Sleep Disorders Unit, Dept of Thoracic Medicine, U, Medical School/ University of Crete, Greece

Thoracic Medicine/ Medical School

Contact:
Sophia E Schiza
Position:
Assistant Professor of Thoracic Medicine
Address:
Voutes/1352, 71110
City:
Heraklion, Crete
Country:
Greece
Phone:
+30 2810 392433
Fax:
+30 2810 542650
Contact E-mail:
Research Domain
  • Clinical
  • Basic Human
Keywords
  • Molecular Biology-Endocrinology-Biochemistry
  • Sleep and Medical Disorders
  • Epidemiology of Sleep

Laboratory description

Domain research areas are: a)cardiological consequences of sleep breathing disorders (oxidative stress, endothelial dysfunction, inflamation), b) erectile dysfunction in patients with sleep breathing disorders, c) mechanisms affecting sleep in patients hospitalized in Acute Coronary Units, d) influence of sex and aging in diagnosis, natural history and in the cardiological consequences in patients with sleep breathing disorders, e) the role of Mediterranean diet and exercise as an adjuntive therapy in sleep apnea patients, particulary in inflamatory response, f) idiopathic fibrosis and sleep apnea, incidence, pathogenetic mechanisms and treatment adherence


Technical Capabilities and areas of expertise

Six full PSG, 2 portable, 2 EtCO2, 4 oximeters, 1 NPT
Full time operating CPAP Clinic
In conjuction with our Molecular Biology departement we perform inflamatory markers analysis, PCR as well as mRNA extraction


Selected Publications in the 5 past years:

1.Effect of Mediterranean diet on lipid peroxidation marker TBARS in obese patients with OSAHS under CPAP treatment: a randomised trial.Papandreou C, Schiza SE, Tzatzarakis MN, Kavalakis M, Hatzis CM, Tsatsakis AM, Kafatos AG, Siafakas NM, Tzanakis NE. Sleep Breath. 2011 Sep 15
2.CRP evolution pattern in CPAP-treated obstructive sleep apnea patients. Does gender play a role? Mermigkis D, Kallergis E, Mavroudi E, Varouchakis G, Tzortzaki E, Siafakas N, Schiza SE. Sleep Breath. 2011 Sep 1
3.C-reactive protein evolution in obstructive sleep apnoea patients under CPAP therapy.Schiza SE, Mermigkis C, Panagiotis P, Bouloukaki I, Kallergis E, Tzanakis N, Tzortzaki E, Vlachaki E, Siafakas NM. Eur J Clin Invest. 2010 Nov;40(11):968-75
4.Evidence of dysregulated affect indicated by high alexithymia in obstructive sleep apnea. Nikolaou A, Schiza SE, Chatzi L, Koudas V, Fokos S, Solidaki E, Bitsios P. J Sleep Res. 2011 Mar;20(1 Pt 1):92-100
5.Sleep patterns in patients with acute coronary syndromes.
Schiza SE, Simantirakis E, Bouloukaki I, Mermigkis C, Arfanakis D, Chrysostomakis S, Chlouverakis G, Kallergis EM, Vardas P, Siafakas NM.Sleep Med. 2010 Feb;11(2):149-53
6.Sleep-disordered breathing in heart failure and the effect of cardiac resynchronization therapy. Simantirakis EN, Schiza SE, Siafakas NS, Vardas PE. Europace. 2008 Sep;10(9):1029-33
7.Prediction of obstructive sleep apnea syndrome in a large Greek population. Bouloukaki I, Kapsimalis F, Mermigkis C, Kryger M, Tzanakis N, Panagou P, Moniaki V, Vlachaki EM, Varouchakis G, Siafakas NM, Schiza SE. Sleep Breath. 2010 Sep 25
8.Gluteal adipose-tissue polyunsaturated fatty-acids profiles and depressive symptoms in obese adults with obstructive sleep apnea hypopnea syndrome: a cross-sectional study.Papandreou C, Schiza SE, Tsibinos G, Mermigkis C, Hatzis CM, Kafatos AG, Siafakas NM, Fragkiadakis GA, Tzanakis NE. Pharmacol Biochem Behav. 2011 Apr;98(2):316-9
9. Utility of formulas predicting the optimal nasal continuous positive airway pressure in a Greek population. Schiza SE, Bouloukaki I, Mermigkis C, Panagou P, Tzanakis N, Moniaki V, Tzortzaki E, Siafakas NM. Sleep Breath. 2011 Sep;15(3):417-23
10. The 5-min pupillary alertness test is sensitive to modafinil: a placebo controlled study in patients with sleep apnea.
Nikolaou A, Schiza SE, Giakoumaki SG, Roussos P, Siafakas N, Bitsios P. Psychopharmacology (Berl). 2008 Feb;196(2):167-75
11. Atrial overdrive pacing for the obstructive sleep apnea-hypopnea syndrome. Simantirakis EN, Schiza SE, Chrysostomakis SI, Chlouverakis GI, Klapsinos NC, Siafakas NM, Vardas PE. N Engl J Med. 2005 Dec 15;353(24):2568-77
12. CPAP treatment in patients with idiopathic pulmonary fibrosis and obstructive sleep apnea-therapeutic difficulties and dilemmas.
Mermigkis C, Mermigkis D, Varouchakis G, Schiza S.
Sleep Breath. 2011 Jan 9


