Helsinki Sleep Clinic – Vitalmed Research Centre

Helsinki Sleep Clinic - Vitalmed Research Centre

Helsinki Sleep Clinic and Research Centre

Helsinki Sleep Clinic

Contact: Markku  
Position: Research Director, Adj. Prof
Address: Sitratori 3, 00420
City: Helsinki
Country: Finland
Contact Email: Contact laboratory
RESEARCH DOMAIN: Methodology / Technology, Clinical, Basic Human
KEYWORDS: Pharmacology Human, Behavioural Sleep Disorders, Paediatric Sleep Disorders, Biological Rhythms, Epidemiology of Sleep, Pharmacology of Sleep, Genetics of Sleep, Sleep and Medical Disorders, Instrumentation-Methodology, Neurological Sleep Disorders


Laboratory Description:

The Helsinki Sleep Clinic has two floors including five bedrooms equipped with telemetric Somnomedics digital devices (DOMINO software). Infrared video is used. Other equipments include Cambridge Neurotech and Somnowatch actigraphies and continuous blood pressure and HRV measurements. The Finnish Narcolepsy Research Centre is situated at the Clinic and we are coordinating the narcolepsy NARPA studies in a Finnish-Swedish consortium. Other members of the consortium include the Biomedicum and Haartman institutes of the Helsinki University, the Finnish Institute for Health and Welfare (THL), and the Karolinska Institutet in Sweden. The research areas include: narcolepsy, sleep apnea, restless legs, RBD, epidemiological sleep research together with the Finnish Twin Registry and molecular biological studies together with the researcher at THL. Currently there is a core group of eight researchers

Additional Descriptors, Keywords:

parasomnias, nocturnal epilepsy, autonomic nervous system, continuous blood pressure, childhood narcolepsy, clinical trials, ambulatory monitoring, developing of new recording methods

KEY Publications of the Laboratory:

1. Partinen M, Kaprio J, Koskenvuo M, Putkonen PTS, Langinvainio H. Genetic and environmental determination of human sleep. Sleep 1983;6:179-185.

2. Koskenvuo M, Kaprio J, Partinen M, Langinvainio H, Sarna S, Heikkilä K. Snoring as a risk factor for hypertension and angina pectoris. Lancet 1985;1:893-896.

3. Partinen M, Palomäki H. Snoring and cerebral infarction. Lancet 1985;ii:1325-1326.

4. Telakivi T, Partinen M, Salmi T, Leinonen L, Härkönen T. Nocturnal periodic breathing in adults with Down’s syndrome. J Ment Def Res 1987;31:31-39.

5. Koskenvuo M, Kaprio J, Telakivi T, Partinen M, Heikkilä K, Sarna S. Snoring as a risk factor for ischaemic heart disease and stroke in men. Br Med J 1987;294:16-19.

6. Pekkarinen T, Partinen M, Pelkonen R, Iivanainen M. Sleep apnoea and daytime sleepiness in acromegaly: relationship to endocrinological factors. Clinical Endocrinology 1987;27:649-654.

7. Palomäki H, Partinen M, Juvela S, Kaste M. Snoring as a risk factor for sleep-related brain infarction. Stroke 1989; 20: 1311-1315.

8. Partinen M, Guilleminault C. Daytime sleepiness and vascular morbidity at seven-year follow-up in obstructive sleep apnea patients. Chest 1990; 97: 27-32.

9. Seppälä T, Partinen M, Penttilä A, Aspholm R, Tiainen E, Kaukiainen A. Sudden death and sleeping history among Finnish men. J Int Med 1991; 229: 23-28.

10. Partinen M, Telakivi T, Kaukiainen A, Salmi T, Färkkilä M, Saijonmaa O, Fyhrquist F. Atrial natriuretic peptide in habitual snorers. Ann Med 1991; 23: 147-151.

11. Palomäki H, Partinen M, Erkinjuntti T, Kaste M. Snoring, sleep apnea syndrome and stroke. Neurology 1992; 42 (6): 75-82.

12. Tiihonen M, Partinen M, Närvänen S. The severity of obstructive sleep apnoea is associated with insulin resistance. J Sleep Res 1993; 2: 56-61.

13. Hublin C, Kaprio J, Partinen M, Koskenvuo M, Heikkilä K. The Ullanlinna Narcolepsy Scale: validation of a measure of symptoms in the narcoleptic syndrome. J Sleep Res 1994; 3: 52-59.

14. Hublin C, Kaprio J, Partinen M, Koskenvuo M, Heikkilä K, Koskimies S, Guilleminault C. The prevalence of narcolepsy: an epidemiologic study of the Finnish narcolepsy cohort. Ann Neurol 1994; 35: 709-716.

15. Partinen M, Gislason T. Basic nordic sleep questionnaire (BNSQ): a quantitated measure of subjective sleep complaints. J Sleep Res 1995; 4 (Suppl 1): 150-155.

16. Kajaste S, Telakivi T, Mustajoki P, Pihl S, Partinen M. Effects of a cognitive-behavioural programme on overweight in obstructive sleep apnoea. J Sleep Res 1994; 3: 245-249.

17. Rinne JO, Hublin C, Partinen M, Ruottinen H, Ruotsalainen U, Någren K, Lehikoinen P, Laihinen A. Positron emission tomography study of human narcolepsy: no increase in striatal dopamine D2-receptors. Neurology, 1995; 45: 1735-1738.

18. Hublin C, Kaprio J, Partinen M, Heikkilä K, Koskenvuo M. Prevalence and genetics of sleepwalking: a population-based twin study. Neurology 1997; 48: 177-181.

19. Ruottinen HM, Partinen M, Hublin C, Bergman J, Haaparanta M, Solin O, Rinne JO. An FDOPA PET study in patients with periodic limb movement disorder and restless legs syndrome. Neurology 2000; 54: 502-504.

20. Kajaste S, Brander P, Telakivi T, Partinen M, Mustajoki P. A cognitive-behavioral weight reduction program in the treatment of obstructive sleep apnea syndrome with or without initial nasal CPAP: a randomized study. Sleep Med 2004; 5: 125-131.

21. Porthan KM, Melin JH, Kupila JT, Venho KK, Partinen MM. Prevalence of sleep apnea syndrome in lone atrial fibrillation: a case-control study. Chest 2004;125(3): 879-85.

22. Hublin C, Partinen M, Koskenvuo M, Kaprio J. Sleep and mortality: a population-based 22- year follow-up study. Sleep 2007, 30 (10): 1245-1253.

23. Paunio T, Korhonen T, Hublin C, Partinen M, Kivimaki M, Koskenvuo M, et al. Longitudinal study on poor sleep and life dissatisfaction in a nationwide cohort of twins. Am J Epidemiol. 2009;169(2):206-13.

24. Nohynek H, Jokinen J, Partinen M, Vaarala O, Kirjavainen T, Sundman J, et al. AS03 adjuvanted AH1N1 vaccine associated with an abrupt increase in the incidence of childhood narcolepsy in Finland. PLoS ONE. 2012;PONE-D-11-23379R1, 1035-44.

25. Partinen M, Saarenpää-Heikkilä O, Ilveskoski I, Hublin C, Linna M, Olsén P, et al. Increased incidence and clinical picture of childhood narcolepsy observed after the 2009 H1N1 pandemic vaccination campaign in Finland Plos ONE. 2012;7 (3): e33723. doi: 10.137/journal.pone.0033723.