ESADA Network – Summary on a Productive and Successful Year 2018

Published in ESRS Newsletter December 2018

The ESADA network has had a productive and successful year 2018. A number of topics listed below are hopefully of interest for ESRS members and the scientific community engaged in sleep apnea management and research.

I.    Publications from the ESADA study group 2018

  1. Fixed But Not Autoadjusting Positive Airway Pressure Attenuates the Time-dependent Decline in Glomerular Filtration Rate in Patients With OSA. Marrone O, Cibella F, Pépin JL, Grote L, Verbraecken J, Saaresranta T, Kvamme JA, Basoglu OK, Lombardi C, McNicholas WT, Hedner J, Bonsignore MR; ESADA Network. Chest. 2018.
  2. Change in weight and central obesity by positive airway pressure treatment in obstructive sleep apnea patients: longitudinal data from the ESADA cohort. Basoglu OK, Zou D, Tasbakan MS, Hedner J, Ryan S, Verbraecken J, Escourrou P, Antalainen U, Kvamme JA, Bonsignore MR, Schiza S, Grote L; ESADA Study Group. J Sleep Res. 2018
  3. Clinical presentation of patients  with suspected OSA and self-reported physician-diagnosed asthma in the ESADA cohort. Maria R. Bonsignore, Jean-Louis Pepin, Ulla Anttalainen, Sophia E. Schiza, Ozen K. Basoglu,  Athanasia Pataka, Paschalis Steiropoulos, Zoran Dogas, Ludger Grote, Jan Hedner,  Walter T. McNicholas, Oreste Marrone. J Sleep Research 2018.
  4. Obstructive Sleep Apnea independently predicts lipid levels: Data from the European Sleep Apnea  Database (ESADA). Canan Gunduz, Ozen K. Basoglu, Jan Hedner, Ding Zou, Maria R Bonsignore, Holger Hein, Richard Staats, Athanasia Pataka, Ferran Barbe, Pavel Sliwinski, Brian D. Kent, Jean Lois Pepin, Ludger Grote : Respirology 2018.
  5. Use of the Clinical Global Impression Scale in Sleep Apnea Patients – Results from the ESADA Database. Marijke Dieltjens, Johan A. Verbraecken, Jan Hedner, Olivier M. Vanderveken, Paschalis Steiropoulos, John A. Kvamme, Tarja Saaresranta, Ruzena Tkacova, Oreste Marrone, Zoran Dogas, Sofia Schiza, Ludger Grote.Sleep Medicine 2018 (in press).
  6. Insomnia symptoms combined with nocturnal hypoxia associate with cardiovascular comorbidity in the European sleep apnoea cohort (ESADA). Ulla Anttalainen, Ludger Grote; Ingo Fietze; Renata Riha; Silke Ryan; Richard Staats; Jan Hedner; Tarja Saaresranta. Sleep and Breathing 2018 (in press).
  7. The European Sleep Apnoea Database ESADA: ERS Clinical Research Collaboration: past, present and future. Bonsignore MR, Hedner J. Eur Respir J. 2018.

II.    ESADA Scientific Workshop Meeting on “Big data in OSA”
Palermo, Italy; July 6-7, 2018 

Short summary
A two-day meeting has been organized in Palermo by the ERS Clinical Research Collaboration: European Sleep Apnea DAtabase (ESADA) consortium, to address the topic of “Big Data in Obstructive Sleep Apnea”. We agreed on policies and common scientific projects for merging sleep apnea cohorts and databases from FRANCE, ITALY, GERMANY, SWEDEN, GREECE, BELGIUM and ROMANIA. We expect from this European dataset of more than 150,000 OSA patients a gain in knowledge regarding clusters of phenotypes, regional and gender variations and impact of environmental factors. Artificial intelligence will be used for developing predictive algorithms of treatment responses and in particular CPAP adherence. Expected original results and building such a network will provide a strong rationale for future application to European projects (H2020), industrial collaborations, and design of large scale randomized controlled trials, beside improvements in personalized OSA care.

Maria R Bonsignore and Oreste Marrone, Palermo, Italy
Jan Hedner, Gothenburg, Sweden

Ludger Grote, Gothenburg, Sweden
Jean-Louis Pepin, Grenoble, France
Sebastien Bailly, Grenoble, France
Stefan Mihaicuta, Timisoara, Romania
Sofia Schiza, Crete, Greece
Frederick Gagnadoux, Angers, France
Thomas Penzel, Berlin, Germany
Johan Verbraecken, Antwerp, Belgium
Gianfranco Parati, Milan, Italy
Tarja Saaresranta, Turku, Finland (Skype)
George Vavougios, Larissa, Greece, (Skype)


III.    Presentation of the ESADA at major European Meetings during 2018

ESRS Congress Basel

  1. Hypertension control in OSA – data from the European Sleep Apnea Database
    Svedmyr S, Sweden (poster)
  2. Clinical judgement in mild OSA – data from the European Sleep Apnoea Database (ESADA) study
    I. Bouloukaki, Greece (poster)
  3. Positional dependency in mild obstructive sleep apnoea in the European Sleep Apnoea Database (ESADA) study.
    I. Bouloukaki, Greece (poster)
  4. Arrhythmias and sleep related breathing disorders: data from the European Sleep Apnoea Database (ESADA)
    C. Lombardi, Italy (oral presentation)
  5. Sleep fragmentation in sleep disordered breathing based on a large database (ESADA)
    T. Penzel, Germany (oral presentation)
  6. Seasonal differences in obstructive sleep apnea severity. Results from the European Sleep Apnea Database (ESADA)
    R. Staats, Portugal (oral presentation)European Sleep Apnea Network Symposium: New insights in the Clinical Picture of Sleep Apnea – findings from the European Sleep Apnea Database (ESADA)
  7. The 10th Anniversary of the ESADA database – lessons learned and visions for the future.
    Jan Hedner, Sweden (oral presentation)
  8. Clinical Phenotypes of obstructive sleep apnea – a cluster analysis using ‘Big data’
    Sebastien Bailly, France (oral presentation)
  9. Mild sleep apnea – the European perspective
    Izolde Bouloukaki, Greece (oral presentation)
  10. Metabolic consequences of sleep apnea and the impact of treatment
    Canan Gunduz, Turkey (oral presentation)

ERS Congress Paris

  1. Hypoxia and cardiovascular comorbidity in the ESADA OSA patients with insomnia symptoms
    Ulla Anttalainen (Finland) (oral presentation)
  2. Mild obstructive sleep apnoea (OSA) and arterial hypertension in the
    European Sleep Apnoea Database (ESADA) cohort study.
    Sofia Schiza (Greece), (oral presentation)
  3. Determinants of daytime sleepiness in mild obstructive sleep apnoea syndrome.
    Data from the European Sleep Apnoea Database (ESADA) cohort study.
    Paschalis Steiropoulos (Greece) (poster discussion)
  4. Positional obstructive sleep apnea in the European Sleep Apnoea Database (ESADA) study
    Izolde Bouloukaki (Greece), (poster discussion)

Ludger Grote on behalf of the ESADA study group, European Sleep Apnea Network

Newsletter December 2018

Sleep Apnea Network / European Sleep Apnea Database – ESADA