Key Publications of the Laboratory:

1. Atrial overdrive pacing for the obstructive sleep apnea-hypopnea syndrome. Simantirakis EN, Schiza SE, Chrysostomakis SI, Chlouverakis GI, Klapsinos NC, Siafakas NM, Vardas PE. N Engl J Med. 2005 Dec 15;353(24):2568-77
2. C-reactive protein evolution in obstructive sleep apnoea patients under CPAP therapy.Schiza SE, Mermigkis C, Panagiotis P, Bouloukaki I, Kallergis E, Tzanakis N, Tzortzaki E, Vlachaki E, Siafakas NM. Eur J Clin Invest. 2010 Nov;40(11):968-75
3. Evidence of dysregulated affect indicated by high alexithymia in obstructive sleep apnea. Nikolaou A, Schiza SE, Chatzi L, Koudas V, Fokos S, Solidaki E, Bitsios P.
J Sleep Res. 2011 Mar;20(1 Pt 1):92-100
4. Utility of formulas predicting the optimal nasal continuous positive airway pressure in a Greek population.
Schiza SE, Bouloukaki I, Mermigkis C, Panagou P, Tzanakis N, Moniaki V, Tzortzaki E, Siafakas NM. Sleep Breath. 2011 Sep;15(3):417-23
5.Pupil miosis within 5 minutes in darkness is a valid and sensitive quantitative measure of alertness: application in daytime sleepiness associated with sleep apnea. Bitsios P, Schiza SE, Giakoumaki SG, Savidou K, Alegakis AK, Siafakas N. Sleep. 2006 Nov;29(11):1482-8
6. Sleep patterns in patients with acute coronary syndromes.
Schiza SE, Simantirakis E, Bouloukaki I, Mermigkis C, Arfanakis D, Chrysostomakis S, Chlouverakis G, Kallergis EM, Vardas P, Siafakas NM. Sleep Med. 2010 Feb;11(2):149-53
7. Prediction of obstructive sleep apnea syndrome in a large Greek population. Bouloukaki I, Kapsimalis F, Mermigkis C, Kryger M, Tzanakis N, Panagou P, Moniaki V, Vlachaki EM, Varouchakis G, Siafakas NM, Schiza SE. Sleep Breath. 2010 Sep 25
8. Severe bradyarrhythmias in patients with sleep apnoea: the effect of continuous positive airway pressure treatment: a long-term evaluation using an insertable loop recorder. Simantirakis EN, Schiza SI, Marketou ME, Chrysostomakis SI, Chlouverakis GI, Klapsinos NC, Siafakas NS, Vardas PE. Eur Heart J. 2004 Jun;25(12):1070-6
9. Effect of Mediterranean diet on lipid peroxidation marker TBARS in obese patients with OSAHS under CPAP treatment: a randomised trial. Papandreou C, Schiza SE, Tzatzarakis MN, Kavalakis M, Hatzis CM, Tsatsakis AM, Kafatos AG, Siafakas NM, Tzanakis NE. Sleep Breath. 2011 Sep 15
10. CRP evolution pattern in CPAP-treated obstructive sleep apnea patients. Does gender play a role? Mermigkis C, Bouloukaki I, Mermigkis D, Kallergis E, Mavroudi E, Varouchakis G, Tzortzaki E, Siafakas N, Schiza SE. Sleep Breath. 2011 Sep 1


Other laboratory Members

Title:  BSc

Name:  Dimitrios Manios

Position:  Sleep Technician

Email:  bageraman@yahoo.gr

Title:  BSc

Name:  Eleni Mauroudi

Position:  Sleep Technician

Email:  elenima23@hotmail.com

Title:  BSc

Name:  Violeta Moniaki

Position:  Sleep Technician

Email:  vmoniaki@yahoo.gr

Title:  PhD MD

Name:  Izolthi Bouloukaki

Position:  Consultant

Email:  izolthi@gmail.com

Title:  BSc

Name:  Ioanna Fanouraki

Position:  Sleep Technician

Email:  gianna@gmail.com

Title:  PhD MD

Name:  Nikolaos M Siafakas

Position:  Professor of Thoracic Medicine, Head of Dept of Thoracic Medicine

Email:  pneumon@med.uoc.r


Collaborations

Title:  PhD MD

Name:  Nikos Tzanakis

Position:  Associate Professore of Epidemiology

Institution:  Medical School, University of Crete, Greece

Title:  PhD MD

Name:  Eleni Tzortzaki

Position:  Assistant Professor of Thoracic Medicine

Institution:  Dept of Molecular Biology, dept of Thoracic Medicine, University of Crete, Greece

Title:  PhD MD

Name:  Eleutherios M Kallergis

Position:  Consultant of Cardiology and Arrythiology Dept

Institution:  Cardiology Departement, University Hospital of Heraklion, Crete, Greece

Title:  PhD MD

Name:  Emmanuel Simantirakis

Position:  Assistant Professor of Cardiology

Institution:  Cardiology dept, University Hospital of Heraclion, Crete, Greece

Title:  PhD MD

Name:  Charalampos Mermigkis

Position:  Head of Sleep Disorders Unit

Institution:  401 Military Hospital, Athens


Past Members

Title:  PhD MD

Name:  Elina Vlachaki

Position:  Consultant

Email:  elina@otenet.gr

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