Sleep Apnea Network / European Sleep Apnea Database – ESADA

The ESADA study was started as a joint project within the European Union COST action B26 network of nationally appointed sleep apnea experts in 2007. To date (January 2021) there are 39 contributing and 29 actively recruiting centers across Europe and data from in excess of 34 000 patients with close to 55 000 visits have been entered so far. Current and past ESADA collaborators are listed below. Since 2016, the ESADA has been supported from the European Respiratory Society through Clinical Research Collaboration (CRC) grants.

The ESADA serves as a reference database on European sleep apnea patients and current research is focused on the identification of specific sleep apnea phenotypes and longitudinal treatment outcomes. Thirty scientific communications based on the data assembled by the ESADA network have been published so far (see listing below). The ESADA also serves as a bridge for education and knowledge transfer between the various participating centers. There are ongoing efforts to generate collaborative ties between ESADA and other large European databases in sleep apnea research. The ESADA is a strong partner with 24 participating centers in the EU funded SLEEP REVOLUTION project.

Publications

Publications of the ESADA group

2020

  • M. Wächter, J.W. Kantelhardt, M.R. Bonsignore, I. Bouloukaki, P. Escourrou, I. Fietze, L. Grote, D. Korzybski, C. Lombardi, O. Marrone, I. Paranicova, A. Pataka, S. Ryan, S. Schiza, P. Sliwinski, P. Steiropoulos, J. Verbraecken, T. Penzel, ESADA Study Group. Unique sleep-stage transitions determined by obstructive sleep apnea severity, age and gender. J Sleep Research 2020 Apr;29(2):e12895.
  • Grote L, McNicholas WT, Hedner J; ESADA collaborators. Sleep apnoea management in Europe during the COVID-19 pandemic: data from the European Sleep Apnoea Database (ESADA). Eur Respir J. 2020;55(6):2001323. Published 2020 Jun 18. doi:10.1183/13993003.01323-2020.
  • Marrone O, Cibella F, Roisman G, et al. Effects of sleep apnea and kidney dysfunction on objective sleep quality in non-dialyzed patients with chronic kidney disease: an ESADA study. J Clin Sleep Med. 2020;10.5664/jcsm.8542.
  • Bouloukaki I, Grote L, McNicholas WT, et al. Mild obstructive sleep apnea increases hypertension risk, challenging traditional severity classification. J Clin Sleep Med. 2020;16(6):889-898. doi:10.5664/jcsm.8354
  • Gunduz C, Basoglu OK, Kvamme JA, Verbraecken J, Anttalainen U, Marrone O, Steiropoulos P, Roisman G, Joppa P, Hein H, Trakada G, Hedner J, Grote L. Long-term positive airway pressure therapy is associated with reduced total cholesterol levels in patients with obstructive sleep apnea: data from the European Sleep Apnea Database (ESADA.) Sleep Medicine 2020; 75: 201-209
  • Svedmyr S, Hedner J, Zou D, Parati G, Ryan S, Hein H, Pepin JL, Tkacova R, Marrone O, Schiza S, Basoglu O, Grote L: Superior hypertension control with betablockade in the European Sleep Apnea Database. J Hypertension. 2020.
  • Bailly S, Grote L, Hedner J, Schiza S, McNicholas WT, Basoglu OK, Lombardi C, Dogas Z, Roisman G, Pataka A, Bonsignore MR, Pepin JL: Clusters of sleep apnoea phenotypes: A European perspective study from the ESADA database. Respirology 2020
  • Pengo M, Faini A, Grote L, Ludka L, Joppa P, Pataka A, Dogas Z, Mihaicuta S, Hein H, Anttalainen U, Ryan S, Lombardi C, and Parati G. Impact of sleep apnea on cardioembolic risk in patients with atrial fibrillation: data from the ESADA cohort. Stroke. 2020
  • Riha R, Kotoulas SC, Pataka A, Kvamme JA, Joppa P, Hedner J. Obstructive Sleep Apnoea in adult atients post-tonsillectomy. Sleep Medicine
  • W. Randerath, S. Herkenrath, M. Treml, L. Grote, J. Hedner, M. R. Bonsignore, J. L. Pépin, S. Ryan, S. Schiza, J. Verbraecken, W. T. McNicholas, A. Pataka, P. Sliwinski, OK Basoglu. Evaluation of a multicomponent grading system (Baveno classification) for obstructive sleep apnoea. ERJ Open. 2021, in press.

