Sleep research in psychiatry, University of Bern

University Hospital of Psychiatry and Psychotherapy

Christoph Nissen
Chief physician, research group leader
Bolligenstr. 111
Research Domain
  • Clinical
  • Basic Human
  • Sleep and Psychiatry-Personality Disorders
  • Behavioural Sleep Disorders
  • Sleep Physiology-Neurophysiology in Human
  • Learning, Memory, Cognition
Current Announcements

Please refer to the website for ongoing activities.

Laboratory description

Sleep and mental health are highly interrelated. The overarching aim of our research is to investigate and modulate sleep to contribute to the understanding of the pathophysiology and to the development of new treatments of mental disorders.

Key Publications of the Laboratory:
Please note that most of the work has been conducted by the Nissen group at the University of Freiburg, Germany. C. Nissen moved to Bern, Switzerland, in 2017.

Maier JG, Kuhn M, Mainberger F, Nachtsheim K, Guo S, Bucsenez U, Feige B,
Mikutta C, Spiegelhalder K, Klöppel S, Normann C, Riemann D, Nissen C. Sleep
orchestrates indices of local plasticity and global network stability in the
human cortex. Sleep. 2019 Apr 1;42(4). pii: zsy263. doi: 10.1093/sleep/zsy263.
PubMed PMID: 30590809.

Kuhn M, Mainberger F, Feige B, Maier JG, Mall V, Jung NH, Reis J, Klöppel S,
Normann C, Nissen C. State-Dependent Partial Occlusion of Cortical LTP-Like
Plasticity in Major Depression. Neuropsychopharmacology. 2016 Oct;41(11):2794.
doi: 10.1038/npp.2016.97. PubMed PMID: 27609501; PubMed Central PMCID:

Kuhn M, Wolf E, Maier JG, Mainberger F, Feige B, Schmid H, Bürklin J, Maywald
S, Mall V, Jung NH, Reis J, Spiegelhalder K, Klöppel S, Sterr A, Eckert A,
Riemann D, Normann C, Nissen C. Sleep recalibrates homeostatic and associative
synaptic plasticity in the human cortex. Nat Commun. 2016 Aug 23;7:12455. doi:
10.1038/ncomms12455. PubMed PMID: 27551934; PubMed Central PMCID: PMC4996971.

Frase L, Piosczyk H, Zittel S, Jahn F, Selhausen P, Krone L, Feige B,
Mainberger F, Maier JG, Kuhn M, Klöppel S, Normann C, Sterr A, Spiegelhalder K,
Riemann D, Nitsche MA, Nissen C. Modulation of Total Sleep Time by Transcranial
Direct Current Stimulation (tDCS). Neuropsychopharmacology. 2016
Sep;41(10):2577-86. doi: 10.1038/npp.2016.65. Epub 2016 May 4. PubMed PMID:
27143601; PubMed Central PMCID: PMC4987856.

Krone L, Frase L, Piosczyk H, Selhausen P, Zittel S, Jahn F, Kuhn M, Feige B,
Mainberger F, Klöppel S, Riemann D, Spiegelhalder K, Baglioni C, Sterr A, Nissen
C. Top-down control of arousal and sleep: Fundamentals and clinical implications.
Sleep Med Rev. 2017 Feb;31:17-24. doi: 10.1016/j.smrv.2015.12.005. Epub 2016 Jan
14. Review. PubMed PMID: 26883160.

Wolf E, Kuhn M, Normann C, Mainberger F, Maier JG, Maywald S, Bredl A,
Klöppel S, Biber K, van Calker D, Riemann D, Sterr A, Nissen C. Synaptic
plasticity model of therapeutic sleep deprivation in major depression. Sleep Med
Rev. 2016 Dec;30:53-62. doi: 10.1016/j.smrv.2015.11.003. Epub 2015 Nov 30.
Review. PubMed PMID: 26803484.



Title:  PhD

Name:  Dieter Riemann

Title:  MD

Name:  Claudio Bassetti

Title:  PhD

Name:  Antoine Admantidis

© 2021 European Sleep Research Society.
All rights reserved.
October 21st, 2021