CPAP Effects on Energy Expenditure, Intake, Hormonal Regulation, and Body Composition: A Randomized Trial
Dr. Pei-Lin Lee
Serves as Clinical Associate Professor, School of Medicine, National Taiwan University; Director, Sleep Disorders Center, National Taiwan University Hospital Hsin-Chu Branch; Consultant, Center of Sleep Disorder, National Taiwan University Hospital. Her current research focuses on the era of new technology and big data in sleep medicine; and intervention on sleep and cardiometabolism in sleep disordered breathing.
CPAP effect on energy balance, hormone, and body composition
The physiological basis and clinical relevance of weight gain following CPAP therapy remain insufficiently defined. This study found that CPAP-induced weight gain was probably primarily due to increases in fat-free mass, with no measurable changes in resting energy expenditure, physical activity, or significant increases in reported caloric intake. Given the potential underestimation in dietary reporting, the observed gain—together with hormonal and behavioural changes—suggests a subtle positive energy balance. These findings indicate that post-CPAP weight gain may not reflect adverse metabolic effects and highlight the value of assessing body composition, rather than weight alone, in clinical follow-up.
Resources:
Pei-Lin Lee, Meng-Yueh Chien, Shang-Ru Lai, Joshua J Gooley, Hsin-Chun Feng, Shih-Kuo Chen, Ming-Tzer Lin, Yung-Hsuan Chen, Hung-Chih Chiu, Po-Kang Liu, Bo-Wen Ku, Su-Mei Wang, Chin-Hao Chang, Wei-Shiung Yang, Chong-Jen Yu (2026), Continuous positive airway pressure effects on energy expenditure, intake, hormonal regulation, and body composition: a randomized trial, Sleep
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