2019

  • Dieltjens M, Verbraecken JA, Hedner J,  Vanderveken JM,  Steiropoulos P, Kvamme JA, Saaresranta T, Tkacova R, Marrone O, Dogas Z, Schiza S,  Grote L; The Clinical Global Impression in OSA is Influenced by Gender and Age -  Results from the ESADA Database. ESADA network. Sleep Med. 2019 Jul;59:56-65. doi: 10.1016/j.sleep.2018.10.028. Epub 2018 Nov.
  • Marrone O, Cibella F, Pépin JL, Grote L, Verbraecken J, Saaresranta T, Kvamme JA, Basoglu OK, Lombardi C, McNicholas WT, Hedner J, Bonsignore MR. Comment to the Editorial by KS Park and EW Kang "Is only fixed positive airway pressure a robust tool for kidney protection in patients with obstructive sleep apnea?" JThorac Dis. 2019 Mar;11(Suppl 3):S480-S482.
  • Pataka A, Bonsignore MR, Ryan S, Riha RL, Pepin JL, Schiza S, Basoglu OK, Sliwinski P, Ludka O, Steiropoulos P, Anttalainen U, McNicholas WT, Hedner J, Grote. OSA and cancer prevalence – data from the ESADA study. ERJ. 2019, 20 June: 53(6). pii: 1900091. doi: 10.1183/13993003. 00091-2019.
  • Gunduz C, Basoglu OK, Hedner J, et al. Hyperlipidaemia prevalence and cholesterol control in obstructive sleep apnoea: Data from the European sleep apnea database (ESADA). J Intern Med. 2019;286(6):676-688. doi:10.1111/joim.12952
  • Penzel T. Use of large patient registries in sleep apnea patients - Results from the ESADA database. Sleep Med. 2019;59:66. doi:10.1016/j.sleep.2019.01.002
  • Lombardi C, Parati G, Soranna D, et al. Periodic limb movements during sleep and blood pressure changes in sleep apnoea: Data from the European Sleep Apnoea Database. Respirology. 2019;10.1111/resp.13760.
  • Anttalainen U, Grote L, Fietze I, et al. Insomnia symptoms combined with nocturnal hypoxia associate with cardiovascular comorbidity in the European sleep apnea cohort (ESADA). Sleep Breath. 2019;23(3):805-814. doi:10.1007/s11325-018-1757-9 

2018

  • Marrone O, Cibella F, Pépin JL, Grote L, Verbraecken J, Saaresranta T, Kvamme JA, Basoglu OK, Lombardi C, McNicholas WT, Hedner J, Bonsignore MR; ESADA Network. Fixed But Not Autoadjusting Positive Airway Pressure Attenuates the Time-dependent Decline in Glomerular Filtration Rate in Patients With OSA. Chest. 2018: S0012-3692(18)30634-2. doi: 10.1016/j.chest.2018.04.020. PubMed PMID: 29698721.
  • Basoglu OK, Zou D, Tasbakan MS, Hedner J, Ryan S, Verbraecken J, Escourrou P, Antalainen U, Kvamme JA, Bonsignore MR, Schiza S, Grote L; ESADA Study Group. Change in weight and central obesity by positive airway pressure treatment in obstructive sleep apnea patients: longitudinal data from the ESADA cohort. J Sleep Res. 2018 May 24:e12705. doi: 10.1111/jsr.12705. PubMed PMID: 29797754.
  • Maria R. Bonsignore, Jean-Louis Pepin, Ulla Anttalainen, Sophia E. Schiza, Ozen K. Basoglu, Athanasia Pataka, Paschalis Steiropoulos, Zoran Dogas, Ludger Grote, Jan Hedner, Walter T. McNicholas, Oreste Marrone: Clinical presentation of patients with suspected OSA and self-reported physician-diagnosed asthma in the ESADA cohort. J Sleep Research 2018. Jul 11:e12729. doi: 10.1111/jsr.12729
  • Canan Gunduz, Ozen K. Basoglu, Jan Hedner, Ding Zou, Maria R Bonsignore, Holger Hein, Richard Staats, Athanasia Pataka, Ferran Barbe, Pavel Sliwinski, Brian D. Kent, Jean Lois Pepin, Ludger Grote : Obstructive Sleep Apnea independently predicts lipid levels: Data from the European Sleep Apnea Database (ESADA). Respirology 2018, in press.

