The sleep laboratory at the University Hospital of Geneva has as the main mission the diagnosis and treatment of sleep disorders.
The current research projects concern insomnia and excessive daytime sleepiness, by studying oscillatory neuronal activity.
The main techniques used for projects are EEG devices and psycho-physiological tools.
Technical Capabilities and areas of expertise
The sleep laboratory has the infrastructure for clinical and research polysomnographic studies. In addition it has EEG devices for clinical and research (high resolution EEG).
The laboratory team has developed expertise on imaging, and EEG signal processing.
Additional Descriptors, Keywords
Attention, aging, depression, sleep apnea.
Selected Publications in the 5 past years:
1 Perrig S, Espa-Cervena K, Pépin J-L. [Sleep disorder and pain: the good hypnotic]. Rev Med Suisse 2011;7:1414–8–1420.
2 Perogamvros L, Baud P, Hasler R, Cloninger CR, Schwartz S, Perrig S. Active Reward Processing during Human Sleep: Insights from Sleep-Related Eating Disorder. Front Neurol 2012;3:168.
3 Adler D, Perrig S, Takahashi H, Espa F, Rodenstein D, Pépin J-L, et al. Polysomnography in stable COPD under non-invasive ventilation to reduce patient-ventilator asynchrony and morning breathlessness. Sleep & Breathing = Schlaf & Atmung 2012;16:1081–90.
4 Contal O, Adler D, Borel J-C, Espa F, Perrig S, Rodenstein D, et al. Impact of different backup respiratory rates on the efficacy of noninvasive positive pressure ventilation in obesity hypoventilation syndrome: a randomized trial. Chest 2013;143:37–46.
5 Perogamvros L, Leemann B, Perrig S, Schnider A. Sleep paralysis in Parkinson’s disease. Parkinsonism Relat Disord 2013;19:273–4.
6 Deiber M-P, Ibañez V, Missonnier P, Rodriguez C, Giannakopoulos P. Age-associated modulations of cerebral oscillatory patterns related to attention control. Neuroimage 2013;82:531–46.
7 Cervena K, Espa F, Perogamvros L, Perrig S, Merica H, Ibañez V. Spectral analysis of the sleep onset period in primary insomnia. Clin Neurophysiol 2014;125:979–87.
8 Contal O, Pépin J-L, Borel J-C, Espa F, Perrig S, Lücker L-M, et al. Underlying Mechanisms for Coexisting Central and Obstructive Sleep Apnea: Nocturnal PaCO2 and Poor Sleep Quality Are Key Issues. Respiration 2015;89:416–9.
9 Perogamvros L, Aberg K, Gex-Fabry M, Perrig S, Cloninger CR, Schwartz S. Increased Reward-Related Behaviors during Sleep and Wakefulness in Sleepwalking and Idiopathic Nightmares. PLoS ONE 2015.
10 Georges M, Adler D, Contal O, Espa F, Perrig S, Pépin J-L, et al. Reliability of Apnea-Hypopnea Index Measured by a Home Bi-Level Pressure Support Ventilator Versus a Polysomnographic Assessment. Respir Care 2015;60:1051–6.
11 Bayer L, Constantinescu I, Perrig S, Vienne J, Vidal P-P, Muhlethaler M, et al. Rocking synchronizes brain waves during a short nap. Curr Biol 2011;21:R461–2.
12 Perogamvros L, Pépin J-L, Thorens G, Mégevand P, Claudel E, Espa F, et al. Baclofen-Associated Onset of Central Sleep Apnea in Alcohol Use Disorder: A Case Report. Respiration 2015;90:507–11.
Key Publications of the Laboratory:
1 Sforza E., Jouny C., Ibanez V. Time-dependent variation in cerebral and autonomic activity during periodic leg movements in sleep: implications for arousal mechanisms. Clin Neurophysiol 2002; 113: 883-891.
2 Sforza E, Jouny C, Ibanez V. Time course of arousal response during periodic leg movements in patients with periodic leg movements and restless legs syndrome. Clin Neurophysiol 2003;114:1116–24.
3 Lavoie S., De Bilbao F., Haba-rubio J., Ibanez V., Sforza E.. Influence of sleep stage and wakefulness on spectral EEG activity and heart rate variations around periodic leg movements. Clinical Neurophysiol. 2004; 115, 2236-2246.
4 Haba-Rubio J, Janssens J-P, Rochat T, Sforza E. Rapid eye movement-related disordered breathing: clinical and polysomnographic features. Chest 2005;128:3350–7.
5 Sforza E, Pichot V, Cervena K, Barthélémy J-C, Roche F. Cardiac variability and heart-rate increment as a marker of sleep fragmentation in patients with a sleep disorder: a preliminary study. Sleep 2007;30:43–51.
6 Cervena K, Espa F, Perogamvros L, Perrig S, Merica H, Ibañez V. Spectral analysis of the sleep onset period in primary insomnia. Clin Neurophysiol 2014;125:979–87.
7 Perogamvros L, Pépin J-L, Thorens G, Mégevand P, Claudel E, Espa F, et al. Baclofen-Associated Onset of Central Sleep Apnea in Alcohol Use Disorder: A Case Report. Respiration 2015;90:507–11.
Current/Completed Grants (past 5 years):
FNRS (swiss national research founding) N° : 320030_149695 (2014-2016). “ Interference of excessive daytime sleepiness with cerebral attention networks.” 404’297 CHF. PI: Dr. Ibanez (Current Grant)
FNRS Décision IZ74Z0_137415. (2011-2014). “ Knowledge Based Partnership for Development of Sleep Medecine Research Platform and Promotion of sleep science in Georgia”. PI: Dr. Katerina Espa-Cervena.
Other laboratory Members
Name: Katerina ESPA-CERVENA
Position: Physician (psychiatrist)
Name: Stephen PERRIG
Position: Physician (neurologist)
Name: Laurence Bayer
Position: Research senior
Name: Dan ADLER
Position: physician (pneumologist)
Name: Jean-Louis Pepin
Position: physician (pneumologist)
Institution: University Hospital of Grenoble
Name: Natalie Darchia
Position: Professor, Research senior
Institution: University of Georgia
Name: Emilia Sforza
Name: Jose Haba-Rubio