleep Clinic consists of sleep medicine specialists who also possess extensive experience in the scientific research of sleep disorders. The main interest of research at Oivauni is focused on sleep disordered breathing (SDB) and in more detail examining the association between SDB and metabolism. The laboratory has also been actively involved in epidemiological research regarding sleep duration and diabetes. Furthermore, research on restless legs syndrome has recently been commenced.


Additional Descriptors, Keywords

Sleep disordered breathing, restless legs syndrome, sleep duration, type 2 diabetes, cardiovascular diseases, metabolism, lifestyle intervention


Selected Publications in the 5 past years:

1. Blomster H, Kemppainen T, Numminen J, Ruoppi P, Sahlman J, Seppä J, Tuomilehto H. Impaired nasal breathing may prevent the beneficial effect of weight loss in the treatment of OSA. (Accepted for publication in Rhinology)

2. Tuomilehto H. Lifestyle intervention should be included in the treatment of all overweight patients with obstructive sleep apnoea. Evidence Based Medicine 2011 Sep 6. [Epub ahead of print]

3. Pahkala R, Puustinen R, Tuomilehto H, Ahlberg J, Seppä J. Pathogenesis of sleep disordered breathing- the role of craniofacial structure. Acta Odontol Scand. 2011;3:137-43.

4. Tuomilehto H, Gylling H, Peltonen M, Martikainen T, Sahlman J, Kokkarinen J, Randell J, Tukiainen H, Vanninen E, Partinen M, Tuomilehto J, Uusitupa M, Seppä J. Sustained improvement in mild obstructive sleep apnea by diet and physical activity based lifestyle intervention- post-interventional follow-up. Am J Clin Nutr 2010;92:688-692.

5. Sahlman J, Herder C Seppä J, Peltonen M, Peuhkurinen K, Gylling H, Vanninen E, Tukiainen H, Partinen M, Uusitupa M, Tuomilehto H. Effect of lifestyle intervention on inflammation in patients with mild obstructive sleep apnoea. Nutr Metab Cardiovasc Dis. 2010 Dec 28. [Epub ahead of print]

6. Sahlman J, Peltonen M, Miettinen K, Punnonen K, Peuhkurinen K, Vanninen E, Tuomilehto H. Activation of inflammatory cytokine system in mild obstructive sleep apnea. J Sleep Res. 2010 Jun 1;19(2):341-348.

7. Tuomilehto H, Peltonen M, Partinen M, Lavigne G, Eriksson JG, Aunola S, Keinänen-Kiukaanniemi S, Ilanne-Parikka P, Uusitupa M, Tuomilehto J, Lindström J. On the behalf of the Finnish Diabetes Prevention Study Group. Sleep duration, lifestyle intervention and incidence of type 2 diabetes in impaired glucose tolerance. The Finnish Diabetes Prevention Study. Diabetes Care. 2009 Nov;32(11):1965-71.

8. Tuomilehto H, Seppä J, Partinen M, Peltonen M, Gylling H, Tuomilehto J, Vanninen E, Kokkarinen J, Sahlman J, Martikainen T, Randell J, Tukiainen H, Uusitupa M. Lifestyle Intervention with Weight Reduction-First Line Treatment in Mild Obstructive Sleep Apnea. Am J Respir Crit Care Med 2009 Feb 15;179(4):320-7.

9. Tiihonen P, Hukkanen T, Tuomilehto H, Mervaala E, Töyräs J. Evaluation of a novel ambulatory device for screening of sleep apnea. Telemed J E Health. 2009 Apr;15(3):283-9.

10. Tiihonen P, Hukkanen T, Tuomilehto H, Mervaala E, Pääkkönen A, Töyräs J. Accuracy of automatic analysis of ambulatory recordings of nocturnal breathing disorders is significantly instrumentation dependent. J Med Eng Technol. 2009 Apr 16:1-8.

11. Sahlman J, Seppä J, Peltonen M, Pukkila M, Partinen M, Tuomilehto H. Surgical intervention represents a feasible option for patients with mild obstructive sleep apnoea. Acta Otolaryngol. 2009 Nov;129(11):1266-73

12. Tuomilehto H, Seppä J, Gylling H, Uusitupa M. Obstruktiivinen uniapnea ja lihavuus – elämäntapamuutokset ensisijainen hoitomuoto. Pääkirjoitus, Duodecim 2009;125(9):931-34. Editorial, in Finnish language

13. Kemppainen T, Ruoppi P, Seppä J, Sahlman J, Tukiainen H, Gylling H, Vanninen E, Tuomilehto H. Effect of weight loss program on rhinometric measurements in overweight patients with OSA. Am J Rhinol 2008;22(4):410-415.

14. Tuomilehto H, Peltonen M, Partinen M, Seppä J, Timo Saaristo, Eeva Korpi-Hyövälti, Heikki Oksa, Juha Saltevo, Hannu Puolijoki, Mauno Vanhala, Jaakko Tuomilehto. Sleep duration is associated with an increased risk for the prevalence of type 2 diabetes in middle-aged women – the FIN-D2D survey. Sleep Medicine 2008;9(3):221-227.