2016

  • Marrone O, Battaglia S, Steiropoulos P, Basoglu OK, Kvamme JA, Ryan S, Pepin JL, Verbraecken J, Grote L, Hedner J, Bonsignore MR; ESADA study group. Chronic kidney disease in European patients with obstructive sleep apnea: the ESADA cohort study. J Sleep Res. 2016 Dec;25(6):739-745. doi: 10.1111/jsr.12426. PubMed PMID: 27191365.
  • Saaresranta T, Hedner J, Bonsignore MR, Riha RL, McNicholas WT, Penzel T, Anttalainen U, Kvamme JA, Pretl M, Sliwinski P, Verbraecken J, Grote L; ESADA Study Group. Clinical Phenotypes and Comorbidity in European Sleep Apnoea Patients. PLoS One. 2016 Oct 4;11(10):e0163439. doi: 10.1371/journal.pone.0163439.PubMed PMID: 27701416.

2015

  • Escourrou P, Grote L, Penzel T, Mcnicholas WT, Verbraecken J, Tkacova R, Riha RL, Hedner J; ESADA Study Group. The diagnostic method has a strong influence on classification of obstructive sleep apnea. J Sleep Res. 2015 Dec;24(6):730-8. doi: 10.1111/jsr.12318. Epub 2015 Aug 14. PubMed PMID: 26511017.

2014

  • Karimi M, Hedner J, Lombardi C, Mcnicholas WT, Penzel T, Riha RL, Rodenstein D, Grote L; Esada Study Group. Driving habits and risk factors for traffic accidents among sleep apnea patients--a European multi-centre cohort study. J Sleep Res. 2014 Dec;23(6):689-699. doi: 10.1111/jsr.12171. PubMed PMID: 25040185.
  • Kent BD, Grote L, Ryan S, Pépin JL, Bonsignore MR, Tkacova R, Saaresranta T, Verbraecken J, Lévy P, Hedner J, McNicholas WT. Diabetes mellitus prevalence and control in sleep-disordered breathing: the European Sleep Apnea Cohort (ESADA) study. Chest. 2014 Oct;146(4):982-990. doi: 10.1378/chest.13-2403. PubMed PMID: 24831859.
  • Kent BD, Grote L, Bonsignore MR, Saaresranta T, Verbraecken J, Lévy P, Sliwinski P, Tkacova R, Kvamme JA, Fietze I, Hedner J, McNicholas WT; European Sleep Apnoea Database collaborators. Sleep apnoea severity independently predicts glycaemic health in nondiabetic subjects: the ESADA study. Eur Respir J. 2014 Jul;44(1):130-9. doi: 10.1183/09031936.00162713. PubMed PMID: 24696120.
  • Tkacova R, McNicholas WT, Javorsky M, Fietze I, Sliwinski P, Parati G, Grote L, Hedner J; European Sleep Apnoea Database study collaborators. Nocturnal intermittent hypoxia predicts prevalent hypertension in the European Sleep Apnoea Database cohort study. Eur Respir J. 2014 Oct;44(4):931-41. doi: 10.1183/09031936.00225113. PubMed PMID: 25102963.

2011

  • Hedner J, Grote L, Bonsignore M, McNicholas W, Lavie P, Parati G, Sliwinski P, Barbé F, De Backer W, Escourrou P, Fietze I, Kvamme JA, Lombardi C, Marrone O, Masa JF, Montserrat JM, Penzel T, Pretl M, Riha R, Rodenstein D, Saaresranta T, Schulz R, Tkacova R, Varoneckas G, Vitols A, Vrints H, Zielinski J. The European Sleep Apnoea Database (ESADA): report from 22 European sleep laboratories. Eur Respir J. 2011 Sep;38(3):635-42. doi: 10.1183/09031936.00046710.

Publications of the COST Action B26

  • Parati G, Lombardi C, Hedner J, Bonsignore MR, Grote L, Tkacova R, Lévy P, Riha R, Bassetti C, Narkiewicz K, Mancia G, McNicholas WT; EU COST Action B26 members. Recommendations for the management of patients with obstructive sleep apnoea and hypertension. Eur Respir J. 2013 Mar;41(3):523-38. doi: 10.1183/09031936.00226711. PubMed PMID: 23397300.
  • Parati G, Lombardi C, Hedner J, Bonsignore MR, Grote L, Tkacova R, Levy P, Riha R, Bassetti C, Narkiewicz K, Mancia G, McNicholas WT; European Respiratory Society; EU COST ACTION B26 members. Position paper on the management of patients with obstructive sleep apnea and hypertension: joint recommendations by the European Society of Hypertension, by the European Respiratory Society and by the members of European COST (COoperation in Scientific and Technological research) ACTION B26 on obstructive sleep apnea. J Hypertens. 2012 Apr;30(4):633-46. doi: 10.1097/HJH.0b013e328350e53b. PubMed PMID: 22406463.
  • Bonsignore MR, McNicholas WT, Montserrat JM, Eckel J. Adipose tissue inobesity and obstructive sleep apnoea. Eur Respir J. 2012 Mar;39(3):746-67. doi: 10.1183/09031936.00047010. Review. PubMed PMID: 21920888.
  • Fietze I, Penzel T, Alonderis A, Barbe F, Bonsignore MR, Calverly P, De Backer W, Diefenbach K, Donic V, Eijsvogel MM, Franklin KA, Gislason T, Grote L, Hedner J, Jennum P, Lavie L, Lavie P, Levy P, Lombardi C, Mallin W, Marrone O,Montserrat JM, Papathanasiou ES, Parati G, Plywaczewski R, Pretl M, Riha RL, Rodenstein D, Saaresranta T, Schulz R, Sliwinski P, Steiropoulos P, Svaza J, Tomori Z, Tonnesen P, Varoneckas G, Verbraecken J, Vesely J, Vitols A, Zielinski J, McNicholas WT; COST Action B26 Group. Management of obstructive sleep apnea in Europe. Sleep Med. 2011 Feb;12(2):190-7. doi: 10.1016/j.sleep.2010.10.003.PubMed PMID: 21167776.
  • Rodenstein D; Cost-B26 Action on Sleep Apnoea Syndrome. Driving in Europe: the need of a common policy for drivers with obstructive sleep apnoea syndrome. J Sleep Res. 2008 Sep;17(3):281-4. doi: 10.1111/j.1365-2869.2008.00669.x. Epub 2008 Jul 22. PubMed PMID: 18651866.
  • Riha RL, Diefenbach K, Jennum P, McNicholas WT; Management Committee, COST B26 Action on Sleep Apnoea Syndrome. Genetic aspects of hypertension and metabolic disease in the obstructive sleep apnoea-hypopnoea syndrome. Sleep Med Rev. 2008 Feb;12(1):49-63. doi: 10.1016/j.smrv.2007.08.004. Review. PubMed PMID: 18201663.
  • McNicholas WT, Bonsigore MR; Management Committee of EU COST ACTION B26. Sleep apnoea as an independent risk factor for cardiovascular disease: current evidence, basic mechanisms and research priorities. Eur Respir J. 2007 Jan;29(1):156-78. Review. Mar;29(3):614.PubMed PMID: 17197482.

Collaborators in the ESADA project (current and past)