15. Tuomilehto H, Peltonen M, Partinen M, Seppä J, Timo Saaristo, Eeva Korpi-Hyövälti, Heikki Oksa, Juha Saltevo, Hannu Puolijoki, Mauno Vanhala, Jaakko Tuomilehto. Sleep-disordered breathing is related to an increased risk for type 2 diabetes in middle-aged men, but not in women – the FIN D2D-survey. Diabetes Obes Metab. 2008;10(6):468-475.

16. Sahlman JO, Pukkila M, Seppä J, Tuomilehto H. Evolution of mild obstructive sleep apnea after different treatments. Laryngoscope 2007;117:1107-1111.


Key Publications of the Laboratory:

1. Tuomilehto H, Peltonen M, Partinen M, Seppä J, Timo Saaristo, Eeva Korpi-Hyövälti, Heikki Oksa, Juha Saltevo, Hannu Puolijoki, Mauno Vanhala, Jaakko Tuomilehto. Sleep duration is associated with an increased risk for the prevalence of type 2 diabetes in middle-aged women – the FIN-D2D survey. Sleep Medicine 2008;9(3):221-227.

2. Tuomilehto H, Peltonen M, Partinen M, Seppä J, Timo Saaristo, Eeva Korpi-Hyövälti, Heikki Oksa, Juha Saltevo, Hannu Puolijoki, Mauno Vanhala, Jaakko Tuomilehto. Sleep-disordered breathing is related to an increased risk for type 2 diabetes in middle-aged men, but not in women – the FIN D2D-survey. Diabetes Obes Metab. 2008;10(6):468-475.

3. Tuomilehto H, Peltonen M, Partinen M, Lavigne G, Eriksson JG, Aunola S, Keinänen-Kiukaanniemi S, Ilanne-Parikka P, Uusitupa M, Tuomilehto J, Lindström J. On the behalf of the Finnish Diabetes Prevention Study Group. Sleep duration, lifestyle intervention and incidence of type 2 diabetes in impaired glucose tolerance. The Finnish Diabetes Prevention Study. Diabetes Care. 2009 Nov;32(11):1965-71.

4. Tuomilehto H, Seppä J, Partinen M, Peltonen M, Gylling H, Tuomilehto J, Vanninen E, Kokkarinen J, Sahlman J, Martikainen T, Randell J, Tukiainen H, Uusitupa M. Lifestyle Intervention with Weight Reduction-First Line Treatment in Mild Obstructive Sleep Apnea. Am J Respir Crit Care Med 2009 Feb 15;179(4):320-7.

5. Tuomilehto H, Gylling H, Peltonen M, Martikainen T, Sahlman J, Kokkarinen J, Randell J, Tukiainen H, Vanninen E, Partinen M, Tuomilehto J, Uusitupa M, Seppä J. Sustained improvement in mild obstructive sleep apnea by diet and physical activity based lifestyle intervention- post-interventional follow-up. Am J Clin Nutr 2010;92:688-692.

6. Sahlman J, Herder C Seppä J, Peltonen M, Peuhkurinen K, Gylling H, Vanninen E, Tukiainen H, Partinen M, Uusitupa M, Tuomilehto H. Effect of lifestyle intervention on inflammation in patients with mild obstructive sleep apnoea. Nutr Metab Cardiovasc Dis. 2010 Dec 28. [Epub ahead of print]

8. Sahlman J, Peltonen M, Miettinen K, Punnonen K, Peuhkurinen K, Vanninen E, Tuomilehto H. Activation of inflammatory cytokine system in mild obstructive sleep apnea. J Sleep Res. 2010 Jun 1;19(2):341-348.


Current/Completed Grants (past 5 years):

Academy of Finland 2008-10
Finnish Cultural Foundation 2008-2010
Paulo Foundation 2008-2011
Juho Vainio Foundation 2005-2011
EVO-funding of Kuopio University hospital 2009-2014
EU-funding (FP7-HEALTH-2011-stage2) 2012-2016


Other laboratory Members

Title:  PhD MD

Name:  Grigori Smirnov

Position:  physician

Email:  grigori.smirnov@oivauni.fi

Title:  PhD MD

Name:  Markku Peltonen

Position:  statistician

Email:  markku.peltonen@thl.fi


Collaborations

Title:  PhD MD

Name:  Markku Partinen

Position:  associate professor

Institution:  Helsinki Sleep Clinic

Title:  PhD MD

Name:  Matti Uusitupa

Position:  professor

Institution:  University of Eastern Finland

Title:  PhD MD

Name:  Rafael Gabriel

Position:  professor

Institution:  Fundación para la Investigación Biomedica del Hospital Universitario La Paz, Madrid, Spain

Title:  PhD MD

Name:  Jaakko Tuomilehto

Position:  professor

Institution:  Research Unit of Spanish National Network of Cardiovascular Research, Madrid, Spain.

Title:  PhD MD

Name:  Christian Herder

Position:  associate professor

Institution:  Heinrich Heine University Düsseldorf, German Diabetes Center, Germany

Title:  PhD MD

Name:  Juha Hartikainen

Position:  professor

Institution:  Kuopio University hospital

Title:  PhD MD

Name:  Jari Ahlberg

Position:  associate professor

Institution:  University of Helsinki, Dental Faculty

Title:  PhD MD

Name:  Frank Lobbezoo

Position:  professor

Institution:  Department of Oral Kinesiology, Academic Centre for Dentistry Amsterdam

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