  1. Alexandroupolis, Greece
  • Steiropoulos P, Sleep Unit, Department of Pneumonology, Democritus University of Thrace, Alexandroupolis, Greece
  1. Antwerp, Belgium
  • Verbraecken J, Multidisciplinary Sleep Disorders Centre, Antwerp University Hospital and University of Antwerp, Antwerp, Belgium
  • Petiet E, Multidisciplinary Sleep Disorders Centre, Antwerp University Hospital and University of Antwerp, Antwerp, Belgium
  1. Athens, Greece
  1. Barcelona, Spain (inactive)
  • Montserrat JM, Hospital Clinic i Provincial de Barcelona, Barcelona, IDIBAPS Barcelona and CIBERes, Madrid, Spain
  1. Berlin, Germany
  • Fietze I, Schlafmedizinisches Zentrum, Charité – Universitätsmedizin Berlin, Germany
  • Penzel T, Schlafmedizinisches Zentrum, Charité – Universitätsmedizin Berlin, Germany
  • Naima Laharnar, Schlafmedizinisches Zentrum, Charité – Universitätsmedizin Berlin, Germany
  1. Brno, Czech Republic
  • Ondrej Ludka, Department of Cardiology, University Hospital Brno and International Clinical Research Center, St. Ann´s University Hospital, Brno, Czech Republic
  1. Brussels, Belgium (inactive)
  1. Caeceres, Spain (inactive)
  • Masa JF, Hospital San Pedro de Alcàntara, Cáceres, Spain
  1. Crete, Greece
  • Bouloukaki I. Sleep Disorders Unit, Department of Respiratory Medicine, Medical School, University of Crete, Greece
  • Schiza S, Sleep Disorders Unit, Department of Respiratory Medicine, Medical School, University of Crete, Greece
  1. Dublin, Ireland
  • Kent B, Guy's and St Thomas' NHS Foundation Trust , Guy's Hospital, London, UK
  • McNicholas WT, Department of Respiratory Medicine, St. Vincent´s University Hospital, Dublin, Ireland
  • Ryan S, Pulmonary and SleepDisorders Unit, St. Vincent’sUniversityHospital, Dublin, Ireland
  1. Edinburgh, United Kingdom
  • Riha RL, Department of Sleep Medicine, Royal Infirmary Edinburgh, Scotland
  1. Förde, Norway
  • Kvamme JA, Sleep Laboratory, ENT Department, Førde Central Hospital, Førde, Norway
  1. Giessen, Germany (inactive)
  • Schulz R, Sleep Disorders Centre, University of Giessen, Lung Centre, Giessen, Germany
  1. Gothenburg, Sweden
  • Ding Zou, Sleep Disorders Center, Pulmonary Department, Sahlgrenska University Hospital, and Center of Sleep and Wake Disorders, Sahlgrenska Academy, Gothenburg University, Göteborg, Sweden
  • Grote L, Sleep Disorders Center, Pulmonary Department, Sahlgrenska University Hospital, and Center of Sleep and Wake Disorders, Sahlgrenska Academy, Gothenburg University, Göteborg, Sweden
  • Hedner J, Sleep Disorders Center, Pulmonary Department, Sahlgrenska University Hospital, and Center of Sleep and Wake Disorders, Sahlgrenska Academy, Gothenburg University, Göteborg, Sweden
  1. Grenoble, France
  • Pépin JL, Université Grenoble Alpes, INSERM HP2 (U1042) and Grenoble University Hospital, Grenoble, France
  • Levy P, Université Grenoble Alpes, INSERM HP2 (U1042) and Grenoble University Hospital, Grenoble, France
  • Bailly S, Université Grenoble Alpes, INSERM HP2 (U1042) and Grenoble University Hospital, Grenoble, France
  1. Haifa, Israel (inactive)
  • Lena Lavie and Peretz Lavie, Centre for Sleep Medicine, Technion Institute of Technology, Haifa, Israel
  1. Hamburg, Germany
  • Hein H, Sleep Disorders Center, St. Adolf Stift, Reinbeck, Germany
  1. Izmir, Turkey
  • Basoglu OK, Department of Chest Diseases, Ege University, Izmir, Turkey
  • Tasbakan MS, Department of Chest Diseases, Ege University, Izmir, Turkey
  1. Klapeida, Lithuania (inactive)
  • Varoneckas G, Institute Psychophysiology and Rehabilitation, Palanga, Lithuania
  1. Klecany, Czech Republic
  • Buskova J, Department of Sleep Medicine, National Institute of Mental Health, Klecany, Czech Republic
  1. Kosice, Slovakia
  • Joppa P, Department of Respiratory Medicine and Tuberculosis, Faculty of Medicine, P.J.Safarik University and L. Pasteur University Hospital, Kosice, Slovakia
  • Tkacova R, Department of Respiratory Medicine and Tuberculosis, Faculty of Medicine, P.J.Safarik University and L. Pasteur University Hospital, Kosice, Slovakia
  1. Lisbon, Portugal
  • Staats R, Department of Respiratory Medicine, Hospital de Santa Maria, Lisbon, Portugal
  1. Leuven, Belgium
  • Dries Testelmans, Sleep Disorders Centre, University Hospital Gasthuisberg, Leuven, Belgium
  1. Lleida, Spain (inactive)
  • Barbé F, Servei Pneumologia  Hospital Arnau de Vilanova and Hospital Santa Maria, Lleida, and CIBERes, Madrid,  Spain

   25. Mainz, Germany

  • Haralampos Gouveris, ENT department at Mainz University Hospital, Mainz, Germany
  1. Milano, Italy
  • Lombardi C, Istituto Auxologico Italiano, IRCCS, Department of Cardiovascular, Neural and Metabolic Sciences, St. Luke Hospital, Milan  &  Department of Medicine and Surgery; University of Milano-Bicocca, Milan, Italy.
  • Parati G, Istituto Auxologico Italiano, IRCCS, Department of Cardiovascular, Neural and Metabolic Sciences, St. Luke Hospital, Milan  &  Department of Medicine and Surgery; University of Milano-Bicocca, Milan, Italy.
  1. Palermo, Italy
  • Bonsignore MR, PROMISE Dept., University of Palermo, Palermo, Italy
  • Marrone O, CNR Istituto per la Ricerca e l'Innovazione Biomedica, Palermo, Italy

  1. Pavia, Italy
  • Francesco Fanfulla, Unità Operativa di Medicina del Sonno, Istituto Scientifico di Pavia IRCCS, Pavia, Italy
  1. Paris, France
  • Escourrou P, Service dÉxplorations Fonctionnelles Multidisciplinaires Hospital Antoine Beclere, Clamart, France
  • Petitjean M, Unité de Médecine du Sommeil, Hopital Antoine-Beclere, Clamart, France
  • Roisman G, Unité de Médecine du Sommeil, Hopital Antoine-Beclere, Clamart, France
  1. Porto, Portugal
  • Marta Drummond, Pulmonology Department Hospital São João, Medicine Faculty of Porto University, Porto, Portugal
  • Mafalda van Zeller, Pulmonology Department Hospital São João, Medicine Faculty of Porto University, Porto, Portugal
  1. Prague, Czech Republic (inactive)
  • Pretl M,Centre for Sleep and Waking Disorders, Department of Neurology, First Faculty of Medicine, Charles University, Prague, and Inspamed, Neurology and Sleep Laboratory, Prague, Czech Republic
  1. Riga, Latvia (inactive)
  • Vitols A, Institute of Cardiology, University of Latvia, Riga, Latvia
  1. Solingen, Germany
  • Simon Herkenrath, Sleep Disorders Centre, Pulmonary Clinic, Solingen, Germany
  • Winfried Randerath, Sleep Disorders Centre, Pulmonary Clinic, Solingen, Germany
  1. Split, Croatia
  • Dogas Z, Sleep Medicine Center, Department of Neuroscience, University of Split School of Medicine, Split, Croatia
  • Galic, T, Sleep Medicine Center, Department of Neuroscience, University of Split School of Medicine, Split, Croatia
  1. Thessaloniki, Greece
  • Pataka A, Respiratory Failure Unit, G. Papanikolaou Hospital, Thessalonika, Greece
  1. Timisoara, Rumania
  • Stefan Mihaicuta, Pulmonary Department, Victor Babes University of Medicine and Pharmacy, Victor Babes Hospital, Timisoara, Rumania
  1. Turku, Finland
  • Anttalainen U, Division of Medicine, Department of Pulmonary Diseases, Turku University Hospital and Sleep Research Centre, Department of Pulmonary Diseases and Clinical Allergology, University of Turku, Finland
  • Saaresranta T, Division of Medicine, Department of Pulmonary Diseases, Turku University Hospital and Sleep Research Centre, Department of Pulmonary Diseases and Clinical Allergology, University of Turku, Finland

Warsaw, Poland

  • 38. Institute of Tuberculosis and Lung Diseases
    Sliwinski P, 2nd Department of Respiratory Medicine, Institute of Tuberculosis and Lung Diseases, Warsaw, Poland
  • Plywaczewski R, 2nd Department of Respiratory Medicine, Institute of Tuberculosis and Lung Diseases, Warsaw, Poland

  1. Medical University of Warzaw (inactive)
  • Bielicki P, Department of Internal Medicine, Pneumonology and Allergology, Medical University of Warsaw, Warsaw, Poland

 

Centers with start-up process:

ENT department at Mainz University, Germany and Pulmonary Department, University Hospital, Istanbul, Turkey

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